John Wambaugh

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi Simulating quantitative cellular responses using asynchronous threshold Boolean network ensembles
    John Jack
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    BMC Syst Biol 5:109. 2011
  2. ncbi Comparing models for perfluorooctanoic acid pharmacokinetics using Bayesian analysis
    John F Wambaugh
    National Center for Computational Toxicology, US EPA, Research Triangle Park, NC 27711, USA
    J Pharmacokinet Pharmacodyn 35:683-712. 2008
  3. ncbi Simulating microdosimetry in a virtual hepatic lobule
    John Wambaugh
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
    PLoS Comput Biol 6:e1000756. 2010
  4. ncbi Virtual tissues in toxicology
    Imran Shah
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health B Crit Rev 13:314-28. 2010
  5. ncbi Using nuclear receptor activity to stratify hepatocarcinogens
    Imran Shah
    National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e14584. 2011

Detail Information

Publications5

  1. ncbi Simulating quantitative cellular responses using asynchronous threshold Boolean network ensembles
    John Jack
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    BMC Syst Biol 5:109. 2011
    ..This results in noisy but highly reproducible aggregate level responses that are consistent with experimental data...
  2. ncbi Comparing models for perfluorooctanoic acid pharmacokinetics using Bayesian analysis
    John F Wambaugh
    National Center for Computational Toxicology, US EPA, Research Triangle Park, NC 27711, USA
    J Pharmacokinet Pharmacodyn 35:683-712. 2008
    ..We conclude that the available data may support more models for PFOA PK beyond two-compartments and that the methods employed here will be generally useful for more complicated, including PBPK, models...
  3. ncbi Simulating microdosimetry in a virtual hepatic lobule
    John Wambaugh
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
    PLoS Comput Biol 6:e1000756. 2010
    ..The mass-balanced graphical approach to modeling the hepatic lobule is computationally efficient for simulating long-term exposure, modular for incorporating complex cellular interactions, and flexible for dealing with evolving tissues...
  4. ncbi Virtual tissues in toxicology
    Imran Shah
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health B Crit Rev 13:314-28. 2010
    ..This investigation presents the motivation, implementation, and application of VT with examples from hepatotoxicity and carcinogenesis...
  5. ncbi Using nuclear receptor activity to stratify hepatocarcinogens
    Imran Shah
    National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e14584. 2011
    ..Here we report on a systematic analysis of new in vitro human NR activity data on 309 environmental chemicals in relationship to their liver cancer-related chronic outcomes in rodents...