Research Topics
Species | ADHIP N MAJUMDARSummaryAffiliation: Wayne State University Country: USA Publications
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Detail Information
Publications
Age-associated loss of heterozygosity of tumor suppressor genes in the gastric mucosa of humansLathika Moragoda
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Am J Physiol Gastrointest Liver Physiol 282:G932-6. 2002..Our observation that subjects over 60 yr of age show mutation in one or more of the tumor suppressor genes suggests an age-related increase in predisposition of the stomach to neoplasia...- Chemopreventive role of folic acid in colorectal cancerAdhip P N Majumdar
Veterans Affairs Medical Center, Karmanos Cancer Institute, Department of Internal Medicine, Wayne State University, Detroit, Michigan 48201, USA
Front Biosci 9:2725-32. 2004..The folic acid mediated reduction of EGFR function could partly be the result of suppression of EGFR gene through increased methylation of CpG sequences within its promoter... - EGFR regulation of colon cancer stem-like cells during aging and in response to the colonic carcinogen dimethylhydrazineJyoti Nautiyal
John D Dingell VA Medical Center, 4646 John R, Rm B 4238, Detroit, MI 48201
Am J Physiol Gastrointest Liver Physiol 302:G655-63. 2012..EGFR inhibition attenuates these changes, indicating a role for EGFR in age- and mutagen-associated changes in CSLCs... - The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheresShailender S Kanwar
Department of Internal Medicine, School of Medicine, Wayne State University, Detroit, MI 48201, USA
Mol Cancer 9:212. 2010..Human colon cancer cells HCT-116 (p53 wild type; K-ras mutant), HCT-116 (p53 null; K-ras mutant) and HT-29 (p53 mutant) were used... - Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cellsJyoti Nautiyal
Veterans Affairs Medical Center, Wayne State University, Detroit, MI 48201, USA
J Mol Signal 6:7. 2011..Our data suggest that the combination therapy of dasatinib and curcumin may be a therapeutic strategy for re-emergence of chemo-resistant colon cancer by targeting CSC sub-population... - Curcumin synergizes with resveratrol to inhibit colon cancerAdhip P N Majumdar
John D Dingell VA Medical Center, 4646 John R, Room B 4238, Detroit, MI 48201, USA
Nutr Cancer 61:544-53. 2009..Our current data suggest that the combination of curcumin and resveratrol could be an effective preventive/therapeutic strategy for colon cancer... - Cell cycle and apoptosis regulatory protein-1: a novel regulator of apoptosis in the colonic mucosa during agingAdhip P N Majumdar
Veterans Affairs Medical Center, Wayne State University, Detroit, MI 48201, USA
Am J Physiol Gastrointest Liver Physiol 293:G1215-22. 2007..Taken together, our data suggest that not only EGFR but also its other members are involved in regulating colonic mucosal growth during aging and that CARP-1 may play a crucial role in transducing EGFRs signals... - Therapeutic potential of EGFR-related protein, a universal EGFR family antagonistAdhip P N Majumdar
John D Dingell VA Medical Center, 4646 John R Room B 4238, Detroit, MI 48201, USA
Future Oncol 1:235-45. 2005.... - Phosphatidylinositol 3-kinase/Akt signaling stimulates colonic mucosal cell survival during agingAdhip P N Majumdar
Veterans Affairs Medical Center, and Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA
Am J Physiol Gastrointest Liver Physiol 290:G49-55. 2006..We conclude that the constitutive activation of the PI3K/Akt-signaling pathway is partly responsible for the age-related increase in colonic mucosal cell survival. This is evident throughout the entire length of the colonic crypt... - Regulation of gastrointestinal mucosal growth during agingA P N Majumdar
Veterans Administration Medical Center, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48322, USA
J Physiol Pharmacol 54:143-54. 2003.... - Schlafen-3 decreases cancer stem cell marker expression and autocrine/juxtacrine signaling in FOLFOX-resistant colon cancer cellsPhil Sun Oh
Veterans Affairs Medical Center, Wayne State University, Detroit, Michigan, USA
Am J Physiol Gastrointest Liver Physiol 301:G347-55. 2011..Thus Slfn-3 expression may render colon CSCs more susceptible to cancer chemotherapeutics... - EGFR(S) inhibitors in the treatment of gastro-intestinal cancers: what's new?Shailender Singh Kanwar
Veterans Affairs Medical Center, Wayne State University, Detroit, MI 48201, USA
Curr Drug Targets 11:682-98. 2010..Current review describes the recent role of targeted therapies, specifically EGFR inhibitors in the treatment of GI cancers. Importance of dietary agents in the treatment and prevention of GI cancers is also reviewed... - Folic acid-mediated inhibition of serum-induced activation of EGFR promoter in colon cancer cellsKiran K Nagothu
Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
Am J Physiol Gastrointest Liver Physiol 287:G541-6. 2004..This could partly be responsible for FA-mediated inhibition of growth-related processes in colorectal neoplasia... - Mechanisms of curcumin- and EGF-receptor related protein (ERRP)-dependent growth inhibition of colon cancer cellsSudha Reddy
Veterans Affairs Medical Center, Karmanos Cancer Institute, Department of Internal Medicine, Michigan 48201, USA
Nutr Cancer 55:185-94. 2006..The superior effects of the combinatorial treatment could partly be attributed to inhibition of constitutive activation of EGFRs and IGF-1R signaling pathways... - Transactivator of transcription-tagged cell cycle and apoptosis regulatory protein-1 peptides suppress the growth of human breast cancer cells in vitro and in vivoLiyue Zhang
Veterans Affairs Medical Center, Wayne State University, Detroit, Michigan 48201, USA
Mol Cancer Ther 6:1661-72. 2007..We conclude that CARP-1 is a suppressor of human breast cancer growth, and its expression is diminished in tumors, in part, by methylation-dependent silencing... - Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1RBhaumik B Patel
John D Dingell VA Medical Center, Wayne State University, Detroit, MI 48201, USA
Int J Cancer 122:267-73. 2008..We also suggest that inclusion of curcumin to the conventional chemotherapeutic agent(s)/regimen could be an effective therapeutic strategy for colorectal cancer... - Expression of EGF-receptor related protein (ERRP) decreases in gastric mucosa during aging and carcinogenesisAdhip P N Majumdar
Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
Dig Dis Sci 48:856-64. 2003..We conclude that increased activation of EGFR in the gastric mucosa during aging and carcinogenesis may partly be due to the loss of ERRP... - Regulation of TGF-alpha-induced activation of AP-1 in the aging gastric mucosaZhi-Qiang Xiao
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Am J Physiol Gastrointest Liver Physiol 285:G396-403. 2003.... - Expression of intestinal ornithine decarboxylase during postnatal development in neonatal ratsChuan Hao Lin
Department of Pediatrics, Division of Gastroenterology and Nutrition, Wayne State University and Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit 48201, USA
Biochim Biophys Acta 1589:298-304. 2002..A better understanding of the regulation of polyamine biosynthesis during postnatal development of the small intestine will provide insights contributing to the maturation of the small intestine... - Cell cycle- and apoptosis-regulatory protein-1 is involved in apoptosis signaling by epidermal growth factor receptorArun K Rishi
Veterans Affairs Medical Center, Wayne State Umiversity, Detroit, Michigan 48201, USA
J Biol Chem 281:13188-98. 2006..Together, data demonstrate that tyrosine 192 of CARP-1 is a target of apoptosis signaling, and CARP-1, in turn, promotes apoptosis by activating p38 MAPK and caspase-9... - Antitumor activity of epidermal growth factor receptor-related protein is mediated by inactivation of ErbB receptors and nuclear factor-kappaB in pancreatic cancerYuxiang Zhang
Department of Pathology, Karmanos Cancer Institute, Wayne State University of Medicine, Detroit, MI 48201, USA
Cancer Res 66:1025-32. 2006..In summary, our results suggest that ERRP is an effective pan-erbB inhibitor, which could be a potential therapeutic agent for pancreatic cancers expressing different levels and subclasses of erbB family of proteins... - Epidermal growth factor receptor (EGFR)-related protein inhibits multiple members of the EGFR family in colon and breast cancer cellsHu Xu
John D Dingell Veterans Affairs Medical Center, 4646 John R, Room B 4238, Detroit, MI 48201, USA
Mol Cancer Ther 4:435-42. 2005..Our results suggest that ERRP is an effective pan-erbB inhibitor and, thus, may be a potential therapeutic agent for a wide variety of epithelial cancers expressing different levels and subclasses of EGFRs... - Folic acid reduces nuclear translocation of beta-catenin in rectal mucosal crypts of patients with colorectal adenomasRichard Jaszewski
Division of Gastroenterology, and Department of Internal Medicine, Veterans Affairs Medical Center, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Cancer Lett 206:27-33. 2004..05) and cellular expression of pGSK3beta (P < 0.01) when compared to placebo. Folic acid may exert its chemopreventive effect, at least in part, through inhibition of nuclear translocation of beta-catenin... - Epidermal growth factor receptor-related protein inhibits cell growth and induces apoptosis of BxPC3 pancreatic cancer cellsYuxiang Zhang
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
Cancer Res 65:3877-82. 2005..We also suggest that ERRP could be a potential therapeutic agent for pancreatic cancer... - Folic acid mediated attenuation of loss of heterozygosity of DCC tumor suppressor gene in the colonic mucosa of patients with colorectal adenomasKiran K Nagothu
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
Cancer Detect Prev 27:297-304. 2003..Taken together, our data suggest that one of the ways folate may exert its chemopreventive effect is by stabilizing certain tumor suppressor gene(s) and preventing further increases in proliferation... - Expression of epidermal growth factor-receptor related protein (ERRP) in human colorectal carcinogenesisRichard Jaszewski
Veterans Affairs Medical Center, Karmanos Cancer Institute, Wayne State University School of Medicine, Research Service 151, 4646 John R, Detroit, MI 48201, USA
Cancer Lett 213:249-55. 2004..002) tumors, respectively. ERRP expression became more attenuated in polyps with increasing grades of dysplasia. In contrast, expression of EGFR was inversely related to ERRP in representative samples of normal and neoplastic tissues... - Age-related loss of EGF-receptor related protein (ERRP) in the aging colon is a potential risk factor for colon cancerEva M Schmelz
Karmanos Cancer Institute, Wayne State University School of Medicine, VA Medical Center 151, 4646 John R Street, Detroit, MI 48201, USA
Mech Ageing Dev 125:917-22. 2004..We also suggest that loss of ERRP could be a risk factor for developing colorectal cancer in the older population... - Reduced expression of epidermal growth factor receptor-related protein in hepatocellular carcinoma: implications for cancer growthWoo Sung Moon
Department of Medicine, VA Medical Center, Long Beach and The University of California, Irvine, CA 90822-5201, USA
Digestion 69:219-24. 2004..The inverse relationship between ERRP expression, proliferative activity of tumor cells and tumor size suggests that in some HCC, ERRP is a negative regulator of HCC growth... - EGF-receptor related protein causes cell cycle arrest and induces apoptosis of colon cancer cells in vitro and in vivoEdi Levi
Veterans Affairs Medical Center, Pathology and Laboratory Medicine Service, Wayne State University School of Medicine, Detroit, MI 48201, USA
Anticancer Res 24:2885-91. 2004.... - Epidermal growth factor receptor-related protein: a potential therapeutic agent for colorectal cancerDorota J Marciniak
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA
Gastroenterology 124:1337-47. 2003..CONCLUSIONS: We propose that epidermal growth factor receptor-related protein inhibits cellular growth by attenuating epidermal growth factor receptor signaling processes and is an effective therapeutic agent for colorectal cancer... - Exfoliated cells in stool: a source for reverse transcription-PCR-based analysis of biomarkers of gastrointestinal cancerYing Jie Yu
Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA
Cancer Epidemiol Biomarkers Prev 17:455-8. 2008..Of all the preservative methods tested, RNAlater had the best performance in terms of overall quality, quantity, and level of genomic DNA contamination, and thus deserves further investigation... - Epidermal growth factor receptor-related peptide inhibits growth of PC-3 prostate cancer cellsDorota J Marciniak
Departments of Internal Medicine and Pathology, John D. Dingell Veterans Affairs Medical Center, Karmanos Cancer Center, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Mol Cancer Ther 3:1615-21. 2004..In summary, our data show that ERRP inhibits the growth of prostate cancer cells by attenuating EGFR signaling processes. ERRP could potentially be an effective therapeutic agent for prostate cancer... - Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related proteinEva M Schmelz
Department of Nutrition and Food Science, Wayne State University, Detriot, Michigan 48220, USA
Cancer Res 67:5389-96. 2007..In conclusion, our data show that ERRP is effective in regressing both early and intermediate intestinal lesions and could be an effective therapeutic agent for colon cancer... - Emerging therapies in gastrointestinal cancersJyoti Nautiyal
Karmanos Cancer Institute, Detroit, MI 48201, United States
World J Gastroenterol 12:7440-50. 2006..It also emphasizes the need to develop pan-ErbB inhibitors and discusses EGF-Receptor Related Protein, a recently isolated negative regulator of EGFR as a potential pan-ErbB therapeutic for a wide variety of epithelial cancers... - EGF receptor-related protein (ERRP) inhibits invasion of colon cancer cells and tubule formation by endothelial cells in vitroArun K Rishi
Veterans Affairs Medical Center, Detroit, Michigan 48201, USA
Anticancer Res 26:1029-37. 2006..In summary, it was demonstrated that ERRP not only inhibits cell growth, but also the processes of cell invasion and blood vessel formation that are critical for the development and progression of carcinogenesis... - Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437Arun K Rishi
Veterans Affairs Medical Center, Department of Internal Medicine and Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
J Biol Chem 278:33422-35. 2003..Identification of CARP-1 as a key mediator of signaling by CD437 or adriamycin allows for delineation of pathways that, in turn, may prove beneficial for design and targeting of novel antitumor agents... - Epidermal growth factor receptor-related protein inhibits cell growth and invasion in pancreatic cancerZhiwei Wang
Departments of Pathology and Internal Medicine, Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University, 110 East Warren Avenue, Detroit, MI 48201, USA
Cancer Res 66:7653-60. 2006..We conclude that ERRP could be an effective agent for inhibiting tumor growth and invasion for the treatment of pancreatic cancer...