Research Topics
| Beau AncesSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Detail Information
Publications
Independent effects of HIV, aging, and HAART on brain volumetric measuresBeau M Ances
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
J Acquir Immune Defic Syndr 59:469-77. 2012..Neurocognitive impairment remains prevalent in HIV-infected (HIV+) individuals despite highly active antiretroviral therapy (HAART). We assessed the impact of HIV, HAART, and aging using structural neuroimaging...
Pathogenesis of HIV in the central nervous systemVictor Valcour
Memory and Aging Center, University of California San Francisco, 94143 1207, USA
Curr HIV/AIDS Rep 8:54-61. 2011..This review highlights recent investigations of HIV-related CNS injury with emphasis on cART-era neuropathological mechanisms in the context of both US and international settings...
11C-PiB imaging of human immunodeficiency virus-associated neurocognitive disorderBeau M Ances
Department of Neurology, Washington University in St Louis, Campus Box 8111, 660 S Euclid Ave, St Louis, MO 63110, USA
Arch Neurol 69:72-7. 2012....
HIV and chronic methamphetamine dependence affect cerebral blood flowBeau M Ances
Department of Neurology, Washington University in St Louis, 660 South Euclid Ave, Box 08111, St Louis, MO 63110, USA
J Neuroimmune Pharmacol 6:409-19. 2011..Abnormalities in CBF could serve as a surrogate measure for assessing the chronic effects of HIV and previous METH dependence on brain function...
Test-retest stability of calibrated BOLD-fMRI in HIV- and HIV+ subjectsBeau Ances
Department of Neurology, Washington University in St Louis, St Louis, MO, USA
Neuroimage 54:2156-62. 2011..In contrast, these values have greater variability in clinically stable HIV+ subjects and may reflect alterations in coupling between CBF and CMRO(2) with disease...
Cognitively unimpaired HIV-positive subjects do not have increased 11C-PiB: a case-control studyB M Ances
Department of Neurology, Washington University, St Louis, MO 63110, USA
Neurology 75:111-5. 2010..We evaluated the amyloid-binding agent (11)C-Pittsburgh compound B ((11)C-PiB), a biomarker for Alphabeta42 deposition, in cognitively unimpaired HIV+ (n = 10) participants and matched community controls without dementia (n = 20)...
HIV infection and aging independently affect brain function as measured by functional magnetic resonance imagingBeau M Ances
Department of Neurology, Washington University, St Louis, Missouri, USA
J Infect Dis 201:336-40. 2010..In the future, fMRI could be a noninvasive biomarker to assess HIV infection in the brain...
Interaction between nitric oxide synthase inhibitor induced oscillations and the activation flow coupling responseBeau M Ances
Department of Neurology, Washington University in St Louis, 660 South Euclid Avenue, St Louis, MO 63110, USA
Brain Res 1309:19-28. 2010..Nitric oxide may therefore modulate the effects of other vasodilators involved in vasomotion oscillations and the AFC response...
Role of metabolic syndrome components in HIV-associated sensory neuropathyBeau M Ances
Department of Neurology, Washington University, St Louis, 660 South Euclid Avenue, Box 8111, St Louis, MO 63110, USA
AIDS 23:2317-22. 2009..We examined whether MetS or its components predispose individuals to HIV-associated sensory neuropathy (HIV-SN)...
Resting cerebral blood flow: a potential biomarker of the effects of HIV in the brainB M Ances
Department of Neurology, Washington University in St Louis, MO, USA
Neurology 73:702-8. 2009..We examined the impact of HIV on resting cerebral blood flow (rCBF) within the lenticular nuclei (LN) and visual cortex (VC)...
Role of metabolic syndrome components in human immunodeficiency virus-associated strokeBeau M Ances
Department of Neurology, Washington University in St Louis, St Louis, Missouri 63110, USA
J Neurovirol 15:249-56. 2009..Reducing MetS component levels in HIV+ patients could therefore protect them from subsequent stroke...
Rituximab-associated progressive multifocal leukoencephalopathy in rheumatoid arthritisDavid B Clifford
Department of Neurology, Washington University, St Louis, MO 63110, USA
Arch Neurol 68:1156-64. 2011..To describe the development of progressive multifocal leukoencephalopathy (PML) in patients with rheumatoid arthritis (RA) treated with rituximab...
Signal averaged laser Doppler measurements of activation-flow coupling in the rat forepaw somatosensory cortexJ A Detre
Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
Brain Res 796:91-8. 1998..This finding was also observed during hypercapnia. Characterization of AFC in the model provides a background for future studies of the effects of pharmacological manipulation or pathophysiological states...
The effects of graded hypercapnia on the activation flow coupling response due to forepaw stimulation in alpha-chloralose anesthetized ratsB M Ances
Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Brain Res 911:82-8. 2001..However, the absolute magnitude of the LD(CBF) change was independent of CO(2) concentration. The temporal dynamics of the LD(CBF) response during hypercapnia were significantly prolonged compared to baseline conditions (P<0.05)...
Temporal dynamics of the partial pressure of brain tissue oxygen during functional forepaw stimulation in ratsB M Ances
Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
Neurosci Lett 306:106-10. 2001..A sustained post-stimulus undershoot in tissue pO2 was observed only for the 1 min stimulus. These findings suggest a complex dynamic relationship between oxygen utilization and blood flow...
Sex differences in the cerebral blood flow response after brief hypercapnia in the ratB M Ances
Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia 19104, USA
Neurosci Lett 304:57-60. 2001..These results suggest that estrogen may modulate the upregulation of the CBF response observed after transient hypercapnia...
Dynamic changes in cerebral blood flow, O2 tension, and calculated cerebral metabolic rate of O2 during functional activation using oxygen phosphorescence quenchingB M Ances
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Cereb Blood Flow Metab 21:511-6. 2001..These results suggest that a complex relation exists, with comparable changes in CBF and CMRO2 initially occurring after stimulation but excessive changes in CBF compared with CMRO2 arising with protracted stimulation...
