Research Topics
| ALEXANDRE ESTEVES MEDINASummaryAffiliation: Virginia Commonwealth University Country: USA Publications
Research Grants
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Detail Information
Publications
Fetal alcohol spectrum disorders and abnormal neuronal plasticityAlexandre E Medina
Department of Anatomy and Neurobiology, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298 0709, USA
Neuroscientist 17:274-87. 2011..In this review, the author discuss the mechanisms that lead to these abnormalities and comment on recent pharmacological approaches that have been showing promising results in improving neuronal plasticity in FASD...- Neocortical plasticity deficits in fetal alcohol spectrum disorders: lessons from barrel and visual cortexAlexandre E Medina
Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0709, USA
J Neurosci Res 86:256-63. 2008..In this Mini-Review, we discuss the effects of ethanol exposure during development on neuronal plasticity and suggest environmental and pharmacological approaches to ameliorate these problems... - Restoration of neuronal plasticity by a phosphodiesterase type 1 inhibitor in a model of fetal alcohol exposureAlexandre E Medina
Department of Anatomy and Neurobiology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, USA
J Neurosci 26:1057-60. 2006..Our finding should contribute to a better understanding and treatment of cognitive deficits associated with mental disorders, such as FAS... - Early alcohol exposure impairs ocular dominance plasticity throughout the critical periodAlexandre E Medina
Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, 1101 E Marshall Street, Sanger Hall Room 12 042, Richmond, VA 23298 0709, USA
Brain Res Dev Brain Res 157:107-11. 2005..This finding provides evidence that early alcohol exposure does not affect the timing or duration of the critical period of OD plasticity and suggests an enduring impairment of neural plasticity in FAS... - Early alcohol exposure induces persistent alteration of cortical columnar organization and reduced orientation selectivity in the visual cortexAlexandre E Medina
Deptartment of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Box 0709, 1101 East Marshall St, Rm. 12-042, Richmond, VA 23298-0709, USA
J Neurophysiol 93:1317-25. 2005..These findings indicate that alcohol exposure during a brief period of development disrupts cortical processing of sensory information at a later age and suggest a neurobiological substrate for some types of sensory deficits in FAS... - Overexpression of serum response factor restores ocular dominance plasticity in a model of fetal alcohol spectrum disordersArco P Paul
Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0709, USA
J Neurosci 30:2513-20. 2010..This finding suggests that overexpression of SRF in astrocytes may reduce the deficits in neuronal plasticity seen in models of FASD... - Neonatal alcohol exposure induces long-lasting impairment of visual cortical plasticity in ferretsAlexandre E Medina
Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298-0709, USA
J Neurosci 23:10002-12. 2003..This model provides a novel approach to investigate the consequences of fetal alcohol exposure and should contribute to elucidate how alcohol disrupts neural plasticity... - Activation of NMDA receptors is necessary for the recovery of cortical binocularityThomas E Krahe
Department of Anatomy and Neurobiology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298 0709, USA
J Neurophysiol 103:2700-6. 2010..These findings provide an important new insight for a specific role of NMDARs in the recovery of cortical binocularity from the effects of MD... - Phosphodiesterase type 4 inhibition does not restore ocular dominance plasticity in a ferret model of fetal alcohol spectrum disordersThomas E Krahe
Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0709, USA
Alcohol Clin Exp Res 34:493-8. 2010..This disruption can be reversed, however, by treating animals with a Phosphodiesterase (PDE) type 1 inhibitor long after the period of alcohol exposure... - Phosphodiesterase inhibition increases CREB phosphorylation and restores orientation selectivity in a model of fetal alcohol spectrum disordersThomas E Krahe
Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
PLoS ONE 4:e6643. 2009..There is growing evidence that some of these sensory processing problems may be related to altered cortical maps caused by impaired developmental neuronal plasticity... - Do cross-modal projections always result in multisensory integration?Brian L Allman
Department of Anatomy and Neurobiology, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA
Cereb Cortex 18:2066-76. 2008.... - Protein synthesis-independent plasticity mediates rapid and precise recovery of deprived eye responsesThomas E Krahe
Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, 1101 East Marshall Street, Richmond, Virginia 23298, USA
Neuron 48:329-43. 2005.... - The effects of callosal agenesis on the susceptibility to seizures elicited by pentylenetetrazol in BALB/cCF miceAlexandre E Medina
Laboratório de Neurofisiologia e Avaliação Neurocomportamental, DCF IBRAG, Universidade do Estado do Rio de Janeiro, Boulevard 28 de Setembro, 87, Rio de Janeiro, RJ, 20 551 030, Brazil
Pharmacol Biochem Behav 71:97-102. 2002..No significant differences were found for the 50-mg/kg dose as a result of the fact that most animals displayed RBC. These data indicate that callosal development and sex are important factors affecting seizure susceptibility... - Phosphodiesterase type 1 inhibition improves learning in rats exposed to alcohol during the third trimester equivalent of human gestationClaudio C Filgueiras
Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA 23298 0709, United States
Neurosci Lett 473:202-7. 2010..Our results show that inhibition of PDE1 improves learning and memory deficits in rats early exposed to alcohol and provide evidence for the potential therapeutic use of vinpocetine in FASD... - Sex differences in the incidence of total callosal agenesis in BALB/cCF miceAlex C Manhães
Laboratório de Neurofisiologia e Avaliação Neurocomportamental, Departamento de Ciencias Fisiologicas, IBRAG, Universidade do Estado do Rio de Janeiro, Boulevard 28 de Setembro, 87, fundos, 5 andar, Rio de Janeiro 20 551 030, Brazil
Neurosci Lett 325:159-62. 2002..This last result suggests that sex is a relevant factor in callosal development in its earliest stages of formation... - Recovery of cortical binocularity and orientation selectivity after the critical period for ocular dominance plasticityDavid S Liao
Dept. of Anatomy and Neurobiology, Virginia Commonwealth Univ. School of Medicine, 1101 E. Marshall St, Sanger Hall Rm. 12-042, Richmond VA 23298-0709, USA
J Neurophysiol 92:2113-21. 2004..Collectively, these results indicate that there is potential for recovery of cortical binocularity and deprived eye orientation selectivity after the end of the critical period for ocular dominance plasticity...
Research Grants
- Alcohol in Neocortex Development and PlasticityALEXANDRE MEDINA; Fiscal Year: 2007..The results of these studies may one day contribute to devise therapeutic interventions that will prevent or alleviate morbidity in FAS. ..
- Alcohol in Neocortex Development and PlasticityALEXANDRE MEDINA; Fiscal Year: 2009..The results of these studies may one day contribute to devise therapeutic interventions that will prevent or alleviate morbidity in FAS. ..
- Alcohol in Neocortex Development and PlasticityALEXANDRE ESTEVES MEDINA; Fiscal Year: 2010..As corollary, improvement of astrocytes function can lead to an increase in neuronal plasticity. These studies should contribute to devise therapeutic interventions that may alleviate morbidity in FASD. ..