Thomas B Knudsen

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB
    Thomas B Knudsen
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Reprod Toxicol 28:209-19. 2009
  2. ncbi Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets
    Thomas B Knudsen
    National Center for Computational Toxicology B205 01, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 282:1-15. 2011
  3. ncbi Disruption of embryonic vascular development in predictive toxicology
    Thomas B Knudsen
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res C Embryo Today 93:312-23. 2011
  4. ncbi Developmental toxicity testing for safety assessment: new approaches and technologies
    Thomas B Knudsen
    National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res B Dev Reprod Toxicol 92:413-20. 2011
  5. ncbi The Hemimelic extra toes mouse mutant: Historical perspective on unraveling mechanisms of dysmorphogenesis
    Thomas B Knudsen
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res C Embryo Today 90:155-62. 2010
  6. ncbi Environmental impact on vascular development predicted by high-throughput screening
    Nicole C Kleinstreuer
    National Center for Computational Toxiciology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 119:1596-603. 2011
  7. ncbi Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data
    Nisha S Sipes
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 124:109-27. 2011
  8. ncbi Endocrine profiling and prioritization of environmental chemicals using ToxCast data
    David M Reif
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 118:1714-20. 2010
  9. ncbi In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 118:485-92. 2010
  10. ncbi Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Chem Res Toxicol 24:451-62. 2011

Detail Information

Publications17

  1. ncbi Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB
    Thomas B Knudsen
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Reprod Toxicol 28:209-19. 2009
    ..This novel data model provides an important public resource for cross-scale modeling and predictive understanding of developmental processes and toxicities...
  2. ncbi Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets
    Thomas B Knudsen
    National Center for Computational Toxicology B205 01, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 282:1-15. 2011
    ..The primary dataset, summary data and details on quality control checks are available for download at http://www.epa.gov/ncct/toxcast/...
  3. ncbi Disruption of embryonic vascular development in predictive toxicology
    Thomas B Knudsen
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res C Embryo Today 93:312-23. 2011
    ..As such, an adverse outcome pathway perspective of embryonic vascular development can help identify useful information for assessing adverse outcomes relevant to risk assessment and efficient use of resources for validation...
  4. ncbi Developmental toxicity testing for safety assessment: new approaches and technologies
    Thomas B Knudsen
    National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res B Dev Reprod Toxicol 92:413-20. 2011
    ..Though a daunting task, technologies are being developed and utilized to make that goal reachable...
  5. ncbi The Hemimelic extra toes mouse mutant: Historical perspective on unraveling mechanisms of dysmorphogenesis
    Thomas B Knudsen
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res C Embryo Today 90:155-62. 2010
    ....
  6. ncbi Environmental impact on vascular development predicted by high-throughput screening
    Nicole C Kleinstreuer
    National Center for Computational Toxiciology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 119:1596-603. 2011
    ....
  7. ncbi Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data
    Nisha S Sipes
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 124:109-27. 2011
    ..This work indicates the utility of HTS assays for developing pathway-level models predictive of developmental toxicity...
  8. ncbi Endocrine profiling and prioritization of environmental chemicals using ToxCast data
    David M Reif
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 118:1714-20. 2010
    ..S. EPA's Endocrine Disruptor Screening Program (EDSP) has been charged with screening pesticide chemicals and environmental contaminants for their potential to affect the endocrine systems of humans and wildlife...
  9. ncbi In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 118:485-92. 2010
    ..The U.S. Environmental Protection Agency's ToxCast program aims to address these concerns by screening and prioritizing chemicals for potential human toxicity using in vitro assays and in silico approaches...
  10. ncbi Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Chem Res Toxicol 24:451-62. 2011
    ....
  11. ncbi Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay
    Kelly J Chandler
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e18540. 2011
    ..Taken together, these results provide an initial characterization of metabolic and regulatory pathways by which some environmental chemicals may act to disrupt ES cell growth and differentiation...
  12. ncbi Predictive model of rat reproductive toxicity from ToxCast high throughput screening
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Biol Reprod 85:327-39. 2011
    ....
  13. ncbi Zebrafish: as an integrative model for twenty-first century toxicity testing
    Nisha S Sipes
    National Center for Computational Toxicology, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Birth Defects Res C Embryo Today 93:256-67. 2011
    ..Cross-species comparisons implied a common basis for biological pathways associated with neuronal defects, extracellular matrix remodeling, and mitotic arrest...
  14. ncbi Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Sci Technol 44:5979-85. 2010
    ..Two dispersants, JD 2000 and SAF-RON GOLD, were significantly less cytotoxic than the others with LC50 values approaching or exceeding 1000 ppm...
  15. ncbi Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing program
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Syst Biol Reprod Med 58:3-9. 2012
    ....
  16. ncbi Exposure-disease continuum for 2-chloro-2'-deoxyadenosine (2-CdA), a prototype teratogen: induction of lumbar hernia in the rat and species comparison for the teratogenic responses
    Christopher Lau
    Reproductive Toxicology Division, NHEERL, ORD, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Teratology 66:6-18. 2002
    ..The current study examined the teratogenic potential of this drug in the rat and compared the adverse developmental outcomes with the other species...
  17. ncbi Using pathway modules as targets for assay development in xenobiotic screening
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mol Biosyst 8:531-42. 2012
    ..These selected genes could then form the basis for a battery to test for pathway-chemical interactions under many biological contexts using throughput expression-based assays...