Yongwoo Lee

Summary

Affiliation: Virginia Polytechnic Institute and State University
Country: USA

Publications

  1. ncbi Effects of acute ingestion of different fats on oxidative stress and inflammation in overweight and obese adults
    Abigail D Peairs
    Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Nutr J 10:122. 2011
  2. ncbi Human immunodeficiency virus-1 Tat protein up-regulates interleukin-6 and interleukin-8 expression in human breast cancer cells
    Y W Lee
    Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Inflamm Res 54:380-9. 2005
  3. ncbi Protective effects of genistein on proinflammatory pathways in human brain microvascular endothelial cells
    Yong W Lee
    Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University Virginia Tech, Blacksburg, VA 24061, USA
    J Nutr Biochem 19:819-25. 2008
  4. ncbi Role of interleukin-4 in atherosclerosis
    Yong Woo Lee
    Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Arch Pharm Res 29:1-15. 2006
  5. ncbi Oxidative mechanisms of IL-4-induced IL-6 expression in vascular endothelium
    Yong Woo Lee
    Laboratory of Vascular Biology, Department of Biomedical Sciences and Pathobiology, School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24061, USA
    Cytokine 49:73-9. 2010
  6. ncbi Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain
    Won Hee Lee
    School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University Virginia Tech, Blacksburg, Virginia 24061, USA
    Int J Radiat Biol 86:132-44. 2010
  7. ncbi Role of NADPH oxidase in interleukin-4-induced monocyte chemoattractant protein-1 expression in vascular endothelium
    Yong Woo Lee
    Department of Biomedical Sciences and Pathobiology, School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University Virginia Tech, Blacksburg, VA 24061, USA
    Inflamm Res 59:755-65. 2010
  8. ncbi Taste and odor abnormalities in cancer patients
    Jae Hee Hong
    Department of Food Science and Technology, Virginia Tech, Blacksburg, Virginia 24061, USA
    J Support Oncol 7:58-65. 2009
  9. ncbi A novel in vitro ischemia/reperfusion injury model
    Won Hee Lee
    School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University Virginia Tech, Blacksburg, VA 24061, USA
    Arch Pharm Res 32:421-9. 2009
  10. ncbi Aging attenuates radiation-induced expression of pro-inflammatory mediators in rat brain
    Won Hee Lee
    School of Biomedical Engineering and Sciences, Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University Virginia Tech, Blacksburg, VA 24061, USA
    Neurosci Lett 476:89-93. 2010

Research Grants

  1. Role of p38 MAPK in IL-4-induced IL-6 expression in vascular endothelium
    Yongwoo Lee; Fiscal Year: 2007

Collaborators

  • W E Sonntag
  • Jae Hee Hong
  • Avi Nath
  • Bernhard Hennig
  • Michal Toborek
  • Won Hee Lee
  • Govinder Flora
  • Sung Yong Eum
  • Hong Pu
  • Abigail D Peairs
  • Kentaro Hayashi
  • Jing Tian
  • Wangsun Choi
  • William Maragos
  • Rosario Garrido
  • Simone Kaiser
  • Janet W Rankin
  • Han Yan
  • Matthew Mitschelen
  • Sungkwon Kang
  • Pavlos P Vlachos
  • Ibolya E Andras
  • R Ravikumar
  • Hans Christian Bauer
  • Larry W Robertson
  • Hans-Christian Bauer
  • Andrzej Malecki

Detail Information

Publications25

  1. ncbi Effects of acute ingestion of different fats on oxidative stress and inflammation in overweight and obese adults
    Abigail D Peairs
    Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Nutr J 10:122. 2011
    ....
  2. ncbi Human immunodeficiency virus-1 Tat protein up-regulates interleukin-6 and interleukin-8 expression in human breast cancer cells
    Y W Lee
    Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Inflamm Res 54:380-9. 2005
    ..To examine whether HIV-1 Tat protein increases the metastatic potential of human breast cancer cells through induction of pro-inflammatory tumor microenvironment...
  3. ncbi Protective effects of genistein on proinflammatory pathways in human brain microvascular endothelial cells
    Yong W Lee
    Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University Virginia Tech, Blacksburg, VA 24061, USA
    J Nutr Biochem 19:819-25. 2008
    ..Our results suggest that genistein may attenuate proinflammatory pathways through inhibition of cytokine-induced overexpression of proinflammatory mediators and inflammatory reactions in human brain microvascular endothelial cells...
  4. ncbi Role of interleukin-4 in atherosclerosis
    Yong Woo Lee
    Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Arch Pharm Res 29:1-15. 2006
    ....
  5. ncbi Oxidative mechanisms of IL-4-induced IL-6 expression in vascular endothelium
    Yong Woo Lee
    Laboratory of Vascular Biology, Department of Biomedical Sciences and Pathobiology, School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24061, USA
    Cytokine 49:73-9. 2010
    ..These results demonstrate that IL-4 up-regulates IL-6 expression in vascular endothelium through NOX-mediated ROS generation...
  6. ncbi Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain
    Won Hee Lee
    School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University Virginia Tech, Blacksburg, Virginia 24061, USA
    Int J Radiat Biol 86:132-44. 2010
    ..In the present study, we investigate the hypothesis that brain irradiation induces regionally specific alterations in cytokine gene and protein expression...
  7. ncbi Role of NADPH oxidase in interleukin-4-induced monocyte chemoattractant protein-1 expression in vascular endothelium
    Yong Woo Lee
    Department of Biomedical Sciences and Pathobiology, School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University Virginia Tech, Blacksburg, VA 24061, USA
    Inflamm Res 59:755-65. 2010
    ....
  8. ncbi Taste and odor abnormalities in cancer patients
    Jae Hee Hong
    Department of Food Science and Technology, Virginia Tech, Blacksburg, Virginia 24061, USA
    J Support Oncol 7:58-65. 2009
    ..Understanding the types and causes of taste and odor dysfunctions will enable researchers and physicians to develop treatments for these conditions and thereby improve patient quality of life...
  9. ncbi A novel in vitro ischemia/reperfusion injury model
    Won Hee Lee
    School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University Virginia Tech, Blacksburg, VA 24061, USA
    Arch Pharm Res 32:421-9. 2009
    ....
  10. ncbi Aging attenuates radiation-induced expression of pro-inflammatory mediators in rat brain
    Won Hee Lee
    School of Biomedical Engineering and Sciences, Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University Virginia Tech, Blacksburg, VA 24061, USA
    Neurosci Lett 476:89-93. 2010
    ..These results provide evidence for the first time that radiation-induced pro-inflammatory responses in the brain are suppressed in aged animals...
  11. ncbi HIV-Tat protein induces oxidative and inflammatory pathways in brain endothelium
    Michal Toborek
    Department of Surgery, Animal Sciences and Neurology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Neurochem 84:169-79. 2003
    ..These changes can directly lead to disruption of the BBB. Thus, Tat can play an important role in the development of detrimental vascular changes in the brains of HIV-infected patients...
  12. ncbi HIV-Tat protein induces P-glycoprotein expression in brain microvascular endothelial cells
    Kentaro Hayashi
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Surgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Neurochem 93:1231-41. 2005
    ..These results suggest that Tat-induced overexpression of P-gp in brain microvessels may have significant implications for the development of resistance to HAART and may be a contributing factor for low efficacy of HAART in the CNS...
  13. ncbi Interplay between epidermal growth factor receptor and Janus kinase 3 regulates polychlorinated biphenyl-induced matrix metalloproteinase-3 expression and transendothelial migration of tumor cells
    Sung Yong Eum
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Surgery, University of Kentucky, Lexington, USA
    Mol Cancer Res 4:361-70. 2006
    ....
  14. ncbi Gene expression profile in interleukin-4-stimulated human vascular endothelial cells
    Yong Woo Lee
    Department of Surgery Division of Neurosurgery, University of Kentucky College of Medicine, 800 Rose Street, Lexington, Kentucky 40536, USA
    Mol Med 10:19-27. 2004
    ..In addition, a better understanding of IL-4-induced vascular injury at the level of gene expression could lead to the identification of new therapeutic strategies for atherosclerosis...
  15. ncbi Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cells
    Yong Woo Lee
    Department of Surgery Division of Neurosurgery, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Cardiovasc Res 63:139-48. 2004
    ..In the present study, we assessed the hypothesis that estrogen may attenuate the HIV Tat protein-induced inflammatory pathways in human vascular endothelium...
  16. ncbi HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain
    Hong Pu
    Department of Surgery Neurosurgery, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Mol Cell Neurosci 24:224-37. 2003
    ..These data demonstrate that intracerebral administration of Tat can induce profound proinflammatory effects in the brain, leading to monocyte infiltration...
  17. ncbi Proinflammatory synergism of ethanol and HIV-1 Tat protein in brain tissue
    Govinder Flora
    Department of Surgery, University of Kentucky, Lexington, KY 40536, USA
    Exp Neurol 191:2-12. 2005
    ..Such potentiation of proinflammatory stimulation may further contribute to CNS pathology in HIV-infected patients who are alcohol abusers...
  18. ncbi VEGF regulates PCB 104-mediated stimulation of permeability and transmigration of breast cancer cells in human microvascular endothelial cells
    Sung Yong Eum
    Department of Surgery, University of Kentucky, Lexington, KY 40536, USA
    Exp Cell Res 296:231-44. 2004
    ..These results indicate that PCB 104 may contribute to tumor metastasis by inducing VEGF overexpression that stimulates endothelial hyperpermeability and transendothelial migration of cancer cells...
  19. ncbi PCB 104-induced proinflammatory reactions in human vascular endothelial cells: relationship to cancer metastasis and atherogenesis
    Wangsun Choi
    Department of Surgery, University of Kentucky, Lexington, Kentucky 40536, USA
    Toxicol Sci 75:47-56. 2003
    ..We hypothesize that these proinflammatory processes may contribute to the development of cancer metastasis and/or atherogenesis in patients exposed to PCBs...
  20. ncbi Methamphetamine potentiates HIV-1 Tat protein-mediated activation of redox-sensitive pathways in discrete regions of the brain
    Govinder Flora
    Department of Surgery, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Exp Neurol 179:60-70. 2003
    ..Such synergistic proinflammatory stimulation may have significant implications in HIV-infected patients who abuse drugs...
  21. ncbi Redox-regulated mechanisms of IL-4-induced MCP-1 expression in human vascular endothelial cells
    Yong Woo Lee
    Department of Surgery, University of Kentucky Medical Center, Lexington 40536, USA
    Am J Physiol Heart Circ Physiol 284:H185-92. 2003
    ..These results demonstrate that IL-4-dependent MCP-1 induction in HUVEC is mediated by redox-regulated STAT1 activation...
  22. ncbi Methamphetamine activates DNA binding of specific redox-responsive transcription factors in mouse brain
    Yong Woo Lee
    Division of Neurosurgery, Department of Surgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Neurosci Res 70:82-9. 2002
    ..These results suggest that METH-induced oxidative stress may trigger the molecular signaling pathways via specific and selective activation of AP-1 and CREB...
  23. ncbi Methamphetamine-induced TNF-alpha gene expression and activation of AP-1 in discrete regions of mouse brain: potential role of reactive oxygen intermediates and lipid peroxidation
    Govinder Flora
    Departments of Surgery, University of Kentucky, Lexington 40536, USA
    Neuromolecular Med 2:71-85. 2002
    ..Furthermore, these data provide evidence for the role of oxidative stress in the neurotoxic effects of METH...
  24. ncbi Measurement of inflammatory properties of fatty acids in human endothelial cells
    Michal Toborek
    Department of Surgery, Division of Neurosurgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    Methods Enzymol 352:198-219. 2002
  25. ncbi Unsaturated fatty acids selectively induce an inflammatory environment in human endothelial cells
    Michal Toborek
    Department of Surgery, University of Kentucky Medical Center, Lexington 40536, USA
    Am J Clin Nutr 75:119-25. 2002
    ..However, the specific effects of fatty acids on inflammatory responses in endothelial cells are not fully understood...

Research Grants1

  1. Role of p38 MAPK in IL-4-induced IL-6 expression in vascular endothelium
    Yongwoo Lee; Fiscal Year: 2007
    ..More importantly, it will help develop new therapeutic approaches to translate these basic laboratory discoveries into clinically effective treatments for over 50 million Americans at cardiovascular risk. ..