Research Topics
Species | Marcus E RaichleSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Brain work and brain imagingMarcus E Raichle
Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Annu Rev Neurosci 29:449-76. 2006..Finally, neuroimaging, with its unique metabolic perspective, has alerted us to the ongoing and costly intrinsic activity within brain systems that most likely represents the largest fraction of the brain's functional activity...- Neuroscience. The brain's dark energyMarcus E Raichle
Department of Radiology [corrected, Washington University School of Medicine, St. Louis, MO 63110, USA. [corrected
Science 314:1249-50. 2006 - The restless brainMarcus E Raichle
Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Brain Connect 1:3-12. 2011..In this essay, some of the unique features of intrinsic activity are reviewed, as it relates to our understanding of brain organization... - Appraising the brain's energy budgetMarcus E Raichle
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Proc Natl Acad Sci U S A 99:10237-9. 2002 - Intrinsic brain activity sets the stage for expression of motivated behaviorMarcus E Raichle
Department of Radiology, Washington University, St Louis, Missouri 63110, USA
J Comp Neurol 493:167-76. 2005..Distinguishing intrinsic from evoked activity in the context of functional brain imaging experiments is challenging, however. Here we review some evolving strategies for doing so... - A default mode of brain function: a brief history of an evolving ideaMarcus E Raichle
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Neuroimage 37:1083-90; discussion 1097-9. 2007..Most critically, this work has called attention to the importance of intrinsic functional activity in assessing brain behavior relationships... - A brief history of human brain mappingMarcus E Raichle
Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
Trends Neurosci 32:118-26. 2009..Although much of this work has transpired over the past couple of decades, its roots can be traced back more than a century... - A default mode of brain functionM E Raichle
Mallinckrodt Institute of Radiology and Departments of Neurology and Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 98:676-82. 2001..These decreases suggest the existence of an organized, baseline default mode of brain function that is suspended during specific goal-directed behaviors... - Functional brain imaging and human brain functionMarcus E Raichle
Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Neurosci 23:3959-62. 2003 - Two views of brain functionMarcus E Raichle
Departments of Radiology, Neurology, Neurobiology and Biomedical Engineering, Washington University School of Medicine, 4525 Scott Avenue, Room 2116, St Louis, MO 63110, USA
Trends Cogn Sci 14:180-90. 2010.... - The neural correlates of consciousness: an analysis of cognitive skill learningM E Raichle
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Philos Trans R Soc Lond B Biol Sci 353:1889-901. 1998.... - Chapter 18: the origins of functional brain imaging in humansMarcus E Raichle
Department of Radiology and Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Handb Clin Neurol 95:257-68. 2010..While much of this work has transpired over the past couple of decades, its roots can be traced back more than a century... - Mapping the human brain at rest with diffuse optical tomographyBrian R White
Department of Physics, Washington University, St Louis, MO, USA
Conf Proc IEEE Eng Med Biol Soc 2009:4070-2. 2009.... - Transient BOLD responses at block transitionsMichael D Fox
Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Neuroimage 28:956-66. 2005..Relevance of the current findings to studies of exogenous attention, task shifting, and the BOLD overshoot is discussed... - Preoperative sensorimotor mapping in brain tumor patients using spontaneous fluctuations in neuronal activity imaged with functional magnetic resonance imaging: initial experienceDongyang Zhang
Department of Radiology, Washington University in St Louis, St Louis, Missouri 63110, USA
Neurosurgery 65:226-36. 2009..To describe initial experience with resting-state correlation mapping as a potential aid for presurgical planning of brain tumor resection... - Distinct brain networks for adaptive and stable task control in humansNico U F Dosenbach
Department of Radiology, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 104:11073-8. 2007..These two independent networks appear to operate on different time scales and affect downstream processing via dissociable mechanisms... - Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderlyYvette I Sheline
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
Biol Psychiatry 67:584-7. 2010.... - The default mode network and self-referential processes in depressionYvette I Sheline
Department of Psychiatry, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 106:1942-7. 2009..These findings provide a brain network framework within which to consider the pathophysiology of depression... - Noninvasive functional and structural connectivity mapping of the human thalamocortical systemDongyang Zhang
Department of Radiology, Washington University, St Louis, MO 63110, USA
Cereb Cortex 20:1187-94. 2010..However, important differences between structural and functional mapping results are also manifest which suggests a more complex interpretation and emphasizes the unique contributions from structural and functional mapping... - Coherent spontaneous activity identifies a hippocampal-parietal memory networkJustin L Vincent
Mallinckrodt Institute of Radiology, and Department of Neurology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110, USA
J Neurophysiol 96:3517-31. 2006..These regions showed greater activity to successfully recollected items as compared with other trial types. Together, these results associate specific regions of parietal cortex that are sensitive to successful recollection with the HF... - The global signal and observed anticorrelated resting state brain networksMichael D Fox
Departments of Radiology, Washington University in St Louis, St Louis, Missouri, USA
J Neurophysiol 101:3270-83. 2009.... - Intrinsic fluctuations within cortical systems account for intertrial variability in human behaviorMichael D Fox
Department of Radiology, Washington University, St Louis, MO 63110, USA
Neuron 56:171-84. 2007..In addition to establishing a functional and behavioral significance of intrinsic brain activity, these results lend new insight into the origins of variability in human behavior... - The maturing architecture of the brain's default networkDamien A Fair
Department of Neurology, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 105:4028-32. 2008..We found that the default regions are only sparsely functionally connected at early school age (7-9 years old); over development, these regions integrate into a cohesive, interconnected network... - A method for using blocked and event-related fMRI data to study "resting state" functional connectivityDamien A Fair
Department of Neurology, Washington University School of Medicine, Campus Box 8111, 660 S Euclid, St Louis, MO 63110, USA
Neuroimage 35:396-405. 2007..Although using event-related data residuals for resting state functional connectivity may still be useful, results should be interpreted with care... - Development of distinct control networks through segregation and integrationDamien A Fair
Departments of Neurology, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 104:13507-12. 2007..Delay/disruption in the developmental processes of segregation and integration may play a role in disorders of control, such as autism, attention deficit hyperactivity disorder, and Tourette's syndrome... - Spontaneous neuronal activity distinguishes human dorsal and ventral attention systemsMichael D Fox
Department of Radiology, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 103:10046-51. 2006..These findings demonstrate that the neuroanatomical substrates of human attention persist in the absence of external events, reflected in the correlation structure of spontaneous activity... - Intrinsic functional relations between human cerebral cortex and thalamusDongyang Zhang
Washington University, Department of Radiology, Campus Box 8225, 510 South Kingshighway Blvd, St Louis, MO 63110, USA
J Neurophysiol 100:1740-8. 2008..These results extend our understanding of the intrinsic network organization of the human brain to the thalamus and highlight the potential of resting-state fMRI BOLD imaging to elucidate thalamocortical relationships... - Electrophysiological correlates of the brain's intrinsic large-scale functional architectureBiyu J He
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 105:16039-44. 2008..Our results provide an important bridge between the large-scale brain networks readily revealed by spontaneous BOLD signals and their underlying neurophysiology... - Resting-state functional connectivity in the human brain revealed with diffuse optical tomographyBrian R White
Department of Radiology, Washington University, St Louis, MO 63110, USA
Neuroimage 47:148-56. 2009..In addition, the comprehensive hemoglobin contrasts of fc-DOT enable innovative studies of the biophysical origin of the functional connectivity signal... - The fMRI signal, slow cortical potential and consciousnessBiyu J He
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
Trends Cogn Sci 13:302-9. 2009..This hypothesis, unlike several previous theories of consciousness, is firmly rooted in physiology and as such is entirely amenable to empirical testing... - Regional aerobic glycolysis in the human brainS Neil Vaishnavi
Department of Radiology, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 107:17757-62. 2010.... - The temporal structures and functional significance of scale-free brain activityBiyu J He
Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
Neuron 66:353-69. 2010..Our findings reveal robust temporal structures and behavioral significance of scale-free brain activity and should motivate future study on its physiological mechanisms and cognitive implications... - Resting states affect spontaneous BOLD oscillations in sensory and paralimbic cortexMark McAvoy
Department of Radiology, Washington University School of Medicine, 4525 Scott Ave, Campus Box 8225, Rm 2110, St Louis, MO 63110, USA
J Neurophysiol 100:922-31. 2008..In conclusion, changes in resting state were associated with synchronous modulations of spontaneous BOLD oscillations in cortical sensory areas driven by two spatially overlapping, but temporally uncorrelated signals... - The human brain is intrinsically organized into dynamic, anticorrelated functional networksMichael D Fox
Department of Radiology, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 102:9673-8. 2005..We suggest that both task-driven neuronal responses and behavior are reflections of this dynamic, ongoing, functional organization of the brain... - Spatial correlation between brain aerobic glycolysis and amyloid-? (A? ) depositionAndrei G Vlassenko
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 107:17763-7. 2010.... - Cortical network functional connectivity in the descent to sleepLinda J Larson-Prior
Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 106:4489-94. 2009..Rather, accumulating evidence supports the hypothesis that spontaneous BOLD fluctuations reflect processes that maintain the integrity of functional systems in the brain... - Premotor functional connectivity predicts impulsivity in juvenile offendersBenjamin J Shannon
Department of Radiology, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 108:11241-5. 2011..This observation suggests that impulsivity in the offender population is a consequence of a delay in typical development, rather than a distinct abnormality... - Evidence for a frontoparietal control system revealed by intrinsic functional connectivityJustin L Vincent
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
J Neurophysiol 100:3328-42. 2008..The frontoparietal control system is therefore anatomically positioned to integrate information from these two opposing brain systems... - Disease and the brain's dark energyDongyang Zhang
Mallinckrodt Institute of Radiology, Washington University, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
Nat Rev Neurol 6:15-28. 2010..To end the article, we explore some of the basic science pursuits that have been undertaken to further understand the physiology behind intrinsic activity as imaged with BOLD fMRI... - Modulation of the brain's functional network architecture in the transition from wake to sleepLinda J Larson-Prior
Neuroimaging Laboratory, Mallinckrodt Institute of Radiology, Washington University in St Louis, St Louis, MO, USA
Prog Brain Res 193:277-94. 2011..These data clarify the complex and dynamic nature of the transitional period between wake and sleep and suggest the need for more studies investigating the dynamics of these processes... - Bidirectional Relationship between Functional Connectivity and Amyloid-? Deposition in Mouse BrainAdam W Bero
Departments of Neurology, Developmental Biology, Radiology, Biomedical Engineering, and Anatomy and Neurobiology, Hope Center for Neurological Disorders, and Charles F and Joanne Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63110, and Department of Physics, Washington University, St Louis, Missouri 63130
J Neurosci 32:4334-40. 2012.... - Symmetry of cortical folding abnormalities in Williams syndrome revealed by surface-based analysesDavid C Van Essen
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 26:5470-83. 2006..These findings provide insights regarding possible developmental mechanisms that give rise to folding abnormalities and to the spectrum of behavioral characteristics associated with WS... - Emotion-induced changes in human medial prefrontal cortex: I. During cognitive task performanceJ R Simpson
Mallinckrodt Institute of Radiology, and Departments of Anatomy and Neurobiology, Psychiatry, and Neurology, Washington University School of Medicine, St Louis, MO, 63110, USA
Proc Natl Acad Sci U S A 98:683-7. 2001..Taken together, these results suggest that the MPFC is part of a network, including the hypothalamus and brainstem, whose activity reflects a dynamic interplay between cognitive task performance and emotion... - Effect of practice on reading performance and brain functionDeborah L Kerr
Department of Radiology, Campus Box 8225, 4525 Scott Street, Washington University School of Medicine, St. Louis, MO 63110, USA
Neuroreport 15:607-10. 2004.... - Neuronal activity regulates the regional vulnerability to amyloid-? depositionAdam W Bero
Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA
Nat Neurosci 14:750-6. 2011..Long-term unilateral vibrissal deprivation decreased amyloid plaque formation and growth. Our results suggest a mechanism to account for the vulnerability of specific brain regions to A? deposition in Alzheimer's disease... - Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responsesMichael D Fox
Department of Radiology, Washington University in St Louis, St Louis, Missouri 63110, USA
Nat Neurosci 9:23-5. 2006.... - The BOLD onset transient: identification of novel functional differences in schizophreniaMichael D Fox
Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
Neuroimage 25:771-82. 2005..Relevance of these findings to both an interpretation of the onset transient and the pathology of schizophrenia are discussed... - Spontaneous fluctuations in brain activity observed with functional magnetic resonance imagingMichael D Fox
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, Missouri 63110, USA
Nat Rev Neurosci 8:700-11. 2007..Although several challenges remain, these studies have provided insight into the intrinsic functional architecture of the brain, variability in behaviour and potential physiological correlates of neurological and psychiatric disease... - Regulation of blood flow in activated human brain by cytosolic NADH/NAD+ ratioAndrei G Vlassenko
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, MO 63110, USA
Proc Natl Acad Sci U S A 103:1964-9. 2006.... - Increased lactate/pyruvate ratio augments blood flow in physiologically activated human brainMark A Mintun
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 101:659-64. 2004..Our observations support the hypothesis that an increase in the NADH/NAD(+) ratio activates signaling pathways to selectively increase CBF in the physiologically stimulated brain regions... - Tracking neuronal fiber pathways in the living human brainT E Conturo
Department of Radiology and Neuroimaging Laboratory, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 96:10422-7. 1999..This approach enhances the power of modern imaging by enabling study of fiber connections among anatomically and functionally defined brain regions in individual human subjects... - Default brain functionality in blind peopleH Burton
Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 101:15500-5. 2004..More generally, these results support the notion that the brain largely operates intrinsically, with sensory information modulating rather than determining system operations... - Blood flow and oxygen delivery to human brain during functional activity: theoretical modeling and experimental dataM A Mintun
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 98:6859-64. 2001..These findings strongly indicate that the increase in CBF associated with physiological activation is regulated by factors other than local requirements in oxygen... - Functional MRI studies of word-stem completion: reliability across laboratories and comparison to blood flow imaging with PETJ G Ojemann
Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110
Hum Brain Mapp 6:203-15. 1998..A further implication of the consistencies, which extended to both increases and decreases in signal, is that the underlying brain physiology leading to BOLD contrast may be more similar to blood flow than originally appreciated... - The effects of practice on the functional anatomy of task performanceS E Petersen
Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 95:853-60. 1998..The specific regions used for scaffolding and storage appear to be task dependent... - Coupling between changes in human brain temperature and oxidative metabolism during prolonged visual stimulationD A Yablonskiy
Mallinckrodt Institute of Radiology, 4525 Scott Avenue, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 97:7603-8. 2000.... - Adaptive changes in early and late blind: a FMRI study of verb generation to heard nounsH Burton
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurophysiol 88:3359-71. 2002..It remains possible that these responses represent adaptations which initially are for processing either sound or touch, but which are later generalized to the other modality during acquisition of Braille reading skills... - Adaptive changes in early and late blind: a fMRI study of Braille readingH Burton
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurophysiol 87:589-607. 2002..It is argued that these responses may represent critical language processing mechanisms normally present in visual cortex... - Preserved speech abilities and compensation following prefrontal damageR L Buckner
Department of Neurology, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 93:1249-53. 1996..We used functional brain imaging with positron emission tomography (PET) as a basis for this study... - Tactile attention tasks enhance activation in somatosensory regions of parietal cortex: a positron emission tomography studyH Burton
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Cereb Cortex 9:662-74. 1999..These non-sensory areas may constitute a network that provides a source of modulating influences on the earlier stage, sensory areas... - A common network of functional areas for attention and eye movementsM Corbetta
Department of Neurology, McDonnell Center for Higher Brain Functions, Washington University School of Medicine, St Louis, Missouri 63110, USA
Neuron 21:761-73. 1998..This anatomical overlap is consistent with the hypothesis that attentional and oculomotor processes are tightly integrated at the neural level... - Direct comparison of episodic encoding and retrieval of words: an event-related fMRI studyK B McDermott
Washington University School of Medicine, St Louis, MO, USA
Memory 7:661-78. 1999..Regions more active in retrieval than encoding included bilateral inferior parietal cortex, bilateral precuneus, right frontal polar cortex, right dorsolateral prefrontal cortex, and right inferior frontal/insular cortex... - Searching for a baseline: functional imaging and the resting human brainD A Gusnard
The Mallinckrodt Institute of Radiology, Washington University, St Louis, Missouri 63110, USA
Nat Rev Neurosci 2:685-94. 2001..We explore this possibility, including the manner in which we might define a baseline and the implications of such a baseline for our understanding of brain function... - Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain functionD A Gusnard
Mallinckrodt Institute of Radiology and Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 98:4259-64. 2001..We suggest that a useful way to explore the neurobiology of the self is to explore the nature of default state activity... - Detection of blast-related traumatic brain injury in U.S. military personnelChristine L Mac Donald
Washington University School of Medicine, St Louis, MO 63110, USA
N Engl J Med 364:2091-100. 2011..Blast-related traumatic brain injuries have been common in the Iraq and Afghanistan wars, but fundamental questions about the nature of these injuries remain unanswered... - Persistence and brain circuitryDebra A Gusnard
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 100:3479-84. 2003..These findings represent a fresh approach to linking normal individual differences in personality and behavior to specific neuronal structures and subsystems... - Loss of resting interhemispheric functional connectivity after complete section of the corpus callosumJames M Johnston
Department of Neurosurgery, Washington University, St Louis, Missouri 63110, USA
J Neurosci 28:6453-8. 2008..Such observations have the potential to increase our understanding of large-scale brain systems in health and disease as well as improve the treatment of neurologic disorders... - Emotion-induced changes in human medial prefrontal cortex: II. During anticipatory anxietyJ R Simpson
Mallinckrodt Institute of Radiology, and Departments of Anatomy and Neurobiology, Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA
Proc Natl Acad Sci U S A 98:688-93. 2001..The characterization of such relationships within the human brain enables new insights into the integration of cognition and emotion... - Intrinsic functional architecture in the anaesthetized monkey brainJ L Vincent
Department of Radiology, Washington University in St Louis, Missouri 63110, USA
Nature 447:83-6. 2007..Our results indicate that coherent system fluctuations probably reflect an evolutionarily conserved aspect of brain functional organization that transcends levels of consciousness... - Human brain activity time-locked to perceptual event boundariesJ M Zacks
Department of Psychology, Washington University, One Brookings Drive, Saint Louis, Missouri 63130, USA
Nat Neurosci 4:651-5. 2001..Activity within this network may provide a basis for parsing the temporally evolving environment into meaningful units... - Integration of emotion and cognition in the lateral prefrontal cortexJeremy R Gray
Department of Psychology, Washington University, One Brookings Drive, St. Louis, MO 63130, USA
Proc Natl Acad Sci U S A 99:4115-20. 2002..Other regions in lateral PFC showed hemispheric specialization for emotion and for stimuli separately, consistent with a hierarchical and hemisphere-based mechanism of integration... - Volumetric reduction in left subgenual prefrontal cortex in early onset depressionKelly N Botteron
Department of Radiology, School of Medicine, Washington University, 660 South Euclid Avenue, Box 8134, St. Louis, MO 63110, USA
Biol Psychiatry 51:342-4. 2002..CONCLUSIONS: Left subgenual cingulate volume reductions are present in young women with adolescent onset MD... - Functional deactivations: change with age and dementia of the Alzheimer typeCindy Lustig
Department of Psychology, Washington University, St Louis, MO 63130, USA
Proc Natl Acad Sci U S A 100:14504-9. 2003.... - Verbal memory deficit following traumatic brain injury: assessment using advanced MRI methodsC L MacDonald
Departments of Neurology, Washington University, St Louis, MO 63110, USA
Neurology 71:1199-201. 2008 - Detection of cortical activation during averaged single trials of a cognitive task using functional magnetic resonance imagingR L Buckner
Department of Radiology, Massachusetts General Hospital Nuclear Magnetic Resonance Center, Charlestown 02129, USA
Proc Natl Acad Sci U S A 93:14878-83. 1996..Such paradigms will provide experimental flexibility and time-resolved data for individual brain regions on a trial-by-trial basis... - Disruption of large-scale brain systems in advanced agingJessica R Andrews-Hanna
Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
Neuron 56:924-35. 2007..These results suggest that cognitive decline in normal aging arises from functional disruption in the coordination of large-scale brain systems that support cognition... - A proposal for a Decade of the Mind initiativeJames S Albus
Science 317:1321. 2007 - Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolismWayne C Drevets
Neuroimaging in Mood and Anxiety Disorders Section, National Institutes of Health, NIMH MIB, Bethesda, MD 20892, USA
Eur Neuropsychopharmacol 12:527-44. 2002.... - Glucose metabolism in the amygdala in depression: relationship to diagnostic subtype and plasma cortisol levelsWayne C Drevets
Section on Neuroimaging of Mood and Anxiety Disorders, Molecular Imaging Branch, NIH National Institute of Mental Health, Building 1, Room B3 10, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
Pharmacol Biochem Behav 71:431-47. 2002....