James P Bennett

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi ALS spinal neurons show varied and reduced mtDNA gene copy numbers and increased mtDNA gene deletions
    Paula M Keeney
    Department of Neurology, University of Virginia, Charlottesville, Virginia, USA
    Mol Neurodegener 5:21. 2010
  2. ncbi Parkinson's disease brain mitochondria have impaired respirasome assembly, age-related increases in distribution of oxidative damage to mtDNA and no differences in heteroplasmic mtDNA mutation abundance
    Charles R Arthur
    Morris K Udall Parkinson s Disease Research Center of Excellence, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mol Neurodegener 4:37. 2009
  3. ncbi Recombinant mitochondrial transcription factor A with N-terminal mitochondrial transduction domain increases respiration and mitochondrial gene expression
    Shilpa Iyer
    Center for the Study of Neurodegenerative Diseases and The Morris K Udall Parkinson s Disease Research Center of Excellence, University of Virginia, PO Box 800394, Charlottesville, VA 22908, United States
    Mitochondrion 9:196-203. 2009
  4. ncbi Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin
    Ravindar R Thomas
    Morris Udall Parkinson s Disease Research Center of Excellence, University of Virginia, Charlottesville, VA, United States
    Mitochondrion 11:108-18. 2011
  5. ncbi Cybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationships
    Paula M Keeney
    Morris K Udall Parkinson s Research Center of Excellence, University of Virginia, PO Box 800394, Charlottesville, VA 22908, USA
    Exp Neurol 220:374-82. 2009
  6. ncbi Nerve growth factor attenuates oxidant-induced ?-amyloid neurotoxicity in sporadic Alzheimer's disease cybrids
    Isaac G Onyango
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA
    J Neurochem 114:1605-18. 2010
  7. ncbi Relationships among molecular genetic and respiratory properties of Parkinson's disease cybrid cells show similarities to Parkinson's brain tissues
    M Kathleen Borland
    Center for the Study of Neurodegenerative Diseases, University of Virginia, Charlottesville, Virginia, USA
    Biochim Biophys Acta 1792:68-74. 2009
  8. ncbi Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells
    M Kathleen Borland
    Center for the Study of Neurodegenerative Diseases and Morris K, Udall Parkinson s Disease Research Center of Excellence, University of Virginia, Charlottesville, Virginia, USA
    Mol Neurodegener 3:21. 2008
  9. ncbi The mitochondrial secret(ase) of Alzheimer's disease
    Kisha J Young
    Neuroscience Graduate Program and Medical Scientist Training Program, University of Virginia School of Medicine, Charlottesville, VA, USA
    J Alzheimers Dis 20:S381-400. 2010
  10. ncbi Mitochondrial gene therapy augments mitochondrial physiology in a Parkinson's disease cell model
    Paula M Keeney
    Morris K Udall Parkinson s Disease Research Center of Excellence, University of Virginia, Charlottesville, VA 22908, USA
    Hum Gene Ther 20:897-907. 2009

Research Grants

  1. OXIDATIVE STRESS IN PARKINSON'S DISEASE
    James Bennett; Fiscal Year: 2004

Collaborators

  • Patricia A Trimmer
  • Shaharyar M Khan
  • Roderick Capaldi
  • Isaac G Onyango
  • Lei Liu
  • Paula M Keeney
  • Lisa D Dunham
  • Ravindar R Thomas
  • M Kathleen Borland
  • Francisco R Portell
  • Shilpa Iyer
  • Caitlin K Quigley
  • Kisha J Young
  • Kristen E Bergquist
  • Stephanie L Morton
  • Charles R Arthur
  • Jeremy D Rubinstein
  • Rafal M Smigrodzki
  • Jing Xie
  • Christina M Papageorge
  • Kathleen M Schwarz
  • K P Mohanakumar
  • Kp Mohanakumar

Detail Information

Publications10

  1. ncbi ALS spinal neurons show varied and reduced mtDNA gene copy numbers and increased mtDNA gene deletions
    Paula M Keeney
    Department of Neurology, University of Virginia, Charlottesville, Virginia, USA
    Mol Neurodegener 5:21. 2010
    ..It is presently unknown whether mtDNA abnormalities are present in single human ALS neurons...
  2. ncbi Parkinson's disease brain mitochondria have impaired respirasome assembly, age-related increases in distribution of oxidative damage to mtDNA and no differences in heteroplasmic mtDNA mutation abundance
    Charles R Arthur
    Morris K Udall Parkinson s Disease Research Center of Excellence, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mol Neurodegener 4:37. 2009
    ..abstract:..
  3. ncbi Recombinant mitochondrial transcription factor A with N-terminal mitochondrial transduction domain increases respiration and mitochondrial gene expression
    Shilpa Iyer
    Center for the Study of Neurodegenerative Diseases and The Morris K Udall Parkinson s Disease Research Center of Excellence, University of Virginia, PO Box 800394, Charlottesville, VA 22908, United States
    Mitochondrion 9:196-203. 2009
    ..MTD-TFAM increases mitochondrial bioenergetics and holds promise for treatment of mitochondrial diseases involving deficiencies of energy production...
  4. ncbi Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin
    Ravindar R Thomas
    Morris Udall Parkinson s Disease Research Center of Excellence, University of Virginia, Charlottesville, VA, United States
    Mitochondrion 11:108-18. 2011
    ..rhTFAM treatment improved motor recovery rate after treatment with MPTP and dose-dependently improved survival in the lipopolysaccharide model of endotoxin sepsis...
  5. ncbi Cybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationships
    Paula M Keeney
    Morris K Udall Parkinson s Research Center of Excellence, University of Virginia, PO Box 800394, Charlottesville, VA 22908, USA
    Exp Neurol 220:374-82. 2009
    ..Cybrids remain a valuable model for some aspects of sPD but their heterogeneity mitigates against a simple designation of sPD phenotype in this cell model...
  6. ncbi Nerve growth factor attenuates oxidant-induced ?-amyloid neurotoxicity in sporadic Alzheimer's disease cybrids
    Isaac G Onyango
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA
    J Neurochem 114:1605-18. 2010
    ....
  7. ncbi Relationships among molecular genetic and respiratory properties of Parkinson's disease cybrid cells show similarities to Parkinson's brain tissues
    M Kathleen Borland
    Center for the Study of Neurodegenerative Diseases, University of Virginia, Charlottesville, Virginia, USA
    Biochim Biophys Acta 1792:68-74. 2009
    ..This will require characterization of the abnormalities and dynamics of mtDNA changes propagated through sPD cybrids over time...
  8. ncbi Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells
    M Kathleen Borland
    Center for the Study of Neurodegenerative Diseases and Morris K, Udall Parkinson s Disease Research Center of Excellence, University of Virginia, Charlottesville, Virginia, USA
    Mol Neurodegener 3:21. 2008
    ..The vast majority of Parkinson's disease occurs sporadically, and current models of sporadic Parkinson's disease (sPD) can utilize directly infused or systemic neurotoxins...
  9. ncbi The mitochondrial secret(ase) of Alzheimer's disease
    Kisha J Young
    Neuroscience Graduate Program and Medical Scientist Training Program, University of Virginia School of Medicine, Charlottesville, VA, USA
    J Alzheimers Dis 20:S381-400. 2010
    ....
  10. ncbi Mitochondrial gene therapy augments mitochondrial physiology in a Parkinson's disease cell model
    Paula M Keeney
    Morris K Udall Parkinson s Disease Research Center of Excellence, University of Virginia, Charlottesville, VA 22908, USA
    Hum Gene Ther 20:897-907. 2009
    ..It also is unclear whether single-donor gDNA for generating mtDNA would be a preferred therapeutic compared with the pooled gDNA used in this study...

Research Grants7

  1. OXIDATIVE STRESS IN PARKINSON'S DISEASE
    James Bennett; Fiscal Year: 2004
    ..Paradigms for evaluating neuroprotective therapies will also be developed to allow targeted approaches to correcting consequences of increased oxidative stress in cells. ..