Research Topics
Species | M R GrafSummaryAffiliation: Virginia Commonwealth University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Interleukin-6 transduction of a rat T9 glioma clone results in attenuated tumorigenicity and induces glioma immunity in Fischer F344 ratsM R Graf
Department of Neurosurgery, Virginia Commonwealth University and Medical College of Virginia, Richmond 23298 0709, USA
J Neurooncol 45:209-18. 1999..F parental cells (p = 0.003). This study demonstrates that IL-6 secretion attenuates SC and IC glioma growth and SC rejection of IL-6 secreting T9.F cells induces long-term glioma immunity which is effective in the brain...- Development of systemic immunity to glioblastoma multiforme using tumor cells genetically engineered to express the membrane-associated isoform of macrophage colony-stimulating factorM R Graf
Department of Molecular Biology, University of California, Irvine 92697, USA
J Immunol 163:5544-51. 1999..Subcutaneous immunization with viable T9/mM-CSF cells was effective in eradicating i.c. T9 tumors... - The anti-tumor effects of androstene steroids exhibit a strict structure-activity relationship dependent upon the orientation of the hydroxyl group on carbon-17Martin R Graf
Department of Neurosurgery Harold F Young Neurosurgical Center and the Massey Cancer Center, Virginia Commonwealth University Medical Center, P O Box 980631, 1200 E Broad Street, Richmond, VA 23298 0631, USA
Chem Biol Drug Des 74:625-9. 2009..These results indicate that the position of the hydroxyl group on C-17 dictates the anti-tumor activity of the androstenes and must be in the alpha-configuration, demonstrating a strict structure-activity relationship... - Autophagy and the functional roles of Atg5 and beclin-1 in the anti-tumor effects of 3beta androstene 17alpha diol neuro-steroid on malignant glioma cellsMartin R Graf
Department of Neurosurgery Harold F Young Neurosurgical Center and Massey Cancer Center, Virginia Commonwealth University Medical Center, PO Box 980631, Richmond, VA 23298 0631, USA
J Steroid Biochem Mol Biol 115:137-45. 2009..These results demonstrate that 17alpha-AED possesses significant anti-glioma activity when used at pharmacologically relevant concentrations in vitro and the cytotoxic effects are resultant from the induction of autophagy... - The neuro-steroid, 3beta androstene 17alpha diol exhibits potent cytotoxic effects on human malignant glioma and lymphoma cells through different programmed cell death pathwaysM R Graf
Department of Neurosurgery and the Massey Cancer Center, Virginia Commonwealth University Medical Center, PO Box 980631, Richmond, VA 23298 0631, USA
Br J Cancer 97:619-27. 2007..These cytotoxic effects may utilize a non-apoptotic pathway in malignant glioma cells... - Tumor infiltration by myeloid suppressor cells in response to T cell activation in rat gliomasMartin R Graf
Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia, 23298 0631, USA
J Neurooncol 73:29-36. 2005..These results suggest that MSC infiltration and unregulated tumor growth in response to vaccination is T cell-dependent; is not unique to the T9 glioma; and can be recapitulated with an alternate immunization approach... - Contrasting effects of interleukin-2 secretion by rat glioma cells contingent upon anatomical location: accelerated tumorigenesis in the central nervous system and complete rejection in the peripheryMartin R Graf
Department of Anatomy and Neurobiology, Medical College of Virginia, Virginia Commonwealth University, P O Box 980709 MCV Station, Richmond, VA 23298 0709, USA
J Neuroimmunol 140:49-60. 2003..F cells. Intracranial T9.F/IL2/#12 tumors were markedly infiltrated by CD4(+) and CD8(+) T cells, natural killer (NK)-T cells and myeloid progenitor cells, whereas subcutaneous T9.F/IL2/#12 tumors contained an elevated level of NK cells... - IL-6 secretion by a rat T9 glioma clone induces a neutrophil-dependent antitumor response with resultant cellular, antiglioma immunityM R Graf
Division of Neurosurgery, Virginia Commonwealth University Medical College of Virginia, Richmond, VA 23198, USA
J Immunol 166:121-9. 2001.... - Irradiated tumor cell vaccine for treatment of an established glioma. I. Successful treatment with combined radiotherapy and cellular vaccinationMartin R Graf
Department of Anatomy and Division of Neurosurgery, Virginia Commonwealth University Medical College of Virginia, 1101 E Marshall Street, P O Box 980709, Richmond, VA 23198 0709, USA
Cancer Immunol Immunother 51:179-89. 2002.... - Cytotoxic T cells infiltrating a glioma express an aberrant phenotype that is associated with decreased function and apoptosisR M Prins
Department of Anatomy, Virginia Commonwealth University Medical College of Virginia School of Medicine, Richmond 23298 0709, USA
Cancer Immunol Immunother 50:285-92. 2001..These results suggest that the aberrant CTL phenotype found in the TIL of glioma-bearing rats may be novel signals for their impending death and degenerating anti-tumor immune function... - Tumor-infiltrating, myeloid-derived suppressor cells inhibit T cell activity by nitric oxide production in an intracranial rat glioma + vaccination modelWentao Jia
Department of Neurosurgery, Virginia Commonwealth, Richmond, VA 23298 0631, USA
J Neuroimmunol 223:20-30. 2010..These findings suggest that neuro-immunomodulation by MDSC in rat gliomas maybe mediated by a pathway requiring NO production... - Irradiated tumor cell vaccine for treatment of an established glioma. II. Expansion of myeloid suppressor cells that promote tumor progressionRobert M Prins
Department of Anatomy, Virginia Commonwealth University Medical College of Virginia, 1101 E Marshall Street, P O Box 980709, MCV Station, Richmond, VA 23198 0709, USA
Cancer Immunol Immunother 51:190-9. 2002..Therefore, we believe that an MSC population is responsible for inhibiting the anti-tumor T cell response, resulting in the enhanced growth of the i.c. glioma, and may represent a significant obstacle to immune-based therapies... - Effect of WT1 gene silencing on the tumorigenicity of human glioblastoma multiforme cellsAaron J Clark
Department of Anatomy and Neurobiology, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, Virginia 23298 0631, USA
J Neurosurg 112:18-25. 2010..Studies of nonglioma cell lines have demonstrated that WT1 promotes cell proliferation and survival; however, this ability has not been rigorously analyzed in human GBM... - Down-regulation of Wilms' tumor 1 expression in glioblastoma cells increases radiosensitivity independently of p53Aaron J Clark
Department of Neurosurgery, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, VA 23298 0631, USA
J Neurooncol 83:163-72. 2007..Anti-WT1 strategies may, therefore, prove useful in improving the response of glioblastoma to radiotherapy, thus potentially improving patient survival... - Thymic function and output of recent thymic emigrant T cells during intracranial glioma progressionRobert M Prins
Department of Anatomy and Surgery, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA, USA
J Neurooncol 64:45-54. 2003..Our findings may shed light on the significance of thymic function for anti-glioma immunity and the response to immunotherapeutic treatment paradigms... - FTY720 reduces inflammation and promotes functional recovery after spinal cord injuryKangmin D Lee
Department of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia, USA
J Neurotrauma 26:2335-44. 2009..Collectively these results demonstrate the neuroprotective potential of FTY720 treatment after experimental SCI...