G Dow

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. ncbi Effect of sample size and P-value filtering techniques on the detection of transcriptional changes induced in rat neuroblastoma (NG108) cells by mefloquine
    Geoffrey S Dow
    Department of Parasitology, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Malar J 2:4. 2003
  2. ncbi The antimalarial potential of 4-quinolinecarbinolamines may be limited due to neurotoxicity and cross-resistance in mefloquine-resistant Plasmodium falciparum strains
    Geoffrey S Dow
    Parasitology Department, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Antimicrob Agents Chemother 48:2624-32. 2004
  3. ncbi The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro
    Geoffrey S Dow
    Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Malar J 2:14. 2003
  4. ncbi Transcriptional profiling of mefloquine-induced disruption of calcium homeostasis in neurons in vitro
    Geoffrey S Dow
    Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Genomics 86:539-50. 2005
  5. ncbi Mefloquine induces dose-related neurological effects in a rat model
    G Dow
    Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, USA
    Antimicrob Agents Chemother 50:1045-53. 2006
  6. ncbi Utility of alkylaminoquinolinyl methanols as new antimalarial drugs
    G S Dow
    Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
    Antimicrob Agents Chemother 50:4132-43. 2006
  7. ncbi A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum
    Yufeng Chen
    Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA
    J Med Chem 51:3437-48. 2008

Collaborators

Detail Information

Publications7

  1. ncbi Effect of sample size and P-value filtering techniques on the detection of transcriptional changes induced in rat neuroblastoma (NG108) cells by mefloquine
    Geoffrey S Dow
    Department of Parasitology, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Malar J 2:4. 2003
    ..However, this utility may be compromised if sample sizes are too low or the filtering methods used to identify differentially expressed genes are inappropriate...
  2. ncbi The antimalarial potential of 4-quinolinecarbinolamines may be limited due to neurotoxicity and cross-resistance in mefloquine-resistant Plasmodium falciparum strains
    Geoffrey S Dow
    Parasitology Department, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Antimicrob Agents Chemother 48:2624-32. 2004
    ..Extension of this in silico screening approach may aid in the identification of less-neurotoxic quinoline analogs...
  3. ncbi The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro
    Geoffrey S Dow
    Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Malar J 2:14. 2003
    ..We investigated the possibility that the acute in vitro neurotoxicity of mefloquine might be mediated through a disruptive effect of the drug on endoplasmic reticulum (ER) calcium homeostasis...
  4. ncbi Transcriptional profiling of mefloquine-induced disruption of calcium homeostasis in neurons in vitro
    Geoffrey S Dow
    Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Genomics 86:539-50. 2005
    ..These data may aid interpretation of expression of results from future in vivo studies...
  5. ncbi Mefloquine induces dose-related neurological effects in a rat model
    G Dow
    Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, USA
    Antimicrob Agents Chemother 50:1045-53. 2006
    ..Collectively, these data suggest that there may be a biological basis for some of the clinical neurological effects associated with mefloquine...
  6. ncbi Utility of alkylaminoquinolinyl methanols as new antimalarial drugs
    G S Dow
    Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
    Antimicrob Agents Chemother 50:4132-43. 2006
    ....
  7. ncbi A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum
    Yufeng Chen
    Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA
    J Med Chem 51:3437-48. 2008
    ..Lastly, these new HDACIs were studied for both their anticancer and antimalarial activity, which serve to validate the superior activity of the HDACI 10c...