Research Topics
| G D ShanksSummaryAffiliation: Walter Reed Army Medical Center Country: USA Publications
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Detail Information
Publications
Changing patterns of clinical malaria since 1965 among a tea estate population located in the Kenyan highlandsG D Shanks
US Army Medical Research Unit Kenya
Trans R Soc Trop Med Hyg 94:253-5. 2000..The coincident arrival of chloroquine resistance during the late 1980s in the subregion suggests that drug resistance is a key factor in the current pattern and burden of malaria among this highland population...
Malaria chemoprophylaxis in the age of drug resistance. II. Drugs that may be available in the futureG D Shanks
US Army Medical Component of the Armed Forces Research Institute of Medical Sciences, 315 6 Rajvithi Road, Bangkok 10400, Thailand
Clin Infect Dis 33:381-5. 2001..Its long half-life allows for infrequent dosing (currently tested at 200 mg base/week), and its effect on parasites at the liver stage may allow for drug discontinuation at the time of departure from the area of endemicity...
A new primaquine analogue, tafenoquine (WR 238605), for prophylaxis against Plasmodium falciparum malariaG D Shanks
US Army Medical Research Unit, Nairobi, Kenya
Clin Infect Dis 33:1968-74. 2001..Prophylactic regimens of 200 mg or 400 mg of tafenoquine, taken weekly for < or =13 weeks, are highly efficacious in preventing falciparum malaria and are well tolerated...
Meteorologic influences on Plasmodium falciparum malaria in the Highland Tea Estates of Kericho, Western KenyaG Dennis Shanks
U S Army Medical Research Unit Kenya, Nairobi, Africa
Emerg Infect Dis 8:1404-8. 2002..We conclude that climate changes have not caused the highland malaria resurgence in western Kenya...
Travel as a risk factor for uncomplicated Plasmodium falciparum malaria in the highlands of western KenyaG D Shanks
US Army Medical Research Unit Kenya, Box 30137, Nairobi, Kenya
Trans R Soc Trop Med Hyg 99:71-4. 2005..An increase in population gametocytaemia is possibly due to increased chloroquine resistance and suppressed infections contracted outside of the tea estates...
Malaria in Kenya's western highlandsG Dennis Shanks
US Army Medical Research Unit-Kenya, Nairobi, Kenya
Emerg Infect Dis 11:1425-32. 2005..Antimalarial drugs can limit the pool of gametocytes available to infect mosquitoes during the brief transmission season...
Modern malaria chemoprophylaxisG Dennis Shanks
Australian Army Malaria Institute, Brisbane, Queensland, Australia
Drugs 65:2091-110. 2005..Travellers with a significant exposure to malaria require a comprehensive plan for prevention that includes anti-mosquito measures but which is still primarily be based on the regular use of efficacious antimalarial medications...
Deaths from bacterial pneumonia during 1918-19 influenza pandemicJohn F Brundage
Armed Forces Health Surveillance Center, Silver Spring, Maryland 20910, USA
Emerg Infect Dis 14:1193-9. 2008..g., with bacterial vaccines and antimicrobial drugs), particularly if a pandemic strain-specific vaccine is unavailable or inaccessible to isolated, crowded, or medically underserved populations...
Travel as a risk factor for malaria requiring hospitalization on a highland tea plantation in western KenyaG Dennis Shanks
US Army Medical Research Unit--Kenya
J Travel Med 11:354-7. 2004..CONCLUSIONS: Travel within Kenya is a significant risk factor for hospitalization owing to malaria on the tea estates; expatriate travelers need to be aware that the East African highlands cannot be regarded as malaria free...
Drug-free holidays: pre-travel versus during travel malaria chemoprophylaxisG Dennis Shanks
Am J Trop Med Hyg 77:1-2. 2007..Treatment regimens of antimalarial drugs taken prior to travel could protect persons for up to one month of exposure. We urge additional testing of pre-travel malaria chemoprophylaxis regimens...
Climate change and the resurgence of malaria in the East African highlandsSimon I Hay
TALA Research Group, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Nature 415:905-9. 2002..A high degree of temporal and spatial variation in the climate of East Africa suggests further that claimed associations between local malaria resurgences and regional changes in climate are overly simplistic...
Hot topic or hot air? Climate change and malaria resurgence in East African highlandsSimon I Hay
Dept of Zoology, University of Oxford, UK
Trends Parasitol 18:530-4. 2002..We find the widespread increase in resistance of the malaria parasite to drugs and the decrease in vector control activities to be more likely driving forces behind the malaria resurgence...
Mefloquine--its 20 years in the Thai Malaria Control ProgramChansuda Wongsrichanalai
US Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Southeast Asian J Trop Med Public Health 35:300-8. 2004..Thailand is the country with the most experience in the use of this drug in a malaria control program. We present here a review of mefloquine's pharmacology and usage in Thailand...
Climate variability and malaria epidemics in the highlands of East AfricaSimon I Hay
Department of Zoology, University of Oxford, South Parks Road, Oxford, UK, OX1 3PS
Trends Parasitol 21:52-3. 2005..If proven, this would be an interesting result but we believe that the methods used do not test the hypothesis suggested...
Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a Toll-like receptor 9-dependent pathwaySathit Pichyangkul
Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
J Immunol 172:4926-33. 2004....
What really happened during the 1918 influenza pandemic? The importance of bacterial secondary infectionsJohn F Brundage
J Infect Dis 196:1717-8; author reply 1718-9. 2007
Malaria's indirect contribution to all-cause mortality in the Andaman Islands during the colonial eraG Dennis Shanks
Australian Army Malaria Institute, Enoggera, Australia
Lancet Infect Dis 8:564-70. 2008..Deaths secondary to malaria (indirect malaria mortality) were at least as great as mortality directly attributed to malaria infections...
Global warming and malaria: a call for accuracyPaul Reitera
Institut Pasteur, Paris, France
Lancet Infect Dis 4:323-4. 2004
