Research Topics
| Sam A DeadwylerSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
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Detail Information
Publications
Short-term memory is modulated by the spontaneous release of endocannabinoids: evidence from hippocampal population codesSam A Deadwyler
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157 1083, USA
Behav Pharmacol 18:571-80. 2007..The findings therefore indicate a direct relationship between the actions of endocannabinoids on hippocampal processes and the ability to encode information into short-term memory...- Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neuronsRobert E Hampson
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
Hippocampus 13:543-56. 2003.... - Memory encoding in hippocampal ensembles is negatively influenced by cannabinoid CB1 receptorsRobert E Hampson
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Behav Pharmacol 22:335-46. 2011.... - Endocannabinoids modulate encoding of sequential memory in the rat hippocampusSam A Deadwyler
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157 1083, USA
Psychopharmacology (Berl) 198:577-86. 2008.... - Cannabinoid receptor activation modifies NMDA receptor mediated release of intracellular calcium: implications for endocannabinoid control of hippocampal neural plasticityRobert E Hampson
Dept of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Neuropharmacology 60:944-52. 2011.... - Neural activity in frontal cortical cell layers: evidence for columnar sensorimotor processingIoan Opris
Wake Forest University Medical School, Winston Salem, NC 27157, USA
J Cogn Neurosci 23:1507-21. 2011..The results provide required evidence in support of previously suggested task-related sensorimotor processing in the FCx via functionally segregated minicolumns... - Temporal coupling between subicular and hippocampal neurons underlies retention of trial-specific eventsSam A Deadwyler
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, United States
Behav Brain Res 174:272-80. 2006.... - Temporal firing characteristics and the strategic role of subicular neurons in short-term memoryRobert E Hampson
Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Hippocampus 13:529-41. 2003.... - Effects of cocaine rewards on neural representations of cognitive demand in nonhuman primatesRobert E Hampson
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
Psychopharmacology (Berl) 213:105-18. 2011..These regions are critical to many aspects of drug abuse; however recent investigations in addicted individuals have reported possible cognitive deficits that impact recovery and other therapeutic interventions... - Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primatesSam A Deadwyler
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
J Neurosci 27:14239-47. 2007..These findings provide strong evidence for the effectiveness of intranasal orexin-A in alleviating cognitive deficits produced by loss of sleep... - Functional significance of cannabinoid-mediated, depolarization-induced suppression of inhibition (DSI) in the hippocampusRobert E Hampson
Wake Forest University Health Sciences, Department of Physiology and Pharmacology, Winston-Salem, North Carolina 27157, USA
J Neurophysiol 90:55-64. 2003..Under the conditions tested, the normal firing patterns of hippocampal neurons that occur in vivo do not appear to elicit DSI... - Differential but complementary mnemonic functions of the hippocampus and subiculumSam A Deadwyler
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Neuron 42:465-76. 2004..The remaining 25% of trials were at risk due to inherent idiosyncrasies by which hippocampal and subicular neurons encoded information and became errors when the random sequence of trials conflicted with these constraints... - Categorization in the monkey hippocampus: a possible mechanism for encoding information into memoryRobert E Hampson
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
Proc Natl Acad Sci U S A 101:3184-9. 2004..Just as in humans, different monkeys attended to and selected different aspects of the same stimulus image, most likely reflecting different histories, strategies, and expectations residing within individual hippocampal networks... - Reward, memory and substance abuse: functional neuronal circuits in the nucleus accumbensSam A Deadwyler
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
Neurosci Biobehav Rev 27:703-11. 2004..e. future) reward contingencies... - A wireless recording system that utilizes Bluetooth technology to transmit neural activity in freely moving animalsRobert E Hampson
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, United States
J Neurosci Methods 182:195-204. 2009..Continuous recordings over very large distance separations from the monitor station are demonstrated providing experimenters with recording advantages not previously available with other telemetry devices... - Electrophysiological correlates of abused drugs: relation to natural rewardsSam A Deadwyler
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Ann N Y Acad Sci 1187:140-7. 2010..This report explores how abused drugs alter neuron firing in reward-sensitive brain regions and how those alterations effect drug-seeking activity in animals and humans... - Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primatesLinda J Porrino
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA
PLoS Biol 3:e299. 2005.... - "Keeping on track": firing of hippocampal neurons during delayed-nonmatch-to-sample performanceRobert E Hampson
Department of Physiology and Pharmacology and the Neuroscience Program, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
J Neurosci 22:RC198. 2002..1999b) and reaffirmed the potential existence of a functional topography within hippocampus... - A novel tetrode microdrive for simultaneous multi-neuron recording from different regions of primate brainLucas Santos
Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC 27157 1083, USA
J Neurosci Methods 205:368-74. 2012..The device has extensive application to primate models for the detection and study of inoperative or maladaptive neural circuits related to human neurological disorders... - A model for assessing cognitive impairment after fractionated whole-brain irradiation in nonhuman primatesMike E Robbins
Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Radiat Res 175:519-25. 2011..Results from this pilot study suggest that the radiation-induced changes in cognition and brain metabolism observed in rhesus monkeys may be similar to those observed in brain tumor patients receiving brain irradiation... - Modeling hippocampal nonlinear dynamic transformations with principal dynamic modesSpiros H Courellis
Biomedical Engineering Department, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, USA
Conf Proc IEEE Eng Med Biol Soc 1:2300-3. 2006..The resulting PDM models are comparable in performance to the Volterra models and require significantly less representational and implementational overhead... - Experience-dependent regulation of the immediate-early gene arc differs across brain regionsMichele P Kelly
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 23:6443-51. 2003.... - Nonlinear dynamic modeling of spike train transformations for hippocampal-cortical prosthesesDong Song
Department of Biomedical Engineering, Program in Neuroscience, Center for Neural Engineering, University of Southern California, Los Angeles, CA 90089, USA
IEEE Trans Biomed Eng 54:1053-66. 2007..Second- and third-order nonlinear models were found to successfully predict the CA1 output spike distribution based on CA3 input spike trains. First-order, linear models were shown to be insufficient... - A multi-input modeling approach to quantify hippocampal nonlinear dynamic transformationsTheodoros P Zanos
Dept of Biomed Eng, Univ of Southern California, Los Angeles, CA 90089, USA
Conf Proc IEEE Eng Med Biol Soc 1:4967-70. 2006..Representative sets of kernels illustrate the variability of the dynamics of the CA3-CA1 transformations. Our model's predictive accuracy was evaluated using ROC curves... - Physiologically plausible stochastic nonlinear kernel models of spike train to spike train transformationDong Song
Dpet of Biomed Eng, Univ of Southern California, Los Angeles, CA 90089, USA
Conf Proc IEEE Eng Med Biol Soc 1:6129-32. 2006..First order, linear model is shown to be insufficient. Second and third order nonlinear models can successfully predict the output spike distribution... - Nonlinear modeling of causal interrelationships in neuronal ensemblesTheodoros P Zanos
Biomedical Engineering Department, Biomimetic Microelectronic Systems Engineering Resource Center BMES ERC, Biomedical Simulations Resource BMSR, University of Southern California, Los Angeles, CA 90089 USA
IEEE Trans Neural Syst Rehabil Eng 16:336-52. 2008..Illustrative examples are presented for a simulated system and for an actual application using multiunit data recordings from the hippocampus of a behaving rat... - Statistical selection of multiple-input multiple-output nonlinear dynamic models of spike train transformationDong Song
Department of Biomedical Engineering, Center for Neural Engineering, University of Southern California, Los Angeles, CA 90089 USA
Conf Proc IEEE Eng Med Biol Soc 2007:4727-30. 2007..These models could be used to analyze the functional interactions between neurons during behavior... - The endocannabinoid system: a modulator of brain-behavioral processesSam A Deadwyler
Psychopharmacology (Berl) 198:447-8. 2008