KAREN L O'MALLEY

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi Activation of metabotropic glutamate receptor mGlu5 on nuclear membranes mediates intranuclear Ca2+ changes in heterologous cell types and neurons
    KAREN L O'MALLEY
    Department of Anatomy, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:28210-9. 2003
  2. ncbi 6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death
    Alison I Bernstein
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St, Louis, MO 63110, USA
    Mol Neurodegener 6:2. 2011
  3. ncbi Targeted expression of BCL-2 attenuates MPP+ but not 6-OHDA induced cell death in dopaminergic neurons
    KAREN L O'MALLEY
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63108, USA
    Neurobiol Dis 14:43-51. 2003
  4. ncbi Intracellular metabotropic glutamate receptor 5 (mGluR5) activates signaling cascades distinct from cell surface counterparts
    Yuh Jiin I Jong
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 284:35827-38. 2009
  5. ncbi Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein
    Vikas Kumar
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 287:5412-25. 2012
  6. ncbi Wld(S) mice are protected against the Parkinsonian mimetic MPTP
    Daphne M Hasbani
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Campus Box 8108, 660 S Euclid Ave, St Louis, MO 63110, USA
    Exp Neurol 202:93-9. 2006
  7. ncbi Nuclear localization of functional metabotropic glutamate receptor mGlu1 in HEK293 cells and cortical neurons: role in nuclear calcium mobilization and development
    Yuh Jiin I Jong
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurochem 101:458-69. 2007
  8. ncbi Activated nuclear metabotropic glutamate receptor mGlu5 couples to nuclear Gq/11 proteins to generate inositol 1,4,5-trisphosphate-mediated nuclear Ca2+ release
    Vikas Kumar
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 283:14072-83. 2008
  9. ncbi The Parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons
    Jeong Sook Kim-Han
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Neurosci 31:7212-21. 2011
  10. ncbi Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo
    Daphne M Hasbani
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:9428-33. 2005

Research Grants

  1. Signaling By Nuclear G-Protein Coupled Receptors
    KAREN O MALLEY; Fiscal Year: 2005
  2. Metabotropic Receptors: Structure/Function/Regulation
    KAREN O MALLEY; Fiscal Year: 2006
  3. MECHANISMS OF NEURONAL DEATH IN PARKINSON'S DISEASE
    KAREN O MALLEY; Fiscal Year: 2009
  4. Functional Consequences of Nuclear mGlu5 Receptor Activation
    KAREN O MALLEY; Fiscal Year: 2007
  5. TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENES
    KAREN O MALLEY; Fiscal Year: 2007
  6. MECHANISMS OF NEURONAL DEATH IN PARKINSON'S DISEASE
    KAREN O MALLEY; Fiscal Year: 2007
  7. TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENES
    KAREN O MALLEY; Fiscal Year: 2001
  8. MODULATION OF DOPAMINE AUTORECEPTOR FUNCTION BY COCAINE
    KAREN O MALLEY; Fiscal Year: 2001
  9. TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENES
    KAREN O MALLEY; Fiscal Year: 1991
  10. MECHANISMS OF NEURONAL DEATH IN PARKINSON'S DISEASE
    KAREN L O apos MALLEY; Fiscal Year: 2010

Collaborators

  • David H Gutmann
  • Jian Liu
  • Francisco A Perez
  • Carmelo Romano
  • Julie Lotharius
  • Carla M Yuede
  • KAREN O MALLEY
  • Yuh Jiin I Jong
  • KAREN L O apos MALLEY
  • Vikas Kumar
  • Jeong Sook Kim-Han
  • Daphne M Hasbani
  • Alison I Bernstein
  • Jacquelyn A Brown
  • Yuh-Jiin I Jong
  • William A Holtz
  • Penny J Jensen
  • Narendrakumar Ramanan
  • Paul G Fahey
  • Sean P Garrison
  • Jo Ann Antenor-Dorsey
  • Gerard P Zambetti
  • Ryan J Emnett
  • Sara B Conyers
  • David F Wozniak
  • Crystal R White
  • Katherine E Schwetye
  • Jay M Turetzky
  • Richard D Palmiter
  • Benedict J Alter

Detail Information

Publications14

  1. ncbi Activation of metabotropic glutamate receptor mGlu5 on nuclear membranes mediates intranuclear Ca2+ changes in heterologous cell types and neurons
    KAREN L O'MALLEY
    Department of Anatomy, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:28210-9. 2003
    ..Similarly, activation of mGlu5 receptors expressed on neuronal nuclei led to sustained Ca2+ oscillatory responses. These results suggest mGlu5 may mediate intranuclear signaling pathways...
  2. ncbi 6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death
    Alison I Bernstein
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St, Louis, MO 63110, USA
    Mol Neurodegener 6:2. 2011
    ..abstract:..
  3. ncbi Targeted expression of BCL-2 attenuates MPP+ but not 6-OHDA induced cell death in dopaminergic neurons
    KAREN L O'MALLEY
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63108, USA
    Neurobiol Dis 14:43-51. 2003
    ..Thus, differential cell death pathways are associated with these cytotoxic signals in primary models of Parkinson's disease...
  4. ncbi Intracellular metabotropic glutamate receptor 5 (mGluR5) activates signaling cascades distinct from cell surface counterparts
    Yuh Jiin I Jong
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 284:35827-38. 2009
    ..Glutamate activation of intracellular mGluR5 serves an important role in the regulation of nuclear Ca(2+), transcriptional activation, and gene expression necessary for physiological processes such as synaptic plasticity...
  5. ncbi Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein
    Vikas Kumar
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 287:5412-25. 2012
    ..Taken together, these data highlight the importance of intracellular mGluR5 in the cascade of events associated with sustained synaptic transmission...
  6. ncbi Wld(S) mice are protected against the Parkinsonian mimetic MPTP
    Daphne M Hasbani
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Campus Box 8108, 660 S Euclid Ave, St Louis, MO 63110, USA
    Exp Neurol 202:93-9. 2006
    ..These results suggest new therapeutic avenues for Parkinson's disease...
  7. ncbi Nuclear localization of functional metabotropic glutamate receptor mGlu1 in HEK293 cells and cortical neurons: role in nuclear calcium mobilization and development
    Yuh Jiin I Jong
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurochem 101:458-69. 2007
    ....
  8. ncbi Activated nuclear metabotropic glutamate receptor mGlu5 couples to nuclear Gq/11 proteins to generate inositol 1,4,5-trisphosphate-mediated nuclear Ca2+ release
    Vikas Kumar
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 283:14072-83. 2008
    ..Thus the nucleus can function as an autonomous organelle independent of signals originating in the cytoplasm, and nuclear mGlu5 receptors play a dynamic role in mobilizing Ca2+ in a specific, localized fashion...
  9. ncbi The Parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons
    Jeong Sook Kim-Han
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Neurosci 31:7212-21. 2011
    ..Since these drugs also rescued processes from degeneration, these findings emphasize the need to develop therapeutics aimed at axons as well as cell bodies to preserve "normal" circuitry and function as long as possible...
  10. ncbi Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo
    Daphne M Hasbani
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:9428-33. 2005
    ..These results suggest that DA does not contribute to acute MPTP toxicity in vivo...
  11. ncbi Alpha-synuclein protects naive but not dbcAMP-treated dopaminergic cell types from 1-methyl-4-phenylpyridinium toxicity
    Penny J Jensen
    Washington University School of Medicine, Anatomy and Neurobiology Department, St Louis, Missouri 63110, USA
    J Neurochem 86:196-209. 2003
    ..These results suggest that the normal physiological role for alpha-synuclein may change during development...
  12. ncbi Cell stress induced by the parkinsonian mimetic, 6-hydroxydopamine, is concurrent with oxidation of the chaperone, ERp57, and aggresome formation
    Jeong Sook Kim-Han
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Antioxid Redox Signal 9:2255-64. 2007
    ..Understanding the signaling mechanisms associated with parkinsonian mimetics, as well as their temporal induction, may aid in designing better interventions in models of PD...
  13. ncbi Microarray expression profiling identifies early signaling transcripts associated with 6-OHDA-induced dopaminergic cell death
    William A Holtz
    Washington University School of Medicine, Anatomy and Neurobiology Department, St Louis, MO 63110, USA
    Antioxid Redox Signal 7:639-48. 2005
    ..Taken together, these data support the notion that oxidative stress and protein dysfunction play a role in Parkinson's disease, as well as provide a time course for many of the molecular events associated with 6-OHDA neurotoxicity...
  14. ncbi Reduced striatal dopamine underlies the attention system dysfunction in neurofibromatosis-1 mutant mice
    Jacquelyn A Brown
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Hum Mol Genet 19:4515-28. 2010
    ..Collectively, these data establish abnormal DA homeostasis as the primary biochemical defect underlying the attention system dysfunction in Nf1 GEM relevant to children with NF1...

Research Grants40

  1. Signaling By Nuclear G-Protein Coupled Receptors
    KAREN O MALLEY; Fiscal Year: 2005
    ..Direct nuclear calcium regulation represents a novel signaling strategy by which intracellular receptors such as mGlu5 may play a pivotal role in generating and shaping intracellular Ca2+ signals ..
  2. Metabotropic Receptors: Structure/Function/Regulation
    KAREN O MALLEY; Fiscal Year: 2006
    ..We anticipate that these investigations of mGluR dimerization will deepen our understanding of neural communication and signal transduction, processes that underlie brain function and dysfunction. ..
  3. MECHANISMS OF NEURONAL DEATH IN PARKINSON'S DISEASE
    KAREN O MALLEY; Fiscal Year: 2009
    ....
  4. Functional Consequences of Nuclear mGlu5 Receptor Activation
    KAREN O MALLEY; Fiscal Year: 2007
    ....
  5. TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENES
    KAREN O MALLEY; Fiscal Year: 2007
    ..Knowledge gained from these studies may offer new routes for therapeutic intervention. ..
  6. MECHANISMS OF NEURONAL DEATH IN PARKINSON'S DISEASE
    KAREN O MALLEY; Fiscal Year: 2007
    ....
  7. TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENES
    KAREN O MALLEY; Fiscal Year: 2001
    ..Conceivably, knowledge gained from these studies may offer new routes for therapeutic intervention. ..
  8. MODULATION OF DOPAMINE AUTORECEPTOR FUNCTION BY COCAINE
    KAREN O MALLEY; Fiscal Year: 2001
    ..Taken together these studies will significantly extend our ongoing efforts to understand the complex receptor/presynaptic effector interactions involved in the reinforcing and behavioral sensitization effects of cocaine. ..
  9. TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENES
    KAREN O MALLEY; Fiscal Year: 1991
    ..Understanding such structural requirements will help us understand the mechanisms which contribute to neuronal phonotypic diversity and development and perhaps, atypical catecholamine expression...
  10. MECHANISMS OF NEURONAL DEATH IN PARKINSON'S DISEASE
    KAREN L O apos MALLEY; Fiscal Year: 2010
    ....