Research Topics
Genomes and GenesSpecies | Sonia HassanSummaryAffiliation: Wayne State University Country: USA Publications
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Publications
The transcriptome of the uterine cervix before and after spontaneous term parturitionSonia S Hassan
Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA
Am J Obstet Gynecol 195:778-86. 2006..This study was designed to identify genes differentially expressed in the human uterine cervix after spontaneous term labor...- The molecular basis for sonographic cervical shortening at term: identification of differentially expressed genes and the epithelial-mesenchymal transition as a function of cervical lengthSonia S Hassan
Department of Obstetrics and Gynecology, Wayne State University Hutzel Women s Hospital, 3990 John R, Detroit, MI 48201, USA
Am J Obstet Gynecol 203:472.e1-472.e14. 2010..The purpose of this study was to determine whether cervical shortening of a ripe cervix at term is associated with changes in the cervical transcriptome... - The transcriptome of cervical ripening in human pregnancy before the onset of labor at term: identification of novel molecular functions involved in this processSonia S Hassan
Department of Obstetrics and Gynecology, Wayne State University Hutzel Women s Hospital, Detroit, MI 48201, USA
J Matern Fetal Neonatal Med 22:1183-93. 2009..The aim of this study was to identify changes in the cervical transcriptome in the human uterine cervix as a function of ripening before the onset of labor... - A sonographic short cervix as the only clinical manifestation of intra-amniotic infectionSonia Hassan
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Wayne State University, Hutzel Women s Hospital, 3990 John R, 7 Brush North, MFM Mail Drawer 163, Detroit, MI 48201, USA
J Perinat Med 34:13-9. 2006..This study was conducted to determine the rate of MIAC and intra-amniotic inflammation in patients with a cervical length < 25 mm in the mid-trimester... - Signature pathways identified from gene expression profiles in the human uterine cervix before and after spontaneous term parturitionSonia S Hassan
Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA
Am J Obstet Gynecol 197:250.e1-7. 2007..This study aimed to discover "signature pathways" that characterize biologic processes, based on genes differentially expressed in the uterine cervix before and after spontaneous labor... - Tissue factor and its natural inhibitor in pre-eclampsia and SGAOffer Erez
Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI 48201, USA
J Matern Fetal Neonatal Med 21:855-69. 2008..The aim of this study was to determine the maternal plasma concentrations of TF and its primary inhibitor, tissue factor pathway inhibitor (TFPI), in women who delivered small for gestational age (SGA) neonates, and in pre-eclampsia... - The frequency and clinical significance of intra-amniotic infection and/or inflammation in women with placenta previa and vaginal bleeding: an unexpected observationIchchha Madan
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland and Detroit, MI 48201, USA
J Perinat Med 38:275-9. 2010..The aim of this study was to determine the frequency and clinical significance of IAI in women with placenta previa and vaginal bleeding in the absence of preterm labor... - Acute pyelonephritis during pregnancy changes the balance of angiogenic and anti-angiogenic factors in maternal plasmaTinnakorn Chaiworapongsa
Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, Michigan, USA
J Matern Fetal Neonatal Med 23:167-78. 2010.... - Amniotic fluid angiopoietin-2 in term and preterm parturition, and intra-amniotic infection/inflammationPercy Pacora
Perinatology Research Branch, NICHD NIH DHHS, Wayne State University Hutzel Women s Hospital, Detroit, MI 48201, USA
J Perinat Med 37:503-11. 2009.... - Visfatin/Pre-B cell colony-enhancing factor in amniotic fluid in normal pregnancy, spontaneous labor at term, preterm labor and prelabor rupture of membranes: an association with subclinical intrauterine infection in preterm parturitionShali Mazaki-Tovi
Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, USA
J Perinat Med 36:485-96. 2008.... - Evidence in support of a role for anti-angiogenic factors in preterm prelabor rupture of membranesZeynep Alpay Savasan
Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, Michigan, USA
J Matern Fetal Neonatal Med 23:828-41. 2010..The purpose of this study was to determine whether the soluble form of VEGFR-1 and -2 concentrations in amniotic fluid (AF) change with preterm PROM, intra-amniotic infection/inflammation (IAI), or parturition... - A role of the anti-angiogenic factor sVEGFR-1 in the 'mirror syndrome' (Ballantyne's syndrome)Jimmy Espinoza
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, Michigan, Detroit, USA
J Matern Fetal Neonatal Med 19:607-13. 2006..Preeclampsia occurs in approximately 50% of these cases. Soluble vascular endothelial growth factor receptor-1 (sVEGFR-1), an anti-angiogenic factor, has been implicated in the pathophysiology of preeclampsia (PE)... - Fetal membranes as an interface between inflammation and metabolism: increased aquaporin 9 expression in the presence of spontaneous labor at term and chorioamnionitisPooja Mittal
Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, Michigan, USA
J Matern Fetal Neonatal Med 22:1167-75. 2009.... - MicroRNA expression profiling of the human uterine cervix after term labor and deliverySonia S Hassan
Department of Obstetrics and Gynecology, Wayne State University Hutzel Hospital, Detroit, MI, USA
Am J Obstet Gynecol 202:80.e1-8. 2010..MicroRNAs (miRNAs) are noncoding RNAs involved in posttranscriptional regulation of target genes. The objective of this study was to determine the miRNA expression profile of the human uterine cervix after spontaneous term labor (TL)... - Serum and plasma determination of angiogenic and anti-angiogenic factors yield different results: the need for standardization in clinical practiceGiovanna Ogge
Perinatology Research Branch, NICHD NIH DHHS, Detroit, Michigan, USA
J Matern Fetal Neonatal Med 23:820-7. 2010..The purpose of this study was to determine if there are differences in the concentrations of these analytes between plasma and serum in normal pregnancy and in preeclampsia... - Coexpression of myofibroblast and macrophage markers: novel evidence for an in vivo plasticity of chorioamniotic mesodermal cells of the human placentaSung Su Kim
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD and Detroit, MI 48201, USA
Lab Invest 88:365-74. 2008.... - Leukocyte pyruvate kinase expression is reduced in normal human pregnancy but not in pre-eclampsiaYi Xu
Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA
Am J Reprod Immunol 64:137-51. 2010..To examine the immunoregulatory role of glycolysis in pregnancy, we evaluated the properties of pyruvate kinase in leukocytes from non-pregnant women and those with normal pregnancy and pre-eclampsia... - Maternal plasma visfatin in preterm laborShali Mazaki-Tovi
Intramural Division, Perinatology Research Branch, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 22:693-704. 2009..The aim of this study was to determine whether spontaneous PTL with intact membranes and intra-amniotic infection/inflammation (IAI) is associated with changes in maternal plasma circulating visfatin concentrations... - Evidence of changes in the immunophenotype and metabolic characteristics (intracellular reactive oxygen radicals) of fetal, but not maternal, monocytes and granulocytes in the fetal inflammatory response syndromeSun Kwon Kim
Perinatology Research Branch, NICHD, NIH, DHHS, Wayne State University Hutzel Women s Hospital, Detroit, MI 48201, USA
J Perinat Med 37:543-52. 2009..The aim of this study was to determine whether fetal and maternal granulocytes and monocytes have the phenotypic and metabolic characteristics of activation in cases with FIRS... - Adiponectin in amniotic fluid in normal pregnancy, spontaneous labor at term, and preterm labor: a novel association with intra-amniotic infection/inflammationShali Mazaki-Tovi
Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 23:120-30. 2010.... - A subset of patients destined to develop spontaneous preterm labor has an abnormal angiogenic/anti-angiogenic profile in maternal plasma: evidence in support of pathophysiologic heterogeneity of preterm labor derived from a longitudinal studyTinnakorn Chaiworapongsa
Perinatology Research Branch, NICHD NIH DHHS, Detroit, Michigan, USA
J Matern Fetal Neonatal Med 22:1122-39. 2009..The aim of this study was to determine if patients prior to the clinical diagnosis of PTL leading to preterm delivery had plasma concentrations of angiogenic and anti-angiogenic factors different from normal pregnant women... - Repeatability and reproducibility of fetal cardiac ventricular volume calculations using spatiotemporal image correlation and virtual organ computer-aided analysisNeil Hamill
Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Wayne State University, Detroit, MI 48201, USA
J Ultrasound Med 28:1301-11. 2009.... - Unexplained fetal death is associated with increased concentrations of anti-angiogenic factors in amniotic fluidTinnakorn Chaiworapongsa
Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI 48201, USA
J Matern Fetal Neonatal Med 23:794-805. 2010..These observations indicate that an excess of anti-angiogenic factors in the amniotic cavity is associated with unexplained fetal death especially in preterm gestations... - Soluble receptor for advanced glycation end products (sRAGE) and endogenous secretory RAGE (esRAGE) in amniotic fluid: modulation by infection and inflammationRoberto Romero
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Perinat Med 36:388-98. 2008..The objective of this study was to determine whether intra-amniotic infection/inflammation (IAI) is associated with changes in the amniotic fluid concentration of sRAGE and esRAGE... - Retinol binding protein 4--a novel association with early-onset preeclampsiaEdi Vaisbuch
Intramural Division, Perinatology Research Branch, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, USA
J Perinat Med 38:129-39. 2010..The aim of this study was to determine whether there are changes in maternal plasma concentrations of RBP4 in patients with PE and in those with an SGA neonate or FD... - Isobaric labeling and tandem mass spectrometry: a novel approach for profiling and quantifying proteins differentially expressed in amniotic fluid in preterm labor with and without intra-amniotic infection/inflammationRoberto Romero
Perinatology Research Branch, National Institute of Child Heath and Human Development NIH DHSS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 23:261-80. 2010.... - Chorioamnionitis and increased galectin-1 expression in PPROM --an anti-inflammatory response in the fetal membranes?Nandor Gabor Than
Perinatology Research Branch, NICHD NIH DHHS, Wayne State University Hutzel Women s Hospital, 3990 John R, Box 4, Detroit, MI 48201, USA
Am J Reprod Immunol 60:298-311. 2008..Galectin-1 can regulate immune responses upon infection and inflammation. We determined galectin-1 expression in the chorioamniotic membranes and its changes during histological chorioamnionitis... - A role for mannose-binding lectin, a component of the innate immune system in pre-eclampsiaNandor Gabor Than
Perinatology Research Branch, NICHD NIH DHHS, Wayne State University Hutzel Women s Hospital, 3990 John R, Box 4, Detroit, MI 48201, USA
Am J Reprod Immunol 60:333-45. 2008..The objective of this study was to determine maternal plasma MBL concentrations in normal pregnant women and patients with pre-eclampsia... - CXCL6 (granulocyte chemotactic protein-2): a novel chemokine involved in the innate immune response of the amniotic cavityPooja Mittal
Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Am J Reprod Immunol 60:246-57. 2008..The purpose of this study was to determine if CXCL6 is present in amniotic fluid (AF) and if CXCL6 concentrations in AF change with labor (pre-term and term) or intra-amniotic infection/inflammation (IAI)... - Fragment Bb in amniotic fluid: evidence for complement activation by the alternative pathway in women with intra-amniotic infection/inflammationEdi Vaisbuch
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 22:905-16. 2009..The aim of this study was to determine whether the amniotic fluid (AF) concentrations of fragment Bb change with gestational age, spontaneous labor (term and preterm) and in the presence of intra-amniotic infection/inflammation (IAI)... - High tissue factor activity and low tissue factor pathway inhibitor concentrations in patients with preterm laborOffer Erez
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
J Matern Fetal Neonatal Med 23:23-33. 2010..The aims of this study were to determine whether spontaneous PTL with intact membranes is associated with changes in the maternal plasma concentrations and activity of TF as well as tissue factor pathway inhibitor (TFPI)... - A link between a hemostatic disorder and preterm PROM: a role for tissue factor and tissue factor pathway inhibitorOffer Erez
Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, Michigan, USA
J Matern Fetal Neonatal Med 21:732-44. 2008..A decidual hemostatic disorder may link vaginal bleeding, PPROM and placental abruption. This study was conducted to determine the behaviour of maternal TF and its natural inhibitor, the tissue factor pathway inhibitor (TFPI) in PPROM... - Widespread microbial invasion of the chorioamniotic membranes is a consequence and not a cause of intra-amniotic infectionMi Jeong Kim
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
Lab Invest 89:924-36. 2009..This study emphasizes the importance of assessing the intra-amniotic compartment for diagnosis and treatment of preterm birth... - Amniotic fluid fetal hemoglobin in normal pregnancies and pregnancies complicated with preterm labor or prelabor rupture of membranesEdi Vaisbuch
Perinatology Research Branch, NICHD, NIH, DHHS, Wayne State University, Hutzel Women s Hospital, 3990 John R, Box 4, Detroit, MI 48201, USA
J Matern Fetal Neonatal Med 22:388-97. 2009.... - Evidence of maternal platelet activation, excessive thrombin generation, and high amniotic fluid tissue factor immunoreactivity and functional activity in patients with fetal deathOffer Erez
Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 22:672-87. 2009.... - Amniotic fluid sTREM-1 in normal pregnancy, spontaneous parturition at term and preterm, and intra-amniotic infection/inflammationJuan Pedro Kusanovic
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 23:34-47. 2010..The aim of this study was to determine the effect of gestational age, parturition (term and preterm) and IAI in the amniotic fluid (AF) concentrations of sTREM-1... - Resistin in amniotic fluid and its association with intra-amniotic infection and inflammationJuan Pedro Kusanovic
Perinatology Research Branch, NICHD NIH DHHS, Wayne State University HutzelWomen s Hospital, Detroit, MI 48201, USA
J Matern Fetal Neonatal Med 21:902-16. 2008.... - A role for CXCL13 (BCA-1) in pregnancy and intra-amniotic infection/inflammationChia Ling Nhan-Chang
Perinatology Research Branch, Intramural Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD NIH DHHS, Hutzel Women s Hospital, Detroit, MI 48201, USA
J Matern Fetal Neonatal Med 21:763-75. 2008.... - First-trimester maternal serum PP13 in the risk assessment for preeclampsiaRoberto Romero
Department of Health and Human Services, Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
Am J Obstet Gynecol 199:122.e1-122.e11. 2008..The objective of the study was to determine whether first-trimester maternal serum placental protein 13 (PP13) concentrations can be used in the risk assessment for preeclampsia... - Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranesRoberto Romero
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
Am J Obstet Gynecol 202:431.e1-34. 2010..The purpose of this study was to determine whether maternal/fetal single nucleotide polymorphisms (SNPs) in candidate genes are associated with spontaneous preterm labor/delivery... - An imbalance between angiogenic and anti-angiogenic factors precedes fetal death in a subset of patients: results of a longitudinal studyRoberto Romero
Perinatology Research Branch, NICHD, NIH, DHHS, Wayne State University Hutzel Women s Hospital, 3990 John R, Box 4, Detroit, MI 48201, USA
J Matern Fetal Neonatal Med 23:1384-99. 2010..The anti-angiogenic factors studied were sVEGFR-1 and soluble endoglin (sEng), and the angiogenic factor, placental growth factor (PlGF)... - The role of the sagittal view of the ductal arch in identification of fetuses with conotruncal anomalies using 4-dimensional ultrasonographyJimmy Espinoza
Perinatology Research Branch, NICHD NIH DHHS, Wayne State University Hutzel Women s Hospital, 3990 John R, Box 4, Detroit, MI 48201 USA
J Ultrasound Med 26:1181-8; quiz 1189-90. 2007..This study was designed to determine the role of this ultrasonographic plane for the prenatal diagnosis of conotruncal anomalies... - A decrease in maternal plasma concentrations of sVEGFR-2 precedes the clinical diagnosis of preeclampsiaTinnakorn Chaiworapongsa
Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI 48201, USA
Am J Obstet Gynecol 202:550.e1-10. 2010..The aim of this study was to examine if maternal plasma concentrations of soluble vascular endothelial growth factor receptor (sVEGFR)-2 change prior to the diagnosis of preeclampsia... - The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranesLara A Friel
Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA
J Perinat Med 35:385-93. 2007..The objective of this study was to determine whether amniotic fluid (AF) S100B concentrations change with advancing gestational age and intra-amniotic infection (IAI)... - Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at termPooja Mittal
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Perinat Med 38:617-43. 2010..to characterize the transcriptome of human myometrium during spontaneous labor at term... - A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)Roberto Romero
Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services, Bethesda, MD, USA
Am J Obstet Gynecol 203:361.e1-361.e30. 2010..We sought to determine whether maternal/fetal single-nucleotide polymorphisms (SNPs) in candidate genes are associated with preterm prelabor rupture of membranes (pPROM)... - Timing of fetal nucleated red blood cell count elevation in response to acute hypoxiaSean C Blackwell
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA
Biol Neonate 85:217-20. 2004..0; p = 0.04) after exposure. There were no differences between groups 36, 48, and 60 h after exposure. In the near-term rat fetus, acute hypoxia was associated with a delayed but transient increase in peripheral nucleated RBC counts... - Abnormal amniotic fluid volume as a screening test prior to targeted ultrasoundSean C Blackwell
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Hutzel Hospital Wayne State University, 4707 St Antoine Boulevard, Detroit, MI 48201, U S A
Med Sci Monit 9:MT119-22. 2003.... - Maternal death following cardiopulmonary collapse after delivery: amniotic fluid embolism or septic shock due to intrauterine infection?Roberto Romero
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
Am J Reprod Immunol 64:113-25. 2010..The amniotic fluid embolism (AFE) syndrome is a catastrophic complication of pregnancy frequently associated with maternal death. The causes and mechanisms of disease responsible for this syndrome remain elusive... - Evidence for differential regulation of the adipokine visfatin in the maternal and fetal compartments in normal spontaneous labor at termShali Mazaki-Tovi
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, and Detroit, MI, USA
J Perinat Med 38:281-8. 2010..The aim of this study was to determine if the presence of labor at term is associated with alterations in maternal and neonatal plasma visfatin concentrations... - A systematic approach to the use of the multiplanar display in evaluation of abnormal vascular connections to the fetal heart using 4-dimensional ultrasonographyJimmy Espinoza
Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
J Ultrasound Med 26:1461-7. 2007..This study was designed to determine the clinical utility of the multiplanar display in the examination of abnormal vascular connections to the fetal heart... - The clinical significance of eosinophils in the amniotic fluid in preterm laborRoberto Romero
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 23:320-9. 2010..The goal of this study was to determine whether women presenting with preterm labor with eosinophils in the amniotic fluid had a different outcome than those without eosinophils as the predominant white blood cell in the amniotic cavity... - Severe preeclampsia is characterized by increased placental expression of galectin-1Nandor Gabor Than
Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, Michigan 48201, USA
J Matern Fetal Neonatal Med 21:429-42. 2008..To test this hypothesis, we studied placental galectin-1 mRNA and protein expression and localization in women with preeclampsia (PE) and in those who delivered a small-for-gestational age (SGA) neonate... - Preeclampsia and small-for-gestational age are associated with decreased concentrations of a factor involved in angiogenesis: soluble Tie-2Francesca Gotsch
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 21:389-402. 2008..The purpose of this study was to determine whether patients with preeclampsia and mothers who deliver a SGA neonate have changes in the plasma concentrations of sTie-2... - Proteomic analysis of amniotic fluid to identify women with preterm labor and intra-amniotic inflammation/infection: the use of a novel computational method to analyze mass spectrometric profilingRoberto Romero
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 21:367-88. 2008..The purpose of this study was to combine a novel computational method of pattern discovery with mass spectrometric proteomic profiling of amniotic fluid to discover biomarkers of intra-amniotic infection/inflammation (IAI)... - Changes in amniotic fluid concentration of thrombin-antithrombin III complexes in patients with preterm labor: evidence of an increased thrombin generationOffer Erez
Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 22:971-82. 2009..The aim of this study was to determine whether intra-amniotic infection/inflammation (IAI) is associated with increased amniotic fluid (AF) thrombin generation in women with preterm and term deliveries... - Relationship between meconium staining and amniotic fluid volume in term pregnanciesSean C Blackwell
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA
Fetal Diagn Ther 17:78-82. 2002..Our purpose was to evaluate the relationship between meconium-stained amniotic fluid (MEC-AF) and amniotic fluid volume (AFV) and their impact on the risk of cesarean delivery for fetal indications in term pregnancies... - The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational ageOffer Erez
Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 21:279-87. 2008.... - A prospective cohort study of the value of maternal plasma concentrations of angiogenic and anti-angiogenic factors in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsiaJuan Pedro Kusanovic
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 22:1021-38. 2009..This study was conducted to examine the role of maternal plasma PlGF, sEng, and sVEGFR-1 concentrations in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia... - The ninety-fifth percentile for growth discordance predicts complications of twin pregnancyMark E Redman
Wayne State University Hutzel Hospital, Detroit, Mich, USA
Am J Obstet Gynecol 187:667-71. 2002..Our purpose was to define twin growth discordance on the basis of perinatal outcome... - Could alterations in maternal plasma visfatin concentration participate in the phenotype definition of preeclampsia and SGA?Shali Mazaki-Tovi
Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, and Detroit, MI 48201, USA
J Matern Fetal Neonatal Med 23:857-68. 2010..Visfatin is a novel adipocytokine with metabolic and immunomodulating properties. The objective of this study was to determine whether preeclampsia and SGA are associated with alterations in maternal circulating visfatin concentrations... - Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host diseaseMi Jeong Kim
Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 and Detroit, MI 48201, USA
J Immunol 182:3919-27. 2009..We propose that VUE be a unique state combining maternal allograft rejection and maternal antifetal graft-vs-host disease mechanisms... - Maternal serum adiponectin multimers in patients with a small-for-gestational-age newbornShali Mazaki-Tovi
Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Detroit, MI 48201, USA
J Perinat Med 37:623-35. 2009..Thus, the aim of this study was to determine if third trimester adiponectin concentrations differed between women with normal weight infants and those with an SGA neonate... - Maternal plasma concentration of the pro-inflammatory adipokine pre-B-cell-enhancing factor (PBEF)/visfatin is elevated in pregnant patients with acute pyelonephritisShali Mazaki-Tovi
Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, USA
Am J Reprod Immunol 63:252-62. 2010..The aim of this study was to determine whether pyelonephritis during pregnancy is associated with changes in maternal plasma visfatin concentration in normal weight and overweight/obese patients... - Maternal serum adiponectin multimers in preeclampsiaShali Mazaki-Tovi
Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, USA
J Perinat Med 37:349-63. 2009..The aim of this study was to determine whether preeclampsia is associated with changes in circulating adiponectin multimers... - Maternal plasma retinol binding protein 4 in acute pyelonephritis during pregnancyEdi Vaisbuch
Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, and Detroit, MI, USA
J Perinat Med 38:359-66. 2010..The aim of this study was to determine whether there are changes in maternal plasma concentrations of RBP4 in pregnant women with acute pyelonephritis... - A novel signaling pathway impact analysisAdi Laurentiu Tarca
Department of Computer Science, Wayne State University, 431 State Hall, Detroit, MI 48202, USA
Bioinformatics 25:75-82. 2009..Both approaches treat the pathways as simple sets of genes, disregarding the complex gene interactions that these pathways are built to describe... - Maternal serum soluble CD30 is increased in pregnancies complicated with acute pyelonephritisJuan Pedro Kusanovic
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 20:803-11. 2007..The objective of this study was to determine whether there are changes in the serum concentration of sCD30 in pregnant women with pyelonephritis... - Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancyFrancesca Gotsch
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 20:735-44. 2007..The purpose of this study was to determine whether maternal serum concentrations of CXCL10/IP-10 change in patients with acute pyelonephritis during pregnancy... - An episode of preterm labor is a risk factor for the birth of a small-for-gestational-age neonateJimmy Espinoza
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
Am J Obstet Gynecol 196:574.e1-5; discussion 574.e5-6. 2007..The objective of this study was to compare the frequency of small-for-gestational-age (SGA) neonates among patients with an episode of increased uterine contractility who delivered at term and those who delivered preterm... - Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsiaBeth L Pineles
Perinatology Research Branch, National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services, Bethesda, MD, USA
Am J Obstet Gynecol 196:261.e1-6. 2007..MicroRNAs (miRNAs) are critical posttranscriptional regulators of gene expression. This study was performed to determine whether preeclampsia and SGA are associated with alterations in placental miRNA expression... - CXCL10/IP-10: a missing link between inflammation and anti-angiogenesis in preeclampsia?Francesca Gotsch
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 20:777-92. 2007..The aim of this study was to determine whether preeclampsia and delivery of a small for gestational age (SGA) neonate are associated with changes in maternal serum concentration of CXCL10/IP-10... - Maternal serum soluble CD30 is increased in normal pregnancy, but decreased in preeclampsia and small for gestational age pregnanciesJuan Pedro Kusanovic
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 20:867-78. 2007..The objective of this study was to determine whether the maternal serum concentration of sCD30 changes with normal pregnancy, as well as in mothers with preeclampsia and those who deliver SGA neonates... - Detection of a microbial biofilm in intraamniotic infectionRoberto Romero
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
Am J Obstet Gynecol 198:135.e1-5. 2008..A case is presented in which "amniotic fluid sludge" was found to contain microbial biofilms. This represents the first report of a microbial biofilm in the amniotic cavity... - Total hemoglobin concentration in amniotic fluid is increased in intraamniotic infection/inflammationEdi Vaisbuch
Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services, Bethesda, MD, USA
Am J Obstet Gynecol 199:426.e1-7. 2008..The aim of this study was to determine whether there is an association between total hemoglobin concentration in AF and gestational age, spontaneous labor (term and preterm), and the presence or absence of IAI... - The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: a role for interleukin-10Francesca Gotsch
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 21:529-47. 2008..The objectives of this study were to determine whether there is a relationship between amniotic fluid concentrations of IL-10 and gestational age, parturition (at term and preterm), and intra-amniotic infection/inflammation (IAI)... - Exodus-1 (CCL20): evidence for the participation of this chemokine in spontaneous labor at term, preterm labor, and intrauterine infectionNeil Hamill
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Perinat Med 36:217-27. 2008.... - Amniotic fluid heat shock protein 70 concentration in histologic chorioamnionitis, term and preterm parturitionTinnakorn Chaiworapongsa
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 21:449-61. 2008..This study was conducted to determine the changes in amniotic fluid HSP70 concentrations during pregnancy, term and preterm parturition, intra-amniotic infection (IAI), and histologic chorioamnionitis... - Over-expression of the thrombin receptor (PAR-1) in the placenta in preeclampsia: a mechanism for the intersection of coagulation and inflammationOffer Erez
Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 21:345-55. 2008..The aim of this study was to determine whether preterm PE is associated with changes in placental expression of PAR-1... - Twin-to-twin transfusion syndrome: an antiangiogenic state?Juan Pedro Kusanovic
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, MD, USA
Am J Obstet Gynecol 198:382.e1-8. 2008..This study was conducted to determine maternal plasma concentrations of placental growth factor (PlGF), soluble VEGFR-1, and soluble endoglin (s-Eng) in monochorionic-diamniotic pregnancies with and without TTTS... - The maternal plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated in SGA and the magnitude of the increase relates to Doppler abnormalities in the maternal and fetal circulationTinnakorn Chaiworapongsa
Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
J Matern Fetal Neonatal Med 21:25-40. 2008.... - Recurrent preterm birthShali Mazaki Tovi
Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, USA
Semin Perinatol 31:142-58. 2007..Patients with a history of an indicated preterm birth are at risk not only for recurrence of this subtype, but also for spontaneous preterm birth. Individuals of black origin have a higher rate of recurrent preterm birth... - A randomized trial of amnioreduction versus septostomy in the treatment of twin-twin transfusion syndromeKenneth J Moise
Department of Obstetrics and Gynecology of the University of North Carolina School of Medicine, Chapel Hill, NC, USA
Am J Obstet Gynecol 193:701-7. 2005..Removal of excessive amounts of amniotic fluid through serial amniocenteses (amnioreduction) has been the mainstay of therapy. We sought to compare amnioreduction to intentional perforation of the intervening twin membrane (septostomy)... - Plasma protein Z concentrations in pregnant women with idiopathic intrauterine bleeding and in women with spontaneous preterm laborJuan Pedro Kusanovic
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 20:453-63. 2007..The objective of this study was to examine maternal plasma concentrations of protein Z in normal pregnancies, as well as in those presenting with spontaneous preterm labor (PTL) and intrauterine bleeding during pregnancy... - The fetal inflammatory response syndromeFrancesca Gotsch
Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, Maryland, USA
Clin Obstet Gynecol 50:652-83. 2007..This article reviews the fetal systemic inflammatory response as a mechanism of disease. Potential interventions to control an exaggerated inflammatory response in utero are also described... - Resistin: a hormone which induces insulin resistance is increased in normal pregnancyJyh Kae Nien
Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, USA
J Perinat Med 35:513-21. 2007.... - Adiponectin in severe preeclampsiaJyh Kae Nien
Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, USA
J Perinat Med 35:503-12. 2007.... - Plasma adiponectin concentrations in non-pregnant, normal and overweight pregnant womenJyh Kae Nien
Perinatology Research Branch, Intramural Division, NICHD NIH DHHS, Hutzel Women s Hospital, Bethesda, MD, USA
J Perinat Med 35:522-31. 2007..The aims of this study were to determine normal maternal plasma concentrations of adiponectin throughout gestation and to explore the relationships between plasma adiponectin concentration, pregnancy, and maternal overweight... - Association of maternal histocompatibility at class II HLA loci with maternal microchimerism in the fetusStanley M Berry
Division of Maternal Fetal Medicine, Wayne State University, Detroit, MI 48201, USA
Pediatr Res 56:73-8. 2004..There was no relationship between maternal microchimerism and maternal-fetal HLA compatibility at other HLA loci or with gestational age, fetal anomalies, or red cell or platelet isoimmunity...