Research Topics
| G R MatyasSummaryAffiliation: Walter Reed Army Medical Center Country: USA Publications
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Detail Information
Publications
Induction and detection of antibodies to squalene. II. Optimization of the assay for murine antibodiesGary R Matyas
Department of Membrane Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
J Immunol Methods 267:119-29. 2002..The assay was highly reproducible both from lot to lot of plates and from experiment to experiment...- In vitro binding of anthrax protective antigen on bacteriophage T4 capsid surface through Hoc-capsid interactions: a strategy for efficient display of large full-length proteinsSathish B Shivachandra
Department of Biology, The Catholic University of America, Washington, DC 20064, USA
Virology 345:190-8. 2006..The in vitro display on phage T4 offers a novel platform for potential construction of customized vaccines against anthrax and other infectious diseases... - HIV-1, lipid rafts, and antibodies to liposomes: implications for anti-viral-neutralizing antibodiesCarl R Alving
Department of Vaccine Production and Delivery, Division of Retrovirology, US Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, MD 20850, USA
Mol Membr Biol 23:453-65. 2006..The possibility is proposed that liposomal lipids, or liposome-protein combinations, could be useful as antigens for inducing broadly neutralizing antibodies to HIV-1... - Induction and detection of antibodies to squaleneG R Matyas
Department of Membrane Biochemistry, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
J Immunol Methods 245:1-14. 2000..We conclude that SQE is a weak antigen, but that antibodies that specifically bind to SQE can be readily induced by immunization with [L(71% SQE+LA)] and detected by ELISA with PVDF membranes coated with SQE... - Detection of antibodies to squalene: III. Naturally occurring antibodies to squalene in humans and miceGary R Matyas
Department of Membrane Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
J Immunol Methods 286:47-67. 2004..7%) and males (12.5%). We conclude that antibodies to SQE occur naturally in humans; have an increased prevalence in females; are not correlated with vaccination with AVA; and appear to increase in prevalence with age... - Cytotoxic T lymphocytes to Ebola Zaire virus are induced in mice by immunization with liposomes containing lipid AM Rao
Department of Membrane Biochemistry, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
Vaccine 17:2991-8. 1999..The identification of an Ebola GP-specific CTL epitope and the requirement of liposomal lipid A for CTL memory recall responses could prove to be a promising approach for developing a vaccine against Ebola virus infection... - Transcutaneous immunization with bacterial ADP-ribosylating exotoxins as antigens and adjuvantsG M Glenn
Department of Membrane Biochemistry, Walter Reed Army Institute of Research, Washington, D C 20307 5100, USA
Infect Immun 67:1100-6. 1999..Thus, TCI appears to induce potent, protective immune responses to both systemic and mucosal challenge and offers significant potential practical advantages for vaccine delivery... - Correlation between lethal toxin-neutralizing antibody titers and protection from intranasal challenge with Bacillus anthracis Ames strain spores in mice after transcutaneous immunization with recombinant anthrax protective antigenKristina K Peachman
Department of Vaccine Production and Delivery, Division of Retrovirology, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 1600 East Gude Drive, Rockville, MD 20850, USA
Infect Immun 74:794-7. 2006..Future experiments with rabbits and nonhuman primates should confirm the significance of protection by this vaccine strategy... - Multicomponent anthrax toxin display and delivery using bacteriophage T4Sathish B Shivachandra
Department of Biology, 103 McCort Ward Hall, The Catholic University of America, 620 Michigan Ave, NE, Washington, DC 20064, USA
Vaccine 25:1225-35. 2007..These features offer novel avenues to develop customized multicomponent vaccines against anthrax and other pathogenic diseases... - Calcium modulation of monoclonal antibody binding to phosphatidylinositol phosphateZoltan Beck
Henry M Jackson Foundation for Military Medical Research, USA
Biochem Biophys Res Commun 354:747-51. 2007..However, 4E10 binds to liposomal PIP in a two-stage process involving first Ca(2+)-modulated binding to the PIP polar headgroup, followed by irreversible binding to liposomal hydrophobic groups... - Liposome-stabilized oil-in-water emulsions as adjuvants: increased emulsion stability promotes induction of cytotoxic T lymphocytes against an HIV envelope antigenRoberta L Richards
Department of Membrane Biochemistry, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
Immunol Cell Biol 82:531-8. 2004..We conclude that stable liposomal oil-in-water emulsions provide an effective means of obtaining both antibody and CTL responses against an HIV envelope antigen... - Immunostimulatory CpG motifs induce CTL responses to HIV type I oligomeric gp140 envelope proteinMangala Rao
Department of Membrane Biochemistry, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
Immunol Cell Biol 82:523-30. 2004..These results can have significant implications in directing the Th1 or Th2 differentiation of antigen-specific immune responses in the context of vaccine development... - Needle-free skin patch vaccination method for anthraxGary R Matyas
Department of Membrane Biochemistry, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
Infect Immun 72:1181-3. 2004..In addition, rPA alone exhibited adjuvant activity for TCI. Forty-six weeks after completion of TCI, 100% protection was observed against lethal anthrax challenge... - Induction of immune responses in mice and monkeys to Ebola virus after immunization with liposome-encapsulated irradiated Ebola virus: protection in mice requires CD4(+) T cellsMangala Rao
Department of Membrane Biochemistry, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910 7500, USA
J Virol 76:9176-85. 2002..Although immunization of the monkeys with L(EV)-induced virus-neutralizing antibodies against EBO-Z caused a slight delay in the onset of illness, it did not prevent death... - Antibodies induced by liposomal protein exhibit dual binding to protein and lipid epitopesNicos Karasavvas
Division of Retrovirology, Walter Reed Army Institute of Research, US Military HIV Research Program, Department of Vaccine Production and Delivery, 1600 East Gude Drive, Rockville, MD 20850, USA
Biochem Biophys Res Commun 366:982-7. 2008..Surface plasmon resonance studies with the former antibody showed that the liposomal cholesterol and liposomal gp140 each contributed to the overall binding energy of the antibody to liposomes containing cholesterol and protein... - Oil-in-water liposomal emulsions for vaccine deliveryGary R Matyas
Department of Membrane Biochemistry, Walter Reed Army Institute of Research, Washington, D.C. 20307, USA
Methods Enzymol 373:34-50. 2003 - Monoclonal antibodies to phosphatidylinositol phosphate neutralize human immunodeficiency virus type 1: role of phosphate-binding subsitesBruce K Brown
Henry M Jackson Foundation, 13 Taft Court, Rockville, Maryland 20850, USA
J Virol 81:2087-91. 2007..The data suggest that PIP or related lipids having free phosphates could serve as targets for the neutralization of HIV-1...