Research Topics
| G WattSummaryAffiliation: Walter Reed Army Medical Center Country: USA Publications
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Detail Information
Publications
Differentiating dengue virus infection from scrub typhus in Thai adults with feverGeorge Watt
Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Am J Trop Med Hyg 68:536-8. 2003..Prospective evaluations of the usefulness of these simple criteria to differentiate scrub typhus from dengue infection are needed in other areas, particularly where rapid confirmatory diagnostic tests are not available...- Decrease in human immunodeficiency virus type 1 load during acute dengue feverGeorge Watt
Department of Retrovirology, US Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Clin Infect Dis 36:1067-9. 2003.... - Possible scrub typhus coinfections in Thai agricultural workers hospitalized with leptospirosisGeorge Watt
Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Am J Trop Med Hyg 68:89-91. 2003..Physicians should consider the possibility of scrub typhus infection in leptospirosis patients who respond poorly to treatment or who have atypical disease manifestations... - Blinded, placebo-controlled trial of antiparasitic drugs for trichinosis myositisG Watt
HIV Interaction Section, Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, APO AP 96546
J Infect Dis 182:371-4. 2000..05). However, 30% of volunteers could not tolerate the side effects of thiabendazole. In summary, Trichinella myositis responds to thiabendazole and to mebendazole... - Acute undifferentiated fever caused by infection with Japanese encephalitis virusGeorge Watt
Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Am J Trop Med Hyg 68:704-6. 2003..Infection with Japanese encephalitis virus is an underappreciated cause of acute undifferentiated fever in Asia... - Passive transfer of scrub typhus plasma to patients with AIDS: a descriptive clinical studyG Watt
Retrovirology Department, USAMC, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
QJM 94:599-607. 2001..Whether variability in the results is due to different scrub typhus infections, different HIV infections or different individual responses, is unclear... - A pilot study of N-acetylcysteine as adjunctive therapy for severe malariaG Watt
Department of Retrovirology, USAMC, Armed Forces Research Institute of Medical Sciences AFRIMS, Bangkok, Thailand
QJM 95:285-90. 2002..N-acetylcysteine (NAC) is a safe compound that inhibits tumour necrosis factor (TNF) and impedes cytoadherence, both of which have been implicated in the pathogenesis of malaria complications... - Orientia tsutsugamushi in peripheral white blood cells of patients with acute scrub typhusD S Walsh
Department of Immunology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Am J Trop Med Hyg 65:899-901. 2001..tsutsugamushi were mononuclear and were detected on each day of sampling. The presence of O. tsutsugamushi in peripheral white blood cells of patients with acute scrub typhus is a new finding with clinical and pathogenic implications... - Azithromycin activities against Orientia tsutsugamushi strains isolated in cases of scrub typhus in Northern ThailandG Watt
Department of Retrovirology, U S Army Component, Bangkok, Thailand
Antimicrob Agents Chemother 43:2817-8. 1999..Azithromycin and doxycycline yielded comparable mouse survival rates (73 and 79%, respectively; P > 0.5). Symptoms, signs, and fever in two pregnant women abated rapidly with azithromycin. Prospective human trials are needed... - Performance of a dot blot immunoassay for the rapid diagnosis of scrub typhus in a longitudinal case seriesG Watt
Department of Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
J Infect Dis 177:800-2. 1998..The specificity of both antigen concentrations was 98%. This study establishes that scrub typhus can be confirmed serologically by use of a dipstick assay and that serodiagnosis can be effectively tailored to a target population... - Short report: prospective evaluation of a multi-test strip for the diagnoses of scrub and murine typhus, leptospirosis, dengue Fever, and Salmonella typhi infectionGeorge Watt
Mahidol Maryland Tropical Disease Research Program, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Am J Trop Med Hyg 72:10-2. 2005..The kit gave multiple positive test results in 33 of 36 patients with defined infections and was therefore not a useful admission diagnostic tool... - Scrub typhus infections poorly responsive to antibiotics in northern ThailandG Watt
Department of Medicine, US Army Component, AFRIMS, Bangkok, Thailand
Lancet 348:86-9. 1996.... - Possible acute coinfections in Thai malaria patientsTasawan Singhsilarak
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Southeast Asian J Trop Med Public Health 37:1-4. 2006..Mixed infections would have multiple implications for clinicians, including unexpected clinical findings and apparent poor responses to antimalarial treatment in patients thought only to have malaria... - Hand rash in trichinosisD S Walsh
Departments of Immunology and Medicine, and Retrovirology, U S Army Medical Component, Armed Forces Research Institute of Medical Sciences AFRIMS, Bangkok, Thailand
Clin Exp Dermatol 26:272-3. 2001..Here, we describe an unusual hand rash noted in several patients enrolled in a treatment study for trichinosis... - Acute scrub typhus in Northern Thailand: EKG changesGeorge Watt
Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Southeast Asian J Trop Med Public Health 33:312-3. 2002..These results suggest that EKG changes in scrub typhus acquired in areas of diminished antibiotic susceptibility are similar to those observed in O. tsutsugamushi infection acquired elsewhere... - Diagnosis of human leptospirosis by monoclonal antibody-based antigen detection in urinePatcharin Saengjaruk
Department of Microbiology and Immunology, Mahidol University, Bangkok, Thailand
J Clin Microbiol 40:480-9. 2002..The reasons for this positivity are discussed. The detection of antigen in urine by the monoclonal antibody-based dot-ELISA has high potential for rapid, sensitive, and specific diagnosis of leptospirosis at a low cost... - Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malariaP Teja-Isavadharm
Department of Immunology and Medicine, US Army Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Am J Trop Med Hyg 65:717-21. 2001..13+/-0.52 hr, respectively (P > 0.5). Both drug metabolism and tissue protein binding could contribute to the differences between the antimalarial activity of artemisinin drugs in healthy volunteers and malaria infected patients... - Scrub typhus and tropical rickettsiosesGeorge Watt
Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Curr Opin Infect Dis 16:429-36. 2003..An update of recent research findings is therefore particularly timely for the nonspecialist physician... - Short report: detection of Orientia tsutsugamushi in clinical samples by quantitative real-time polymerase chain reactionTasawan Singhsilarak
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Am J Trop Med Hyg 72:640-1. 2005..The assay was unreactive in all 12 individuals without scrub typhus infection. This is the first demonstration of a sensitive and specific real-time qPCR assay for human scrub typhus infection... - Prevalence of relative bradycardia in Orientia tsutsugamushi infectionDavid M Aronoff
Division of Infectious Diseases, Department of Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109 0642, USA
Am J Trop Med Hyg 68:477-9. 2003..These data demonstrate that relative bradycardia frequently accompanies mild infection with O. tsutsugamushi and that baseline cardiovascular parameters may affect the febrile heart rate response to scrub typhus... - HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, ThailandBruce Shiramizu
Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USA
Int J Med Sci 4:13-8. 2007..These results are consistent with a previous report among HAART-experienced subjects, thus further implicating HIV DNA in the pathogenesis of HAD...