Detail Information
Publications
Prediction of drug particle size and content uniformity in low-dose solid dosage formsChien Yueh Huang
Pharmaceutical Development, Wyeth Research, 401 N Middletown Road, Pearl River, NY 10965, United States
Int J Pharm 383:70-80. 2010..Furthermore, we showed quantitatively the lowest dose limit can be drastically reduced if a cut-off size is imposed by removing oversized particles...
Asymmetry effect of particle size distribution on content uniformity and over-potency risk in low-dose solid drugsChien Yueh Huang
Pharmaceutical Development, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
J Pharm Sci 99:4351-62. 2010..It was found that for a given specification of volume median and 90% diameters (d(50) and d(90)), the dosage strength must increase by 10 times if the API asymmetry parameter changes from 1 (log-normal) to 1.1...
