Wayne Ray

..We sought to assess the positive predictive value (PPV) of a computer case definition to detect incident cases of DKA, using automated records of Tennessee Medicaid as the data source and medical record confirmation as a "gold standard."..

..Proton-pump inhibitors (PPIs) and clopidogrel are frequently coprescribed, although the benefits and harms of their concurrent use are unclear...

..The cardiovascular safety of individual nonsteroidal antiinflammatory drugs (NSAIDs) is highly controversial, particularly in persons with serious coronary heart disease...

..However, the relative clinical effectiveness of these therapeutic alternatives is understudied...

..This study assessed whether this racial disparity is present among patients with a very high risk of severe mood disorders--that is, those with completed suicides...

..We performed an observational cohort study to determine the influence of race, sex and other sociodemographic factors on early ART discontinuations among HIV-infected persons...

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..We examined the effect of race on CRC outcomes in a population-based study of elderly Tennesseeans who had identical healthcare coverage - simultaneous enrollment in both Medicaid and Medicare...

..Implementation of disease-specific computerized physician order entry (CPOE) discharge tools may improve compliance with these measures...

..This article thus argues that such designs should be used more frequently in pharmacoepidemiology...

..To identify frequencies of prescribing for antipsychotics among all US children...

..The aim of this study was to test whether a training program in safety practices for staff could reduce fall-related injuries in long-term care facilities...

..For high-risk children with asthma enrolled in Medicaid, loss of Medicaid coverage is a potential threat to access to quality asthma care...

..This study evaluates the effect of resident physician work hour limits on surgical patient safety...

..We conducted a study to assess the association between exposure to ACE inhibitors during the first trimester of pregnancy only and the risk of congenital malformations...

..The purpose of this study was to quantify the rate of exposures to antidepressants during pregnancy in a large cohort of women...

..Recent studies suggest that the success of preventive measures is dependent on compliance with ventilator bundle parameters...

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..To assess the positive predictive value of computerized records in a linked database of vital records and infant claims, with medical record confirmation to detect congenital malformations in a Medicaid population...

..Although this summary score has a number of advantages, there is concern that it may result in underestimation of the standard error of the exposure estimate and thus inflate the number of statistically significant results...

..To test the hypothesis that children enrolled in Medicaid managed care health plans that provide asthma-specific communication to providers would be more likely to have adequate asthma medication filling...

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..However, less is known regarding the cardiac safety of the atypical antipsychotic drugs, which have largely replaced the older agents in clinical practice...

..We investigated whether inhibition of endogenous angiotensin II signaling reduces the recurrence rate of atrial fibrillation (AF) in patients enrolled in the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study...

..We did an observational study to measure the effects of NANSAIDs, including naproxen, on risk of serious coronary heart disease...

..We studied the effect of this transition on the continuity of antipsychotic therapy among patients with severe mental illness who had previously adhered to treatment...

..We used data from an historical cohort study to demonstrate the extent of misclassification potentially induced by this practice...

..This study was designed to determine adherence to outpatient beta-blocker therapy following acute myocardial infarction (AMI)...

..93 (1.09-3.42, p=0.024). By contrast, there was no evidence of raised risk of CHD among users of rofecoxib at doses of 25 mg or less or among users of other NSAIDs...

..Documenting patterns of use for medications with potential for suboptimal use and adverse effects, such as oral corticosteroids, would be useful...

..To determine the frequency of use of recommended gastroprotective strategies in a cohort of patients receiving recurrent treatment with nonsteroidal antiinflammatory drugs (NSAIDs)...

..To assess the association between prenatal antibiotics, including erythromycin, and infantile hypertrophic pyloric stenosis in a large cohort of infants...

..To assess the link between very early erythromycin exposure and pyloric stenosis in young infants...

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..We thus sought to quantify the risk of sudden cardiac death among TCA users, according to dose, as well as among users of selective serotonin reuptake inhibitors (SSRIs)...

..We studied the association between the use of erythromycin and the risk of sudden death from cardiac causes and whether this risk was increased with the concurrent use of strong inhibitors of CYP3A...

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..Thus chronic use of high doses of rofecoxib has implications for patient safety...

..This study was designed to assess outpatient angiotensin-converting enzyme inhibitor (ACEI) use after heart failure (HF) hospitalization...

..0% of combinations to 20.8% during the same periods (P < 0.001). Use of PIs and statins has increased in the adult TennCare population. Contraindicated combinations have decreased but remain unacceptably high...

..The study of community dwelling Tennessee Medicaid enrollees 30-74 years of age utilized a linked database with Medicaid inpatient/outpatient files, state death certificate files, and a state 'all-payers' hospital discharge file...

..85 in year 3, and 0.74 vs 0.90 in year 4). CONCLUSION: The utilization of health care resources in patients treated surgically for GERD is associated with a modest decrease in the use of GERD-related medications and GERD-related visits...

..The objective of the study was to identify angiotensin-converting enzyme (ACE) inhibitor prescription-filling trends in pregnant women...

..CONCLUSIONS: A program congruent with existing personnel and practices of home health agencies improved medication use in a vulnerable population and was particularly effective in reducing therapeutic duplication...

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..Our objective was to assess adherence to evidence-based guidelines by providers of the Department of Veterans Affairs nationwide...

..As a result, the challenge of early detection has largely shifted to the US postmarketing systems...

..The study will provide data that clinicians need to prescribe these widely used medications in a way that minimizes the risk of sudden cardiac death. ..

..These projects are tightly linked to our theme/sub-theme and have the potential to materially improve clinical practice in highly vulnerable populations that often are under-represented in other research programs. ..

..The study will provide data that clinicians need to prescribe these widely used medications in a way that minimizes the risk of sudden cardiac death. ..