Sandra Zinkel

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi A role for proapoptotic BID in the DNA-damage response
    Sandra S Zinkel
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 122:579-91. 2005
  2. ncbi Function of BID -- a molecule of the bcl-2 family -- in ischemic cell death in the brain
    Nikolaus Plesnila
    Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Eur Surg Res 34:37-41. 2002
  3. ncbi Proapoptotic BID is required for myeloid homeostasis and tumor suppression
    Sandra S Zinkel
    Howard Hughes Medical Institute, Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Genes Dev 17:229-39. 2003
  4. ncbi BID binds to replication protein A and stimulates ATR function following replicative stress
    Yang Liu
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Mol Cell Biol 31:4298-309. 2011
  5. ncbi Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease
    Jing Wang
    Department of Pathology and Medicine, Howard Hughes Medical Institute, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 24:368-81. 2005
  6. ncbi Bid plays a role in the DNA damage response
    Sandra S Zinkel
    Cell 130:9-10; author reply 10-1. 2007

Research Grants

  1. Bid Function in Myeloid Homeostasis and Leukemogenesis
    Sandra Zinkel; Fiscal Year: 2006
  2. Pro-apoptotic BID in DNA Damage and Leukemogenesis
    Sandra Zinkel; Fiscal Year: 2007
  3. Pro-apoptotic BID in DNA Damage and Leukemogenesis
    Sandra Zinkel; Fiscal Year: 2009
  4. Pro-apoptotic BID in DNA Damage and Leukemogenesis
    Sandra S Zinkel; Fiscal Year: 2010

Collaborators

Detail Information

Publications6

  1. ncbi A role for proapoptotic BID in the DNA-damage response
    Sandra S Zinkel
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 122:579-91. 2005
    ..We further demonstrate that this role is mediated through BID phosphorylation by the DNA-damage kinase ATM. These results establish a link between proapoptotic Bid and the DNA-damage response...
  2. ncbi Function of BID -- a molecule of the bcl-2 family -- in ischemic cell death in the brain
    Nikolaus Plesnila
    Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Eur Surg Res 34:37-41. 2002
    ..The findings indicate that the proapoptotic molecule BID may contribute to the demise of nerve cells from cerebral ischemia by release of cytochrome c and activation of caspase...
  3. ncbi Proapoptotic BID is required for myeloid homeostasis and tumor suppression
    Sandra S Zinkel
    Howard Hughes Medical Institute, Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Genes Dev 17:229-39. 2003
    ..Moreover, progression to CMML indicates that an upstream BH3-only molecule, BID, is required to suppress tumorigenesis...
  4. ncbi BID binds to replication protein A and stimulates ATR function following replicative stress
    Yang Liu
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Mol Cell Biol 31:4298-309. 2011
    ..We propose a model in which BID associates with RPA and stimulates the recruitment and/or stabilization of ATR-ATRIP to the DNA damage sensor complex...
  5. ncbi Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease
    Jing Wang
    Department of Pathology and Medicine, Howard Hughes Medical Institute, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 24:368-81. 2005
    ..This model of MLL-CBP therapy-related myeloproliferative disease demonstrates the selectivity of this MLL fusion for GMP cells and its ability to initiate leukemogenesis in conjunction with cooperating mutations...
  6. ncbi Bid plays a role in the DNA damage response
    Sandra S Zinkel
    Cell 130:9-10; author reply 10-1. 2007

Research Grants6

  1. Bid Function in Myeloid Homeostasis and Leukemogenesis
    Sandra Zinkel; Fiscal Year: 2006
    ..Define the role of Bid in myeloid homeostasis. 2. Define the role of Bid in myeloid leukemogenesis. 3. Identify the secondary genetic changes that cooperate with loss of Bid in leukemogenesis. ..
  2. Pro-apoptotic BID in DNA Damage and Leukemogenesis
    Sandra Zinkel; Fiscal Year: 2007
    ....
  3. Pro-apoptotic BID in DNA Damage and Leukemogenesis
    Sandra Zinkel; Fiscal Year: 2009
    ....
  4. Pro-apoptotic BID in DNA Damage and Leukemogenesis
    Sandra S Zinkel; Fiscal Year: 2010
    ....