Research Topics
| David L VeselySummaryCountry: USA Publications
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Publications
Natriuretic peptides and acute renal failureDavid L Vesely
Department of Medicine, University of South Florida Cardiac Hormone Center, and James A Haley Veterans Medical Center, Tampa, Florida 33612, USA
Am J Physiol Renal Physiol 285:F167-77. 2003..Vessel dilator decreases mortality in ARF from 88 to 14% at day 6 of ARF, even when given 2 days after renal failure has been established...- Atrial natriuretic peptides: anticancer agentsDavid L Vesely
Department of Internal Medicine, University of South Florida Cardiac Hormone Center, Tampa, 33612, USA
J Investig Med 53:360-5. 2005..Vessel dilator, LANP, and kaliuretic peptide within 1 week decrease the volume by 49%, 28%, and 11% of the human pancreatic adenocarcinomas, which, with current anticancer treatment, have a mean survival of only 4 months... - Discovery of new cardiovascular hormones for the treatment of congestive heart failureDavid L Vesely
Department of Internal Medicine, USF Cardiac Hormone and Health Sciences Center, Tampa, Florida 33612, USA
Cardiovasc Hematol Disord Drug Targets 7:47-62. 2007..This review will focus on six cardiac hormones' discovery, identification and comparison of their beneficial effects and side effects in humans with congestive heart failure... - Elimination of up to 80% of human pancreatic adenocarcinomas in athymic mice by cardiac hormonesDavid L Vesely
Department of Internal Medicine, University of South Florida Cardiac Hormone Center, and James A Haley Veterans Medical Center, Tampa, FL, USA
In Vivo 21:445-51. 2007..Four cardiac hormones have anticancer effects in vitro: i) atrial natriuretic peptide (ANP), ii) vessel dilator, iii) long acting natriuretic peptide (LANP), and iv) kaliuretic peptide... - Atrial natriuretic peptide prohormone gene expression: hormones and diseases that upregulate its expressionDavid L Vesely
Department of Medicine, Physiology and Biophysics, University of South Florida Cardiac Hormone Center and James A Haley Veterans Medical Center, Tampa, Florida 33612, USA
IUBMB Life 53:153-9. 2002..Enhanced proANP gene expression is found in congestive heart failure, hypertension, and cirrhosis with ascites. The proANP gene is present with invertebrates and plants as well as in humans and other vertebrates... - Which of the cardiac natriuretic peptides is most effective for the treatment of congestive heart failure, renal failure and cancer?David L Vesely
University of South Florida Cardiac Hormone Center and James A Haley Veteran s Medical Center, Tampa, Florida, USA
Clin Exp Pharmacol Physiol 33:169-76. 2006..In vivo, vessel dilator, LANP and kaliuretic peptide completely stop the growth of human pancreatic adenocarcinomas in athymic mice and decrease their tumour volume by 49, 28 and 11%, respectively in 1 week... - Urodilatin: a better natriuretic peptide?David L Vesely
USF Cardiac Hormone Center, James A Haley Veterans Medical Center, 13000 Bruce B Downs Boulevard, Tampa, FL 33612, USA
Curr Heart Fail Rep 4:147-52. 2007.... - Four cardiac hormones cause cell death of melanoma cells and inhibit their DNA synthesisBrian A Vesely
Departments of Internal Medicine, University of South Florida Cardiac Hormone Center, Tampa, Florida 33612, USA
Am J Med Sci 334:342-9. 2007..Four cardiac hormones ie, atrial natriuretic peptide, vessel dilator, long-acting natriuretic peptide, and kaliuretic peptide, have significant anticancer effects in adenocarcinomas... - Novel therapeutic approach for cancer using four cardiovascular hormonesD L Vesely
University of South Florida Cardiac Hormone Center, Tampa, FL 33612, USA
Eur J Clin Invest 34:674-82. 2004..e. vessel dilator, long-acting natriuretic peptide, kaliuretic peptide and ANP, which decrease the number of human pancreatic adenocarcinoma cells in culture by 65%, 47%, 37%, and 34%, respectively... - Four cardiac hormones eliminate up to two-thirds of human breast cancers in athymic miceDavid L Vesely
Department of Internal Medicine, University of South Florida Cardiac Hormone Center, Tampa, FL 33612, USA
In Vivo 21:973-8. 2007..Four cardiac hormones i.e. atrial natriuretic peptide (ANP), vessel dilator, long acting natriuretic peptide (LANP) and kaliuretic peptide have anticancer effects in vitro... - Atrial natriuretic peptide and long acting natriuretic peptide inhibit MEK 1/2 activation in human prostate cancer cellsYing Sun
Department of Internal Medicine, University of South Florida Cardiac Hormone Center and James A Haley Veterans Medical Center, Tampa, FL 33612, USA
Anticancer Res 27:3813-8. 2007..Atrial natriuretic peptide and long acting natriuretic peptide have anticancer effects in human prostate adenocarcinomas... - Four cardiac hormones eliminate up to 82% of human medullary thyroid carcinoma cells within 24 hoursEhrentraud J Eichelbaum
Department of Internal Medicine, James A. Haley Veterans Medical Center, Tampa, FL 33612, USA
Endocrine 30:325-32. 2006..These results indicate the four cardiac hormones have potent anticancer effects by eliminating up to 82% of human medullary thyroid carcinoma cells within 24 h of treatment... - Four cardiac hormones eliminate 4-fold more human glioblastoma cells than the green mamba snake peptideBrian A Vesely
Department of Internal Medicine, James A Haley Veterans Medical Center, Tampa, FL 33612, USA
Cancer Lett 254:94-101. 2007..3- to 3.8-fold in the glioblastoma cells. Natriuretic peptide receptors (NPR)-A and -C were present. Conclusion: four cardiac hormones eliminate up to 75% of glioblastoma cells via cyclic GMP-mediated up to 87% decrease in DNA synthesis... - Vessel dilator and kaliuretic peptide inhibit Ras in human prostate cancer cellsYing Sun
USF Cardiac Hormone Center, J A Haley Veterans Medical Center, Tampa, Florida 33612, USA
Anticancer Res 29:971-5. 2009..Vessel dilator and kaliuretic peptide have anticancer effects in human prostate adenocarcinomas... - Vessel dilator and kaliuretic peptide inhibit MEK 1/2 activation in human prostate cancer cellsYing Sun
Department of Internal Medicine, University of South Florida Cardiac Hormone Center and James A Haley Veterans Medical Center, Tampa, Florida 33612, USA
Anticancer Res 27:1387-92. 2007..Vessel dilator and kaliuretic peptide have anticancer effects in human prostate adenocarcinomas... - Twice-weekly intravenous treatment of pancreatic cancer with atrial natriuretic peptide and vessel dilatorAnne Lenz
Department of Internal Medicine, University of South Florida Cardiac Hormone Center, Tampa, FL 33612, USA
In Vivo 24:125-9. 2010..Atrial natriuretic peptide (ANP) and vessel dilator eliminate 80% and 33% of human pancreatic adenocarcinomas growing in athymic mice when given subcutaneously for 28 days via osmotic pumps... - Four peptides decrease human colon adenocarcinoma cell number and DNA synthesis via cyclic GMPWilliam R Gower
Department of Internal Medicine, University of South Florida Cardiac Hormone Center and James A. Haley Veterans Medical Center, Tampa, 33612, USA
Int J Gastrointest Cancer 36:77-87. 2005..CONCLUSIONS: Four peptide hormones eliminate up to 97% of colon cancer cells within 24 h with their DNA effects specifically mediated by cyclic GMP... - Primary malignant tumors of the heart: four cardiovascular hormones decrease the number and DNA synthesis of human angiosarcoma cellsBrian A Vesely
Department of Biochemistry and Molecular Biology, University of South Florida Cardiac Hormone Center Tampa, FL 33612, USA
Cardiology 105:226-33. 2006..The natriuretic peptide receptor C was present. CONCLUSIONS: Four cardiovascular hormones decrease the number of angiosarcoma cells within 24 h via inhibition of DNA synthesis mediated in part by cyclic GMP... - Atrial natriuretic peptide and long-acting natriuretic peptide inhibit ras in human prostate cancer cellsYing Sun
Department of Internal Medicine, University of South Florida Cardiac Hormone Center, and James A Haley Veterans Medical Center 151, Tampa, Florida 33612, U S A
Anticancer Res 29:1889-93. 2009..Atrial natriuretic peptide and long-acting natriuretic peptide have anticancer effects in human prostate adenocarcinoma... - Effects of cardiac hormones on arterial pressure and sodium excretion in NPRA knockout miceJohn R Dietz
Department of Physiology and Biophysics, University of South Florida, College of Medicine, Tampa, Florida 33612, USA
Exp Biol Med (Maywood) 229:813-8. 2004..05) in the WT mice but had no significant effect in the KO mice. Thus, acute renal and MAP responses to atrial extracts require the NPRA receptor... - Atrial natriuretic peptide and long acting natriuretic peptide inhibit ERK 1/2 in prostate cancer cellsYing Sun
Department of Internal Medicine, University of South Florida Cardiac Hormone Center and James A. Haley Veterans Medical Center Tampa, Florida 33612, USA
Anticancer Res 26:4143-8. 2006..CONCLUSION: ANP and LANP both inhibit ERK 1/2 kinase mediated via cyclic GMP as part of their anticancer mechanism(s) of action... - Epidermal growth factor's activation of Ras is inhibited by four cardiac hormonesYing Sun
University of South Florida Cardiac Hormone Center and James A Haley Veterans Medical Center, Tampa, FL 33612, USA
Eur J Clin Invest 40:408-13. 2010..e. atrial natriuretic peptide, vessel dilator, kaliuretic peptide and long-acting natriuretic peptide, have anticancer effects in vitro and in vivo. Epidermal growth factor's mechanism of cancer formation involves the activation of Ras... - Vessel dilator and kaliuretic peptide inhibit ERK 1/2 activation in human prostate cancer cellsYing Sun
Department of Internal Medicine, University of South Florida Cardiac Hormone Center and James A. Haley Veterans Medical Center Tampa, Florida 33612, USA
Anticancer Res 26:3217-22. 2006..CONCLUSION: Vessel dilator and kaliuretic peptide both inhibit ERK 1/2 kinase mediated via cyclic GMP as part of their anticancer mechanism(s) of action... - Vessel dilator: most potent of the atrial natriuretic peptides in decreasing the number and DNA synthesis of human squamous lung cancer cellsBrian A Vesely
Department of Biochemistry and Molecular Biology, Internal Medicine, Physiology and Biophysics, University of South Florida Cardiac Hormone Center, and James A. Haley Veteran's Administration Medical Center, 13000 Bruce B. Downs Blvd, Tampa, FL 33612, USA
Cancer Lett 233:226-31. 2006..Thus, vessel dilator significantly decreased the number of human squamous lung cancer cells and their DNA synthesis, mediated in part by cyclic GMP, more than other peptide hormones... - Immunocytochemical localization of atrial natriuretic peptide, vessel dilator, long-acting natriuretic peptide, and kaliuretic peptide in human pancreatic adenocarcinomasSabiha R Saba
Department of Biochemistry and Molecular Biology, University of South Florida Cardiac Hormone Center, Tampa 33612, Florida, USA
J Histochem Cytochem 53:989-95. 2005.... - Combined treatment with vessel dilator and kaliuretic hormone in persons with congestive heart failureHamang Patel
U.S.F. Cardiac Hormone Center, Department of Medicine, University of South Florida Health Sciences Center, and Medicine and Pharmacy Services, James A. Haley Veterans Medical Center, Tampa, Florida 33612, USA
Exp Biol Med (Maywood) 229:521-7. 2004..These data indicate that vessel dilator and kaliuretic hormone have diuretic and natriuretic effects when used in combination, but these effects are not additive over their individual effects in persons with CHF... - Four cardiac hormones increase circulating concentrations of luteinizing hormone and testosteroneDavid L Vesely
University of South Florida Cardiac Hormone Center, Department of Biochemistry, James A Haley Veterans Medical Center, Tampa 33612, USA
Endocrine 17:145-50. 2002..These data suggest that four peptide hormones-ANH, LANH, vessel dilator, and kaliuretic hormone-increase the circulating con-centrations of LH and testosterone in humans... - Four peptides decrease the number of human pancreatic adenocarcinoma cellsB A Vesely
Department of Medicine, University of South Florida Cardiac Hormone Center, Tampa, FL 33612, USA
Eur J Clin Invest 33:998-1005. 2003..Their mechanism of doing so is via inhibition of DNA synthesis mediated in part by cyclic GMP... - Metabolic targets of cardiac hormones' therapeutic anti-cancer effectsDavid L Vesely
Departments of Medicine, Molecular Pharmacology and Physiology, and Cardiac Hormone Center, James A Haley Veterans Medical Center and University of South Florida Health Sciences Center, Tampa, Florida 33612, USA
Curr Pharm Des 16:1159-66. 2010..The final step in their anticancer mechanism of action is that they enter the nucleus as demonstrated by immunfluorescence to inhibit DNA synthesis within cancer cells... - Vessel dilator and C-type natriuretic peptide enhance the proliferation of human osteoblastsAnne Lenz
Department of Internal Medicine, University of South Florida School of Medicine, James A Haley Veterans Medical Center, Tampa, Florida 33612, USA
Pediatr Res 68:405-8. 2010..Vessel dilator stimulates osteoblast proliferation whereas most current therapies of osteoporosis target osteoclasts... - Neutralization of proANP (1-30) exacerbates hypertension in the spontaneously hypertensive ratJohn R Dietz
Department of Physiology and Biophysics, University of South Florida College of Medicine, Box 8, Tampa, FL 33612, USA
Clin Exp Pharmacol Physiol 30:627-31. 2003..005. 5. These results suggest a protective role for proANP (1-30) in the SHR model of hypertension... - Atrial natriuretic hormone prohormone gene expression in cardiac and extra-cardiac tissues of diabetic Goto-Kakizaki ratsWilliam R Gower
Department of Biochemistry and Molecular Biology, James A Haley Veterans Hospital, Tampa, FL 33612, USA
Mol Cell Biochem 252:263-71. 2003..Diabetes is the first disease in which there is more upregulation of ANH prohormone in extracardiac tissues compared to upregulation within the heart itself... - Four peptide hormones' specific decrease (up to 97%) of human prostate carcinoma cellsB A Vesely
University of South Florida Cardiac Hormone Center and James A. Haley Veterans Medical Center, Tampa, FL 33612, USA
Eur J Clin Invest 35:700-10. 2005..CONCLUSIONS: These results indicate that these peptide hormones' anticancer effects are specific. Furthermore, they have very potent effects of eliminating up to 97% of prostate cancer cells within 24 h of treatment... - Four peptide hormones decrease the number of human breast adenocarcinoma cellsB A Vesely
Department of Biochemistry and Molecular Biology, University of South Florida Cardiac Hormone Center and James A. Haley Veteran's Administration Medical Center, Tampa, FL, USA
Eur J Clin Invest 35:60-9. 2005..Their mechanism of doing so involves inhibition of DNA synthesis and a decrease in cells in the S phase of the cell cycle mediated in part by cyclic GMP... - Coronary vascular effects of vasoactive intestinal peptide in the isolated perfused rat heartDarrell R Sawmiller
Department of Internal Medicine, University of South Florida Health Science Center, 12901 Bruce B Downs Blvd, MDC 19, Tampa, FL 33612 4799, USA
Neuropeptides 38:289-97. 2004..This vasodilatory effect involves binding to specific coronary cell surface receptors, VPAC1 and/or VPAC2, and is dependent on cyclic AMP only during maximal vasodilation... - Four cardiac hormones cause death of human cancer cells but not of healthy cellsWilliam P Skelton
1Duke University, Trinity College of Arts and Sciences, Durham, NC 27708, USA
Anticancer Res 31:395-402. 2011..Four cardiac hormones, namely, vessel dilator, long-acting natriuretic peptide, atrial natriuretic peptide and kaliuretic peptide, have anticancer effects but whether they cause cell death of human cancer cells or normal cells is unknown... - Atrial natriuretic hormone, vessel dilator, long-acting natriuretic hormone, and kaliuretic hormone decrease the circulating concentrations of total and tree T4 and free T3 with reciprocal increase in TSHD L Vesely
University of South Florida Cardiac Hormone Center, Tampa 33612, USA
J Clin Endocrinol Metab 86:5438-42. 2001.... - Atrial natriuretic hormone, vessel dilator, long-acting natriuretic hormone, and kaliuretic hormone decrease the circulating concentrations of CRH, corticotropin, and cortisolD L Vesely
Division of Cardiology, Department of Internal Medicine, University of South Florida Health Sciences Center, Tampa, Florida 33612, USA
J Clin Endocrinol Metab 86:4244-9. 2001.... - Evidence for an atrial natriuretic peptide-like gene in plantsM D Vesely
Department of Biochemistry and Molecular Biology, University of South Florida Health Sciences Center and James A Haley Veterans Hospital, Tampa 33612, USA
Exp Biol Med (Maywood) 226:61-5. 2001..The demonstration of the ANP gene sequences and expression of the ANP-like gene in plants suggests that plants and animals may have evolved much more similarly than previously thought... - Atrial natriuretic hormone, vessel dilator, long acting natriuretic hormone, and kaliuretic hormone decrease circulating prolactin concentrationsD L Vesely
University of South Florida Cardiac Hormone Center, Tampa, FL 33612, USA
Horm Metab Res 34:245-9. 2002.... - Cardiac hormones eliminate some human squamous lung carcinomas in athymic miceA Lenz
University of South Florida Cardiac Hormone Center and James A Haley Veterans Medical Center, Tampa, FL, USA
Eur J Clin Invest 40:242-9. 2010..Four cardiac hormones synthesized by the same gene, i.e. atrial natriuretic peptide, vessel dilator, long acting natriuretic peptide and kaliuretic peptide, have anticancer effects in vitro... - Circadian distribution of hematology variables in subjects with multiple sclerosisE L Kanabrocki
Department Nuclear Medicine, University of South Florida, Tampa, FL, USA
Clin Ter 157:241-7. 2006..In addition, the elevation in circulating monocytes in MS patients is consistent with the inflammatory nature of the disease... - Vessel dilator, long acting natriuretic peptide, and kaliuretic peptide increase circulating prostaglandin E2D L Vesely
Department of Medicine, University of South Florida Health Sciences Center and James A Haley Veterans Hospital, Tampa 33612, USA
Life Sci 66:905-13. 2000..This investigation demonstrates that 1) three endogenous peptide hormones increase PGE2 in the circulation and 2) suggests that the known increase in PGE2 in CHF may be in part secondary to these peptides... - Intact negative feedback of four cardiac hormones in congestive heart failureDavid L Vesely
Department of Internal Medicine, Cardiac Hormone Center, University of South Florida Health Sciences Center, Tampa, FL 33612, USA
Metabolism 51:582-8. 2002..The feedback regulation of these hormones found previously in healthy humans is, thus, preserved in persons with CHF despite their increased endogenous circulating concentrations... - Cardiac and kidney hormones cure up to 86% of human small-cell lung cancers in miceE J Eichelbaum
Department of Internal Medicine, University of South Florida Cardiac Hormone Centre and James A Haley Veterans Medical Centre, Tampa, Florida, USA
Eur J Clin Invest 38:562-70. 2008..Four cardiac hormones synthesized by the same gene, i.e. atrial natriuretic peptide, vessel dilator, long acting natriuretic peptide and kaliuretic peptide, and the kidney hormone urodilatin have anticancer effects in vitro... - Long-acting natriuretic peptide, vessel dilator, and kaliuretic peptide enhance urinary excretion rate of albumin, total protein, and beta(2)-microglobulin in patients with congestive heart failureD L Vesely
Department of Internal Medicine, the Cardiac Hormone Center, University of South Florida Health Sciences Center, Tampa, Florida, USA
J Card Fail 7:55-63. 2001..Part of the mechanism of this enhanced protein excretion is the inhibition of proximal tubular reabsorption of protein as shown by the beta(2)-microglobulin data... - Cardiac and renal hormones: anticancer effects in vitro and in vivoDavid L Vesely
Department of Medicine, Cardiac Hormone Center, University of South Florida Health Sciences Center and James A Haley Veterans Medical Center, Tampa, FL, USA
J Investig Med 57:22-8. 2009.... - Gonadotropin-secreting pituitary tumor associated with hypersecretion of testosterone and hypogonadism after hypophysectomyMichelle N Dizon
Department of Internal Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of South Florida Medical School and James A. Haley Veterans Hospital, Tampa, Florida 33612-4798, USA
Endocr Pract 8:225-31. 2002..9 mIU/mL. Thyroid function and adrenal function were normal before and after surgical intervention. CONCLUSION: This rare case indicates that gonadotropin tumors can produce a functional LH that can increase serum testosterone levels... - Natriuretic peptides and genesis of asthma: an emerging paradigm?Shyam S Mohapatra
Division of Allergy and Immunology JMC Airway Disease Research Center, University of South Florida, Tampa, FL 33612, USA
J Allergy Clin Immunol 114:520-6. 2004..Thus natriuretic peptides appear to play a pivotal role in the genesis and control of asthma, and they might provide an important target to modulate allergen-induced immune responses in allergic patients... - Cardiac hormones activate ERK 1/2 kinases in human fibroblastsY Sun
Department of Internal Medicine, Molecular Pharmacology and Physiology, James A Haley Veterans Medical Center and University of South Florida Cardiac Hormone Center, Tampa, Florida 33612, USA
Horm Metab Res 41:197-201. 2009..01). Our results show that both cardiac hormones activate extracellular signal-regulated kinases 1/2 in human fibroblasts, suggesting that they may have a role in enhancing fibroblast proliferation... - Effects of kaliuretic peptide on sodium and water excretion in persons with congestive heart failureA Nasser
U.S.F. Cardiac Hormone Center, Departments of Department of Medicine, James A. Haley Veterans Hospital, Tampa, Florida 33612, USA
Am J Cardiol 88:23-9. 2001..In patients with CHF, kaliuretic peptide causes a natriuresis-a feature not observed in those without sodium retention... - Cardiac natriuretic peptides: hormones with anticancer effects that localize to nucleus, cytoplasm, endothelium, and fibroblasts of human cancersS R Saba
Department of Pathology, University of South Florida, Cardiac Hormone Center, and James A. Haley Veteran's Administration Medical Center Tampa, Florida 33612, USA
Histol Histopathol 21:775-83. 2006.... - Five cardiac hormones decrease the number of human small-cell lung cancer cellsB A Vesely
Department of Internal Medicine, University of South Florida Cardiac Hormone Center, Tampa, FL, USA
Eur J Clin Invest 35:388-98. 2005..Their mechanism of doing so involves inhibition of DNA synthesis mediated in part by cyclic GMP... - Cardiac hormones are c-Jun-N-terminal kinase 2-inhibiting peptidesMeghan L Lane
Department of Medicine, James A Haley VA Medical Center, University of South Florida for Health Sciences, Tampa, FL, USA
Anticancer Res 32:721-5. 2012..Four cardiac peptide hormones, namely vessel dilator, long-acting natriuretic peptide (LANP), kaliuretic peptide, and atrial natriuretic peptide (ANP) have anticancer effects... - Survival with serum sodium level of 180 mEq/L: permanent disorientation to place and timeJoaquin Gomez-Daspet
Department of Internal Medicine, University of South Florida for Health Sciences, James A. Haley Veterans Medical Center, 13000 Bruce B. Downs Blvd, Tampa, Florida 33612, USA
Am J Med Sci 324:321-5. 2002..However, she developed permanent (6 months) disorientation to time and place even when hypernatremia was corrected, which has not been described previously... - D-glucose and NaCl enhance the expression of aquaporin-1: inhibition of both by cholera toxinWheamei Jenq
Division of Nephrology and Hypertension, University of South Florida for Health Sciences, Tampa, FL 33612, USA
Nephron 92:279-86. 2002..To determine whether glucose, NaCl and/or cholera toxin modify the expression of aquaporin-1 (AQP-1) water channel... - Urodilatin and four cardiac hormones decrease human renal carcinoma cell numbersB A Vesely
James A. Haley Veterans Medical Center and University of South Florida Health Sciences Center, Tampa, 33612, USA
Eur J Clin Invest 36:810-9. 2006..CONCLUSIONS: These results indicate that urodilatin and the four cardiac hormones have potent anti-cancer effects by eliminating up to 81% of renal carcinoma cells within 24 h of treatment... - Atrial natriuretic peptide gene transfer by means of intranasal administration attenuates airway reactivity in a mouse model of allergic sensitizationMukesh Kumar
Division of Allergy and Immunology-Joy McCann Culverhouse Airway Disease Center, University of South Florida College of Medicine and James A. Haley Veteran's Hospital, Tampa 33612, USA
J Allergy Clin Immunol 110:879-82. 2002..Mice administered pANP demonstrated significantly less AHR for 20 days after treatment. The results demonstrate that pANP gene transfer protects against AHR and might be useful in the treatment of asthma...