Research Topics
Species | A S PrasadSummaryAffiliation: Wayne State University Country: USA Publications
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Detail Information
Publications
Effects of zinc deficiency on Th1 and Th2 cytokine shiftsA S Prasad
Wayne State University, University Health Center, Detroit, MI 48201, USA
J Infect Dis 182:S62-8. 2000..Decreased production of IL-2 in zinc deficiency may be due to decreased activation of NF-kappaB and subsequent decreased gene expression of IL-2 and IL-2 receptors...- Antioxidant effect of zinc in humansAnanda S Prasad
Department of Medicine, Division of Hematology Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Free Radic Biol Med 37:1182-90. 2004..Zinc administration to human subjects with conditions associated with increased oxidative stress should be explored... - Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stressAnanda S Prasad
Wayne State University School of Medicine, Detroit, MI, and The University of Michigan, Ann Arbor, MI 48201, USA
Am J Clin Nutr 85:837-44. 2007..Zinc deficiency, cell-mediated immune dysfunction, susceptibility to infections, and increased oxidative stress have been observed in elderly subjects (ie, those >55 y old). Zinc is an effective antiinflammatory and antioxidant agent... - Zinc in human health: effect of zinc on immune cellsAnanda S Prasad
Wayne State University School of Medicine, Detroit, Michigan 48201, United States of America
Mol Med 14:353-7. 2008..We have reported recently that in both young adults and elderly subjects, zinc supplementation decreased oxidative stress markers and generation of inflammatory cytokines... - Zinc-suppressed inflammatory cytokines by induction of A20-mediated inhibition of nuclear factor-?BAnanda S Prasad
Department of Internal Medicine, Division of Hematology Oncology, Karmanos Cancer Center, Wayne State University School of Medicine, Detroit, Michigan, USA
Nutrition 27:816-23. 2011.... - Zinc: mechanisms of host defenseAnanda S Prasad
Department of Internal Medicine, Division of Hematology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
J Nutr 137:1345-9. 2007..We conclude that zinc has an important role in cell-mediated immune functions and also functions as antiinflammatory and antioxidant agent... - Clinical, immunological, anti-inflammatory and antioxidant roles of zincAnanda S Prasad
Wayne State University School of Medicine, Detroit, MI 48201, USA
Exp Gerontol 43:370-7. 2008..In cell culture studies, we have observed that zinc induces A20 which inhibits NF-kappaB activation resulting in decreased generation of inflammatory cytokines... - Duration and severity of symptoms and levels of plasma interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor, and adhesion molecules in patients with common cold treated with zinc acetateAnanda S Prasad
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Infect Dis 197:795-802. 2008..Zinc lozenges have been used for treatment of the common cold; however, the results remain controversial... - Zinc: role in immunity, oxidative stress and chronic inflammationAnanda S Prasad
Department of Internal Medicine, Division of Hematology Oncology, Wayne State University, School of Medicine, Detroit, Michigan, USA
Curr Opin Clin Nutr Metab Care 12:646-52. 2009..These efforts were aimed at either supporting immunity by zinc administration or correcting the zinc dependent immune functions in zinc deficient individuals... - Dietary zinc and prostate cancer in the TRAMP mouse modelAnanda S Prasad
Department of Internal Medicine, Division of Hematology Oncology, Wayne State University, Detroit, Michigan 48201, USA
J Med Food 13:70-6. 2010..We conclude that optimal prostate zinc concentration has a protective role against cancer... - Impact of the discovery of human zinc deficiency on healthAnanda S Prasad
Wayne State University School of Medicine, 1122 Elliman Bldg, 421 East Canfield, Detroit, MI 48201, USA
J Am Coll Nutr 28:257-65. 2009..A controlled clinical trial of zinc supplementation in these disorders in order to document the preventive and therapeutic effects of zinc is warranted... - Zinc in cancer preventionAnanda S Prasad
Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Nutr Cancer 61:879-87. 2009..Based on the above, we recommend further studies and propose that zinc should be utilized in the management and chemoprevention of cancer... - Correction of interleukin-2 gene expression by in vitro zinc addition to mononuclear cells from zinc-deficient human subjects: a specific test for zinc deficiency in humansAnanda S Prasad
Department of Medicine, Division of Hematology Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Mich 48201, USA
Transl Res 148:325-33. 2006.... - Zinc enhances the expression of interleukin-2 and interleukin-2 receptors in HUT-78 cells by way of NF-kappaB activationAnanda S Prasad
Department of Medicine, Division of Hematology Oncology, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, University Health Center 5 C, 4201 St Antoine, Detroit, MI 48201, USA
J Lab Clin Med 140:272-89. 2002..We also document that the binding of NF-kappaB to DNA was adversely affected, thereby decreasing the gene expression of IL-2 and IL-2 Ralpha in zinc-deficient HUT-78 cells... - Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in sickle cell disease patientsBin Bao
Department of Internal Medicine, Division of Hematology Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Transl Res 152:67-80. 2008..Zinc supplementation also increased relative levels of IL-2 and IL-2Ralpha mRNAs in phytohemagglutinin-p-stimulated MNCs. These results suggest that zinc supplementation may be beneficial to SCD patients... - Zinc modulates mRNA levels of cytokinesBin Bao
Internal Medicine Department, Wayne State University Medical School, Detroit, MI 48201, USA
Am J Physiol Endocrinol Metab 285:E1095-102. 2003..Our study shows that the effect of zinc on gene expression and production of cytokines is cell lineage specific... - Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agentBin Bao
Department of Internal Medicine, Wayne State University, Detroit, MI, USA
Am J Clin Nutr 91:1634-41. 2010..Zinc is an essential micronutrient that can function as an antiinflammatory and antioxidative agent, and as such, it may have atheroprotective properties... - Zinc activates NF-kappaB in HUT-78 cellsA S Prasad
Department of Medicine, Division of Hematology-Oncology, Wayne State University School of Medicine, Detroit, Michigan, USA
J Lab Clin Med 138:250-6. 2001..We also demonstrate that the binding of recombinant NF-kappaB (p50)(2) to DNA in HUT-78 cells was zinc specific. We conclude that zinc plays an important role in the activation of NF-kappaB in HUT-78 cells... - Zinc up-regulates NF-kappaB activation via phosphorylation of IkappaB in HUT-78 (Th0) cellsBin Bao
Department of Internal Medicine, Wayne State University School of Medicine, 2221 Elliman Building, 421 E Canfield, Detroit, MI, USA
FEBS Lett 581:4507-11. 2007..However, dominant negative IkappaB gene expression decreased these parameters in zinc-sufficient cells, suggesting that zinc increased NF-kappaB activation via IkappaB pathway... - Evidence for reprogramming global gene expression during zinc deficiency in the HUT-78 cell lineFrances W J Beck
Department of Internal Medicine, Division of Hematology, Wayne State University School of Medicine, Detroit, Michigan, USA
Nutrition 22:1045-56. 2006.... - Zinc in cancer preventionAnanda S Prasad
Department of Medicine (Division of Hematology-Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine Detroit, MI 48201, USA
Cancer Metastasis Rev 21:291-5. 2002..Preclinical and clinical studies need to investigate modulation of genetic and epigenetic pathways of carcinogenesis by zinc... - Serum thymulin in human zinc deficiencyA S Prasad
Department of Medicine, Harper Grace Hospital, Detroit, Michigan
J Clin Invest 82:1202-10. 1988..Inasmuch as thymulin is known to induce intra- and extrathymic T cell differentiation, our studies provide a possible mechanism for the role of zinc on T cell functions... - Differential expression of hZnT-4 in human prostate tissuesFrances W J Beck
Department of Internal Medicine, Division of Hematology Oncology and Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Prostate 58:374-81. 2004..It is not known whether loss of zinc, necessary to restrain aggressive growth, results from loss of a single specific or multiple zinc transporters... - Zinc deficiency: its characterization and treatmentAnanda S Prasad
Wayne State University School of Medicine, University Health Center 5C, 4201 St. Antoine, Detroit, MI 48201, USA
Met Ions Biol Syst 41:103-37. 2004 - A new mutation in exon 3 of the SCL39A4 gene in a Tunisian family with severe acrodermatitis enteropathicaSheila P Meftah
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
Nutrition 22:1067-70. 2006..7 kb. We describe a novel mutation in a Tunisian family in which a chain termination codon in exon 3 yielded a truncated ZIP4 zinc transporter protein... - Zinc deficiency in Mexican American children: influence of zinc and other micronutrients on T cells, cytokines, and antiinflammatory plasma proteinsHarold H Sandstead
Division of Human Nutrition, Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555 1109, USA
Am J Clin Nutr 88:1067-73. 2008..The Third National Health and Nutrition Examination Survey suggested some Mexican American children are at risk of zinc deficiency... - Zinc deficiency in patients with sickle cell diseaseAnanda S Prasad
Am J Clin Nutr 75:181-2. 2002 - Zinc deficiencyAnanda S Prasad
BMJ 326:409-10. 2003