Research Topics
| Bradley ThachSummaryAffiliation: Washington University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Deaths and injuries attributed to infant crib bumper padsBradley T Thach
Washington University Department of Pediatrics, St Louis, Missouri 63110, USA
J Pediatr 151:271-4, 274.e1-3. 2007..To document deaths attributed to bumper pads and injuries from their use that are potentially preventable...- Sex-specific quantitative trait loci linked to autoresuscitation failure in SWR/J miceB T Thach
Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
Heredity 103:469-75. 2009..These results establish a genetic basis for AR failure phenotype in mice, with relevance to Sudden Infant Death Syndrome... - Some aspects of clinical relevance in the maturation of respiratory control in infantsBradley T Thach
Edward Mallinckrodt Department of Pediatrics, Washington Univ School of Medicine, St Louis, MO 63110, USA
J Appl Physiol 104:1828-34. 2008..Consequently, it also may have a role in causing SIDS. Maturational changes and/or inadequacy of this reflex may be responsible for pulmonary aspiration and infectious pneumonia in both children and adults... - Tragic and sudden death. Potential and proven mechanisms causing sudden infant death syndromeBradley Thach
Department of Pediatrics, Washington University in St. Louis, MO, USA
EMBO Rep 9:114-8. 2008 - The role of respiratory control disorders in SIDSBradley T Thach
Department of Pediatrics, Washington University School of Medicine, 660 S Euclid, Campus Box 8208, St Louis, MO 63110, USA
Respir Physiol Neurobiol 149:343-53. 2005..In drawing conclusions it is well to recognize that mechanisms leading to death in SIDS are heterogeneous and therefore there is room for several plausible theories for respiratory or circulatory abnormalities contributing to SIDS... - Maturation of cough and other reflexes that protect the fetal and neonatal airwayBradley T Thach
Edward Mallinckrodt Department of Pediatrics, School of Medicine, Washington University, 660 S Euclid Ave, Campus Box 8208, St Louis, MO 63110, USA
Pulm Pharmacol Ther 20:365-70. 2007..Studies in animal models indicate that with maturation, apnea and swallowing components of the LCR decrease while cough becomes increasingly prominent... - Inhibitory effects of hyperthermia on mechanisms involved in autoresuscitation from hypoxic apnea in mice: a model for thermal stress causing SIDSLevent Kahraman
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid, Campus Box 8208, St. Louis, MO 63110, USA
J Appl Physiol 97:669-74. 2004..This may be due, at least in part, to decreased gasp number and duration as well as to hyperthermia-related asynchrony of reflexes regulating heart and gasping frequencies during attempted AR... - Characterization of successful and failed autoresuscitation in human infants, including those dying of SIDSRaghunathan Sridhar
Division of Newborn Medicine, Department of Pediatrics, Washington University, St. Louis, Missouri 63110, USA
Pediatr Pulmonol 36:113-22. 2003..Some SIDS infants appear to be different from infants dying with other diagnoses with respect to efficacy and characteristics of hypoxic gasping... - Influence of sleep position experience on ability of prone-sleeping infants to escape from asphyxiating microenvironments by changing head positionDorota A Paluszynska
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63010, USA
Pediatrics 114:1634-9. 2004..The increased occurrence of the face-down position in such infants is also potentially explained. These findings suggest that airway protective behaviors may be acquired through the mechanism of operant conditioning (learning)... - The role of arousal related brainstem reflexes in causing recovery from upper airway occlusion in infantsHenning Wulbrand
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
Sleep 31:833-40. 2008..Lung inflation is not a prerequisite for the reflex to occur... - Spontaneous arousal activity in infants during NREM and REM sleepFrances McNamara
Edward Mallinckrodt Department of Pediatrics/Newborn Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
J Physiol 538:263-9. 2002..The spontaneous arousal responses occur periodically but with a high level of irregularity and the level of activity is affected by sleep state... - Occurrence and mechanisms of sudden oxygen desaturation in infants who sleep face downAloka L Patel
St Louis Children's Hospital and the Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Pediatrics 111:e328-32. 2003.... - Physiologic studies on swaddling: an ancient child care practice, which may promote the supine position for infant sleepClaudia M Gerard
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
J Pediatr 141:398-403. 2002..The reintroduction of swaddling, without restricting hip movement or chest wall excursion, combined with supine sleeping, may promote further sudden infant death syndrome reduction... - Spontaneous arousals in supine infants while swaddled and unswaddled during rapid eye movement and quiet sleepClaudia M Gerard
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
Pediatrics 110:e70. 2002.... - Racial disparity and modifiable risk factors among infants dying suddenly and unexpectedlyBenjamin Unger
Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Pediatrics 111:E127-31. 2003..We conclude that public health information tailored for the AA community should give equal emphasis to risks and alternatives to bedsharing as to avoidance of the prone position... - Heat stress and sudden infant death syndrome incidence: a United States population epidemiologic studyJoshua R Scheers-Masters
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Pediatrics 113:e586-92. 2004.... - The brainstem and vulnerability to sudden infant death syndromeBradley T Thach
Neurology 61:1170-1. 2003 - Aspiration of gastric contents in sudden infant death syndrome without cardiopulmonary resuscitationHenry F Krous
Department of Pathology, Rady Children s Hospital, San Diego, California 92123, USA
J Pediatr 150:241-6. 2007.... - Sudden infant death syndrome: risk factors for infants found face down differ from other SIDS casesJohn M D Thompson
Department of Pediatrics, University of Auckland, New Zealand
J Pediatr 149:630-633. 2006..CONCLUSIONS: Infants with SIDS in the FD position appear to be a distinct subgroup of SIDS. These differences in risk factors provide clues to mechanisms of death in both SIDS subtypes... - Can we breathe and swallow at the same time?Bradley T Thach
J Appl Physiol 99:1633. 2005 - Where should baby be put back to sleep?Bradley T Thach
J Pediatr 147:6-7. 2005
Research Grants
- CONTROL OF BREATHING IN RECOVERY FROM APNEABradley Thach; Fiscal Year: 2003..Finally, we will study development of the infant's ability to avoid potentially suffocating environments during sleep, and determine the potential role of the infant's past experience on this development. ..
- CONTROL OF BREATHING IN RECOVERY FROM APNEABradley Thach; Fiscal Year: 2007..Finally, we will study Medical Examiner's records (St. Louis, MO.) of infants dying suddenly and unexpectedly to determine if post mortem body temperature indicates involvement of overheating or disorders of thermoregulation in SIDS. ..
- CONTROL OF BREATHING IN RECOVERY FROM APNEABradley Thach; Fiscal Year: 1980..These studies are viewed as relevant to the maturation and development of respiratory control in man and to the clinical syndromes of apnea of prematurity, sleep obstructive apnea and Sudden Infant Death Syndrome (S.I.D.S.)...