Colin Ohrt

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. ncbi Assessment of azithromycin in combination with other antimalarial drugs against Plasmodium falciparum in vitro
    Colin Ohrt
    Department of Pharmacology, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Antimicrob Agents Chemother 46:2518-24. 2002
  2. ncbi Impact of microscopy error on estimates of protective efficacy in malaria-prevention trials
    Colin Ohrt
    Division of Experimental Therapeutics, Silver Spring, Maryland 20910 7500, USA
    J Infect Dis 186:540-6. 2002
  3. ncbi Antimalarial activity of novel 5-aryl-8-aminoquinoline derivatives
    Hiroaki Shiraki
    Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States
    J Med Chem 54:131-42. 2011
  4. ncbi Review: improving the therapeutic index of 8-aminoquinolines by the use of drug combinations: review of the literature and proposal for future investigations
    Hla Y Myint
    Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland National Center for Natural Products Research and Department of Pharmacology, School of Pharmacy, University of Mississippi, University, Mississippi Eijkman Oxford Clinical Research Unit, Jalan Diponegoro No 69, Jakarta, Indonesia Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    Am J Trop Med Hyg 85:1010-4. 2011
  5. ncbi Establishing a malaria diagnostics centre of excellence in Kisumu, Kenya
    Colin Ohrt
    Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
    Malar J 6:79. 2007
  6. ncbi Pilot assessment of the sensitivity of the malaria thin film
    Colin Ohrt
    Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
    Malar J 7:22. 2008
  7. ncbi A randomized, double-blind, safety and tolerability study to assess the ophthalmic and renal effects of tafenoquine 200 mg weekly versus placebo for 6 months in healthy volunteers
    Kevin J Leary
    United States Army Medical Materiel Development Activity, Fort Detrick, Maryland 21702 5009, USA
    Am J Trop Med Hyg 81:356-62. 2009
  8. ncbi Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta)
    Geoffrey S Dow
    Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
    Malar J 10:212. 2011
  9. ncbi Plasmodium falciparum infection during suppressive prophylaxis with mefloquine does not induce an antibody response to merozoite surface protein-1(42)
    James E Moon
    Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Am J Trop Med Hyg 84:825-9. 2011

Detail Information

Publications9

  1. ncbi Assessment of azithromycin in combination with other antimalarial drugs against Plasmodium falciparum in vitro
    Colin Ohrt
    Department of Pharmacology, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Antimicrob Agents Chemother 46:2518-24. 2002
    ..These results suggest that a chloroquine-azithromycin combination should be evaluated for malaria prophylaxis and that a quinine-azithromycin combination should be evaluated for malaria treatment in areas of drug resistance...
  2. ncbi Impact of microscopy error on estimates of protective efficacy in malaria-prevention trials
    Colin Ohrt
    Division of Experimental Therapeutics, Silver Spring, Maryland 20910 7500, USA
    J Infect Dis 186:540-6. 2002
    ..Microscopy error occurs and can affect clinical trial results...
  3. ncbi Antimalarial activity of novel 5-aryl-8-aminoquinoline derivatives
    Hiroaki Shiraki
    Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States
    J Med Chem 54:131-42. 2011
    ..The new compounds showed no significant causal prophylactic activity in mice infected with Plasmodium berghei sporozoites, but are substantially less toxic than 2 and 3 in mouse tests...
  4. ncbi Review: improving the therapeutic index of 8-aminoquinolines by the use of drug combinations: review of the literature and proposal for future investigations
    Hla Y Myint
    Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland National Center for Natural Products Research and Department of Pharmacology, School of Pharmacy, University of Mississippi, University, Mississippi Eijkman Oxford Clinical Research Unit, Jalan Diponegoro No 69, Jakarta, Indonesia Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    Am J Trop Med Hyg 85:1010-4. 2011
    ....
  5. ncbi Establishing a malaria diagnostics centre of excellence in Kisumu, Kenya
    Colin Ohrt
    Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
    Malar J 6:79. 2007
    ..The primary objective was to ensure valid clinical trial and diagnostic test evaluations. Key secondary objectives were technology transfer to host countries, establishment of partnerships, and training of clinical microscopists...
  6. ncbi Pilot assessment of the sensitivity of the malaria thin film
    Colin Ohrt
    Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
    Malar J 7:22. 2008
    ..Surprisingly, the sensitivity of thin smears is not well established and thin smears are not commonly used in the developing world...
  7. ncbi A randomized, double-blind, safety and tolerability study to assess the ophthalmic and renal effects of tafenoquine 200 mg weekly versus placebo for 6 months in healthy volunteers
    Kevin J Leary
    United States Army Medical Materiel Development Activity, Fort Detrick, Maryland 21702 5009, USA
    Am J Trop Med Hyg 81:356-62. 2009
    ..The results of this study showed no clinically significant effects of tafenoquine on ophthalmic or renal function, and support its continued development as an antimalarial drug...
  8. ncbi Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta)
    Geoffrey S Dow
    Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
    Malar J 10:212. 2011
    ..Combination with other antimalarials may mitigate these concerns...
  9. ncbi Plasmodium falciparum infection during suppressive prophylaxis with mefloquine does not induce an antibody response to merozoite surface protein-1(42)
    James E Moon
    Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Am J Trop Med Hyg 84:825-9. 2011
    ..We conclude that malaria infection during suppressive prophylaxis does not induce antibody response to the blood-stage antigen MSP1(42) in a malaria-naïve study population...