Research Topics
| B KisSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
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Publications
Cloning of cyclooxygenase-1b (putative COX-3) in mouseB Kis
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
Inflamm Res 55:274-8. 2006..To clone and sequence cyclooxygenase-1b (COX-1b, also known as COX-3) mRNA and to generate an antibody against the mouse COX-1b protein and to demonstrate its existence in vivo in mouse tissues...- Effects of LPS stimulation on the expression of prostaglandin carriers in the cells of the blood-brain and blood-cerebrospinal fluid barriersBela Kis
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Appl Physiol 100:1392-9. 2006.... - Autocrine peptide mediators of cerebral endothelial cells and their role in the regulation of blood-brain barrierBela Kis
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
Peptides 27:211-22. 2006..In this review, we summarize current knowledge of peptide mediators produced by CECs, such as adrenomedullin, angiotensin, endothelin and several others and their role in the regulation of BBB functions... - Acetaminophen and the cyclooxygenase-3 puzzle: sorting out facts, fictions, and uncertaintiesBela Kis
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Pharmacol Exp Ther 315:1-7. 2005..The aim of this review is to evaluate the literature that seeks to point out critical theoretical and methodological limitations of the COX-3 studies that led several investigators to scientifically questionable conclusions... - Acetaminophen-sensitive prostaglandin production in rat cerebral endothelial cellsBela Kis
Dept of Physiology and Pharmacology, Wake Forest Univ Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
Am J Physiol Regul Integr Comp Physiol 288:R897-902. 2005..Furthermore, our findings support a critical role for cerebral endothelium in the therapeutic actions of acetaminophen in the central nervous system... - Regional distribution of cyclooxygenase-3 mRNA in the rat central nervous systemBela Kis
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
Brain Res Mol Brain Res 126:78-80. 2004..Our results suggest that the expression pattern of COX-3 mRNA in the rat CNS primarily relates to the vascular density of a given region... - The mitochondrial K(ATP) channel opener BMS-191095 induces neuronal preconditioningBela Kis
Department of Physiology and Pharmacology, Wake Forest University, School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Neuroreport 15:345-9. 2004.... - Chronic adrenomedullin treatment improves blood-brain barrier function but has no effects on expression of tight junction proteinsB Kis
Department of Physiology and Pharmacology, Wake Forest University, School of Medicine, Winston Salem, NC 27157, USA
Acta Neurochir Suppl 86:565-8. 2003.... - Diazoxide induces delayed pre-conditioning in cultured rat cortical neuronsBela Kis
Department of Physiology and Pharmacology, Wake Forest University, Winston Salem, North Carolina 27157, USA
J Neurochem 87:969-80. 2003..The succinate dehydrogenase-inhibiting effect of diazoxide is more likely to be involved in this neuroprotection than the opening of mitochondrial ATP-sensitive potassium channels... - Putative cyclooxygenase-3 expression in rat brain cellsBela Kis
Department of Physiology and Pharmacology, Wake Forest University, School of Medicine, Winston Salem, NC 27157, USA
J Cereb Blood Flow Metab 23:1287-92. 2003..In summary, we report, for the first time to our knowledge, that the putative COX-3 mRNA is detectable in rats and is differentially expressed in various cell types from rat brain, as well as that its expression is not stimulated by LPS... - Adrenomedullin, an autocrine mediator of blood-brain barrier functionBela Kis
Department of Physiology and Pharmacology, Wake Forest University, Medical Center Boulevard, Winston Salem, NC 27157, USA
Hypertens Res 26:S61-70. 2003.... - Cerebral endothelial cells are a major source of adrenomedullinB Kis
Department of Physiology, University of Occupational and Environmental Health, Kitakyushu, Japan
J Neuroendocrinol 14:283-93. 2002..Cerebral endothelial cells are a potential source of adrenomedullin in the central nervous system, where adrenomedullin can also be involved in the regulation of neuroendocrine functions... - Adrenomedullin regulates blood-brain barrier functions in vitroB Kis
Department of Physiology, University of Occupational and Environmental Health, Iseigaoka 1-1 Yahatanishi-ku, Kitakyushu 807-8555, Japan
Neuroreport 12:4139-42. 2001..AM treatment resulted in functional activation of P-glycoprotein efflux pump in vitro. Our results indicate that AM as an autocrine mediator plays an important role in the regulation of BBB properties of the cerebral endothelial cells... - Adrenomedullin in the cerebral circulationB Kis
Department of Physiology, University of Occupational and Environmental Health, 807 8555, Kitakyushu, Japan
Peptides 22:1825-34. 2001..In this review, we describe current knowledge about the origin and possible role of adrenomedullin in the regulation of cerebral circulation and blood-brain barrier functions... - Cyclooxygenase-2 mediates the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in ratsT Horiguchi
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, USA, and Department of Neurosurgery, National Hospital Organization Tokyo Medical Center, 2 5 1 Higashigaoka Meguro ku, Tokyo, Japan
Neuroscience 140:723-30. 2006..We conclude that NO-mediated cyclooxygenase-2 upregulation by cortical spreading depression protects the brain against ischemic damage...