Research Topics
| William LovalloSummaryAffiliation: Veterans Affairs Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Sex differences in the hemodynamic responses to mental stress: Effect of caffeine consumptionNoha H Farag
Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
Psychophysiology 43:337-43. 2006..Caffeine enhances the cardiovascular fight-or-flight response pattern to stress in men and women...- Lifetime adversity leads to blunted stress axis reactivity: studies from the Oklahoma Family Health Patterns ProjectWilliam R Lovallo
Behavioral Sciences Laboratories, Veterans Affairs Medical Center, 921 NE 13th Street, Oklahoma City, OK 73104, USA
Biol Psychiatry 71:344-9. 2012..We present evidence that adverse experience in childhood and adolescence can alter core components of the stress axis, including cortisol and heart rate reactivity... - Cardiovascular reactivity: mechanisms and pathways to cardiovascular diseaseWilliam R Lovallo
Veterans Affairs Medical Center and Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, VA Medical Center 151A, 921 NE 13th Street, Oklahoma City, OK 73104, USA
Int J Psychophysiol 58:119-32. 2005..This organization may provide useful insights into the sources of stress reactivity that characterize specific groups at risk and allow inferences as to the source of the disease pathophysiology... - Caffeine stimulation of cortisol secretion across the waking hours in relation to caffeine intake levelsWilliam R Lovallo
Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA
Psychosom Med 67:734-9. 2005..It is not known whether tolerance develops in this response with daily intake of caffeine in the diet. We therefore tested the cortisol response to caffeine challenge after controlled levels of caffeine intake... - The hypothalamic-pituitary-adrenocortical axis in addictionWilliam R Lovallo
Behavioral Sciences Laboratories, 151A, Veterans Affairs Medical Center, 921 NE 13th Street, Oklahoma City, OK 73103, United States
Int J Psychophysiol 59:193-4. 2006 - Cortisol secretion patterns in addiction and addiction riskWilliam R Lovallo
Behavioral Sciences Laboratories 151A, Veterans Affairs Medical Center, 921 NE 13th Street, Oklahoma City, Oklahoma 73104, United States
Int J Psychophysiol 59:195-202. 2006..Continuing research on the relationship between HPA function, stress responsivity, and the addictions may yield insights into how the brain's motivational systems support addictions and risk for addictions... - Cortisol responses to mental stress, exercise, and meals following caffeine intake in men and womenWilliam R Lovallo
Veterans Affairs Medical Center, Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Pharmacol Biochem Behav 83:441-7. 2006..00001). Caffeine may elevate cortisol by stimulating the central nervous system in men but may interact with peripheral metabolic mechanisms in women... - Working memory and decision-making biases in young adults with a family history of alcoholism: studies from the Oklahoma family health patterns projectWilliam R Lovallo
Behavioral Sciences Laboratories, Veterans Affairs Medical Center, and Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
Alcohol Clin Exp Res 30:763-73. 2006..Alcohol misuse is more common in persons with a family history of alcoholism (FH+) than in those with no such history (FH-). Among FH+, behavioral disinhibition and male sex seem to signal the presence of an increased risk... - Acute effects of hydrocortisone on the human brain: an fMRI studyWilliam R Lovallo
Behavioral Sciences Laboratories, Veterans Affairs Medical Center, and Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Psychoneuroendocrinology 35:15-20. 2010..No such effect was seen in the thalamus. Functional MRI appears to be a safe, noninvasive method to study the time course and anatomical effects of glucocorticoids in the human brain... - Do low levels of stress reactivity signal poor states of health?William R Lovallo
University of Oklahoma Health Sciences Center, Psychiatry and Behavioral Sciences, VA Medical Center 151A, 921 NE 13th Street, Oklahoma City, OK 73104, United States
Biol Psychol 86:121-8. 2011..This conceptualization places physical health into the context of behavioral and physiological processes that contribute to homeostasis... - Use of a resting control day in measuring the cortisol response to mental stress: diurnal patterns, time of day, and gender effectsWilliam R Lovallo
Behavioral Sciences Laboratories, Veterans Affairs Medical Center, Oklahoma City, OK 73190, USA
Psychoneuroendocrinology 35:1253-8. 2010..In particular the diurnal control method provided a wider range of stress values that potentially provide a greater range of response values in carrying out analyses of individual differences... - Blood pressure response to caffeine shows incomplete tolerance after short-term regular consumptionWilliam R Lovallo
Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA
Hypertension 43:760-5. 2004..Caffeine may therefore cause persistent BP effects in persons who are regular consumers, even when daily intake is at moderately high levels... - Blunted stress cortisol response in abstinent alcoholic and polysubstance-abusing menW R Lovallo
Behavioral Sciences Laboratories, Veterans Affairs Medical Center, Oklahoma City, Oklahoma 73104, USA
Alcohol Clin Exp Res 24:651-8. 2000..Alcohol increases cortisol secretion acutely and during withdrawal. However, there is little information about abnormalities of hypothalamic-pituitary-adrenocortical (HPA) reactivity in recovering alcoholics... - Psychophysiological reactivity: mechanisms and pathways to cardiovascular diseaseWilliam R Lovallo
Veterans Affairs Medical Center and Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
Psychosom Med 65:36-45. 2003..However, the pathways by which exaggerated reactivity could arise in a given person and the implications of different sources of reactivity for potential disease relationships have received little attention... - Blunted hypothalamic-pituitary-adrenocortical axis responsivity to stress in persons with a family history of alcoholismKristen H Sorocco
Behavioral Sciences Laboratories, Veterans Affairs Medical Center, United States
Int J Psychophysiol 59:210-7. 2006..Disrupted cortisol stress responses may serve as a risk marker for the development of substance use disorders... - Hemodynamic mechanisms underlying the incomplete tolerance to caffeine's pressor effectsNoha H Farag
Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
Am J Cardiol 95:1389-92. 2005..7, p <0.0001). In the subjects who did not develop tolerance, peripheral resistance increased incrementally as the daily dose of caffeine increased (F = 2.8, p = 0.05)... - Cardiovascular effects of caffeine in men and womenTerry R Hartley
Department of Psychiatry and Behavioral Sciences, Veteran's Affairs Medical Center, Oklahoma City, Oklahoma, USA
Am J Cardiol 93:1022-6. 2004..Women who consume a dietary dose of caffeine showed an increase in cardiac output, whereas men showed increased vascular resistance... - Hypothalamic-pituitary-adrenal axis function: relative contributions of perceived stress and obesity in womenNoha H Farag
University of Oklahoma Prevention Research Center, Oklahoma City, Oklahoma, USA
J Womens Health (Larchmt) 17:1647-55. 2008..The goal of this cross-sectional study was to examine associations among diurnal cortisol levels, perceived stress, and obesity patterns... - Caffeine tolerance is incomplete: persistent blood pressure responses in the ambulatory settingNoha H Farag
Veterans Affairs Medical Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
Am J Hypertens 18:714-9. 2005.... - Attenuated heart rate responses to public speaking in individuals with alcohol dependenceTera L Panknin
Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, USA
Alcohol Clin Exp Res 26:841-7. 2002..Cardiovascular responses of AD subjects that are inconsistent with subjective accounts of tension and anxiety suggest a disconnection between perception of threat and resulting physiologic responses in AD subjects... - Deficits in affective prosody comprehension: family history of alcoholism versus alcohol exposureKristen H Sorocco
Behavioral Sciences Laboratories, Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA
Alcohol Alcohol 45:25-9. 2010..The present paper examines whether family history of alcoholism is a contributor to affective prosody deficits in alcoholics... - Altered emotion-modulated startle in young adults with a family history of alcoholismRobert Miranda
Department of Psychiatry and Behavioral Sciences and VA Medical Center, University of Oklahoma Health Sciences Center, Oklahoma City, USA
Alcohol Clin Exp Res 26:441-8. 2002..This method may provide a useful paradigm for testing processing of emotionally relevant stimuli in relation to risk for alcohol use disorders... - Recruitment of healthy participants for studies on risks for alcoholism: effectiveness of random digit diallingKristen H Sorocco
Donald W Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Alcohol Alcohol 41:349-52. 2006..To compare the effectiveness of two strategies for recruiting healthy research volunteers... - Neurological basis of deficits in affective prosody comprehension among alcoholics and fetal alcohol-exposed adultsMarilee Monnot
University of Oklahoma Health Sciences Center, Department of Neurology, Oklahoma City 73104, USA
J Neuropsychiatry Clin Neurosci 14:321-8. 2002..The specific APC impairment found in ALC and FAexp may be a consequence of both callosal and right cortical dysfunction or damage... - Altered affective modulation of the startle reflex in alcoholics with antisocial personality disorderRobert Miranda
Department of Psychiatry and Behavioral Sciences and Veterans Affairs Medical Center, University of Oklahoma Health Sciences Center, Oklahoma City, USA
Alcohol Clin Exp Res 27:1901-11. 2003..The emotion-modulated startle reflex was used to investigate emotional reactivity among alcohol-dependent (AD) men with and without ASPD... - Impulsive errors on a Go-NoGo reaction time task: disinhibitory traits in relation to a family history of alcoholismBuddy Saunders
Behavioral Sciences Laboratories, Veterans Affairs Medical Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73134, USA
Alcohol Clin Exp Res 32:888-94. 2008.... - Physiologic markers of chronic stress in premenopausal, middle-aged womenLynda H Powell
Department of Preventive Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
Psychosom Med 64:502-9. 2002..The purpose of this study was to identify physiological markers of chronic stress in middle-aged women that can be assessed simply and are thus feasible for introduction into large-scale, epidemiologic studies of aging... - Bridging psychology and biology. The analysis of individuals in groupsStephen M Kosslyn
Department of Psychology, Harvard University, 830 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
Am Psychol 57:341-51. 2002.... - caffeine and coffee toleranceWilliam R Lovallo
Circulation 108:e38-40; author reply e38-40. 2003 - Cardiovascular reactivity to psychological challenge: conceptual and measurement considerationsThomas W Kamarck
Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
Psychosom Med 65:9-21. 2003..Continued progress in understanding and measuring reactivity as an individual difference dimension is essential in helping us to evaluate emerging evidence examining the relationship between reactivity and disease risk... - Reduced amygdala activation in young adults at high risk of alcoholism: studies from the Oklahoma family health patterns projectDavid C Glahn
Neuroimaging Core, Department of Psychiatry, University of Texas Health Science Center at San Antonio, Texas, USA
Biol Psychiatry 61:1306-9. 2007..Risk of alcoholism is higher in those with a positive family history (FH+) and in those showing behavioral disinhibition, possibly reflecting altered limbic system function... - Cortisol dysregulation and cognitive impairment in abstinent male alcoholicsAustin L Errico
Bayside Neurorehabilitation Services, Goodwill Industries of Northern New England, Portland, Maine, USA
Alcohol Clin Exp Res 26:1198-204. 2002..Altered stress regulation of the hypothalamic-pituitary-adrenal axis should be studied further as a potential factor related to impaired cognitive function in recovering alcoholics... - Cardiovascular responses to physical and psychological stress in female alcoholics with transitory hypertension after early abstinenceNancy C Bernardy
Dartmouth Medical School and Veterans Affairs Medical Center, White River Junction, Vermont 05009, USA
Alcohol Clin Exp Res 27:1489-98. 2003..Studies of this nature, however, have not been extended to women... - Adrenocortical stress responses and altered working memory performanceMustafa al'Absi
Department of Behavioral Sciences, Physiology, and Family Medicine, University of Minnesota School of Medicine, Duluth 55812, USA
Psychophysiology 39:95-9. 2002..High cortisol responders may have an increased focus on sensory stimuli and a decreased allocation of resources to working memory tasks...
Research Grants
- CAFFEINE INFLUENCES ON EXERCISE AND PSYCHOLOGICAL STRESSWilliam Lovallo; Fiscal Year: 1999..This information will help us to properly evaluate in context the evidence showing that caffeine can alter physiological functions and responses to stress. ..
- BEHAVIORAL MEDICINE: CARDIOVASCULAR DISEASE RESEARCHWilliam Lovallo; Fiscal Year: 2003..U. medical campus. Training will utilize classroom, laboratory, and clinical facilities at several departments and hospitals on campus. ..
- CAFFEINE INFLUENCES ON EXERCISE AND PSYCHOLOGICAL STRESSWilliam Lovallo; Fiscal Year: 2004..This new information should aid in evaluating caffeine's effects over the span of midlife, a time at which the cardiovascular health of women changes markedly relative to men. ..
- Psychophysiological Precursors of AlcoholismWilliam Lovallo; Fiscal Year: 2005..A finding of consistent changes in affective experience, along with altered peripheral physiological responses, can provide insights into the underlying alterations in emotional behavior in risk for alcoholism. ..
- Oklahoma Family Health Patterns: A Study Across GenerationsWilliam R Lovallo; Fiscal Year: 2010..Prevention of complex disorders such as alcoholism requires early identification of those persons who are most at risk, and this project seeks to provide new information about such risk. ..
- CAFFEINE INFLUENCES ON EXERCISE AND PSYCHOLOGICAL STRESSWilliam Lovallo; Fiscal Year: 1993..This research is of practical significance in providing useful information on caffeine's risk potential in hypertensive men...
- Neuroimaging in the Oklahoma Family Health Patterns ProjectWilliam R Lovallo; Fiscal Year: 2011..The proposed positron emission tomography study will provide new and useful information on the underlying brain functional characteristics of these High Risk individuals. ..