Research Topics
| J C RockettSummaryAffiliation: U.S. Environmental Protection Agency Country: USA Publications
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Detail Information
Publications
Use of genomic data in risk assessmentJohn C Rockett
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Genome Biol 3:REPORTS4011. 2002- Application of DNA arrays to toxicologyJ C Rockett
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Environ Health Perspect 107:681-5. 1999..Arrays may also prove useful for monitoring genetic variability and its relationship to toxicant susceptibility in human populations... - Confirming microarray data--is it really necessary?John C Rockett
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Genomics 83:541-9. 2004..We also report the results of a poll in which 76 life science journals were asked about their current or intended policies on the inclusion of corroborative studies in papers containing microarray data... - Surrogate tissue analysis: monitoring toxicant exposure and health status of inaccessible tissues through the analysis of accessible tissues and cellsJohn C Rockett
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Appl Pharmacol 194:189-99. 2004..Also discussed are some of the challenges that must be overcome if the utility of STA is to be proven, and thus permit researchers to move this concept from the laboratory to the clinical environment... - Biomarkers for assessing reproductive development and health: Part 1--Pubertal developmentJohn C Rockett
Gamete and Early Embryo Biology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Environ Health Perspect 112:105-12. 2004..In this review, we discuss some of the current and emerging biomarkers of human pubertal development... - The value of home-based collection of biospecimens in reproductive epidemiologyJohn C Rockett
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Environ Health Perspect 112:94-104. 2004..Such biospecimens are useful in the monitoring of reproductive development and function... - To confirm or not to confirm (microarray data)--that is the questionJohn C Rockett
Reproductive Toxicology Division MD 72, National Health and Environmental Effects Research Laboratory, US EPA, Research Triangle Park, NC 27711, USA
Drug Discov Today 8:343. 2003..A letter discussing the issues surrounding post-hybridization confirmatory studies of microarray data... - Macroresults through microarraysJohn C Rockett
Reproductive Toxicology Division (MD-72, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, 2525 East Highway 54, Durham, NC 27711, USA
Drug Discov Today 7:804-5. 2002 - DNA arrays to monitor gene expression in rat blood and uterus following 17beta-estradiol exposure: biomonitoring environmental effects using surrogate tissuesJohn C Rockett
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 69:49-59. 2002.... - Chip, chip, array! Three chips for post-genomic researchJohn C Rockett
Reproductive Toxicology Division, US Environmental Protection Agency, 2525 East Highway 54, Research Triangle Park, NC 27711, USA
Drug Discov Today 7:458-9. 2002 - Genomic and proteomic techniques applied to reproductive biologyJ C Rockett
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Genome Biol 2:REPORTS4020. 2001..A report on the Frontiers in Reproduction Symposium 2001 'Reproductive genetics, genomics and proteomics: advances in genetic, molecular and bioinformatics techniques', Cambridge, USA, 30 June to 1 July, 2001... - Development of a 950-gene DNA array for examining gene expression patterns in mouse testisJ C Rockett
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Genome Biol 2:RESEARCH0014. 2001..We found that suppliers did not provide an array to suit our particular interest in testicular toxicology, and therefore elected to design and produce our own... - DNA arrays: technology, options and toxicological applicationsJ C Rockett
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, NC 27711, USA
Xenobiotica 30:155-77. 2000..This review discusses the technology behind the production of DNA arrays, the options available to those interested in applying them to their own research, and the possible toxicological applications of this exciting new technology... - Effects of hyperthermia on spermatogenesis, apoptosis, gene expression, and fertility in adult male miceJ C Rockett
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Biol Reprod 65:229-39. 2001..Thus, the array data identify numerous candidate genes for further analysis in the heat-shocked testis model, and suggest multiple possible mechanisms for heat shock-induced infertility... - Biomarkers of reproductive toxicityJohn C Rockett
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Cancer Biomark 1:93-108. 2005.... - Gene expression in head hair follicles plucked from men and womenSung Jae Kim
Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Ann Clin Lab Sci 36:115-26. 2006..The differentially expressed genes could be involved in producing gender and interindividual differences in hair growth... - Effects of storage, RNA extraction, genechip type, and donor sex on gene expression profiling of human whole bloodSung Jae Kim
National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Clin Chem 53:1038-45. 2007..In addition, characterization of interindividual and sex-based variation in gene expression is needed to understand sources and extent of variability... - Effect of conazole fungicides on reproductive development in the female ratJohn C Rockett
Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Reprod Toxicol 22:647-58. 2006..It is concluded that exposure to P, M and T adversely impacted female rodent reproductive development... - Reproductive and genomic effects in testes from mice exposed to the water disinfectant byproduct bromochloroacetic acidDouglas B Tully
National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, 27711, USA
Reprod Toxicol 19:353-66. 2005..Modulated expression of these genes, particularly the 15 expressed in Sertoli cells and spermatids, offers new insights into potential mechanisms of BCA toxicity in the mouse testis... - Gene expression profiling in liver and testis of rats to characterize the toxicity of triazole fungicidesDouglas B Tully
Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Appl Pharmacol 215:260-73. 2006..Triazoles also affected expression of multiple genes involved in steroid hormone metabolism in the two tissues. Thus, gene expression profiles helped identify possible toxicological mechanisms of the triazole fungicides... - Gene expression profiling in the liver of CD-1 mice to characterize the hepatotoxicity of triazole fungicidesAmber K Goetz
Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Appl Pharmacol 215:274-84. 2006..Based on these results, we expanded on our original hypothesis that triazole hepatotoxicity was mediated by CYP induction, to include additional XME genes, many of which are modulated by CAR and PXR... - Probing the nature of microarray-based oligonucleotidesJohn C Rockett
Reproductive Toxicology Division (MD-72, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Drug Discov Today 8:389. 2003 - Gene expression patterns associated with infertility in humans and rodent modelsJohn C Rockett
Reproductive Toxicology Division MD 72, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Mutat Res 549:225-40. 2004.... - Prospective pregnancy study designs for assessing reproductive and developmental toxicantsGermaine M Buck
Epidemiology Branch, National Institute of Child Health and Human Development, National Institutes of Health DHHS, 6100 Executive Boulevard, Rm 7B03, Rockville, MD 20852, USA
Environ Health Perspect 112:79-86. 2004..Length of follow-up varied from 3 to 12 months. A high percentage of women provided urine (57-98%) and blood (86-91%) specimens and most male partners (94-100%) provided semen samples. These data support the feasibility of this design... - Overview of an interlaboratory collaboration on evaluating the effects of model hepatotoxicants on hepatic gene expressionRoger G Ulrich
Rosetta Inpharmatics, Merck Research Laboratories, Kirkland, Washington, USA
Environ Health Perspect 112:423-7. 2004..This effort represents an important first step toward the use of transcriptional profiling in risk assessment... - Success and failure in human spermatogenesis as revealed by teratozoospermic RNAsAdrian E Platts
Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA
Hum Mol Genet 16:763-73. 2007..The origin of the perturbation could be traced as far back as the pachytene stage of spermatogenesis. It is anticipated that this diagnostic strategy will prove valuable for understanding male factor infertility... - Clofibrate-induced gene expression changes in rat liver: a cross-laboratory analysis using membrane cDNA arraysValerie A Baker
Safety and Environmental Assurance Centre, Unilever Research Colworth, Sharnbrook, Bedfordshire, United Kingdom
Environ Health Perspect 112:428-38. 2004..In summary, this study demonstrates the potential for gene expression profiling to identify toxic hazards by the identification of mechanistically relevant markers of toxicity... - Disruption of testosterone homeostasis as a mode of action for the reproductive toxicity of triazole fungicides in the male ratAmber K Goetz
Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695, USA
Toxicol Sci 95:227-39. 2007..These reproductive effects are consistent with the disruption of testosterone homeostasis as a key event in the mode of action for triazole-induced reproductive toxicity... - Biomarkers of ovulation, endometrial receptivity, fertilisation, implantation and early pregnancy progressionKenneth L Campbell
Department of Biology, University of Massachusetts Boston, Boston, MA 02125 3393, USA
Paediatr Perinat Epidemiol 20:13-25. 2006....