Research Topics
| Charles C HongSummaryAffiliation: Vanderbilt University Country: USA Publications
Research Grants
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Detail Information
Publications
Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specificationCharles C Hong
Division of Cardiovascular Medicine, Vanderbilt University Medical Center, 383 PRB, 2220 Pierce Ave, Nashville, TN 37232, USA
Circ Res 103:573-9. 2008....- Large-scale small-molecule screen using zebrafish embryosCharles C Hong
Division of Cardiovascular Medicine, Department of Pharmacology, Vanderbilt University School of Medicine, 383 Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232, USA
Methods Mol Biol 486:43-55. 2009..Thus, in a manner analogous to classical genetic screens, zebrafish chemical screens have the potential to reveal novel insights into complex biological pathways, as well as to identify lead compounds for novel therapeutics... - In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitorsJijun Hao
Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
ACS Chem Biol 5:245-53. 2010.... - Applications of small molecule BMP inhibitors in physiology and diseaseCharles C Hong
Division of Cardiovascular Medicine and Center for Inherited Heart Disease, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, United States
Cytokine Growth Factor Rev 20:409-18. 2009..We also discuss several potential applications for small molecule BMP inhibitors, including stem cell manipulation, and the therapeutic modification of bone remodeling, heterotopic ossification, and iron homeostasis... - Multi-step usage of in vivo models during rational drug design and discoveryCharles H Williams
Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA E mail
Int J Mol Sci 12:2262-74. 2011..This systems biology based approach paired with the power of computational biology; genetics and developmental biology provide a methodological framework to avoid the pitfalls of traditional target based drug design... - Modified mouse embryonic stem cell based assay for quantifying cardiogenic induction efficiencyAda Ao
Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine
J Vis Exp . 2011..In addition, the 96-well format has the potential to be further developed as a high throughput, automated assay to allow for the testing of more sophisticated experimental hypotheses... - Regenerative chemical biology: current challenges and future potentialAda Ao
Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, 2220 Pierce Avenue, 383 PRB, Nashville, TN 37232, USA
Chem Biol 18:413-24. 2011..Current chemical biology studies will provide the archetype for future interdisciplinary collaborations and improve clinical benefits of cell-based therapies... - sFRP2 suppression of bone morphogenic protein (BMP) and Wnt signaling mediates mesenchymal stem cell (MSC) self-renewal promoting engraftment and myocardial repairMaria P Alfaro
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Biol Chem 285:35645-53. 2010..This work provides important new insight into the mechanisms by which sFRP2 increases MSC self-renewal leading to superior tissue engraftment and enhanced wound healing... - Large scale zebrafish-based in vivo small molecule screenJijun Hao
Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine
J Vis Exp . 2010..Here, we demonstrate a simple, practical method for large-scale screening of small molecules using zebrafish embryos... - Application of small organic molecules reveals cooperative TGF? and BMP regulation of mesothelial cell behaviorsEmily E Cross
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States
ACS Chem Biol 6:952-61. 2011..Taken together, these data establish the efficacy of chemical intervention for analysis of epicardial behaviors and provide novel reagents for analysis of epicardial development and repair... - Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cellsJijun Hao
Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
PLoS ONE 3:e2904. 2008..Small molecule modulators of developmental pathways like dorsomorphin could become versatile pharmacological tools for stem cell research and regenerative medicine... - Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signalingCharles C Hong
Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Biol 16:1366-72. 2006..In summary, chemical genetic analysis has uncovered unanticipated opposing roles of PI3K and ERK in artery/vein specification... - Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cellsPaul B Yu
Cardiovascular Research Center and Anesthesia Center for Critical Care Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Biol Chem 283:3877-88. 2008..These data suggest that sustained BMP pathway activation, such as that mediated by BMPRII, is necessary for growth and differentiation control in vascular smooth muscle... - Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolismPaul B Yu
Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
Nat Chem Biol 4:33-41. 2008..These findings suggest an essential physiological role for hepatic BMP signaling in iron-hepcidin homeostasis...
Research Grants
- Chemical Genetics of Vertebrate Vascular DevelopmentCharles Hong; Fiscal Year: 2006..Hong's emergence as an independent investigator in the field of basic vascular biology. ..
- Cardiac Induction by Small Molecule BMP InhibitorsCharles C Hong; Fiscal Year: 2010..This project aims to study how these drugs promote heart cell formation and to examine whether they can boost the beneficial effects of stem cells in a mouse model of heart attacks. ..