Research Topics
| J O FalkinhamSummaryAffiliation: Virginia Polytechnic Institute and State University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Effect of growth in biofilms on chlorine susceptibility of Mycobacterium avium and Mycobacterium intracellulareKeesha A Steed
Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061-0406, USA
Appl Environ Microbiol 72:4007-11. 2006..There was a strong correlation between the chlorine susceptibility of cells of both M. avium and M. intracellulare and cell surface hydrophobicity measured by contact angle for both biofilm- and suspension-grown cells...- Antibacterial activities of dendritic amphiphiles against nontuberculous mycobacteriaJoseph O Falkinham
Department of Biological Science 0406, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
Tuberculosis (Edinb) 92:173-81. 2012.... - Nontuberculous mycobacteria in the environmentJoseph O Falkinham
Department of Biology, Fralin Biotechnology Center, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0346, USA
Clin Chest Med 23:529-51. 2002..In the absence of competitors, even the slowly growing mycobacteria can grow in the distribution system [33]. It is likely that hypersensitivity pneumonitis in lifeguards and therapy pool attendants [139] is caused by a similar scenario... - Effect of different cell fractions of Mycobacterium avium and vaccination regimens on Mycobacterium avium infectionJ O Falkinham
Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
Scand J Immunol 59:478-84. 2004..avium vaccine preparations. Post-infection vaccination of M. avium-infected chickens was also shown to significantly reduce the number of lesions and colony counts... - Growth in catheter biofilms and antibiotic resistance of Mycobacterium aviumJoseph O Falkinham
Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
J Med Microbiol 56:250-4. 2007..5x10(4) c.f.u. cm-2 by 4 weeks. Cells grown in catheter biofilms were significantly more resistant to clarithromycin and rifamycin than cells grown in suspension... - Mycobacterium avium in a shower linked to pulmonary diseaseJoseph O Falkinham
Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0406, USA
J Water Health 6:209-13. 2008..avium isolates from the hot and cold water and showerhead sediment demonstrated a clonal relationship with the patient's M. avium isolate. The data provide evidence that showers may serve as sources of infection by waterborne M. avium... - Factors influencing numbers of Mycobacterium avium, Mycobacterium intracellulare, and other Mycobacteria in drinking water distribution systemsJ O Falkinham
Fralin Biotechnology Center, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0346, USA
Appl Environ Microbiol 67:1225-31. 2001..Evidently, the ecological niches of M. avium and M. intracellulare are distinct... - Surrounded by mycobacteria: nontuberculous mycobacteria in the human environmentJ O Falkinham
Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0406, USA
J Appl Microbiol 107:356-67. 2009.... - Proliferation of antibiotic-producing bacteria and concomitant antibiotic production as the basis for the antibiotic activity of Jordan's red soilsJoseph O Falkinham
Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0406, USA
Appl Environ Microbiol 75:2735-41. 2009..These results suggest that the antibiotic activity of Jordan's red soils is due to the proliferation of antibiotic-producing bacteria... - Impact of human activities on the ecology of nontuberculous mycobacteriaJoseph O Falkinham
Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061 0406, USA
Future Microbiol 5:951-60. 2010..NTM selection may also occur as a consequence of antibiotics in drinking water sources... - Hospital water filters as a source of Mycobacterium avium complexJoseph O Falkinham
Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0406, USA
J Med Microbiol 59:1198-202. 2010..Five of the 22 (23?%) M. avium patient bronchoscopy isolates and 42 of the 56 (75?%) M. intracellulare patient bronchoscopy isolates could have been due to contamination from the water supply... - Nontuberculous mycobacteria from household plumbing of patients with nontuberculous mycobacteria diseaseJoseph O Falkinham
Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0406, USA
Emerg Infect Dis 17:419-24. 2011..1532)... - Factors influencing the chlorine susceptibility of Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceumJoseph O Falkinham
Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA
Appl Environ Microbiol 69:5685-9. 2003..Chlorine-resistant MAIS strains were more hydrophobic and resistant to Tween 80, para-nitrobenzoate, hydroxylamine, and nitrite than were the chlorine-sensitive strains... - Epidemiology of infection by nontuberculous mycobacteria. Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceum in acid, brown-water swamps of the southeastern United States and their association with environmental variablesR A Kirschner
Department of Biology, Virginia Polytechnic Institute and State University, Balcksburg 24061
Am Rev Respir Dis 145:271-5. 1992.... - Epidemiology of infection by nontuberculous mycobacteria IX. Evidence for two DNA homology groups among small plasmids in Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceumM T Jucker
Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061
Am Rev Respir Dis 142:858-62. 1990..3 to 25 kb from environmental and clinical (AIDS and non-AIDS) isolates. There was no hybridization between pVT2 and pLR7. Thus, these two probes define two different groups of small mycobacterial plasmids... - Epidemiology of infection by nontuberculous mycobacteria. VIII. Absence of mycobacteria in chicken litterJ O Falkinham
Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061
Am Rev Respir Dis 139:1347-9. 1989..Further, litter appears bactericidal to these organisms in that less than 1% of cells inoculated survived more than 6 wk, probably because of the high pH of litters... - Arylsulfatase activity of Mycobacterium avium, M. intracellulare, and M. scrofulaceumJ O Falkinham
Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061
Int J Syst Bacteriol 40:66-70. 1990..avium, three in M. intracellulare [82, 5, and 13%], and two in M. scrofulaceum [60 and 40%])... - Fluorescent acid-fast microscopy for measuring phagocytosis of Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceum by Tetrahymena pyriformis and their intracellular growthE D Strahl
Department of Biology, Fralin Biotechnology Center, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0346, USA
Appl Environ Microbiol 67:4432-9. 2001..The growth and viability of T. pyriformis were not affected by mycobacterial infection. The results suggest that free-living phagocytic protozoa may be natural hosts and reservoirs for M. avium, M. intracellulare, and M. scrofulaceum... - A luciferase-based method for assessing chlorine-susceptibility of Mycobacterium aviumH E Cowan
Department of Biology and Fralin Biotechnology Center, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0346, USA
J Microbiol Methods 46:209-15. 2001..It was discovered that chlorine was rapidly lost from suspensions containing 10(6) M. avium cells/ml. The luciferase-based test can be used to rapidly measure susceptibility of M. avium to different disinfectants used in water treatment... - Mycobacterial aerosols and respiratory diseaseJoseph O Falkinham
Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA
Emerg Infect Dis 9:763-7. 2003..Disinfection may select for the predominance and growth of mycobacteria. Therefore, mycobacteria may be responsible, in part, for many outbreaks of hypersensitivity pneumonitis and other respiratory problems in the workplace and home... - Decolorization of malachite green and crystal violet by waterborne pathogenic mycobacteriaJefferson J Jones
Department of Biology, Virginia Union University, Richmond, Virginia 23220, USA
Antimicrob Agents Chemother 47:2323-6. 2003..Decolorization activity of membrane fractions was stimulated by ferrous ion and inhibited by dinitrophenol and metyrapone... - Manganese-oxidizing and -reducing microorganisms isolated from biofilms in chlorinated drinking water systemsJosé M Cerrato
The Charles E Via Jr Department of Civil and Environmental Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0246, USA
Water Res 44:3935-45. 2010..This has important implications for Mn-management strategies, which typically assume Mn-reduction is not possible in the presence of chlorine and oxidizing conditions... - Accumulation and transport of cadmium by tolerant and susceptible strains of Mycobacterium scrofulaceumF X Erardi
Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061
Antimicrob Agents Chemother 33:350-5. 1989..Increased Cd2+ in culture medium resulted in decreased Mn2+ and Zn2+ in cells of the susceptible strain but did not reduce the Mn2+ and Zn2+ content of cells of the tolerant strain... - Effects of biocides and other metal removal fluid constituents on Mycobacterium immunogenumJoseph O Falkinham
Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0406, USA
Appl Environ Microbiol 75:2057-61. 2009..immunogenum cells from MRF systems... - Synthesis and antimicrobial evaluation of water-soluble, dendritic derivatives of epimeric 5alpha-cholestan-3-amines and 5alpha-cholestan-3-yl aminoethanoatesEko W Sugandhi
Department of Chemistry MC 0212, Virginia Tech, Blacksburg, VA 24061, United States
Steroids 72:615-26. 2007..aureus. The best activity, a minimal inhibitory concentration (MIC) of 27 microM, was found for the 3beta epimer of 1 against MRSA... - Synthesis, critical micelle concentrations, and antimycobacterial properties of homologous, dendritic amphiphiles. Probing intrinsic activity and the "cutoff" effectEko W Sugandhi
Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, USA
J Med Chem 50:1645-50. 2007..The hexadecyl homologue is the most active at inhibiting growth with an MIC0 equal to 3.5 x 10-5 M, which is 100-fold below the CMC... - Antimicrobial activity of long-chain, water-soluble, dendritic tricarboxylato amphiphilesAndré A Williams
Department of Chemistry MC 0212, Virginia Tech, Blacksburg, VA 24061, USA
J Antimicrob Chemother 59:451-8. 2007..To measure the antimicrobial activities of three series of homologous, dendritic tricarboxylato (three-headed) amphiphiles against a battery of bacteria and fungi... - Comparing anti-HIV, antibacterial, antifungal, micellar, and cytotoxic properties of tricarboxylato dendritic amphiphilesRichard V Macri
Department of Chemistry 0212, Virginia Tech, Blacksburg, VA 24061, United States
Bioorg Med Chem 17:3162-8. 2009.... - Role of hydrophobicity in bacterial adherence to carbon nanostructures and biofilm formationSonal Mazumder
Department of Engineering Science and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA
Biofouling 26:333-9. 2010..Biofilm formation led to alterations in the hydrophobicity of the substratum surfaces, demonstrating that bacterial cells attached to CNs are capable of modifying the surface characteristics... - Rapid coliphage detection assayJ E Stanek
Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0406, USA
J Virol Methods 91:93-8. 2001..The assay could detect as few as five coliphage per sample without an overnight incubation period. The range of acceptable assay parameters was identified... - Synthesis and antimicrobial activity of symmetrical two-tailed dendritic tricarboxylato amphiphilesEko W Sugandhi
Department of Chemistry MC 0212, Virginia Tech, Blacksburg, VA 24061, USA
Bioorg Med Chem 15:3842-53. 2007..The one case where two-tailed compounds displayed the lowest MICs-3(10,10), 15 microM; 3(11,11), 7.2microM; and 3(12,12), 6.9 microM-was against Cryptococcus neoformans... - Rapid detection of lytic antimicrobial activity against yeast and filamentous fungiSally N Jewell
Fralin Biotechnology Center, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0346, USA
J Microbiol Methods 49:1-9. 2002..The anti-yeast assay has been adapted to a 96-well microtiter format. Both assays provided a rapid, sensitive, and reproducible detection of lytic anti-yeast and anti-fungal activity... - Relationships between Mycobacterium isolates from patients with pulmonary mycobacterial infection and potting soilsMary Ann De Groote
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
Appl Environ Microbiol 72:7602-6. 2006..Thus, potting soils are potential sources of infection by environmental mycobacteria. Use of dust-excluding masks should be considered during potting or other activities that generate aerosol with soil... - Health impacts of environmental mycobacteriaTodd P Primm
Department of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso, El Paso, Texas 79968, USA
Clin Microbiol Rev 17:98-106. 2004..In addition to outright infection, environmental mycobacteria may also play a role in chronic bowl diseases, allergies, immunity to other pulmonary infections, and the efficacy of bacillus Calmette-Guerin vaccination... - Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in IndonesiaJian-Qiao Gu
Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA
J Nat Prod 67:1156-61. 2004..Plumbagin (1) and maritinone (2) were evaluated also for in vivo antitumor activity in the hollow fiber assay, but both were found to be inactive... - Cryptic plasmids of Mycobacterium avium: Tn552 to the rescueCarolyn Kirby
Department of Biomedical Sciences, State University of New York at Albany, NY, USA
Mol Microbiol 43:173-86. 2002..Using this approach, we identified a putative conjugative relaxase, suggesting this myco-bacterial plasmid is transferable, and three genes required for plasmid establishment and replication... - Survival of Mycobacterium avium in a model distribution systemCheryl D Norton
American Water, Quality Control and Research Laboratory, 1115 South Illinois Street, Belleville, IL 62220, USA
Water Res 38:1457-66. 2004..avium complex in drinking water biofilms... - A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabraChen Li
Natural Products Laboratory, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, USA
Org Lett 7:5709-12. 2005..All compounds were evaluated for cytotoxicity against a panel of cancer cells, where 1 displayed the most potent and broadest activity, and against a battery of antimicrobial assays, where all compounds were approximately equipotent...