E S Istvan

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi Structural mechanism for statin inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase
    Eva S Istvan
    Howard Hughes Medical Institute and Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am Heart J 144:S27-32. 2002
  2. ncbi Statin inhibition of HMG-CoA reductase: a 3-dimensional view
    Eva Istvan
    Department of Molecular Microbiology, Howard Hughes Medical Institute, Washington University School of Medicine, Campus Box 8230, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Atheroscler Suppl 4:3-8. 2003
  3. ncbi Bacterial and mammalian HMG-CoA reductases: related enzymes with distinct architectures
    E S Istvan
    Howard Hughes Medical Institute and Department of Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Opin Struct Biol 11:746-51. 2001
  4. ncbi Structural mechanism for statin inhibition of HMG-CoA reductase
    E S Istvan
    Department of Biochemistry, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, TX 75390 9050, USA
    Science 292:1160-4. 2001
  5. ncbi Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis
    E S Istvan
    Howard Hughes Medical Institute, Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, TX 75235 9050, USA
    EMBO J 19:819-30. 2000

Detail Information

Publications5

  1. ncbi Structural mechanism for statin inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase
    Eva S Istvan
    Howard Hughes Medical Institute and Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am Heart J 144:S27-32. 2002
    ..The flexibility of these residues is critical for binding with statins; if ordered, they would sterically hinder such binding...
  2. ncbi Statin inhibition of HMG-CoA reductase: a 3-dimensional view
    Eva Istvan
    Department of Molecular Microbiology, Howard Hughes Medical Institute, Washington University School of Medicine, Campus Box 8230, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Atheroscler Suppl 4:3-8. 2003
    ..Differences in statin structure and binding characteristics may partially contribute to differences in potency of HMG-CoA reductase inhibition and other pharmacologic properties...
  3. ncbi Bacterial and mammalian HMG-CoA reductases: related enzymes with distinct architectures
    E S Istvan
    Howard Hughes Medical Institute and Department of Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Opin Struct Biol 11:746-51. 2001
    ..An appreciation of the remarkable differences in the active site architecture may ultimately lead to the development of novel antibacterial agents...
  4. ncbi Structural mechanism for statin inhibition of HMG-CoA reductase
    E S Istvan
    Department of Biochemistry, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, TX 75390 9050, USA
    Science 292:1160-4. 2001
    ..Near the carboxyl terminus of HMGR, several catalytically relevant residues are disordered in the enzyme-statin complexes. If these residues were not flexible, they would sterically hinder statin binding...
  5. ncbi Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis
    E S Istvan
    Howard Hughes Medical Institute, Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, TX 75235 9050, USA
    EMBO J 19:819-30. 2000
    ..The active site architecture of human HMGR is different from that of bacterial HMGR; this may explain why binding of HMGR inhibitors to bacterial HMGRs has not been reported...