Research Topics
| TIMOTHY NURKIEWICZSummaryAffiliation: West Virginia University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Particulate matter exposure impairs systemic microvascular endothelium-dependent dilationTimothy R Nurkiewicz
Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9229, USA
Environ Health Perspect 112:1299-306. 2004....- Pulmonary nanoparticle exposure disrupts systemic microvascular nitric oxide signalingTimothy R Nurkiewicz
Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
Toxicol Sci 110:191-203. 2009..These results indicate that in conjunction with microvascular dysfunction, nanoparticle exposure also decreases NO bioavailability through at least two functionally distinct mechanisms that may mutually increase local reactive species... - Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunctionTimothy R Nurkiewicz
Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV, USA
Part Fibre Toxicol 5:1. 2008..abstract:.. - Systemic microvascular dysfunction and inflammation after pulmonary particulate matter exposureTimothy R Nurkiewicz
Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9229, USA
Environ Health Perspect 114:412-9. 2006..Collectively, these microvascular observations are consistent with events that contribute to the disruption of the control of peripheral resistance and/or cardiac dysfunction associated with PM exposure... - Hospitalization patterns associated with Appalachian coal miningMichael Hendryx
Department of Community Medicine and Institute for Health Policy Research, West Virginia University, Morgantown, West Virginia 26506, USA
J Toxicol Environ Health A 70:2064-70. 2007..Exposure to particulates or other pollutants generated by coal mining activities may be linked to increased risk of COPD and hypertension hospitalizations. Limitations in the data likely result in an underestimate of associations... - Calcium-independent release of endothelial nitric oxide in the arteriolar network: onset during rapid juvenile growthTimothy R Nurkiewicz
Department of Physiology and Pharmacology, and the Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, West Virginia, USA
Microcirculation 11:453-62. 2004..This is consistent with the idea that microvascular control mechanisms are not fixed at birth, but rather undergo progressive changes in concert with microvascular network growth and changes in tissue metabolic requirements... - High salt intake reduces endothelium-dependent dilation of mouse arterioles via superoxide anion generated from nitric oxide synthaseTimothy R Nurkiewicz
Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, PO Box 9105, Robert C Byrd Health Sciences Center, Morgantown, WV 26506 9105, USA
Am J Physiol Regul Integr Comp Physiol 292:R1550-6. 2007..These data suggest that a high salt diet promotes increased generation of superoxide anion from NOS in the murine skeletal muscle microcirculation, thus impairing endothelium-dependent dilation through reduced NO bioavailability... - Reduced arteriolar responses to skeletal muscle contraction after ingestion of a high salt dietPaul J Marvar
Department of Physiology and Pharmacology, and Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV 265056-9229, USA
J Vasc Res 42:226-36. 2005.... - Decreased arteriolar tetrahydrobiopterin is linked to superoxide generation from nitric oxide synthase in mice fed high saltTimothy R Nurkiewicz
Center for Cardiovascular and Respiratory Sciences, West Virginia University, School of Medicine, Morgantown, WV 26506 9105, USA
Microcirculation 17:147-57. 2010..We explored the possibility that "uncoupled" endothelial nitric oxide synthase (eNOS) is the source of this O(2) (-)... - Age, gender, and hormonal status modulate the vascular toxicity of the diesel exhaust extract phenanthraquinoneRhonda D Prisby
Faculte de Medecine, Laboratoire de Biologie du Tissue Osseux, Université Jean Monnet, Saint Etienne, Cedex, France
J Toxicol Environ Health A 71:464-70. 2008..g., elderly, males, and postmenopausal women) may be more susceptible to the adverse consequences of airborne pollutants...
Research Grants
- Endothelial Transduction of Shear StressTIMOTHY NURKIEWICZ; Fiscal Year: 2003..abstract_text> ..
- Remote Microvascular Dysfunction After Particulate Matter ExposureTIMOTHY NURKIEWICZ; Fiscal Year: 2007..A fundamental understanding of these mechanisms is vital to the prevention and treatment of life-threatening cardiovascular events, and will contribute to control strategy development. ..
- Remote Microvascular Dysfunction After Particulate Matter ExposureTimothy R Nurkiewicz; Fiscal Year: 2010..A fundamental understanding of these mechanisms is vital to the prevention and treatment of life-threatening cardiovascular events, and will contribute to control strategy development. ..