RICHARD OSTLUNDSummaryAffiliation: Washington University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Regulation of cholesterol absorption by phytosterolsRichard E Ostlund
Division of Endocrinology, Metabolism and Lipid Research, Box 8127, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Curr Atheroscler Rep 8:487-91. 2006..Phytosterols appear to be quantitatively as important to cholesterol lowering as reducing saturated fat consumption, and they provide an additional tool for regulation of circulating cholesterol through lifestyle changes...- Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humansRichard E Ostlund
Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, Missouri 63017, USA
Am J Physiol Endocrinol Metab 282:E911-6. 2002..We conclude that the efficiency of phytosterol absorption is lower than what was reported previously and is critically dependent on the structure of both sterol nucleus and side chain... - Phytosterols, cholesterol absorption and healthy dietsRichard E Ostlund
Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, 660 South Euclid Ave, Box 8127, St Louis, MO 63110, USA
Lipids 42:41-5. 2007..The retention of phytosterols during food manufacturing and the use of foods with high phytosterol content may constitute an alternative to the use of supplements... - Phytosterols and cholesterol metabolismRichard E Ostlund
Department of Internal Medicine, Washington University, St Louis, Missouri 63110, USA
Curr Opin Lipidol 15:37-41. 2004..Because they have very low systemic absorption and are already present in healthy diets, increasing the intake of phytosterols may be a practical way to reduce coronary heart disease with minimum risk... - Inhibition of cholesterol absorption by phytosterol-replete wheat germ compared with phytosterol-depleted wheat germRichard E Ostlund
Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Washington University, St Louis, MO 63110, USA
Am J Clin Nutr 77:1385-9. 2003..Low-fat vegetable foods contain phytosterols, but it is not known whether they are in biologically active forms or whether their concentrations are high enough to reduce cholesterol absorption and favorably affect lipid metabolism... - Phytosterols in human nutritionRichard E Ostlund
Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, Washington University, St Louis, Missouri 63110, USA
Annu Rev Nutr 22:533-49. 2002..Increasing the aggregate amount of phytosterols consumed in a variety of foods may be an important way of reducing population cholesterol levels and preventing coronary heart disease... - Fat-free foods supplemented with soy stanol-lecithin powder reduce cholesterol absorption and LDL cholesterolCurtis A Spilburg
Lifeline Technologies, Chesterfield, MO 63017, USA
J Am Diet Assoc 103:577-81. 2003..The objective of this work was to show that fat-free, lecithin-formulated soy stanols lower cholesterol absorption and serum LDL cholesterol... - Phytosterols that are naturally present in commercial corn oil significantly reduce cholesterol absorption in humansRichard E Ostlund
Division of Endocrinology, Diabetes and Metabolism, Washington University, St Louis, MO 63110, USA
Am J Clin Nutr 75:1000-4. 2002..Vegetable oils are the richest dietary source of phytosterols; corn oil contains 0.77% phytosterols by weight... - Phytostanol tablets reduce human LDL-cholesterolTimothy B McPherson
St. Louis College of Pharmacy, 4588 Parkview Place, St. Louis, MO 63110, USA
J Pharm Pharmacol 57:889-96. 2005..Taken together, these studies demonstrate that for maximum LDL-cholesterol reduction activity the stanol lecithin formulation must be delivered in a rapidly dispersible form to reach the site of cholesterol absorption... - Effects of trace components of dietary fat on cholesterol metabolism: phytosterols, oxysterols, and squaleneRichard E Ostlund
Division of Endocrinology, Diabetes, and Metabolism, Washington University, St Louis, MO 63110, USA
Nutr Rev 60:349-59. 2002.... - Reduced intestinal fat absorptive capacity but enhanced susceptibility to diet-induced fatty liver in mice heterozygous for ApoB38.9 truncationXiaobo Lin
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Am J Physiol Gastrointest Liver Physiol 289:G146-52. 2005..Hepatic TG secretion remained impaired in the apob(+/38.9) on the HF diet. Thus the FHBL mice are more susceptible to diet-induced fatty liver despite relatively reduced intestinal TG absorption capacity on a HF diet... - Resistive training and chromium picolinate: effects on inositols and liver and kidney functions in older adultsWayne W Campbell
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA
Int J Sport Nutr Exerc Metab 14:430-42. 2004..These results suggest that RT did not influence the urinary excretions of inositols. High dose Cr-pic did not influence the urinary excretion of inositols and the selected indices of kidney and liver functions in conjunction with RT... - Effect of plant stanol tablets on low-density lipoprotein cholesterol lowering in patients on statin drugsAnne C Goldberg
Department of Internal Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, Missouri, USA
Am J Cardiol 97:376-9. 2006..The additional LDL cholesterol lowering with stanol/lecithin tablets provided a potential adjunctive therapy for patients who have not reached their target LDL cholesterol goal during statin therapy... - A targeted apoB38.9 mutation in mice is associated with reduced hepatic cholesterol synthesis and enhanced lipid peroxidationXiaobo Lin
Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Am J Physiol Gastrointest Liver Physiol 290:G1170-6. 2006..In contrast, apoB38.9 mice effectively maintain cholesterol homeostasis in the liver, at least in part, by reducing hepatic cholesterol synthesis... - Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamstersEmily J Westover
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
J Lipid Res 47:2374-81. 2006..These findings suggest that cholesterol absorption is structurally specific and likely to be mediated by enantiospecific cellular proteins... - Pinitol supplementation does not affect insulin-mediated glucose metabolism and muscle insulin receptor content and phosphorylation in older humansWayne W Campbell
Department of Foods and Nutrition, Purdue University, West Lafayette, IN, USA
J Nutr 134:2998-3003. 2004..These data suggest that pinitol supplementation does not influence whole-body insulin-mediated glucose metabolism and muscle insulin receptor content and phosphorylation in nondiabetic, older people...
Research Grants
- REGULATION OF INTESTINAL CHOLESTEROL ABSORPTIONRICHARD OSTLUND; Fiscal Year: 2007..Successful completion of this work will provide new directions for improving circulating lipoproteins through dietary counseling as well as by changes in industrial food manufacturing. ..
- Pinitol in Human NutritionRICHARD OSTLUND; Fiscal Year: 2004..In the long term it may be possible to improve human hyperinsulinemic states by dietary recommendations or by recovering pinitol from food waste streams. ..
- REGULATION OF INTESTINAL CHOLESTEROL ABSORPTIONRICHARD OSTLUND; Fiscal Year: 2003..Knowledge of the importance of phytosterols, oxysterols and dietary determinants of cholesterol absorption will be used in supporting future dietary recommendations and research. ..