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Species | John W McDonaldSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Publications
Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cordJ W McDonald
Center for the Study of Nervous System Injury, the Restorative Treatment and Research Center and Department of Neurology, Washington University School of Medicine, Box 8111, 660 S Euclid Ave, St Louis, Missouri 63110, USA
Nat Med 5:1410-2. 1999..Furthermore, gait analysis demonstrated that transplanted rats showed hindlimb weight support and partial hindlimb coordination not found in 'sham-operated' controls or control rats transplanted with adult mouse neocortical cells...- Spinal-cord injuryJohn W McDonald
Department of Neurology, Spinal Cord Injury Neuro Rehabilitation Section, and Restorative Treatment and Research Program, Washington University School of Medicine, St Louis, MO 63110, USA
Lancet 359:417-25. 2002..We also discuss new treatment options, including functional electric stimulation and part-weight-supported walking... - Late recovery following spinal cord injury. Case report and review of the literatureJohn W McDonald
Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63108, USA
J Neurosurg 97:252-65. 2002..The role of patterned neural activity in regeneration and recovery of function after SCI therefore appears a fruitful area for future investigation... - Repairing the damaged spinal cord: a summary of our early success with embryonic stem cell transplantation and remyelinationJohn W McDonald
Center for the Study of Nervous System Injury, Spinal Cord Injury Restorative Treatment and Research Program, Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Prog Brain Res 137:299-309. 2002..The role of myelination and remyelination will be discussed in the context of regeneration strategies... - Generating chimeric spinal cord: a novel model for transplantable oligodendrocyte progenitors derived from embryonic stem cellsSudhakar Vadivelu
The International Center for Spinal Cord Injury, Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Neurosurg Focus 19:E3. 2005..Results from the model presented here demonstrate a unique method for examining transplantable oligodendrocyte progenitors derived from ESCs for repair of white matter disease... - Multi-germ layer lineage central nervous system repair: nerve and vascular cell generation by embryonic stem cells transplanted in the injured brainSudhakar Vadivelu
Center for the Study of Nervous System Injury and the Restorative Treatment and Research Program, Washington University School of Medicine, St. Louis, Missouri 63108, USA
J Neurosurg 103:124-35. 2005..The combination of ESC pluripotentiality and multiple germ layer differentiation provides a new conceptual framework for CNS repair... - Repair of the injured spinal cord and the potential of embryonic stem cell transplantationJohn W McDonald
Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri, USA
J Neurotrauma 21:383-93. 2004..These features of ES cells will produce a predictable and explosive growth in scientific tools that will translate into discoveries and rapid progress in neural repair... - Functional electrical stimulation helps replenish progenitor cells in the injured spinal cord of adult ratsDaniel Becker
International Center, for Spinal Cord Injury, Hugo Moser Research Institute, Department of Neurology, Johns Hopkins School of Medicine and Kennedy Krieger Institute, Baltimore, MD 21205, USA
Exp Neurol 222:211-8. 2010..In uninjured rats, FES had no effect on cell birth/survival. This report suggests that controlled electrical activation of the CNS may enhance spontaneous regeneration after neurological injuries... - Restoring function after spinal cord injury: promoting spontaneous regeneration with stem cells and activity-based therapiesVisar Belegu
The International Center for Spinal Cord Injury, Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, 707 North Broadway, Room 518, Baltimore, MD 21205, USA
Neurosurg Clin N Am 18:143-68, xi. 2007.... - Gap junctions and connexon hemichannels in human embryonic stem cellsJames E Huettner
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Stem Cells 24:1654-67. 2006..Human ES cells provide a unique system for the study of human connexin proteins and their potential functions in cellular differentiation and the maintenance of pluripotency... - Repairing the damaged spinal cord: from stem cells to activity-based restoration therapiesJohn W McDonald
Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA
Clin Neurosurg 51:207-27. 2004 - Stem cell transplantation and other novel techniques for promoting recovery from spinal cord injuryTerence M Myckatyn
Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, 4444 Forest Park Boulevard, St. Louis, MO 63108, USA
Transpl Immunol 12:343-58. 2004..The potential role of nerve transfers for reconstructing the injured spinal cord, particularly the cauda equina and lumbosacral plexus, are also described... - Spinal cord injury: promising interventions and realistic goalsJohn W McDonald
Department of Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri 63108, USA
Am J Phys Med Rehabil 82:S38-49. 2003.... - Restoring function after spinal cord injuryDaniel Becker
Department of Neurology, Spinal Cord Injury Neuro-Rehabilitation Section, Restorative Treatment and Research Program, Washington University School of Medicine, St Louis, Missouri 63108, USA
Neurologist 9:1-15. 2003..The ultimate goal is to harness the body's own potential to replace lost central nervous system cells by activation of endogenous progenitor cell repair mechanisms... - AMPA receptors are the major mediators of excitotoxic death in mature oligodendrocytesElizabeth A Leuchtmann
Center for the Study of Nervous System Injury, Washington University School of Medicine, Box 8518, St. Louis, MO 63108, USA
Neurobiol Dis 14:336-48. 2003..We conclude that when mature oligodendrocytes die after exposure to kainate: (1) AMPA receptors are the most important mediators, (2) kainate receptors play a smaller role, and (3) death occurs predominantly by necrosis, not apoptosis... - Rodent models for treatment of spinal cord injury: research trends and progress toward useful repairEphron S Rosenzweig
Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA
Curr Opin Neurol 17:121-31. 2004..We have also catalogued the treatments used in studies published between October 2002 and November 2003, with special attention given to studies in which treatments were delayed for at least 4 days after injury... - Enhanced oligodendrocyte survival after spinal cord injury in Bax-deficient mice and mice with delayed Wallerian degenerationHongxin Dong
Department of Neurology, Spinal Cord Injury Neuro Rehabilitation Section, Restorative Treatment and Research Program, and Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, Missouri 63108, USA
J Neurosci 23:8682-91. 2003..On the basis of these data, we hypothesize that the Wallerian degeneration of white matter axons that follows SCI removes axonal support and induces apoptotic death in oligodendrocytes by triggering Bax expression... - Functional reorganization and stability of somatosensory-motor cortical topography in a tetraplegic subject with late recoveryMaurizio Corbetta
Departments of Neurology, Radiology, Anatomy and Neurobiology, and Neurological Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 99:17066-71. 2002.... - Neurogenesis and neuronal commitment following ischemia in a new mouse model for neonatal strokeS D Kadam
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Brain Res 1208:35-45. 2008..However, the total number of hippocampal SGZ-derived new neurons was reduced bilaterally; in contrast, the SVZ-derived neurogenesis was amplified... - Neurons derived from embryonic stem (ES) cells resemble normal neurons in their vulnerability to excitotoxic deathY Qu
Department of Neurology, Washington University School of Medicine, Box 8111, St, Louis, MO 63110, USA
Exp Neurol 184:326-36. 2003..Thus, ES cells, which are very amenable to genetic manipulation, provide a valid system for studying glutamate receptor-mediated toxicity at the molecular level... - Neurotrophin potentiation of iron-induced spinal cord injuryJ W McDonald
Department of Neurology, Washington University School of Medicine, PO Box 8111, 660 S Euclid Avenue, St Louis, MO 63110-1093, USA
Neuroscience 115:931-9. 2002..These data support the hypothesis that the overall neuroprotective properties of neurotrophins in models of acute injury to the spinal cord may be limited by an underlying potentiation of free radical-mediated necrosis... - Spinal cord injuryC Sadowsky
Department of Neurology, Spinal Cord Injury Neuro-Rehabilitation Section, Washington University School of Medicine, St Louis, MO 63110, USA
Disabil Rehabil 24:680-7. 2002..g. bladder, skin, spasiticity). CONCLUSION: With the recent advances in the neuroscience field, more aggressive interventions geared at secondary injury prevention, neuronal regeneration and functional restoration are emerging... - Delivery of neurotrophin-3 from fibrin enhances neuronal fiber sprouting after spinal cord injurySara J Taylor
Department of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA
J Control Release 113:226-35. 2006..Thus, controlled delivery of NT-3 from fibrin scaffolds enhanced the initial regenerative response by increasing neuronal fiber sprouting and cell migration into the lesion, while functional motor recovery was not observed in this model... - Correction addendum to: Late recovery following spinal cord injuryJohn W McDonald
J Neurosurg 97:405-6. 2002 - Tissue-sparing effect of x-ray microplanar beams particularly in the CNS: is a bystander effect involved?F Avraham Dilmanian
Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Exp Hematol 35:69-77. 2007..The repairs apparently involve the microvasculature and the glial system. We evaluate a hypothesis on the involvement of bystander effects in these repairs... - Neural stem cells reduce brain injury after unilateral carotid ligationAnne M Comi
Division of Neurology and Developmental Medicine, Kennedy Krieger Institute, and Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Pediatr Neurol 38:86-92. 2008..Neural stem cells have the potential to ameliorate ischemic injury in the immature brain, although tumor development is a serious concern... - Controlled release of neurotrophin-3 from fibrin gels for spinal cord injurySara J Taylor
Department of Biomedical Engineering, Washington University, St. Louis, MO, USA
J Control Release 98:281-94. 2004..In a preliminary in vivo study, fibrin gels containing the HBDS and NT-3 showed increased neural fiber density in spinal cord lesions versus unmodified fibrin at 9 days... - Demyelination and remyelination after spinal cord injuryJohn W McDonald
International Center for Spinal Cord Injury, Kennedy Krieger Institute and The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurotrauma 23:345-59. 2006..This review focuses on concepts that are important for developing strategies of repair. The brightest young scientists will be attracted into this exciting field by its near-term potential for human application...