Lawrence A Scheving

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi The emergence of ErbB2 expression in cultured rat hepatocytes correlates with enhanced and diversified EGF-mediated signaling
    Lawrence A Scheving
    Division of Endocrinology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 0710, USA
    Am J Physiol Gastrointest Liver Physiol 291:G16-25. 2006
  2. ncbi Dexamethasone modulates ErbB tyrosine kinase expression and signaling through multiple and redundant mechanisms in cultured rat hepatocytes
    Lawrence A Scheving
    Division of Pediatric Endocrinology, 1055 Medical Research Bldg 4, Vanderbilt University Medical Center, Nashville, TN 37232 0710, USA
    Am J Physiol Gastrointest Liver Physiol 293:G552-9. 2007
  3. ncbi Cultured rat hepatocytes upregulate Akt and ERK in an ErbB-2-dependent manner
    Lawrence A Scheving
    Division of Pediatric Endocrinology, 7410 Medical Research Bldg 4, Vanderbilt Univ Medical Ctr, Nashville, TN 37232 0472, USA
    Am J Physiol Gastrointest Liver Physiol 295:G322-31. 2008
  4. ncbi Diverse expression of ErbB receptor proteins during rat liver development and regeneration
    Robert S Carver
    Department of Cell Biology, the Digestive Disease Research Center, Nashville, Tennessee, USA
    Gastroenterology 123:2017-27. 2002
  5. ncbi Integral role of the EGF receptor in HGF-mediated hepatocyte proliferation
    Lawrence A Scheving
    Department of Pediatrics, Medical Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Biochem Biophys Res Commun 290:197-203. 2002
  6. ncbi Beta-catenin in the liver: an integrator of proliferation and metabolism?
    Lawrence A Scheving
    Gastroenterology 131:1641-3. 2006
  7. ncbi It's about time: clock genes unveiled in the gut
    Lawrence A Scheving
    Gastroenterology 133:1373-6. 2007

Collaborators

  • P Traxler
  • Robert S Carver
  • William E Russell
  • Mary C Stevenson

Detail Information

Publications7

  1. ncbi The emergence of ErbB2 expression in cultured rat hepatocytes correlates with enhanced and diversified EGF-mediated signaling
    Lawrence A Scheving
    Division of Endocrinology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 0710, USA
    Am J Physiol Gastrointest Liver Physiol 291:G16-25. 2006
    ..The ability of insulin to induce ErbB2 suggests both a mechanism for the synergy between insulin and EGF and a possible metabolic control of ErbB2 in vivo...
  2. ncbi Dexamethasone modulates ErbB tyrosine kinase expression and signaling through multiple and redundant mechanisms in cultured rat hepatocytes
    Lawrence A Scheving
    Division of Pediatric Endocrinology, 1055 Medical Research Bldg 4, Vanderbilt University Medical Center, Nashville, TN 37232 0710, USA
    Am J Physiol Gastrointest Liver Physiol 293:G552-9. 2007
    ..Thus 10(-6) M dexamethasone exerts a time-dependent and redundant inhibitory effect on EGFr-mediated proliferative signaling in hepatocytes, targeting not only the ErbB proteins but also their various positive and negative effectors...
  3. ncbi Cultured rat hepatocytes upregulate Akt and ERK in an ErbB-2-dependent manner
    Lawrence A Scheving
    Division of Pediatric Endocrinology, 7410 Medical Research Bldg 4, Vanderbilt Univ Medical Ctr, Nashville, TN 37232 0472, USA
    Am J Physiol Gastrointest Liver Physiol 295:G322-31. 2008
    ..We hypothesize that the induction and activation of ErbB2 increases the expression of these kinases, enhancing the responsiveness of hepatocytes to EGF as they adapt to culture...
  4. ncbi Diverse expression of ErbB receptor proteins during rat liver development and regeneration
    Robert S Carver
    Department of Cell Biology, the Digestive Disease Research Center, Nashville, Tennessee, USA
    Gastroenterology 123:2017-27. 2002
    ..The protein expression and interactions of the ErbB receptors were examined in different liver proliferation models in vivo and in vitro, including ontogeny and regeneration following partial hepatectomy...
  5. ncbi Integral role of the EGF receptor in HGF-mediated hepatocyte proliferation
    Lawrence A Scheving
    Department of Pediatrics, Medical Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Biochem Biophys Res Commun 290:197-203. 2002
    ..The mitogenic effect of HGF may be secondary to increased synthesis or processing of EGFR ligands such as TGF-alpha...
  6. ncbi Beta-catenin in the liver: an integrator of proliferation and metabolism?
    Lawrence A Scheving
    Gastroenterology 131:1641-3. 2006
  7. ncbi It's about time: clock genes unveiled in the gut
    Lawrence A Scheving
    Gastroenterology 133:1373-6. 2007