Research Topics
| C E WoodSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Soy isoflavones, estrogen therapy, and breast cancer risk: analysis and commentaryMark J Messina
Nutrition Matters, Inc, 439 Calhoun Street, Port Townsend, WA 98368, USA
Nutr J 7:17. 2008....- Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeysCharles E Wood
Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Breast Cancer Res Treat 101:125-34. 2007..These findings suggest that oral micronized progesterone has a more favorable effect on risk biomarkers for postmenopausal breast cancer than medroxyprogesterone acetate... - Transcriptional profiles of progestogen effects in the postmenopausal breastCharles E Wood
Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Breast Cancer Res Treat 114:233-42. 2009.... - Breast and uterine effects of soy isoflavones and conjugated equine estrogens in postmenopausal female monkeysCharles E Wood
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
J Clin Endocrinol Metab 89:3462-8. 2004..These findings suggest that high dietary levels of soy isoflavones do not stimulate breast or uterine proliferation in postmenopausal monkeys and may contribute to an estrogen profile associated with reduced breast cancer risk... - Soy isoflavonoid effects on endogenous estrogen metabolism in postmenopausal female monkeysCharles E Wood
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
Carcinogenesis 28:801-8. 2007..01 for all). These findings suggest that long-term exposure to soy isoflavonoids, equol in particular, may facilitate endogenous estrogen clearance and catabolism to more benign 2-hydroxylated metabolites... - Effects of soybean glyceollins and estradiol in postmenopausal female monkeysCharles E Wood
Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Nutr Cancer 56:74-81. 2006..05 for both) but not in the GLY group. These preliminary findings suggest that soybean glyceollins are natural compounds with potential estrogen-modulating properties in the breast... - Mammary gland development in early pubertal female macaquesCharles E Wood
Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Toxicol Pathol 35:795-805. 2007..These findings identify dynamic morphologic changes occurring in the primate breast during early puberty and suggest that estradiol (rather than progesterone) is the predominant hormonal stimulus for early ductal and lobular development... - Novel betapapillomavirus associated with hand and foot papillomas in a cynomolgus macaqueC E Wood
Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Vet Pathol 48:731-6. 2011..These findings characterize a new nonhuman beta-PV and provide additional support for the idea that tissue tropism among ancestral primate PVs developed prior to divergence of certain Old World primate lineages... - Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey modelCharles E Wood
Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Menopause 14:639-47. 2007..To evaluate the effects of oral estradiol given with either oral or intravaginal micronized progesterone (P4) on risk biomarkers for breast cancer in a postmenopausal monkey model... - Adrenocortical effects of oral estrogens and soy isoflavones in female monkeysCharles E Wood
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
J Clin Endocrinol Metab 89:2319-25. 2004..These findings suggest that long-term estrogen treatment may contribute to an androgen-deficient and hypercortisolemic state... - Cervical and vaginal epithelial neoplasms in cynomolgus monkeysC E Wood
Comparative Medicine Clinical Research Center, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
Vet Pathol 41:108-15. 2004..The unique similarities between the observed lesions and those seen in women suggest that macaques may provide a suitable animal model for study of papillomavirus oncogenesis... - Comparative effects of oral conjugated equine estrogens and micronized 17beta-estradiol on breast proliferation: a retrospective analysisCharles E Wood
Departments of 1Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Menopause 15:890-8. 2008..To evaluate the effects of oral conjugated equine estrogens (CEE) and micronized 17beta-estradiol (E2) on breast proliferation in a postmenopausal primate model... - Estrogen effects on epithelial proliferation and benign proliferative lesions in the postmenopausal primate mammary glandCharles E Wood
Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
Lab Invest 88:938-48. 2008.... - Dietary soy isoflavones inhibit estrogen effects in the postmenopausal breastCharles E Wood
Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Cancer Res 66:1241-9. 2006..These findings show that in the presence of estrogen higher doses of dietary soy isoflavones may alter ER signaling and induce selective antagonistic effects in the breast... - Mammary gland and endometrial effects of testosterone in combination with oral estradiol and progesteroneCharles E Wood
Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Menopause 16:466-76. 2009..The goal of this pilot study was to evaluate the effects of testosterone (T) cotherapy on mammary gland and endometrial measures in a postmenopausal primate model... - Effects of soy on the mammary glands of premenopausal female monkeysCharles E Wood
Section on Comparative Medicine, The Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
Fertil Steril 85:1179-86. 2006..To evaluate the interactive effects of dietary soy and menstrual cycle phase on breast proliferation, apoptosis, and sex steroid receptor expression in premenopausal female cynomolgus monkeys... - Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeysCharles E Wood
Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
Biol Reprod 75:477-86. 2006..1 for all). These findings indicate that high doses of dietary soy isoflavonoids have minimal uterotrophic or mammotrophic effects in an established primate model... - Hyperplastic and neoplastic lesions of the mammary gland in macaquesC E Wood
Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Vet Pathol 43:471-83. 2006..These findings suggest that breast cancer is an underreported lesion in macaques and highlight unique morphologic and molecular similarities in breast cancer between human and macaque species... - Characterization and experimental transmission of an oncogenic papillomavirus in female macaquesCharles E Wood
Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
J Virol 81:6339-45. 2007..These findings identify key similarities between macaque and human oncogenic PVs which should prove useful in the study of viral persistence, carcinogenesis, and therapeutic development... - Effects of prior oral contraceptive use and soy isoflavonoids on estrogen-metabolizing cytochrome P450 enzymesL M Scott
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Steroid Biochem Mol Biol 112:179-85. 2008..These results suggest potential mechanisms for prior OC and dietary IF effects on cancer risk in estrogen-responsive tissues... - Cyclic changes in the mammary gland of cynomolgus macaquesPetra Stute
The Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1040, USA
Fertil Steril 82:1160-70. 2004.... - Endometrial profile of tamoxifen and low-dose estradiol combination therapyCharles E Wood
Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC, USA
Clin Cancer Res 16:946-56. 2010..The goal of this study was to evaluate the endometrial profile of low-dose estradiol and the SERM tamoxifen alone and in combination... - Lessons to be learned from animal studies on hormones and the breastThomas B Clarkson
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
Maturitas 49:79-89. 2004.... - Hormonal effects on the mammary gland of postmenopausal nonhuman primatesJ Mark Cline
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Breast Dis 24:59-70. 2005..Future studies of novel selective estrogens, androgens, and dietary estrogens in the macaque model will further contribute to our understanding of breast cancer risk and prevention... - Estrogen/isoflavone interactions in cynomolgus macaques (Macaca fascicularis)J Mark Cline
Wake Forest University Primate Center, Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
Am J Primatol 71:722-31. 2009..Because soy isoflavones are both abundant in standard monkey chow diets and widely available as dietary supplements for human beings, these findings have broad relevance to the health of human and nonhuman primates... - Past oral contraceptive use and current dietary soy isoflavones influence estrogen metabolism in postmenopausal monkeys (Macaca fascicularis)Latanya M Scott
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Cancer Epidemiol Biomarkers Prev 17:2594-602. 2008..Premenopausal OCs may have long-term systemic effects on response to estrogen and its metabolism whereas postmenopausal dietary isoflavones may alter endogenous estrogen metabolism in a modest but selective manner... - Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeysCarol A Shively
Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
Psychoneuroendocrinology 32:981-90. 2007..Further research is needed to explore social context as an important feature of behavioral response to steroid hormone regimens and to verify and extend knowledge of systemic effects of vaginal ring-delivered progestogens... - Cerebral hypoperfusion increases estrogen receptor abundance in the ovine fetal brain and pituitaryCharles E Wood
Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Fla 32610 0274, USA
Neuroendocrinology 87:216-22. 2008.... - Antiestrogenic glyceollins suppress human breast and ovarian carcinoma tumorigenesisVirgilo A Salvo
Section of Hematology and Medical Oncology, Department of Medicine, Tulane Cancer Center, New Orleans, LA 70112, USA
Clin Cancer Res 12:7159-64. 2006..CONCLUSIONS: These findings identify glyceollins as antiestrogenic agents that may be useful in the prevention or treatment of breast and ovarian carcinoma... - Blockade of estrogen receptors decreases CNS and pituitary prostaglandin synthase expression in fetal sheepChristine E Schaub
Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610 0274, USA
Neuroendocrinology 87:121-8. 2008..The present study was designed to test the hypothesis that blockade of estrogen receptors in the fetal brain decrease PGHS-2 expression and reduces fetal HPA axis activity... - Adrenalectomy alters regulation of blood pressure and endothelial nitric oxide synthase in sheep: modulation by estradiolFeng Li
Department of Pharmacodynamics, University of Florida, Gainesville, FL 32610 0487, USA
Am J Physiol Regul Integr Comp Physiol 293:R257-66. 2007..However, the study reveals an important effect of corticosteroid withdrawal on blood pressure, consistent with corticosteroid modulation of baroreflex responsiveness... - Central nervous system prostaglandin endoperoxide synthase-1 and -2 responses to oestradiol and cerebral hypoperfusion in late-gestation fetal sheepCharles E Wood
Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610, USA
J Physiol 549:573-81. 2003..We speculate that at least a part of the effect of oestradiol on fetal HPA axis function is mediated by an interaction between oestradiol and prostaglandin biosynthesis in the fetal brain... - Resuscitation of hemorrhagic shock attenuates intrapulmonary nitric oxide formationChun-Jen Huang
Department of Anesthesiology at Mackay Memorial Hospital, Taipei, Taiwan, ROC
Resuscitation 55:201-9. 2002..We believe that exhaled NO concentrations provide a useful, non-invasive method of monitoring the intrapulmonary inflammatory sequelae of hemorrhagic shock... - Dexamethasone suppresses iNOS yet induces GTPCH and CAT-2 mRNA expression in rat lungsJeffrey W Skimming
Department of Child Health, University of Missouri, Columbia, MO 65212, USA
Am J Physiol Lung Cell Mol Physiol 285:L484-91. 2003..Our results support the idea that dexamethasone inhibits nitric oxide formation in a manner that is independent of tetrahydrobiopterin and arginine transport yet dependent on downregulation of iNOS mRNA expression... - Expression of nitric oxide synthase isoforms in the ovine fetal brain: alteration by hormonal and hemodynamic stimuliCharles E Wood
Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida 32610 0274, USA
J Soc Gynecol Investig 13:329-37. 2006..We propose that, in the fetal brain, cerebral hypoperfusion alters the expression of NOS isoforms, and that estrogen administration modulates the NOS response to hypoperfusion... - The ovine fetal endocrine reflex responses to haemorrhage are not mediated by cardiac nervesCharles E Wood
Department of Physiology, University of Florida College of Medicine, Gainesville, FL 32610 0274, USA
J Physiol 541:613-22. 2002.... - Chronic alterations in ovine maternal corticosteroid levels influence uterine blood flow and placental and fetal growthEllen Jensen
Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610-0487, USA
Am J Physiol Regul Integr Comp Physiol 288:R54-61. 2005..The results of this study demonstrate that maternal plasma cortisol during pregnancy is an important contributor to the maternal environment supporting optimal conditions for fetal homeostasis and somatic growth... - Fetal brain regional responses to cerebral hypoperfusion: modulation by estrogenCharles E Wood
Department of Physiology and Functional Genomics, University of Florida College of Medicine, P O Box 100274, Gainesville, FL 32610 0274, USA
Brain Res 993:84-9. 2003..The measurement of regional Fos responses using Western blot reveals a negative interaction between estrogen and BCO which might result from alterations in cerebral blood flow or metabolism... - Ontogeny of expression of organic anion transporters 1 and 3 in ovine fetal and neonatal kidneyCharles E Wood
Department of Physiology and Functional Genomics, P O Box 100274, University of Florida College of Medicine, Gainesville, FL 32610 0274, USA
Exp Biol Med (Maywood) 230:668-73. 2005.... - Regulation of maternal ACTH in ovine pregnancy: does progesterone play a role?Maureen Keller-Wood
Department of Pharmacodynamics, University of Florida, Gainesville, Florida 32605, USA
Am J Physiol Endocrinol Metab 295:E913-20. 2008..We conclude that increased progesterone does not alter the feedback relation of cortisol to ACTH, but may modulate ACTH indirectly through plasma volume... - Cellular localization of thromboxane synthase in ovine spinal cord and hindbrainDavid Husted
Department of Physiology and Functional Genomics, PO Box 100274, University of Florida College of Medicine, Gainesville, FL 32610 0274, USA
Brain Res 971:107-15. 2003..We conclude that, consistent with physiological evidence, thromboxane synthase is present in brain regions which are important for afferent and efferent cardiovascular signaling... - High-dose angiotensin-converting enzyme inhibition restores body fluid homeostasis in heart-transplant recipientsRandy W Braith
Center for Exercise Science, College of Health and Human Performance, PO Box 118206, University of Florida, Gainesville, FL 32611, USA
J Am Coll Cardiol 41:426-32. 2003..We tested the hypothesis that salt and fluid retention in heart-transplant recipients (HTRs) is caused by a failure to reflexively suppress the renin-angiotensin-aldosterone system (RAAS)... - Biological activity of 17beta-estradiol-3-sulfate in ovine fetal plasma and uptake in fetal brainCharles E Wood
Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida 32610 0274, USA
Endocrinology 144:599-604. 2003..We propose that in late gestation the large circulating pool of sulfoconjugated estrogen is a biologically important source of active hormone that might play a role in the timing of parturition in sheep... - Induction of immunoreactive prostaglandin H synthases 1 and 2 and fos in response to cerebral hypoperfusion in late-gestation fetal sheepHaiyan Tong
Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida 32610, USA
J Soc Gynecol Investig 9:342-50. 2002..CONCLUSION: Cerebral hypoperfusion altered the expression and distribution of prostaglandin biosynthetic enzymes in ovine fetal brain by a mechanism that is independent of baroreceptor and chemoreceptor afferent activity... - The association of low birth weight and physiological risk factors of hypertension in African American adolescentsMaureen McCormick Covelli
College of Nursing Orlando, University of Central Florida, FL, USA
J Cardiovasc Nurs 22:440-7; quiz 448-9. 2007..CONCLUSIONS: Low birth weight African American adolescents demonstrated physiological risk factors for hypertension, and these findings add support to the association between LBW and the development of hypertension... - Genetic AT1A receptor deficiency attenuates cold-induced hypertensionZhongjie Sun
Department of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610 0274, USA
Am J Physiol Regul Integr Comp Physiol 288:R433-9. 2005.... - Increased maternal cortisol in late-gestation ewes decreases fetal cardiac expression of 11beta-HSD2 mRNA and the ratio of AT1 to AT2 receptor mRNASeth A Reini
Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610-0487, USA
Am J Physiol Regul Integr Comp Physiol 291:R1708-16. 2006..These results indicate that cortisol could indeed act in the fetal heart to induce enlargement and suggest that the renin-angiotensin system may play a role... - Differential modulation of ovine fetal ACTH secretion by PGHS-1 and PGHS-2Sharon Reimsnider
Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Fla. 32610-0274, USA
Neuroendocrinology 83:4-11. 2006..CONCLUSION: We conclude that prostaglandin generated in the fetal brain by the action of PGHS-1 augments fetal ACTH reflex responses to BCO but that, in contrast, the action of PGHS-2 is inhibitory to ACTH secretion... - Genomic analysis of neuroendocrine development of fetal brain-pituitary-adrenal axis in late gestationMaureen Keller-Wood
Department of Pharmacodynamics, University of Florida, Gainesville, Florida, USA
Physiol Genomics 24:218-24. 2006..Decreases in expression of GR in pituitary at the end of gestation might contribute to the decreased corticosteroid negative feedback sensitivity at term in this species... - Neuronal prostaglandin endoperoxide synthase 2 responses to oxygen and glucose deprivation are mediated by mitogen-activated protein kinase ERK1/2Daying Zhang
Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610 0264, USA
Brain Res 1060:100-7. 2005..These results indicate that PGHS-2 gene expression is induced by oxygen and glucose deprivation synergistically in neurons, and this induction is mediated by one or more members of the MAPK family... - Ketamine inhibits fetal ACTH responses to cerebral hypoperfusionMelanie J Powers
Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gaineseville, Florida, USA
Am J Physiol Regul Integr Comp Physiol 292:R1542-9. 2007.... - Expression of nitric oxide synthase isoforms is reduced in late-gestation ovine fetal brainstemCharles E Wood
Dept of Physiology and Functional Genomics, University of Florida College of Medicine, P O Box 100274, Gainesville, FL 32610 0274, USA
Am J Physiol Regul Integr Comp Physiol 289:R613-R619. 2005..We speculate that the reduced expression of NOS in this brain region plays a role in the increased fetal baroreflex activity in late gestation... - Does reduction of circulating prostaglandin E2 reduce fetal hypothalamic-pituitary-adrenal axis activity?Sharon K Reimsnider
Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida 32610-0274, USA
J Soc Gynecol Investig 12:e13-9. 2005..We conclude that PGE2 in late-gestation ovine fetal plasma does not tonically stimulate fetal ACTH secretion... - Mineralocorticoid receptor expression in late-gestation ovine fetal lungMaureen Keller-Wood
Department of Pharmacodynamics, College of Pharmacy, and Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, Florida 32610 0487, USA
J Soc Gynecol Investig 12:84-91. 2005..These results indicate that the molecular apparatus for mineralocorticoid-stimulated lung liquid reabsorption is present in epithelium by 120 days' gestation... - Psychosocial and physiological stress among women leaving welfareShawn M Kneipp
University of Florida, USA
West J Nurs Res 29:864-83; discussion 884-95. 2007..Psychosocial stress was not associated with changes in physiologic indicators of stress... - Estrogen/hypothalamus-pituitary-adrenal axis interactions in the fetus: The interplay between placenta and fetal brainCharles E Wood
Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida 32610 0274, USA
J Soc Gynecol Investig 12:67-76. 2005..The hormonal interactions between the placenta and the fetal hypothalamus-pituitary-adrenal (HPA) axis are reviewed... - Ontogenetic changes in the extra-pituitary expression of pro-opiomelanocortin in the developing ovine fetusNyima S Ali
Department of Physiology and Functional Genomics, University of Florida College of Medicine, P.O. Box 100274, Gainesville, FL 32610-0274, USA
Peptides 26:301-6. 2005..We speculate that the decreasing abundance of POMC mRNA and protein reflects decreased release of POMC and POMC-related peptides into the fetal bloodstream... - Oestrogen augments the fetal ovine hypothalamus- pituitary-adrenal axis in response to hypotensionScott C Purinton
Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville 32610, USA
J Physiol 544:919-29. 2002..We conclude that oestradiol augments the activity of the central baroreceptor and chemoreceptor reflex pathways, and that it may influence fetal ACTH secretion via this site of action...
Research Grants
- Progestin Actions in the Primate Breast and UterusCharles Wood; Fiscal Year: 2007..This work will have immediate public health relevance to postmenopausal women seeking the safest form of hormone therapy. ..