JONATHAN BOGAN

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking
    Jonathan S Bogan
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nature 425:727-33. 2003
  2. ncbi Biogenesis and regulation of insulin-responsive vesicles containing GLUT4
    Jonathan S Bogan
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Curr Opin Cell Biol 22:506-12. 2010
  3. ncbi The glucose transporter 4-regulating protein TUG is essential for highly insulin-responsive glucose uptake in 3T3-L1 adipocytes
    Chenfei Yu
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 282:7710-22. 2007
  4. ncbi Cholesterol regulates glucose-stimulated insulin secretion through phosphatidylinositol 4,5-bisphosphate
    Mingming Hao
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University, P O Box 208020, New Haven, CT 06520 8020, USA
    J Biol Chem 284:29489-98. 2009
  5. ncbi Influence of insulin in the ventromedial hypothalamus on pancreatic glucagon secretion in vivo
    Sachin A Paranjape
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes 59:1521-7. 2010
  6. ncbi Intracellular retention and insulin-stimulated mobilization of GLUT4 glucose transporters
    Bradley R Rubin
    Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520 8020, USA
    Vitam Horm 80:155-92. 2009
  7. ncbi Solution structure and backbone dynamics of an N-terminal ubiquitin-like domain in the GLUT4-regulating protein, TUG
    M Cristina Tettamanzi
    Department of Laboratory Medicine, Yale University, New Haven, CT 06520 8035, USA
    Protein Sci 15:498-508. 2006
  8. ncbi T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin
    Christopher Hug
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 101:10308-13. 2004

Research Grants

  1. FUNCTIONAL CLONING OF PROTEINS USED IN GLUT4 TRAFFICKING
    JONATHAN BOGAN; Fiscal Year: 2002
  2. Proteomic charaterization of insulin signaling targets
    JONATHAN BOGAN; Fiscal Year: 2006
  3. Insulin stimulated ubiquitin-like modification
    JONATHAN BOGAN; Fiscal Year: 2009
  4. Insulin stimulated ubiquitin-like modification
    Jonathan S Bogan; Fiscal Year: 2010

Collaborators

Detail Information

Publications8

  1. ncbi Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking
    Jonathan S Bogan
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nature 425:727-33. 2003
    ..Our data suggest that TUG traps endocytosed GLUT4 and tethers it intracellularly, and that insulin mobilizes this pool of retained GLUT4 by releasing this tether...
  2. ncbi Biogenesis and regulation of insulin-responsive vesicles containing GLUT4
    Jonathan S Bogan
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Curr Opin Cell Biol 22:506-12. 2010
    ..In addition to acting at other steps in vesicle recycling, insulin releases this retention mechanism to promote the translocation and fusion of the vesicles at the cell surface...
  3. ncbi The glucose transporter 4-regulating protein TUG is essential for highly insulin-responsive glucose uptake in 3T3-L1 adipocytes
    Chenfei Yu
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 282:7710-22. 2007
    ....
  4. ncbi Cholesterol regulates glucose-stimulated insulin secretion through phosphatidylinositol 4,5-bisphosphate
    Mingming Hao
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University, P O Box 208020, New Haven, CT 06520 8020, USA
    J Biol Chem 284:29489-98. 2009
    ..The inability to increase cytosolic Ca2+ may be the main underlying factor to account for impaired glucose-stimulated insulin secretion in cholesterol-overloaded beta-cells...
  5. ncbi Influence of insulin in the ventromedial hypothalamus on pancreatic glucagon secretion in vivo
    Sachin A Paranjape
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes 59:1521-7. 2010
    ..Insulin released by the beta-cell is thought to act locally to regulate glucagon secretion. The possibility that insulin might also act centrally to modulate islet glucagon secretion has received little attention...
  6. ncbi Intracellular retention and insulin-stimulated mobilization of GLUT4 glucose transporters
    Bradley R Rubin
    Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520 8020, USA
    Vitam Horm 80:155-92. 2009
    ..Finally, it is not known if defects in the formation or intracellular retention of GSVs contribute to human insulin resistance, or play a role in the pathogenesis of type 2 diabetes...
  7. ncbi Solution structure and backbone dynamics of an N-terminal ubiquitin-like domain in the GLUT4-regulating protein, TUG
    M Cristina Tettamanzi
    Department of Laboratory Medicine, Yale University, New Haven, CT 06520 8035, USA
    Protein Sci 15:498-508. 2006
    ..Instead, we speculate on the possible significance of a concentrated area of negative electrostatic potential with increased backbone mobility, both of which are features suggestive of a potential protein-protein interaction site...
  8. ncbi T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin
    Christopher Hug
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 101:10308-13. 2004
    ..Because T-cadherin is a glycosylphosphatidylinositol-anchored extracellular protein, it may act as a coreceptor for an as-yet-unidentified signaling receptor through which adiponectin transmits metabolic signals...

Research Grants7

  1. FUNCTIONAL CLONING OF PROTEINS USED IN GLUT4 TRAFFICKING
    JONATHAN BOGAN; Fiscal Year: 2002
    ..Further subdivision of clonal pools will result in the identification of single cell lines containing cDNAs which alter GLUT4 trafficking, which will be sequenced by PCR. ..
  2. Proteomic charaterization of insulin signaling targets
    JONATHAN BOGAN; Fiscal Year: 2006
    ..Additionally, this work may have broader implications for insulin signaling and for protein targeting. ..
  3. Insulin stimulated ubiquitin-like modification
    JONATHAN BOGAN; Fiscal Year: 2009
    ..It is anticipated that the proposed studies of insulin action and glucose uptake will lead to a greater understanding of mechanisms that may contribute to the development of type 2 diabetes. ..
  4. Insulin stimulated ubiquitin-like modification
    Jonathan S Bogan; Fiscal Year: 2010
    ..It is anticipated that the proposed studies of insulin action and glucose uptake will lead to a greater understanding of mechanisms that may contribute to the development of type 2 diabetes. ..