Jason A Metcalf

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi Mechanism of shortened bones in mucopolysaccharidosis VII
    Jason A Metcalf
    Department of Medicine, Washington University School of Medicine, Campus Box 8125, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    Mol Genet Metab 97:202-11. 2009
  2. ncbi A self-inactivating gamma-retroviral vector reduces manifestations of mucopolysaccharidosis I in mice
    Jason A Metcalf
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Mol Ther 18:334-42. 2010
  3. ncbi Upregulation of elastase activity in aorta in mucopolysaccharidosis I and VII dogs may be due to increased cytokine expression
    Jason A Metcalf
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Genet Metab 99:396-407. 2010

Detail Information

Publications3

  1. ncbi Mechanism of shortened bones in mucopolysaccharidosis VII
    Jason A Metcalf
    Department of Medicine, Washington University School of Medicine, Campus Box 8125, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    Mol Genet Metab 97:202-11. 2009
    ..This suggests that accumulation of C4S in the growth plate leads to reduced expression of LIF and reduced STAT3 tyrosine phosphorylation, which results in reduced chondrocyte proliferation and ultimately shortened bones...
  2. ncbi A self-inactivating gamma-retroviral vector reduces manifestations of mucopolysaccharidosis I in mice
    Jason A Metcalf
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Mol Ther 18:334-42. 2010
    ..A SIN gamma-RV vector ameliorates clinical manifestations of MPS I in mice and should be safer than an LTR-intact gamma-RV...
  3. ncbi Upregulation of elastase activity in aorta in mucopolysaccharidosis I and VII dogs may be due to increased cytokine expression
    Jason A Metcalf
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Genet Metab 99:396-407. 2010
    ..Inhibitors of these enzymes or these cytokine-induced signal transduction pathways might reduce aortic disease in patients with MPS...