Research Topics
| ROBERT F FREEDMANSummaryAffiliation: Wayne State University Country: USA Publications
Research Grants
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Detail Information
Publications
Estrogen raises the sweating threshold in postmenopausal women with hot flashesRobert R Freedman
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
Fertil Steril 77:487-90. 2002....- Pathophysiology and treatment of menopausal hot flashesRobert R Freedman
Obstetrics and Gynecology, Wayne State University School of Medicine, C S Mott Center, 275 E Hancock Avenue, Detroit, MI 48201, USA
Semin Reprod Med 23:117-25. 2005..Estrogen ameliorates hot flashes by increasing the T(c) sweating threshold, although the underlying mechanism is not known. Recent studies of hot flashes during sleep call into question their role in producing sleep disturbance... - Treatment of menopausal hot flashes with 5-hydroxytryptophanRobert R Freedman
Departments of Psychiatry and Behavioral Neurosciences and Obstetrics and Gynecology, Wayne State University School of Medicine, C S Mott Center for Human Growth and Development, 275 E Hancock, Detroit, MI 48201, USA
Maturitas 65:383-5. 2010..Selective, serotonergic, reuptake inhibitors (SSRIs), which increase the amount of serotonin in the synaptic gap, have shown some promise in the amelioration of hot flashes... - Biochemical, metabolic, and vascular mechanisms in menopausal hot flashesR R Freedman
Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
Fertil Steril 70:332-7. 1998..To determine if increases in core body temperature preceding most hot flashes are caused by increased metabolic rate, peripheral vasoconstriction, or central noradrenergic activation... - Effects of symptomatic status and the menstrual cycle on hot flash-related thermoregulatory parametersRobert R Freedman
Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA
Menopause 12:156-9. 2005..To compare core body temperature variation, sweating thresholds, and sweat rate in symptomatic and asymptomatic postmenopausal women and in eumenorrheic women in the follicular and luteal phases... - Thermoregulatory effects of 3,4-methylenedioxymethamphetamine (MDMA) in humansRobert R Freedman
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
Psychopharmacology (Berl) 183:248-56. 2005..In rats, MDMA causes hyperthermia at warm ambient temperatures but hypothermia at cold ones... - Hot flashes: behavioral treatments, mechanisms, and relation to sleepRobert R Freedman
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Am J Med 118:124-30. 2005..Therefore, sleep complaints in women at midlife should not routinely be attributed to hot flashes or to menopause... - Cortical activation during menopausal hot flashesRobert R Freedman
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA
Fertil Steril 85:674-8. 2006..To determine regions of brain activation associated with menopausal hot flashes and sweating... - Effects of REM sleep and ambient temperature on hot flash-induced sleep disturbanceRobert R Freedman
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
Menopause 13:576-83. 2006..To determine whether hot flashes produce sleep disturbance in postmenopausal women... - Miniature hygrometric hot flash recorderRobert R Freedman
Departments of Obstetrics and Gynecology and Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA
Fertil Steril 88:494-6. 2007..To design and test a miniature ambulatory hot flash recorder that uses neither electrodes nor gel... - Sleep disturbance in menopauseRobert R Freedman
Department of Psychiatry, Wayne State University School of Medicine, and Henry Ford Hospital Sleep Disorders Center, Detroit, MI 48201, USA
Menopause 14:826-9. 2007..To determine the sources of sleep complaints in peri- and postmenopausal women reporting disturbed sleep... - Heart rate variability in menopausal hot flashes during sleepRobert R Freedman
Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI 48201, USA
Menopause 18:897-900. 2011..The aim of this study was to determine if heart rate variability changes during hot flashes recorded during sleep... - Lack of sleep disturbance from menopausal hot flashesRobert R Freedman
Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Fertil Steril 82:138-44. 2004..To determine whether hot flashes produce disordered sleep in symptomatic postmenopausal women... - Escitalopram treatment of menopausal hot flashesRobert R Freedman
Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI 48201, USA
Menopause 18:893-6. 2011..The aim of this study was to determine the effects of 10 and 20 mg/day of escitalopram on objectively recorded hot flashes and on the rectal temperature threshold for sweating... - Endothelial and adrenergic dysfunction in Raynaud's phenomenon and sclerodermaR R Freedman
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA
J Rheumatol 26:2386-8. 1999..To investigate the involvement of endothelial and adrenergic mechanisms in patients with Raynaud's phenomenon (RP) and scleroderma... - Effects of menstrual cycle and race on peripheral vascular alpha-adrenergic responsivenessR R Freedman
Departments of Psychiatry and Behavioral Neurosciences and Obstetrics and Gynecology and Internal Medicine Pulmonary, Wayne State University School of Medicine, Detroit, MI, USA
Hypertension 35:795-9. 2000..The lack of luteal-phase reduction in alpha(2)-adrenergic vasoconstriction in black women may contribute to their increased pressor responses to adrenergic stimuli... - Clonidine raises the sweating threshold in symptomatic but not in asymptomatic postmenopausal womenR R Freedman
Wayne State University School of Medicine, Detroit, Michigan, USA
Fertil Steril 74:20-3. 2000..To determine the effects of clonidine, which reduces central sympathetic activation, on the sweating threshold in postmenopausal women with and without hot flashes... - Abnormal responses to endothelial agonists in Raynaud's phenomenon and sclerodermaR R Freedman
Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan, USA
J Rheumatol 28:119-21. 2001..To further specify the site of vascular dysfunction in patients with Raynaud's phenomenon (RP) and scleroderma... - Physiology of hot flashesR R Freedman
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan 48201, USA
Am J Hum Biol 13:453-64. 2001..Clonidine reduces central sympathetic activation, widens the thermoneutral zone, and ameliorates hot flashes. Estrogen virtually eliminates hot flashes but its mechanism of action is not known... - Core body temperature variation in symptomatic and asymptomatic postmenopausal women: brief reportRobert R Freedman
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA
Menopause 9:399-401. 2002..To determine if core body temperature (T) fluctuations occur in asymptomatic as well as symptomatic postmenopausal women... - Increased tyrosine phosphorylation mediates the cooling-induced contraction and increased vascular reactivity of Raynaud's diseasePhilip B Furspan
C S Mott Center, Wayne State University, 275 East Hancock Avenue, Detroit, MI 48201, USA
Arthritis Rheum 50:1578-85. 2004..This study tests the hypothesis that increased PTK activity mediates the increased vascular reactivity to agonists and cooling associated with primary Raynaud's disease (RD)... - Hot flash trends and mechanismsRobert R Freedman
Menopause 9:151-2. 2002 - Measurement of hot flashes by sternal skin conductance and subjective hot flash report in Puebla, MexicoLynnette Leidy Sievert
Department of Anthropology, University of Massachusetts at Amherst, Amherst, Massachusetts 01003 4805, USA
Menopause 9:367-76. 2002..To measure hot flashes by sternal skin conductance in an urban Mexican population and to determine variables associated with hot flash reporting and measurement... - It's all in your headRobert R Freedman
Menopause 12:483. 2005 - A woman attempting to discontinue hormone therapyRobert R Freedman
JAMA 288:2264; author reply 2264-5. 2002 - How much of a difference does it take to make a differenceRobert R Freedman
Fertil Steril 87:1497; author reply 1497-8. 2007 - Hot flashes, core body temperature, and metabolic parameters in breast cancer survivorsJanet S Carpenter
Indiana University School of Nursing, 1111 Middle Drive NU 340D, Indianapolis, IN 46202 5107, USA
Menopause 11:375-81. 2004..To examine core body temperature, energy expenditure, and respiratory quotient among breast cancer survivors experiencing hot flashes and compare these data to published studies from healthy women... - Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American Menopause SocietyWulf H Utian
Menopause 15:584-602. 2008..The benefit-risk ratio for menopausal HT is favorable close to menopause but decreases with aging and with time since menopause in previously untreated women...
Research Grants
- BEHAVIORAL TREATMENT OF MENOPAUSAL HOT FLASHESRobert Freedman; Fiscal Year: 2007....
- BEHAVIORAL TREATMENT OF MENOPAUSAL HOT FLASHESRobert Freedman; Fiscal Year: 2009....
- Sleep Disturbance in MenopauseRobert Freedman; Fiscal Year: 2006..In Study 5, we will determine the effects of elevated sympathetic activation on HFs and sleep using a stimulus that does not, by itself, disrupt sleep (orthostasis). ..
- BEHAVIORAL TREATMENT OF MENOPAUSAL HOT FLASHESRobert Freedman; Fiscal Year: 1993