Research Topics
Species | Bassel Abou-KhalilSummaryAffiliation: Vanderbilt University Country: USA Publications
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Publications
An update on determination of language dominance in screening for epilepsy surgery: the Wada test and newer noninvasive alternativesBassel Abou-Khalil
Department of Neurology, Vanderbilt University, Nashville, TN 37232, USA
Epilepsia 48:442-55. 2007..Some of the techniques also provide localization of language functions, whereas the Wada test is strictly a lateralization method. Based on widespread availability, fMRI will likely be the most widely used alternative...- Resting functional MRI with temporal clustering analysis for localization of epileptic activity without EEGVictoria L Morgan
Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232 2675, USA
Neuroimage 21:473-81. 2004..The greatest potential benefit of this technique will be in the evaluation of patients with suspected extratemporal lobe epilepsy and patients whose standard assessments are discordant... - A new locus for autosomal dominant generalized epilepsy associated with mild mental retardation on chromosome 3pMarcia A Blair
Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232 8552, USA
Epilepsia 52:993-9. 2011..Herein we report results of linkage analysis in a large family with autosomal dominant (AD) generalized epilepsy associated with MR... - Mutations in GABRA1, GABRA5, GABRG2 and GABRD receptor genes are not a major factor in the pathogenesis of familial focal epilepsy preceded by febrile seizuresShaochun Ma
Department of Neurology, Vanderbilt University, Nashville, TN 37232 8552, USA
Neurosci Lett 394:74-8. 2006..We conclude that these genes are not a major genetic factor in familial TLE preceded by FS... - Cluster analysis detection of functional MRI activity in temporal lobe epilepsyVictoria L Morgan
Vanderbilt University Institute for Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University, 1161 21st Avenue South, Nashville, TN 37232 2310, USA
Epilepsy Res 76:22-33. 2007.... - Autosomal dominant lateral temporal epilepsy: two families with novel mutations in the LGI1 genePeter Hedera
Department of Neurology, Program in Human Genetics, Vanderbilt University, Nashville, Tennessee 37232 8552, USA
Epilepsia 45:218-22. 2004..ADLTE is characterized by partial seizures with symptoms suggestive of a lateral temporal onset, including frequent auditory aura. Here we report the results of clinical and genetic analyses of two newly identified families with ADTLE... - Aphasic or amnesic status epilepticus detected on PET but not EEGChristine Dong
Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232, USA
Epilepsia 50:251-5. 2009..To describe five patients with ictal aphasia and one patient with ictal amnesia, who had focal positron emission tomography (PET) hypermetabolism but no clear ictal activity on electroencephalography (EEG)... - Generalized-onset seizures with secondary focal evolutionRandy Williamson
Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA
Epilepsia 50:1827-32. 2009..Generalized-onset seizures that acquire focal features are easily misdiagnosed as complex partial. These seizures have a more favorable response to medications effective against generalized absence and myoclonic seizures... - Functional epileptic network in left mesial temporal lobe epilepsy detected using resting fMRIVictoria L Morgan
AA 1105 MCN, Vanderbilt University Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232 2310, USA
Epilepsy Res 88:168-78. 2010.... - The GABBR1 locus and the G1465A variant is not associated with temporal lobe epilepsy preceded by febrile seizuresShaochun Ma
Department of Neurology, Vanderbilt University, 465 21st Avenue South, 6140 MRB III, Nashville, TN 37232 8552, USA
BMC Med Genet 6:13. 2005..We attempted to replicate this study in our cohort of patients with TLE. Furthermore, we also analyzed the coding sequence of this gene and searched for disease-causing mutations... - Long-term experience with levetiracetamBassel Abou-Khalil
Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 3375, United States
Epileptic Disord 5:S33-7. 2003..Levetiracetam may allow patients to decrease the number of concomi-tant antiepileptic medications or withdraw to monotherapy. Add-on therapy with levetiracetam should be considered when additional control of seizures is needed... - Cross hippocampal influence in mesial temporal lobe epilepsy measured with high temporal resolution functional magnetic resonance imagingVictoria L Morgan
Department of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232 2310, USA
Epilepsia 52:1741-9. 2011..Therefore, the objective of this study was to quantify cross hippocampal influence in mTLE using high temporal resolution fMRI, and to determine its relationship with disease duration... - Epilepsy and the impact of an epileptology clinic for patients with mental retardation and associated disabilities in an institutional settingAmir Arain
Vanderbilt University, Department of Neurology, Nashville, Tennessee 37232, USA
Epilepsia 47:2052-7. 2006..Epilepsy is a common problem in institutionalized patients with multiple handicaps. Limited data exist on the characteristics of epilepsy in this patient population and the impact of systematic evaluation by an epilepsy service... - Propofol withdrawal seizures: non-epileptic nature of seizures in a patient with recently controlled status epilepticusSalman Zubair
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
Epileptic Disord 13:107-10. 2011..We propose that seizure-like phenomena associated with propofol withdrawal may not be ictal in nature and should not lead to unnecessary resumption of propofol infusion without documentation of an epileptic origin by EEG... - Mutations in the GABRA1 and EFHC1 genes are rare in familial juvenile myoclonic epilepsyShaochun Ma
Department of Neurology, Vanderbilt University, 465 21st Avenue South, 6140 MRB III, Nashville, TN 37232 8552, USA
Epilepsy Res 71:129-34. 2006..Our data suggests that the majority of familial AD JME is not caused by mutations in the GABRA1 and EFHC1 genes... - Clinical features of epilepsy in patients with cerebellar structural abnormalities in a referral centerMaria V Recio
Department of Neurology, Vanderbilt University, 2311 Pierce Avenue, Nashville, TN 37232, USA
Epilepsy Res 76:1-5. 2007..The objective of this study was to describe epilepsy localization, clinical features and surgery outcome in patients with epilepsy and cerebellar structural abnormalities... - In vivo hippocampal metabolic dysfunction in human temporal lobe epilepsyRobert C Knowlton
UAB Epilepsy Center, Department of Neurology, University of Alabama at Birmingham School of Medicine, 35294 0021, USA
Arch Neurol 59:1882-6. 2002..The nature of functional metabolic disturbances in mesial temporal lobe epilepsy remains unclear... - Obstructive sleep apnea is associated with seizure occurrence in older adults with epilepsyAnnette M Chihorek
Department of Neurology, Sleep Disorders Division, Vanderbilt University School of Medicine, Nashville, TN 37232 2551, USA
Neurology 69:1823-7. 2007..Our objective was to investigate whether OSA is associated with seizure exacerbation in older adults with epilepsy... - Methods for determination of language dominance: the Wada test and proposed noninvasive alternativesBassel Abou-Khalil
Department of Neurology, Vanderbilt University, A 0118 Medical Center North, Nashville, TN 37232 2551, USA
Curr Neurol Neurosci Rep 7:483-90. 2007..Based on widespread availability and the ability to provide localizing as well as lateralizing information, functional MRI will likely be the most widely used alternative... - Focal seizure propagation illustrated by fMRIHasan H Sonmezturk
Department of Neurology, Division of Epilepsy, Vanderbilt University Medical Center, Nashville, TN 37232 2551, USA
Epileptic Disord 13:92-5. 2011..fMRI can be an effective tool to study seizure onset localization and seizure propagation in patients with frequent recurrent seizures... - Levetiracetam monotherapy in juvenile myoclonic epilepsyDeron V Sharpe
Vanderbilt University Medical Center, Nashville, TN, United States
Seizure 17:64-8. 2008..Valproate, the usual first line agent for JME, has chronic adverse effects, particularly for women of childbearing potential. Since JME requires lifetime treatment, chronic adverse effects of therapy are important consideration... - FDG-PET in the diagnosis of complex partial status epilepticus originating from the frontal lobeAaron Stayman
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
Epilepsy Behav 20:721-4. 2011..FDG-PET is a potentially useful modality for diagnosing nonconvulsive status epilepticus that is not evident on electroencephalography... - Patients visiting the emergency room for seizures: insurance status and clinic follow-upFariba Farhidvash
Department of Neurology, Vanderbilt University Medical Center, A 0118 Medical Center North, Nashville, TN 37232, USA
Seizure 18:644-7. 2009..However, many epilepsy patients use the hospital emergency room (ER) as a primary resource for seizure management. We studied characteristics of these patients in comparison with patients attending an epilepsy clinic... - Benefit-risk assessment of levetiracetam in the treatment of partial seizuresBassel Abou-Khalil
Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
Drug Saf 28:871-90. 2005..Whereas somnolence, asthenia and dizziness were the most prominent adverse effects in clinical trials, behavioural adverse effects have generally been the most common reason for drug discontinuation in clinical practice... - Development of 2dTCA for the detection of irregular, transient BOLD activityVictoria L Morgan
Department of Radiology and Radiological Sciences, Vanderbilt University Institute for Imaging Science, Vanderbilt University, Nashville, Tennessee 37232 2310, USA
Hum Brain Mapp 29:57-69. 2008..A few examples of the successful application of 2dTCA to the localization of interictal activity in preliminary studies of temporal lobe epilepsy are also described... - Rhythmic delta activity represents a form of nonconvulsive status epilepticus in anti-NMDA receptor antibody encephalitisMcNeill P Kirkpatrick
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232 2551, USA
Epilepsy Behav 20:392-4. 2011..Felbamate, which has NMDA receptor antagonist activity, should be studied as a therapeutic agent in this condition... - Long-term efficacy of levetiracetam for partial seizuresBassel Abou-Khalil
Department of Neurology, Vanderbilt University Medical Center, 336 Medical Center South, 2100 Pierce Avenue, Nashville, TN 37212, USA
Seizure 14:577-85. 2005..To obtain descriptive safety and efficacy data for long-term levetiracetam therapy and to allow patients benefiting from add-on levetiracetam to continue treatment until the drug was available commercially... - Can we avoid misdiagnosis of epilepsy by discriminating between wicket rhythms and epileptiform activity?Bassel Abou-Khalil
Epilepsy Division, Vanderbilt University Medical Center, Nashville, TN 37212, USA
Nat Clin Pract Neurol 2:358-9. 2006 - Musicogenic seizures can arise from multiple temporal lobe foci: intracranial EEG analyses of three patientsTania F Tayah
Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232-8552, USA
Epilepsia 47:1402-6. 2006..Patients with medically intractable musicogenic epilepsy and with unilateral ictal onset zones may be considered candidates for resective epilepsy surgery... - Rhythmic ictal nonclonic hand (RINCH) motions: a distinct contralateral sign in temporal lobe epilepsyGeorge R Lee
Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232, USA
Epilepsia 47:2189-92. 2006..CONCLUSIONS: RINCH motions are a distinct ictal sign that could be considered a specific type of automatism. They appear to be a lateralizing contralateral sign and are associated with dystonic posturing in temporal lobe epilepsy... - Seizure freedom off antiepileptic drugs after temporal lobe epilepsy surgeryMuhammad Al Kaylani
Department of Neurology, Vanderbilt University Medical Center, 2311 Pierce Avenue, Nashville, TN 37232, USA
Seizure 16:95-8. 2007..They had a younger age at surgery than the group with seizure recurrence (p=0.01). Earlier surgery may be a favorable predictor for seizure freedom after AED discontinuation... - Levetiracetam treatment of idiopathic generalised epilepsyGregory L Krauss
Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
Seizure 12:617-20. 2003..This is preliminary evidence that LEV is effective for treating idiopathic generalised epilepsy... - Identification of a novel locus for febrile seizures and epilepsy on chromosome 21q22Peter Hedera
Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232 8552, USA
Epilepsia 47:1622-8. 2006..To report results of linkage analysis in a large family with autosomal dominant (AD) febrile seizures (FS) and epilepsy... - Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy SocietyJacqueline A French
Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Epilepsia 45:401-9. 2004..S. Food and Drug Administration] in the treatment of children and adults with newly diagnosed partial and generalized epilepsies... - Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy SocietyJacqueline A French
Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Epilepsia 45:410-23. 2004.... - Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizuresElinor Ben-Menachem
Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Epilepsia 48:1308-17. 2007.... - Posttraumatic stress disorder in a patient with no left amygdalaStephen D Smith
Department of Psychology, University of Winnipeg, Winnipeg, Manitoba, Canada
J Abnorm Psychol 117:479-84. 2008..The authors propose that the right amygdala is preferentially involved in several processes related to the expression of PTSD symptoms, such that the disorder can occur even in the absence of the left amygdala... - Is it time to replace the Wada test?Bassel Abou-Khalil
Neurology 59:160-1. 2002