Research Topics
Species | Bryan A CottonSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategiesBryan A Cotton
Department of General Surgery, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
Shock 26:115-21. 2006..Future resuscitation research is likely to focus on improvements in fluid composition and adjuncts to administration of large volume of fluid...- Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilizationBryan A Cotton
Departments of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Trauma 64:1177-82; discussion 1182-3. 2008.... - Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complicationsBryan A Cotton
Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37212, USA
J Trauma 66:41-8; discussion 48-9. 2009..The purpose of this study was to determine whether MT protocols are associated with increased organ failure and complications... - Beta-blocker exposure is associated with improved survival after severe traumatic brain injuryBryan A Cotton
Departments of Surgery, Vanderbilt University Medical Center, Nashville, TN 37212, USA
J Trauma 62:26-33; discussion 33-5. 2007..Traumatic brain injury (TBI) is often associated with a hyperadrenergic state. We hypothesized that adrenergic blockade would confer improved survival among TBI patients... - Respiratory complications and mortality risk associated with thoracic spine injuryBryan A Cotton
Department of Surgery, Division of Traumatology and Surgical Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Trauma 59:1400-7; discussion 1407-9. 2005..We sought to determine whether high-thoracic (HT) SCI was associated with a similar increased risk of respiratory complications and death... - Increased risk of adrenal insufficiency following etomidate exposure in critically injured patientsBryan A Cotton
Division of Trauma and Surgical Critical Care, Department of Surgery, Vanderbilt University Medical Center, 1211 21st Ave S, 404 Medical Arts Bldg, Nashville, TN 37212, USA
Arch Surg 143:62-7; discussion 67. 2008..Timely diagnosis and treatment of adrenal insufficiency (AI) dramatically reduces mortality in trauma patients. We sought to identify risk factors and populations with a high risk of developing AI... - Impact of closure at the first take back: complication burden and potential overutilization of damage control laparotomyQuinton M Hatch
Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
J Trauma 71:1503-11. 2011.... - Room for (performance) improvement: provider-related factors associated with poor outcomes in massive transfusionBryan A Cotton
Department of Surgery, Center for Translational Injury Research, The University of Texas Health Science Center, Houston, Texas 77030, USA
J Trauma 67:1004-12. 2009..The purpose of this study was to identify the incidence and impact of MT protocol noncompliance and to intervene in provider-related events associated with poor compliance and outcomes... - Pentobarbital coma for refractory intra-cranial hypertension after severe traumatic brain injury: mortality predictions and one-year outcomes in 55 patientsGary T Marshall
Department of Surgery, Division of Trauma and General Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma 69:275-83. 2010..This is a retrospective cohort study of severe TBI patients receiving PBC at Level I Trauma Center and tertiary university hospital... - Genetic variation in complement component 2 of the classical complement pathway is associated with increased mortality and infection: a study of 627 patients with traumaJohn A Morris
Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Trauma 66:1265-70; discussion 1270-2. 2009..Consequently, genetic variation in C2 may stratify patient risk and illuminate underlying mechanisms for therapeutic intervention... - Exsanguination protocol improves survival after major hepatic traumaVictor Zaydfudim
Department of Surgery, Vanderbilt University Medical Center, D 4314 Medical Center North, Nashville, TN 37232 2730, USA
Injury 41:30-4. 2010..We hypothesised that utilisation of our institution's TEP at the initiation of hospital resuscitation would improve survival in patients with significant hepatic trauma... - Use of scene vital signs improves TRISS predicted survival in intubated trauma patientsIgor V Voskresensky
Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
J Surg Res 154:105-11. 2009..The purpose of this study was to assess the impact of scene vital signs on predicting survival in intubated trauma patients... - Massive transfusion protocols for patients with substantial hemorrhagePampee P Young
Department of Pathology, Vanderbilt University School of Medicine, 1161 21st Ave South, C2217A MCN, Nashville, TN 37232, USA
Transfus Med Rev 25:293-303. 2011..However, the use of MTPs remains controversial. This review describes published experiences with MTPs and illustrates the potential value of several MTPs currently utilized by academic transfusion services... - Acute adrenal insufficiency may affect outcome in the trauma patientOscar D Guillamondegui
Department of Surgery, Division of Trauma, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
Am Surg 75:287-90. 2009.... - Postoperative neuromuscular blocker use is associated with higher primary fascial closure rates after damage control laparotomyChadi T Abouassaly
Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Trauma 69:557-61. 2010..The purpose of this study was to determine whether exposure to NMBA is associated a higher likelihood of primary fascial closure... - Prevalence and implications of preinjury warfarin use: an analysis of the National Trauma DatabankLesly A Dossett
Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Arch Surg 146:565-70. 2011..To describe the prevalence of preinjury warfarin use in a large national sample of trauma patients and to define the relationship between preinjury warfarin use and mortality... - Emergency department blood transfusion predicts early massive transfusion and early blood component requirementTimothy C Nunez
Department of Surgery, Brooke Army Medical Center, Fort Sam Houston, Texas, USA
Transfusion 50:1914-20. 2010..The purpose of this study was to evaluate the ability of uncrossmatched transfusions in the emergency department (ED) to predict early (< 6 hr) massive transfusion (MT) of red blood cells (RBCs) and blood components... - Prevalence and risk factors for development of delirium in burn intensive care unit patientsVivek Agarwal
Vanderbilt School of Medicine, Nashville, Tennessee, USA
J Burn Care Res 31:706-15. 2010..Exposure to benzodiazepines was an independent risk factor for delirium, whereas opiates and methadone reduced the risk of developing delirium, possibly through reduction of pain in these patients... - Early prediction of massive transfusion in trauma: simple as ABC (assessment of blood consumption)?Timothy C Nunez
Department of Surgery, Division of Trauma and Surgical Critical Care, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Trauma 66:346-52. 2009..The purpose of this study was to validate previously described MT scoring systems and compare these to a simplified nonlaboratory dependent scoring system (Assessment of Blood Consumption [ABC] score)... - Hyperkalemia following massive transfusion in traumaBrigham K Au
Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Surg Res 157:284-9. 2009..The purpose of the current study was to determine whether critically injured patients receiving massive transfusions are at an increased risk of hyperkalemia... - Optimizing outcomes in damage control resuscitation: identifying blood product ratios associated with improved survivalOliver L Gunter
Department of General Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Trauma 65:527-34. 2008..The purpose of this study was to evaluate whether suggested blood product ratios yield superior survival rates... - Damage control resuscitation is associated with a reduction in resuscitation volumes and improvement in survival in 390 damage control laparotomy patientsBryan A Cotton
Department of Surgery, The University of Texas Health Science Center, Houston, TX, USA
Ann Surg 254:598-605. 2011..To determine whether implementation of damage control resuscitation (DCR) in patients undergoing damage control laparotomy (DCL) translates into improved survival... - Rapid thrombelastography delivers real-time results that predict transfusion within 1 hour of admissionBryan A Cotton
Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
J Trauma 71:407-14; discussion 414-7. 2011..The purpose of this pilot study was to evaluate the timeliness of r-TEG results, their correlation with CCTs, and the ability of r-TEG to predict early blood transfusion... - Donor conversion and organ yield in traumatic brain injury patients: missed opportunities and missed organsClinton D Kemp
Department of Surgery, Division of Trauma, Emergency Surgery, and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Trauma 64:1573-80. 2008..The purpose of this study was to define donation patterns and lost donor opportunities in severe traumatic brain injury (TBI) patients... - Creation, implementation, and maturation of a massive transfusion protocol for the exsanguinating trauma patientTimothy C Nunez
Department of Surgery, Brooke Army Medical Center, Fort Sam Houston, Texas, USA
J Trauma 68:1498-505. 2010..Once implemented, this process may lead to improved clinical outcomes and decreased overall blood utilization with extremely small wastage of vital blood products... - Unique pattern of complications in elderly trauma patients at a Level I trauma centerSasha D Adams
Department of Surgery, Center for Translational Injury Research, The University of Texas Health Science Center, Houston, Texas, USA
J Trauma Acute Care Surg 72:112-8. 2012..We hypothesized that elderly patients would have different complication patterns than their younger counterparts... - How we die: the impact of nonneurologic organ dysfunction after severe traumatic brain injuryClinton D Kemp
Department of Surgery Division of Trauma and Surgical Critical Care, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
Am Surg 74:866-72. 2008..These findings demonstrate the impact of the extracranial manifestations of severe TBI on overall mortality and highlight potential areas for future intervention and research... - Secondary abdominal compartment syndrome after severe extremity injury: are early, aggressive fluid resuscitation strategies to blame?Michael C Madigan
Department of Surgery, Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Trauma 64:280-5. 2008..We hypothesized that poor resuscitation techniques, including early and excessive crystalloid administration, places patients with extremity injuries at risk for developing secondary ACS... - Comparison of massive blood transfusion predictive models in the rural settingNicole J Krumrei
Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA
J Trauma Acute Care Surg 72:211-5. 2012..Our purpose was to validate these MT predictive models in our rural Level I trauma center patient population, using all major trauma victims, regardless of blood product requirements... - Beta-blocker exposure in patients with severe traumatic brain injury (TBI) and cardiac uncouplingWilliam P Riordan
Departments of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
J Trauma 63:503-10; discussion 510-1. 2007..The purpose of the present study was to evaluate the effect of betaB exposure on the mortality risk of patients with severe TBI and early cardiac uncoupling... - Guidelines for prehospital fluid resuscitation in the injured patientBryan A Cotton
Department of Surgery, University of Texas Health Science Center, Houston, Texas 77030, USA
J Trauma 67:389-402. 2009..for access? (3) if access is achieved, should intravenous fluids be administered? (4) if fluids are to be administered, which solution is preferred? and (5) if fluids are to be administered, what volume and rate should be infused?.. - Impact of high-dose antioxidants on outcomes in acutely injured patientsBryan R Collier
Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37212, USA
JPEN J Parenter Enteral Nutr 32:384-8. 2008..The purpose of this study was to evaluate the impact of high-dose antioxidant administration on the mortality rate of acutely injured patients... - Implementation, reliability testing, and compliance monitoring of the Confusion Assessment Method for the Intensive Care Unit in trauma patientsStacie L Soja
Department of Pharmacy, Vanderbilt University Medical Center, Nashville, TN 37212, USA
Intensive Care Med 34:1263-8. 2008..To implement delirium monitoring, test reliability, and monitor compliance of performing the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) in trauma patients... - Emergency airway management in critically injured patients: a survey of U.S. aero-medical transport programsDorsha N James
Department of Emergency Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Resuscitation 80:650-7. 2009..The purpose of this study was to evaluate current practice patterns of airway management in trauma among U.S. aero-medical service (AMS) programs... - All bleeding stops: how we can helpWilliam P Riordan
Vanderbilt University Medical Center, 1211 21stAvenue South, 404 Medical Arts Building, Nashville, TN 37212, USA
Crit Care 14:146. 2010..Many of the recommendations are appropriately broad enough to promote the use of clinical judgment in the application of the guidelines... - Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patientsPratik Pandharipande
Department of Anesthesia Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Trauma 65:34-41. 2008..The purpose of this study was to analyze the prevalence of and risk factors for delirium in surgical and trauma ICU patients... - Transfusion therapy in hemorrhagic shockTimothy C Nunez
Department of Surgery, Brooke Army Medical Center, Fort Sam Houston, USA
Curr Opin Crit Care 15:536-41. 2009..This review will focus on this resuscitation strategy of transfusing blood products (red cells, plasma, and platelets) early and often in the exsanguinating patient... - Prehospital intravenous fluid administration is associated with higher mortality in trauma patients: a National Trauma Data Bank analysisElliott R Haut
Division of Acute Care Surgery, Department of Surgery, The Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287, USA
Ann Surg 253:371-7. 2011..We hypothesized that trauma patients who received prehospital IV fluids have higher mortality than trauma patients who did not receive IV fluids in the prehospital setting... - Straight for the jugular: managing blunt & penetrating neck trauma in the fieldTodd M Burda
Vanderbilt Life Flight, Vanderbilt University Medical Center, Nashville, Tennessee, USA
JEMS 32:40-6, 49. 2007 - Unwarranted national variation in the use of prophylactic inferior vena cava filters after trauma: an analysis of the National Trauma DatabankLesly A Dossett
Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Trauma 70:1066-70; discussion 1070-1. 2011..S. trauma centers would practice according to Eastern Association for the Surgery of Trauma guidelines and that any variation in practice patterns would be due to variations in the number of high-risk patients treated... - Use of goniometry to predict inadequate flexion-extension roentgenograms: a preliminary studyBryan A Cotton
Department of Surgery, Division of Traumatology and Surgical Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
J Trauma 59:396-401. 2005..0 versus 7.69%). Early identification of these patients will help limit the number of inadequate studies obtained and expedite evaluation of high-risk patients... - Penetrating trauma in childrenBryan A Cotton
From the Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
Semin Pediatr Surg 13:87-97. 2004..Management approaches have been adopted in large part from the more robust adult experience. However, application of these strategies to similar life-threatening injuries in the pediatric population appears appropriate... - The utility of clinical and laboratory data for predicting intraabdominal injury among childrenBryan A Cotton
University of Missouri Hospitals and Clinics, Division of General Surgery and Critical Care, Department of Surgery, Columbia, Missouri, USA
J Trauma 56:1068-74; discussion 1074-5. 2004..Application of these findings may be useful in reducing costs and improving the accuracy of diagnosing IAI among children... - Cost-effectiveness of routine radiographs after emergent open cavity operationsLesly A Dossett
Department of Surgery, Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN, USA
Surgery 144:317-21. 2008..We hypothesized that the institutional costs resulting from a RSS would make routine intraoperative radiography (IOR) more cost-effective than surgical counts in preventing RSS after emergent open cavity cases... - Treatments for reversing warfarin anticoagulation in patients with acute intracranial hemorrhage: a structured literature reviewBrett F Bechtel
Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Int J Emerg Med 4:40. 2011..abstract:.. - Long-term cognitive, emotional, and functional outcomes in trauma intensive care unit survivors without intracranial hemorrhageJames C Jackson
Division of Allergy Pulmonary Critical Care Medicine, Center for Health Services Research, Department of Psychiatry, Vanderbilt University School of Medicine, Nashville TN, USA
J Trauma 62:80-8. 2007.... - Necrotizing chest wall infection after blunt trauma: case report and review of the literatureJulian E Losanoff
Department of Surgery, University of Missouri-Columbia, 65212, USA
J Trauma 53:787-9. 2002 - Increased levels of serum S100B protein in critically ill patients without brain injury: Shock 26(1):20-24, 2006Bryan A Cotton
Shock 27:338; author reply 339. 2007 - Re: Increased levels of serum S100B protein in critically ill patients without brain injuryBryan A Cotton
Shock 30:222; author reply 222-3. 2008 - The utility of clinical and laboratory data for predicting intraabdominal injury among childrenBryan A Cotton
J Trauma 58:1306-7. 2005 - Motoric subtypes of delirium in mechanically ventilated surgical and trauma intensive care unit patientsPratik Pandharipande
Vanderbilt University School of Medicine corrected Department of Anesthesia Critical Care Medicine, 1121 21st Ave So, Nashville MAB 526, TN corrected 37212, USA
Intensive Care Med 33:1726-31. 2007..Their use, however, has not been reported in surgical and trauma patients. The objective of this study was to identify the prevalence of the motoric subtypes of delirium in surgical and trauma ICU patients...