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Genomes and GenesSpecies | Patrick M BeardsleySummaryAffiliation: Virginia Commonwealth University Country: USA Publications
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Publications
Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce U50,488-induced diurePatrick M Beardsley
Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
Psychopharmacology (Berl) 210:189-98. 2010..The kappa opioid receptor (KOR) antagonist, JDTic, was reported to prevent stress-induced reinstatement of cocaine-maintained responding and to have antidepressant-like effects...- Cannabinoid CB1 receptor antagonists as potential pharmacotherapies for drug abuse disordersPatrick M Beardsley
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
Int Rev Psychiatry 21:134-42. 2009..This review highlights some of the preclinical and clinical studies that have examined the effects of CB1R antagonists under conditions potentially predictive of their therapeutic efficacy as treatments for drug abuse disorders... - The glial cell modulator and phosphodiesterase inhibitor, AV411 (ibudilast), attenuates prime- and stress-induced methamphetamine relapsePatrick M Beardsley
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 3298 0613, USA
Eur J Pharmacol 637:102-8. 2010..These results thus reinforce interest in atypical neurobiological mechanisms which could be exploited for developing novel medications for treating drug abuse disorders... - Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in ratsPatrick M Beardsley
Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
Psychopharmacology (Berl) 183:118-26. 2005..Antagonism of the kappa opioid receptor (KOR) has been reported to attenuate some effects of stressors, and antagonism of the KOR has been reported to have antidepressant-like properties... - Discriminative stimulus, reinforcing, physical dependence, and antinociceptive effects of oxycodone in mice, rats, and rhesus monkeysPatrick M Beardsley
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, VA 23298, USA
Exp Clin Psychopharmacol 12:163-72. 2004.... - Modulation of the locomotor activating effects of the noncompetitive NMDA receptor antagonist MK801 by dopamine D2/3 receptor agonists in miceCharles D Cook
Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, PO Box 980613, Richmond, VA 23298 0613, USA
Pharmacol Biochem Behav 77:309-18. 2004..These results demonstrate that the DA system, through D2/3 receptor activation, modulates the locomotor activating effects produced by noncompetitive NMDA receptor blockade... - Effect of drug-paired exteroceptive stimulus presentations on methamphetamine reinstatement in ratsKeith L Shelton
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond VA 23298 0613, United States
Pharmacol Biochem Behav 90:434-40. 2008..These data show that methamphetamine priming produces a robust reinstatement effect which can be influenced by drug-paired cues... - Interaction of noncontingent cocaine and contingent drug-paired stimuli on cocaine reinstatementKeith L Shelton
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
Eur J Pharmacol 497:35-40. 2004..The results highlight the important interaction between drug administration and drug-paired environmental stimuli in the reinstatement model... - Effects of combining ethanol (EtOH) with gamma-hydroxybutyrate (GHB) on the discriminative stimulus, locomotor, and motor-impairing functions of GHB in miceCharles D Cook
Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, Smith Building, P.O. Box 980613, Richmond, VA 23298-0613, USA
Psychopharmacology (Berl) 185:112-22. 2006..CONCLUSIONS: Overall, EtOH increased the effects of GHB on several gross measures of behavior and only partially occasioned the discriminative stimulus properties of GHB... - Dose, duration, and pattern of nicotine administration as determinants of behavioral dependence in ratsRobert E Vann
Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, P.O. Box 980613, Richmond, VA 23298, USA
Psychopharmacology (Berl) 184:482-93. 2006.... - Effects of memantine, haloperidol, and cocaine on primary and conditioned reinforcement associated with cocaine in rhesus monkeysJennifer L Newman
Department of Pharmacology and Toxicology, Virginia Commonwealth University, P.O. Box 980613, Richmond, VA 23298, USA
Psychopharmacology (Berl) 185:142-9. 2006..These findings support the hypothesis that the NMDA receptor can play a role in modulating the conditioned and primary reinforcing effects of cocaine... - A method for analyzing strain differences in acquisition of IV cocaine self-administration in miceCristina Vargas-Irwin
Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126 USA
Behav Genet 36:525-35. 2006..In a second stage, strains differences in these indexes were assessed. This two-stage approach is illustrated with drug self-administration data and through a computer simulation... - Attenuation of nicotine's discriminative stimulus effects in rats and its locomotor activity effects in mice by serotonergic 5-HT2A/2C receptor agonistsAngela M Batman
Department of Pharmacology and Toxicology, VCU Medical Center, Virginia Commonwealth University, P.O. Box 980613, 410 North 12th Street, Smith Bld. #756, Richmond, VA 23298-0613, USA
Psychopharmacology (Berl) 179:393-401. 2005.... - The selective dopamine uptake inhibitor, D-84, suppresses cocaine self-administration, but does not occasion cocaine-like levels of generalizationAngela M Batman
Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 N 12th Street, Richmond, VA 23298, USA
Eur J Pharmacol 648:127-32. 2010.... - RTI 113, a 3-phenyltropane analog, produces long-lasting cocaine-like discriminative stimulus effects in rats and squirrel monkeysCharles D Cook
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Smith Building, Richmond, VA 23298 0613, USA
Eur J Pharmacol 442:93-8. 2002..These results, combined with those indicating that RTI 113 decreases cocaine self-administration, suggest that RTI 113, or analogs of RTI 113, may be useful tools for developing potential agonist therapies for cocaine dependence... - Alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors in the nucleus accumbens shell regulate progressive ratio responding maintained by nicotineDarlene H Brunzell
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA
Neuropsychopharmacology 35:665-73. 2010..These data suggest that alpha6beta2(*)nAChRs in the NAc shell regulate motivational aspects of nicotine reinforcement but not nicotine-associated locomotor activation... - Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophreniaJoseph L McClay
Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0533, USA
Neuropsychopharmacology 36:616-26. 2011..This study has generated several novel candidate genes for antipsychotic response. However, our findings will require replication and functional validation. To facilitate replication efforts, we provide all GWAS p-values for download... - Evaluation of the reinforcing effects of the cannabinoid CB1 receptor antagonist, SR141716, in rhesus monkeysPatrick M Beardsley
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 410 North 12th Street, Smith Building 756A, Richmond, VA 23298 0613, USA
Eur J Pharmacol 435:209-16. 2002..Since positive results in self-administration tests are generally predictive of abuse potential, the negative results with SR141716 suggest that this drug would likely have low abuse liability... - The modulatory actions of dopamine D2/3 agonists and antagonists on the locomotor-activating effects of morphine and caffeine in miceCharles D Cook
Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, Smith Building, P O Box 980613, Richmond, VA 23298 0613, USA
Pharmacol Biochem Behav 75:363-71. 2003..These results indicate that modulation of D2/3 receptors can, in turn, alter the locomotor-activating effects of morphine... - Effects of the putative antagonist NCS382 on the behavioral pharmacological actions of gammahydroxybutyrate in miceCharles D Cook
Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, P O Box 980613, Richmond, VA 23298 0613, USA
Psychopharmacology (Berl) 160:99-106. 2002..In addition to its uncertain physiological role, the recent interest in GHB has been engendered by its illicit use and abuse... - The glial cell modulators, ibudilast and its amino analog, AV1013, attenuate methamphetamine locomotor activity and its sensitization in miceSarah E Snider
Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 N 12th Street, Richmond, VA 23298, USA
Eur J Pharmacol 679:75-80. 2012..AV1013 had similar anti-methamphetamine effects, suggesting that glial cell activity, by itself, can modulate methamphetamine's effects and perhaps serve as a medication target for its abuse... - Heroin discriminative stimulus effects of methadone, LAAM and other isomers of acetylmethadol in ratsJennifer L Newman
Department of Psychology, Virginia Commonwealth University, Richmond, VA 23298-0613, USA
Psychopharmacology (Berl) 164:108-14. 2002..CONCLUSIONS: Methadone, LAAM, beta- d-acetylmethadol and alpha- d-acetylmethadol, but not beta- l-acetylmethadol and beta- l-methadol evoke heroin-like discriminative stimulus effects...