Research Topics
| Subramaniam SriramSummaryAffiliation: Vanderbilt University Country: USA Publications
Research Grants
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Detail Information
Publications
Role of glial cells in innate immunity and their role in CNS demyelinationSubramaniam Sriram
Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
J Neuroimmunol 239:13-20. 2011..We propose that activation pathways of receptors of the innate immune system present on oligodendrocytes and astrocytes rather than microglia are central to the pathogenesis of demyelination seen in MS...- Experimental allergic encephalomyelitis: a misleading model of multiple sclerosisSubramaniam Sriram
Department of Neurology, Vanderbilt Medical Center, Nashville, TN 37212, USA
Ann Neurol 58:939-45. 2005..We propose to reconsider the utilization of EAE, especially when this model is used to define therapy. This will also force us to examine MS without the restraints imposed by EAE, as to what it is, rather than what it looks like... - Detection of chlamydial bodies and antigens in the central nervous system of patients with multiple sclerosisSubramaniam Sriram
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
J Infect Dis 192:1219-28. 2005..Results of studies using these different approaches support our suspicion of the presence of chlamydial organisms in the CNS, in a subset of patients with MS... - Pilot study to examine the effect of antibiotic therapy on MRI outcomes in RRMSS Sriram
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
J Neurol Sci 234:87-91. 2005..The reduction in atrophy in patients receiving antibiotics must be viewed with caution, due to the small number of patients studied... - Qualitative and quantitative detection of Chlamydophila pneumoniae DNA in cerebrospinal fluid from multiple sclerosis patients and controlsYi Wei Tang
Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
PLoS ONE 4:e5200. 2009..pneumoniae DNA in CSF. The TaqMan system may not be sensitive enough for diagnostic purposes due to the low C. pneumoniae copies existing in the majority of CSF specimens from MS patients... - Bacterial cell wall products increases stabilization of HIF-1 alpha in an oligodendrocyte cell line preconditioned by cobalt chloride or desferrioxamineSong yi Yao
Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
J Neuroimmunol 200:17-26. 2008..The increase in HIF-1 alpha was due to increased protein stability that was mediated by activation of the ERK-MAP kinase pathway... - Chlamydia pneumoniae infection of the central nervous system worsens experimental allergic encephalitisCaigan Du
Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, TN 37212, USA
J Exp Med 196:1639-44. 2002..pneumoniae results in localized infection in CNS tissues in animals with EAE. We propose that infection of the CNS by C. pneumoniae can amplify the autoreactive pool of lymphocytes and regulate the expression of an autoimmune disease... - Preconditioning with cobalt chloride or desferrioxamine protects oligodendrocyte cell line (MO3.13) from tumor necrosis factor-alpha-mediated cell deathSong yi Yao
Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
J Neurosci Res 86:2403-13. 2008..13 cells, when cultured with TNFalpha after a period of preconditioning by DFO or CoCl(2). These studies suggest that compoundsthat increase HIF-1alpha can function as neuroprotective agents in inflammatory disorders of the CNS... - Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosisFanglin Zhang
Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
PLoS ONE 6:e16795. 2011..While increased expression of HDAC3 is seen in neoplastic cells, the role of HDAC3 in T cells and their role in autoimmune disease is not known... - Comparative study of the presence of Chlamydia pneumoniae in cerebrospinal fluid of Patients with clinically definite and monosymptomatic multiple sclerosisSubramaniam Sriram
Department of Neurology Department of Pathology, Vanderbilt School of Medicine, Nashville, Tennessee, USA
Clin Diagn Lab Immunol 9:1332-7. 2002..pneumoniae in the CSF of MS patients. The presence of C. pneumoniae in patients with monosymptomatic MS would also suggest that infection with the organism occurs early in the course of the disease... - Signaling through JAK2-STAT5 pathway is essential for IL-3-induced activation of microgliaChandramohan Natarajan
Department of Neurology and Pharmacology, Vanderbilt University Medical Center, 1222F VSRH, 2201 Capers Avenue, Nashville, TN 37212, USA
Glia 45:188-96. 2004..These findings highlight the fact that JAK2-STAT5 signaling pathway plays a critical role in mediating IL-3-induced activation of microglia... - Defective ATM-p53-mediated apoptotic pathway in multiple sclerosisXinqing Deng
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
Ann Neurol 58:577-84. 2005..We predict that these fundamental defects likely alter the regulation of the immune population of cells in MS and may contribute to the development or progression of the disease... - Association of Chlamydia pneumoniae with central nervous system diseaseCharles W Stratton
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
Microbes Infect 5:1249-53. 2003..This review addresses the potential and the underlying mechanisms by which C. pneumoniae infections can play a role in such diverse neurological diseases as multiple sclerosis and Alzheimer's disease... - Analysis of t2 intensity by magnetic resonance imaging of deep gray matter nuclei in multiple sclerosis patients: effect of immunomodulatory therapiesSiddharama Pawate
From the Multiple Sclerosis Center, Department of Neurology SP, SA and Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN LW, YS
J Neuroimaging 22:137-44. 2012..To investigate differences in T2 intensity of deep gray matter (dGM) structures by magnetic resonance imaging (MRI) in multiple sclerosis (MS) patients undergoing various immunomodulatory therapies... - Development of chemical exchange saturation transfer at 7 TAdrienne N Dula
Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232 2310, USA
Magn Reson Med 66:831-8. 2011..These results indicate the potential utility of APT at high field as a noninvasive biomarker of white matter pathology, providing complementary information to other MRI methods in current clinical use... - Identification and characterization of the interferon-beta-mediated p53 signal pathway in human peripheral blood mononuclear cellsFanglin Zhang
Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, TN 37212, USA
Immunology 128:e905-18. 2009..These observations suggest that, in spite of the activation of a number of mutually overlapping pathways mediating cell death, cell cycle arrest was the most evident consequence of IFN-beta signalling in PBMC... - Role of microglia in multiple sclerosisXinqing Deng
Multiple Sclerosis Research Laboratory, 1222H Vanderbilt Stallworth Rehabilitation Hospital, Nashville, TN 37212, USA
Curr Neurol Neurosci Rep 5:239-44. 2005..This review examines the current controversies on the pathology of multiple sclerosis and the role played by microglia in the development of central nervous system demyelination... - The spectrum of Susac's syndromeSiddharama Pawate
Multiple Sclerosis Center, Department of Neurology, Vanderbilt University Medical Center, 2201 Childrens Way Room 1222, Nashville, TN 37211, USA
Neurol Sci 30:59-64. 2009..We also report the variable cerebrospinal fluid and brain magnetic resonance imaging findings, and treatment using a combination of steroids and intravenous immunoglobulin, followed by mycophenolate mofetil... - Identification of molecular biomarkers for multiple sclerosisSallyanne C Fossey
Department of Pathology, Vanderbilt University School of Medicine, Nashvill, Tennessee, USA
J Mol Diagn 9:197-204. 2007..This approach may have diagnostic utility not only for multiple sclerosis but also for other clinically complex autoimmune diseases... - Gray matter involvement in multiple sclerosisIstvan Pirko
Department of Neurology, University of Cincinnati, OH, USA
Neurology 68:634-42. 2007..However, continued studies of GM pathology as well as neuronal and axonal involvement in MS and related experimental models are necessary to better understand the etiology and pathogenesis of the degenerative components... - TRAPS and MS: two diseases or an MS mimic?Subramaniam Sriram
Neurology 70:1077-8. 2008 - In regard to Miller et al.: Multiple sclerosis, brain radiotherapy and risk of neurotoxicity: the Mayo Clinic experience (Int J Radiat Oncol Biol Phys 2006;66:1178-1186)Subramaniam Sriram
Int J Radiat Oncol Biol Phys 68:960-1; author reply 961. 2007 - Infectious causes of multiple sclerosisGavin Giovannoni
Department of Neuroinflammation, Institute of Neurology, University College London, UK
Lancet Neurol 5:887-94. 2006 - CNS infection with C. pneumoniae complicated by multiple strokesSubramaniam Sriram
J Neurol 250:1127; author reply 1128. 2003 - Increased severity of experimental allergic encephalomyelitis in lyn-/- mice in the absence of elevated proinflammatory cytokine response in the central nervous systemCaigan Du
Department of Neurology, Multiple Sclerosis Research Center, Vanderbilt University Medical Center, Nashville, TN 37212, USA
J Immunol 168:3105-12. 2002..These observations underscore the potential role of lyn in regulation of Th1-mediated disease and the role of autoantibodies and complement in the development of EAE...
Research Grants
- ANALYSIS OF ASSOCIATION BETWEEN C. PNEUMONIAE AND MSSubramaniam Sriram; Fiscal Year: 2002..Also, the presence of an immune response to C. pneumoniae that is contained within the CNS compartment will constitute strong circumstantial evidence of microbial infection. ..
- Novel oral therapeutics for multiple sclerosisSubramaniam Sriram; Fiscal Year: 2006....