Research Topics
| Steven M RothmanSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Detail Information
Publications
Cooling blocks rat hippocampal neurotransmission by a presynaptic mechanism: observations using 2-photon microscopyXiao Feng Yang
Department of Neurology, Box 8111, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
J Physiol 567:215-24. 2005..This presynaptic effect may account for some of the therapeutic benefits of cooling in epilepsy and possibly stroke...- Optical suppression of seizure-like activity with an LEDSteven M Rothman
Department of Neurology, Hope Center, Washington University School of Medicine, St Louis, MO 63110, United States
Epilepsy Res 74:201-9. 2007.... - Focal cooling for epilepsy: an alternative therapy that might actually workSteven M Rothman
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Epilepsy Behav 7:214-21. 2005..The present review describes the rationale for this research and our progress to date... - Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodentsLin Xu
Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Invest 118:272-80. 2008..Intranasal leptin administration may have potential as an acute abortive treatment for convulsive seizures in emergency situations... - Cooling produces minimal neuropathology in neocortex and hippocampusXiao-feng Yang
Department of Neurology-Box 8111, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA
Neurobiol Dis 23:637-43. 2006..While there may be biochemical and functional alterations in brain cooled as low as 5 degrees C, the neuropathological consequences of brain cooling appear to be insignificant... - Prolonged exposure to levetiracetam reveals a presynaptic effect on neurotransmissionXiao Feng Yang
Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Epilepsia 48:1861-9. 2007..Using a combination of electrophysiological and cellular imaging techniques, we carefully tested the hypothesis that LEV directly interferes with neurotransmitter release... - Levetiracetam has an activity-dependent effect on inhibitory transmissionAnna L Meehan
Department of Neurology, University of Minnesota, Minneapolis, MN, USA
Epilepsia 53:469-76. 2012..Because there are differences in excitatory and inhibitory transmitter release mechanisms, and there are suggestions that neurons differ in their SV2A expression, we were curious whether LEV also reduces inhibitory transmission... - In vivo imaging of dendritic spines during electrographic seizuresNicholas Rensing
Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA
Ann Neurol 58:888-98. 2005..Overall, our results suggest that most neocortical seizures have minimal acute effects on dendrites over several hours, but may predispose to dendritic injury under extreme conditions... - Long-lasting anticonvulsant effect of focal cooling on experimental neocortical seizuresXiao-feng Yang
Department of Neurology, Washington University School of Medicine and St. Louis Children's Hospital, One Children's Place, St. Louis, MO 63110, U.S.A
Epilepsia 44:1500-5. 2003..The physiologic mechanism for this preventive effect requires elucidation... - Kainate seizures cause acute dendritic injury and actin depolymerization in vivoLing Hui Zeng
Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 27:11604-13. 2007.... - Intracerebral temperature alterations associated with focal seizuresXiao-feng Yang
Department of Neurology, Room 12E/25, St. Louis Children's Hospital, Washington University, St. Louis, MO 63110, USA
Epilepsy Res 52:97-105. 2002..In humans, seizures could actually cause a reduction in brain temperature, because brain temperature is normally higher than body temperature... - Stroke in children: Freud's first analysisSteven M Rothman
Department of Neurology, Washington University, St Louis Children's Hospital, St Louis, MO 63110, USA
Lancet 360:1526-7. 2002 - Neocortical seizure termination by focal cooling: temperature dependence and automated seizure detectionXiao-feng Yang
Department of Neurology, Washington University, St. Louis, Missouri, USA
Epilepsia 43:240-5. 2002..However, when coupled with automatic seizure detection, focal cooling remains an attractive option for development as a treatment for focal epilepsy... - Optical control of focal epilepsy in vivo with caged ?-aminobutyric acidXiaofeng Yang
Department of Neurology, University of Minnesota Medical School, Minneapolis, MN 55355, USA
Ann Neurol 71:68-75. 2012.... - CNS-directed AAV2-mediated gene therapy ameliorates functional deficits in a murine model of infantile neuronal ceroid lipofuscinosisMegan A Griffey
Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
Mol Ther 13:538-47. 2006..However, higher levels or a broader distribution of PPT1 expression, or both, will be required for more complete correction of this neurodegenerative disease... - The estrogen receptor is not essential for all estrogen neuroprotection: new evidence from a new analogShuli Xia
Department of Neurology, Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Neurobiol Dis 9:282-93. 2002..Although some of estrogen's neuroprotective effects may depend upon the estrogen receptor, our results suggest the possibility of neuroprotection without hormonal side effects... - Focal cooling devices for the surgical treatment of epilepsyMatthew D Smyth
Department of Neurosurgery, Washington University, St Louis, MO 63110 1077, USA
Neurosurg Clin N Am 22:533-46, vii. 2011..In this article, the authors provide an overview of the historical background, physiology, and animal and human data leading to the development of implantable cooling devices for the treatment of medically refractory epilepsy... - Transcortical cooling inhibits hippocampal-kindled seizures in the ratJustin M Burton
Department of Neurological Surgery, Washington University, St. Louis, Missouri 63110, USA
Epilepsia 46:1881-7. 2005..These findings have important implications for the potential use of implantable cooling devices in humans with refractory epilepsies in or near eloquent cortex or dominant hippocampal formations... - The unilateral cobalt wire model of neocortical epilepsy: a method of producing subacute focal seizures in rodentsJong Hee Chang
Department of Neurosurgery, Yonsei University, Seoul, Korea
Epilepsy Res 61:153-60. 2004..This model should be useful for testing new therapies for neocortical epilepsy...