Research Topics
| Patrick WinterSummaryAffiliation: Washington University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Minute dosages of alpha(nu)beta3-targeted fumagillin nanoparticles impair Vx-2 tumor angiogenesis and development in rabbitsPatrick M Winter
Washington University Medical School, Campus Box 8215, 4320 Forest Park Ave, St Louis, MO 63108, USA
FASEB J 22:2758-67. 2008..These results suggest that alpha(nu)beta(3)-targeted fumagillin nanoparticles could provide a safe and effective means to deliver MetAP2 inhibitors alone or in combination with cytotoxic or immunotherapy...- Emerging nanomedicine opportunities with perfluorocarbon nanoparticlesPatrick M Winter
Medicine and Biomedical Engineering, C TRAIN Group, St Louis, MO 63108, USA
Expert Rev Med Devices 4:137-45. 2007..By combining targeted molecular imaging and localized drug delivery, PFC nanoparticles provide diagnosis and therapy with a single agent... - Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imagingPatrick M Winter
Cardiovascular Magnetic Resonance Laboratories, Department of Medicine, Cardiovascular Division, Barnes Jewish Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
Cancer Res 63:5838-43. 2003.... - Targeted PARACEST nanoparticle contrast agent for the detection of fibrinPatrick M Winter
Department of Medicine, Cardiovascular Division, Washington University, St Louis, Missouri 63108, USA
Magn Reson Med 56:1384-8. 2006..PARACEST nanoparticles were targeted to clots via antifibrin antibodies and produced a contrast-to-noise ratio (CNR) of 10 at the clot surface... - Nanomedicine opportunities in cardiologyGregory Lanza
Med and Biomed Engineering, School of Medicine, Washington University St Louis, 4003 Kingshighway Bldg, St Louis, MO 63130, USA
Ann N Y Acad Sci 1080:451-65. 2006..Moreover, displacement of antiproliferative agents from the intimal surface into the vascular wall is likely to improve rehealing of the endothelium, improving postprocedural management of these patients... - Applications of nanotechnology to atherosclerosis, thrombosis, and vascular biologySamuel A Wickline
Department of Medicine, Washington University, St Louis, MO, USA
Arterioscler Thromb Vasc Biol 26:435-41. 2006..The future of cardiovascular diagnosis already is being impacted by nanosystems that can both diagnose pathology and treat it with targeted delivery systems... - Novel paramagnetic contrast agents for molecular imaging and targeted drug deliveryGregory M Lanza
Division of Cardiology, Campus Box 8086, Washington University Medical School, 600 S Euclid Ave, Saint Louis, MO 63110, USA
Curr Pharm Biotechnol 5:495-507. 2004..The fundamental issues surrounding magnetic contrast agent development, rational drug delivery, MR molecular imaging, and their interdependence are elucidated... - Quantitative "magnetic resonance immunohistochemistry" with ligand-targeted (19)F nanoparticlesAnne M Morawski
Department of Medicine, Washington University, Saint Louis, Missouri 63110, USA
Magn Reson Med 52:1255-62. 2004.... - Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeuticsTrung D Tran
Division of Cardiology, Washington University Medical School, 660 South Euclid Blvd, St Louis, Missouri 63110, USA
Int J Nanomedicine 2:515-26. 2007..One multimodality platform, targeted perfluorocarbon (PFC) nanoparticles, is useful for noninvasive detection with US and MR, targeted drug delivery, and quantification... - Nanomedicine opportunities for cardiovascular disease with perfluorocarbon nanoparticlesGregory M Lanza
Division of Cardiology, Washington University Medical School, Cortex Building, St Louis, MO 63108, USA
Nanomedicine (Lond) 1:321-9. 2006..As illustrated in this article, perfluorocarbon nanoparticles offer new tools to recognize and characterize pathology, to identify and segment high-risk patients and to treat chronic and acute disease... - Targeted antiproliferative drug delivery to vascular smooth muscle cells with a magnetic resonance imaging nanoparticle contrast agent: implications for rational therapy of restenosisGregory M Lanza
Department of Medicine, Division of Cardiology, Washington University Medical School, St Louis, MO 63110, USA
Circulation 106:2842-7. 2002..In the present study, the concept of VSMC-targeted nanoparticles as a drug-delivery platform for the prevention of restenosis after angioplasty is studied... - Molecular imaging and therapy of atherosclerosis with targeted nanoparticlesSamuel A Wickline
Department of Medicine, Washington University, St Louis, Missouri 63110, USA
J Magn Reson Imaging 25:667-80. 2007..We review a variety of nanotechnologies that are capable of detecting early cardiovascular pathology, as well as associated imaging approaches and conjunctive strategies for site-targeted treatment with nanoparticle delivery systems... - Improved molecular imaging contrast agent for detection of human thrombusPatrick M Winter
Cardiovascular MR Laboratories, Department of Medicine, Cardiovascular Division, Barnes-Jewish Hospital, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Magn Reson Med 50:411-6. 2003..45 +/- 0.02 1/s). These studies demonstrate marked improvement in a fibrin-specific molecular imaging agent that might allow sensitive, early detection of vascular microthrombi, the antecedent to stroke and heart attack... - Molecular imaging of angiogenesis in early-stage atherosclerosis with alpha(v)beta3-integrin-targeted nanoparticlesPatrick M Winter
Cardiovascular Magnetic Resonance Laboratories, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Circulation 108:2270-4. 2003..CONCLUSIONS: This molecular imaging approach might provide a method for defining the burden and evolution of atherosclerosis in susceptible individuals as well as responsiveness of individual patients to antiatherosclerotic therapies... - Endothelial alpha(v)beta3 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosisPatrick M Winter
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Arterioscler Thromb Vasc Biol 26:2103-9. 2006.... - Molecular imaging by MRIPatrick M Winter
Cardiovascular Magnetic Resonance Laboratories, Washington University, St. Louis, MO 63110, USA
Curr Cardiol Rep 8:65-9. 2006..If ultimately successful, these emerging molecular imaging agents and techniques will allow early disease recognition and quantification prompting therapeutic intervention before serious sequelae ensue... - Targeted magnetic resonance imaging contrast agentsShelton D Caruthers
Cardiovascular MR Labs, Division of Cardiology, Washington University, St. Louis, Missouri, USA
Methods Mol Med 124:387-400. 2006..As exemplified by perfluorocarbon nanoparticles, these new agents, in combination with the rapid innovations in imaging hardware and software, will allow the emergence of new medical diagnostic and therapeutic paradigms... - Magnetic resonance molecular imaging with nanoparticlesGregory M Lanza
Division of Cardiology, Washington University Medical School, 660 S. Euclid Avenue, St. Louis, MO 63110, USA
J Nucl Cardiol 11:733-43. 2004..Combining high-resolution MR molecular imaging with drug delivery will facilitate verification and quantification of treatment (ie, rational targeted therapy) and will offer new clinical approaches to many diseases... - Molecular MR imaging of melanoma angiogenesis with alphanubeta3-targeted paramagnetic nanoparticlesAnne H Schmieder
Department of Biomedical Engineering, Washington University, 660 South Euclid Avenue, St. Louis, MO 63110, USA
Magn Reson Med 53:621-7. 2005..This technique may be employed to noninvasively detect very small regions of angiogenesis associated with nascent melanoma tumors, and to phenotype and stage early melanoma in a clinical setting... - Magnetic resonance nanoparticles for cardiovascular molecular imaging and therapyTillmann Cyrus
Washington University School of Medicine, Barnes Jewish Hospital, 660 South Euclid Ave, Box 8086, Saint Louis, MO 63110, USA
Expert Rev Cardiovasc Ther 3:705-15. 2005..This review focuses on recent developments of nanoparticle technologies with an emphasis on cardiovascular applications of magnetic resonance imaging... - Molecular imaging of human thrombus with computed tomographyPatrick M Winter
Cardiovascular Magnetic Resonance Laboratory, Washington University, St. Louis, MO, USA
Acad Radiol 12:S9-13. 2005 - Targeted nanoparticles for quantitative imaging of sparse molecular epitopes with MRIAnne M Morawski
Cardiovascular MR Laboratories, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Magn Reson Med 51:480-6. 2004..Thus, for targeted paramagnetic agents carrying high payloads of gadolinium, it is possible to quantify molecular epitopes present in picomolar concentrations in single cells with routine MRI... - In vitro demonstration using 19F magnetic resonance to augment molecular imaging with paramagnetic perfluorocarbon nanoparticles at 1.5 TeslaShelton D Caruthers
Division of Cardiology, Washington University Medical School, St Louis, Missouri 63110, USA
Invest Radiol 41:305-12. 2006..This study explored the use of F spectroscopy and imaging with targeted perfluorocarbon nanoparticles for the simultaneous identification of multiple bio-signatures at 1.5 T... - Molecular imaging and targeted drug delivery with a novel, ligand-directed paramagnetic nanoparticle technologyGregory M Lanza
Department of Medicine, Washington University Medical School, St Louis, MO 63110, USA
Acad Radiol 9:S330-1. 2002 - Spectral properties of a bifunctional PARACEST europium chelate: an intermediate for targeted imaging applicationsChristopher Adair
Macrocyclics, 2110 Research Row, STE 425, Dallas, TX 75235, USA
Contrast Media Mol Imaging 2:55-8. 2007.... - 1H/19F magnetic resonance molecular imaging with perfluorocarbon nanoparticlesGregory M Lanza
Division of Cardiology, Washington University Medical School, St. Louis, MO 63110, USA
Curr Top Dev Biol 70:57-76. 2005..In conjunction with rapid improvements in MR imaging, the prospects for personalized medicine and early recognition and treatment of disease have never been better...
Research Grants
- Molecular Imaging of Angiogenesis by MRIGregory Lanza; Fiscal Year: 2007..Apply mathematical models of tissue compartmentalization to determine the contributions of target binding and vascular permeability to MRI signal enhancement. ..