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Genomes and Genes | A T BrungerSummaryAffiliation: Yale University Country: USA Publications
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Publications
X-ray crystallography and NMR reveal complementary views of structure and dynamicsA T Brunger
Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06250, USA
Nat Struct Biol 4:862-5. 1997..Taken together they can provide an atomic detail picture of macromolecular structure and dynamics which can be used to obtain an understanding of life processes at the molecular level...- Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interactionR B Sutton
The Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06520, USA
J Cell Biol 147:589-98. 1999..A model of synaptotagmin's involvement in Ca(+2)-dependent regulation of membrane fusion through its interaction with the SNARE complex is presented... - Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZF)J Hyman
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
J Cell Biol 149:537-46. 2000..These findings suggest that epsin 1 may function in a signaling pathway connecting the endocytic machinery to the regulation of nuclear function... - Structural insights into the molecular mechanism of Ca(2+)-dependent exocytosisA T Brunger
Department of Molecular Biophysics and Biochemistry, The Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA
Curr Opin Neurobiol 10:293-302. 2000..Ultimately, this knowledge of the structures of higher-order complexes and their dynamic behavior will allow us to obtain a full understanding of the vesicle fusion protein machinery... - Recent developments for the efficient crystallographic refinement of macromolecular structuresA T Brunger
Howard Hughes Medical Institute, Yale University, New Haven, CT 06511, USA
Curr Opin Struct Biol 8:606-11. 1998..In combination with automated model building methods, the amount of manual intervention required to complete and refine a structure is greatly reduced... - Crystallography & NMR system: A new software suite for macromolecular structure determinationA T Brunger
The Howard Hughes Medical Institute, Yale University, New Haven, CT 06511, USA, and Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA
Acta Crystallogr D Biol Crystallogr 54:905-21. 1998..User-friendly task-oriented input files are available for nearly all aspects of macromolecular structure determination by X-ray crystallography and solution NMR... - Dramatic structural and thermodynamic consequences of repacking a protein's hydrophobic coreM A Willis
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
Structure 8:1319-28. 2000..A family of Rop variants in which the hydrophobic core was systematically redesigned has previously been created and characterized... - Crystal structure of the vesicular transport protein Sec17: implications for SNAP function in SNARE complex disassemblyL M Rice
Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06520, USA
Mol Cell 4:85-95. 1999..Possible models of SNAP:SNARE binding suggest that SNAPs may function as lever arms, transmitting forces generated by conformational changes in NSF/Sec18 to drive disassembly of SNARE complexes... - Structural insights into the molecular mechanism of calcium-dependent vesicle-membrane fusionA T Brunger
The Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Curr Opin Struct Biol 11:163-73. 2001..Ultimately, knowledge of the structures of higher-order complexes and their dynamic behavior will be required to obtain a full understanding of the vesicle fusion protein machinery... - Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3AC Ostermeier
The Howard Hughes Medical Institute and Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
Cell 96:363-74. 1999..RabCDRs could be major determinants of effector specificity during vesicle trafficking and fusion... - Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolutionR B Sutton
The Howard Hughes Medical Institute, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
Nature 395:347-53. 1998..These characteristics may be important for membrane fusion and for the binding of regulatory factors affecting neurotransmission... - Folding intermediates of SNARE complex assemblyK M Fiebig
The Howard Hughes Medical Institute, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
Nat Struct Biol 6:117-23. 1999..Our data suggest a directed assembly process beginning distal to the membrane surfaces and proceeding toward them, bringing membranes into close proximity and possibly leading to membrane fusion... - Polar residues drive association of polyleucine transmembrane helicesF X Zhou
Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Ave, New Haven, CT 06520-8114, USA
Proc Natl Acad Sci U S A 98:2250-5. 2001..Furthermore, such interactions can allow structural flexibility required for the function of some membrane proteins... - NMR analysis of helix I from the 5S RNA of Escherichia coliS A White
Department of Chemistry, Yale University, New Haven, Connecticut 06511
Biochemistry 31:1610-21. 1992..The conformations of the terminal residues of helix I, which corresponds to bases (-1)-11 and 108-120 of native 5S RNA, are less well-determined, and their sugar puckers are intermediate between C2' and C3'-endo, on average... - Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognitionD L Daniels
The Howard Hughes Medical Institute and Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
Nat Struct Biol 5:317-25. 1998..The C-terminal carboxylate binding loop of the PDZ domain is structurally conserved in both classes suggesting a generalized carboxylate binding motif (h-Gly-h) where h is a hydrophobic residue... - Helicity, membrane incorporation, orientation and thermal stability of the large conductance mechanosensitive ion channel from E. coliI T Arkin
Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA
Biochim Biophys Acta 1369:131-40. 1998..Here, we present and discuss this initial set of structural data on this new family of ion-channel proteins... - Improved prediction for the structure of the dimeric transmembrane domain of glycophorin A obtained through global searchingP D Adams
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
Proteins 26:257-61. 1996..An increase in the van der Waals interaction energy due to tighter packing compensates for the loss of the interhelical hydrogen bond observed between Thr-87 of each helix in the previous model... - Highly specific interactions between botulinum neurotoxins and synaptic vesicle proteinsA T Brunger
Howard Hughes Medical Institute, Stanford, CA, USA
Cell Mol Life Sci 65:2296-306. 2008..In this review we discuss the structural basis for botulinum toxin's exquisite specificity for its neuronal cell-surface receptors and intracellular SNARE targets... - Human ornithine aminotransferase complexed with L-canaline and gabaculine: structural basis for substrate recognitionS A Shah
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
Structure 5:1067-75. 1997.... - Conformational variability in the refined structure of the chaperonin GroEL at 2.8 A resolutionK Braig
Department of Genetics, Yale University, New Haven, Connecticut 06510, USA
Nat Struct Biol 2:1083-94. 1995..The variability of these regions may play a role in the ability of GroEL to bind a wide variety of substrates... - A smooth and differentiable bulk-solvent model for macromolecular diffractionT D Fenn
Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford, California, USA
Acta Crystallogr D Biol Crystallogr 66:1024-31. 2010..The models are easily implemented into crystallographic software packages and can be used as a general method for bulk-solvent correction in macromolecular crystallography... - Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholambanP D Adams
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
Nat Struct Biol 2:154-62. 1995..The model is a left-handed symmetric homopentamer of alpha-helices with a well-defined channel, lined solely by hydrophobic residues...