M Shiota

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes
    M Shiota
    Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232 0615, USA
    Diabetes 50:622-9. 2001
  2. ncbi Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog
    M Shiota
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Diabetes 47:867-73. 1998
  3. ncbi Combined intraportal infusion of acetylcholine and adrenergic blockers augments net hepatic glucose uptake
    M Shiota
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Am J Physiol Endocrinol Metab 278:E544-52. 2000
  4. ncbi Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog
    Masakazu Shiota
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Diabetes 51:469-78. 2002
  5. ncbi Cell-specific roles of glucokinase in glucose homeostasis
    C Postic
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Recent Prog Horm Res 56:195-217. 2001
  6. ncbi Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism
    P She
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Mol Cell Biol 20:6508-17. 2000
  7. ncbi Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase
    C Postic
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 274:305-15. 1999
  8. ncbi Pancreatic response to mild non-insulin-induced hypoglycemia does not involve extrinsic neural input
    S M Sherck
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232 0615, USA
    Diabetes 50:2487-96. 2001
  9. ncbi Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition
    T L Jetton
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Int J Exp Diabetes Res 2:173-86. 2001
  10. ncbi Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development
    J T Lu
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Mol Cell Neurosci 14:99-120. 1999

Collaborators

Detail Information

Publications14

  1. ncbi Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes
    M Shiota
    Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232 0615, USA
    Diabetes 50:622-9. 2001
    ..Together, these data indicate that increased GK levels dramatically lessen the development of both hyperglycemia and hyperinsulinemia associated with the feeding of an HF diet...
  2. ncbi Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog
    M Shiota
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Diabetes 47:867-73. 1998
    ..These data suggest that glucokinase translocation within the hepatocyte is a major determinant of hepatic glucose uptake by the dog in vivo...
  3. ncbi Combined intraportal infusion of acetylcholine and adrenergic blockers augments net hepatic glucose uptake
    M Shiota
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Am J Physiol Endocrinol Metab 278:E544-52. 2000
    ..4 +/- 0.6 and 4.6 +/- 0.6 mg. kg(-1). min(-1) by 220 and 300 min, respectively. These data are consistent with the hypothesis that alterations in nerve activity contribute to the increase in NHGU seen after portal glucose delivery...
  4. ncbi Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog
    Masakazu Shiota
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Diabetes 51:469-78. 2002
    ..As a result, postprandial hyperglycemia and insulin release by the pancreatic beta-cell were reduced. In conclusion, catalytic amounts of fructose have the ability to improve glucose tolerance...
  5. ncbi Cell-specific roles of glucokinase in glucose homeostasis
    C Postic
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Recent Prog Horm Res 56:195-217. 2001
    ..Moreover, whether the pathophysiology of PHHI also involves multitissue dysfunction remains to be explored...
  6. ncbi Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism
    P She
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Mol Cell Biol 20:6508-17. 2000
    ..Thus, hepatic PEPCK may function more as an integrator of hepatic energy metabolism than as a determinant of gluconeogenesis...
  7. ncbi Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase
    C Postic
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 274:305-15. 1999
    ..Interestingly, hepatic GK knock-out mice also have impaired insulin secretion in response to glucose. These studies indicate that deficiencies in both beta cell and hepatic GK contribute to the hyperglycemia of MODY-2...
  8. ncbi Pancreatic response to mild non-insulin-induced hypoglycemia does not involve extrinsic neural input
    S M Sherck
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232 0615, USA
    Diabetes 50:2487-96. 2001
    ..It thus can be concluded that the responses of alpha- and beta-cells to mild non-insulin-induced hypoglycemia can occur in the absence of extrinsic neural input...
  9. ncbi Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition
    T L Jetton
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Int J Exp Diabetes Res 2:173-86. 2001
    ..These data suggest that a compartmentalization exists of both active GK and the initial sites of glycogen deposition at the hepatocyte surface...
  10. ncbi Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development
    J T Lu
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Mol Cell Neurosci 14:99-120. 1999
    ..These results suggest that alphaCGRP is not required for the systemic regulation of cardiovascular hemodynamics or development of the neuromuscular junction...
  11. ncbi Engineering physiologically regulated insulin secretion in non-beta cells by expressing glucagon-like peptide 1 receptor
    L Wu
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Gene Ther 10:1712-20. 2003
    ..These results demonstrate a new approach to engineer physiologically regulated insulin secretion by non-beta cells...
  12. ncbi Identification of the gene variations in human CD22
    Y Hatta
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Immunogenetics 49:280-6. 1999
    ..These findings indicate that a number of genetic variants are present in CD22, and suggest that CD22 could be considered a candidate for the susceptibility genes to autoimmune diseases...
  13. ncbi Endotoxin modulates arachidonic acid-induced glycogenolysis in the perfused rat liver
    K Kimura
    Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Horm Metab Res 30:178-81. 1998
    ..The release of Tx B2 by AA increased after LPS-injection. These results suggest that priming of hepatic macrophage by endotoxin in vivo enhances Tx synthesis, resulting in modulating hepatic glycogenolysis...
  14. ncbi Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)
    J Fujimoto
    Department of Oncology, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 93:4181-6. 1996
    ..Association of these mutants with GRB2 was still observed, suggesting that interaction of p80 with GRB2 but not with Shc or IRS-1 was relevant for cell transformation...