Research Topics
Species | Daniel ConradSummaryAffiliation: Virginia Commonwealth University Country: USA Publications
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Publications
CD23: an overlooked regulator of allergic diseaseDaniel H Conrad
Department of Microbiology and Immunology, Virginia Commonwealth University, PO Box 980678, Richmond, VA 23298, USA
Curr Allergy Asthma Rep 7:331-7. 2007..Current data suggest that stabilizing cell-surface CD23 would be a natural means to decrease IgE synthesis and thus control type I hypersensitivity...- BCR ligation antagonizes the IL-21 enhancement of anti-CD40/IL-4 plasma cell differentiation and IgE production found in low density human B cell culturesTimothy H Caven
Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298, USA
Cell Immunol 247:49-58. 2007..In summary, IL-21 enhances IgE production at low densities through stimulating cell division and plasma cell differentiation and this activity is reduced upon BCR cross-linking... - Effect of cell density on in vitro mouse immunoglobulin E productionDania Rabah
Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298, USA
Immunology 106:503-10. 2002..These data not only highlight the caveat against using a single B-cell dose for IgE production in vitro but also suggest for the first time a possible IgE regulatory mechanism mediated by cell density... - 129/SvJ mice have mutated CD23 and hyper IgEJill W Ford
Virginia Commonwealth University, Department of Microbiology and Immunology, P O Box 980678, MCV Station, Richmond, VA 23298, USA
Cell Immunol 254:124-34. 2009..Overall, this study further suggests that CD23 is an important regulatory factor for IgE production... - In vivo murine CD23 destabilization enhances CD23 shedding and IgE synthesisJill W Ford
Department of Microbiology and Immunology, Virginia Commonwealth University, PO Box 980678, Richmond, VA 23298, USA
Cell Immunol 243:107-17. 2006..Overall, the data provide a direct demonstration for CD23's role in regulating IgE production in vivo and suggest that therapies aimed at stabilizing cell surface CD23 would be beneficial in controlling allergic disease... - IL-21 dependent IgE production in human and mouse in vitro culture systems is cell density and cell division dependent and is augmented by IL-10Timothy H Caven
Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298, USA
Cell Immunol 238:123-34. 2005.... - Mouse B cell activation is inhibited by CD44 cross-linkingTiana L Wyant
Virginia Commonwealth University MCV, Richmond, VA 23298, USA
Immunol Invest 34:399-416. 2005..These results suggest that CD44 cross-linking could control polyclonal B cell activation by CD40L, but allow sIgM/CD40L activation to continue... - Differential T cell-mediated regulation of CD23 (Fc epsilonRII) in B cells and follicular dendritic cellsSelvakumar Sukumar
Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298, USA
J Immunol 176:4811-7. 2006..Previous studies suggest that high levels of FDC-CD23 inhibit IgE production, and this IFN-gamma and CD40L-mediated up-regulation of FDC-CD23 may explain, at least in part, why Th1 responses are associated with low IgE responses in vivo... - CD23 trimers are preassociated on the cell surface even in the absence of its ligand, IgEMichelle A Kilmon
Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298, USA
J Immunol 172:1065-73. 2004..These data reveal important information about the structure of CD23 that may be useful in modulating IgE production... - CD23 Sheddase A disintegrin and metalloproteinase 10 (ADAM10) is also required for CD23 sorting into B cell-derived exosomesJoel A Mathews
Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
J Biol Chem 285:37531-41. 2010..The increased cleavage at endosomal pH also has implications for other ADAM10 substrates... - ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivoDavid R Gibb
Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
J Exp Med 207:623-35. 2010..Moreover, it has important implications for the treatment of numerous CD23- and Notch-mediated pathologies, ranging from allergy to cancer... - Necessity of the stalk region for immunoglobulin E interaction with CD23Bing-Hung Chen
Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298, USA
Immunology 107:373-81. 2002..The lz-CD23 constructs represent a possible alternative for both blocking the IgE/FcepsilonRI interaction and inhibiting IgE production by B lymphocytes... - Temperature effect on IgE binding to CD23 versus Fc epsilon RIBing-Hung Chen
Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298, USA
J Immunol 170:1839-45. 2003..Changes in CD23 oligomerization also plays a role in the decreased binding seen at physiological temperatures... - Pooled protein immunization for identification of cell surface antigens in Streptococcus sanguinisXiuchun Ge
Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, United States of America
PLoS ONE 5:e11666. 2010..We developed an approach to identify surface antigens rapidly in Streptococcus sanguinis, a common infective endocarditis causative species... - Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cellsYun Dai
Department of Medicine, Virginia Commonwealth University, Medical College of Virginia, Richmond 23298, USA
Blood 103:2761-70. 2004..Together, these findings suggest that a strategy combining UCN-01 with disruption of the IkappaB kinase (IKK)/IkappaB/NF-kappaB pathway warrants attention in MM... - Soluble CD23 monomers inhibit and oligomers stimulate IGE synthesis in human B cellsNatalie McCloskey
Medical Research Council Asthma UK Centre in Allergic Mechanisms of Asthma and the Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London SE1 1UL, United Kingdom
J Biol Chem 282:24083-91. 2007..We show that the monomers inhibit and the oligomer stimulates IgE synthesis in human B cells after heavy chain switching to IgE. CD23 fragments could be targets for therapeutic intervention in allergic disease... - Intestinal epithelial CD23 mediates enhanced antigen transport in allergy: evidence for novel splice formsLinda C H Yu
Intestinal Disease Research Programme, HSC 3N5C, McMaster University, 1200 Main Street W, Hamilton, Ontario, Canada L8N 3Z5
Am J Physiol Gastrointest Liver Physiol 285:G223-34. 2003..Our results suggest that the classic and alternative forms of CD23b display distinct endocytic properties, suggesting that they are likely to play different roles in transepithelial transport of IgE and allergens... - The level of IgE produced by a B cell is regulated by norepinephrine in a p38 MAPK- and CD23-dependent mannerGeorg Pongratz
Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA
J Immunol 177:2926-38. 2006.... - Interaction of a monoclonal IgE-specific antibody with cell-surface IgE-Fc epsilon RI: characterization of equilibrium binding and secretory responseRichard G Posner
Department of Biology, Northern Arizona University, Flagstaff, Arizona 86011, USA
Biochemistry 43:11352-60. 2004..There is no simple relationship between receptor aggregation at equilibrium and the degranulation response. Further studies are needed to establish how 23G3-induced aggregation of IgE-FcepsilonRI correlates with cellular responses... - Differential role for CD23 splice forms in apical to basolateral transcytosis of IgE/allergen complexesGuillaume Montagnac
Department of Infectious Diseases, Cochin Institute, INSERM U567 CNRS UMR 8104 Universitè Paris 5, Paris, France
Traffic 6:230-42. 2005.... - ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23Gisela Weskamp
Arthritis and Tissue Degeneration Program, Hospital for Special Surgery and Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
Nat Immunol 7:1293-8. 2006..Our findings provide a likely target for the treatment of allergic reactions and set the stage for further studies of the involvement of ADAM10 in CD23-dependent pathologies... - Intracellular trafficking of CD23: differential regulation in humans and mice by both extracellular and intracellular exonsGuillaume Montagnac
Department of Infectious Diseases, Cochin Institute, Institut National de la Sante et de la Recherche Medicale, Unité 567, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8104, Universite Paris 5, Paris, France
J Immunol 174:5562-72. 2005....
Research Grants
- STRUCTURE AND FUNCTION OF THE LYMPHOCYTE FCE RECEPTORDaniel H Conrad; Fiscal Year: 2010..This application proposes to study mechanisms involved in this regulation in order to develop new protocols to control allergic disease. ..
- FACSCALIBERDaniel Conrad; Fiscal Year: 2002..In addition, the unit is also available on a charge per hour basis to other users at MCV/NCU after appropriate training. At present, we have seven other laboratories that use the instrument on a less frequent basis. ..
- STRUCTURE/FUNCTION OF THE LYMPHOCYTE FCE RECEPTORDaniel Conrad; Fiscal Year: 2002..New knowledge from these studies may help in the development of new treatments for Type I allergy and for control of inflammatory cytokine release. ..
- STRUCTURE AND FUNCTION OF THE B LYMPHOCYTE FCE RECEPTORDaniel Conrad; Fiscal Year: 2003..Finally, the current grant period has indicated that mouse CD23b is produced in intestinal epithelial cells and the parameters regulating this expression will be explored. ..
- IGE CONTROL BY OVEREXPRESSION OF CD23Daniel Conrad; Fiscal Year: 2003....
- Biacore 3000 shared instrumentDaniel Conrad; Fiscal Year: 2005..Support for the instrument operation and maintenance will be through user fees as well as university support from the cancer center and life sciences center. ..
- STRUCTURE AND FUNCTION OF THE B LYMPHOCYTE FCE RECEPTORDaniel Conrad; Fiscal Year: 2006..Finally, the current grant period has indicated that mouse CD23b is produced in intestinal epithelial cells and the parameters regulating this expression will be explored. ..
- Training in Hypersensitivity and Cancer ImmunologyDaniel Conrad; Fiscal Year: 2006..The participating faculty represent an exceptionally strong and focused community of immunologists that will continue to provide an excellent environment for training. ..
- STRUCTURE AND FUNCTION OF THE B LYMPHOCYTE FCE RECEPTORDaniel Conrad; Fiscal Year: 2007..Finally, the current grant period has indicated that mouse CD23b is produced in intestinal epithelial cells and the parameters regulating this expression will be explored. ..
- STRUCTURE AND FUNCTION OF THE LYMPHOCYTE FC-E RECEPTORDaniel Conrad; Fiscal Year: 1993..Finally, as these findings indicate new roles for IgE complexes, the effect of in vivo targeting the Fc-epsilon-RII on TH phenotype will be assayed...
- STRUCTURE AND FUNCTION OF THE LYMPHOCYTE FCE RECEPTORDaniel Conrad; Fiscal Year: 1992..The overall aim is to gain further insight into the structure and regulation of the low affinity FceR and to determine if FceR/anti-FceR related components are useful in the regulation of IgE synthesis...