Research Topics
| Richard S JudsonSummaryAffiliation: U.S. Environmental Protection Agency Country: USA Publications
| Collaborators
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Detail Information
Publications
Public databases supporting computational toxicologyRichard Judson
National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
J Toxicol Environ Health B Crit Rev 13:218-31. 2010....- The toxicity data landscape for environmental chemicalsRichard Judson
National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Environ Health Perspect 117:685-95. 2009..The main objective of this analysis is to define a list of environmental chemicals that are candidates for the U.S. EPA screening and prioritization process, and to catalog the available toxicology information... - Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activityRichard S Judson
National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Environ Sci Technol 44:5979-85. 2010..Two dispersants, JD 2000 and SAF-RON GOLD, were significantly less cytotoxic than the others with LC50 values approaching or exceeding 1000 ppm... - In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast projectRichard S Judson
National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Environ Health Perspect 118:485-92. 2010..The U.S. Environmental Protection Agency's ToxCast program aims to address these concerns by screening and prioritizing chemicals for potential human toxicity using in vitro assays and in silico approaches... - ACToR--Aggregated Computational Toxicology ResourceRichard Judson
National Center for Computational Toxicology, U S Environmental Protection Agency, 109 T W Alexander Drive, Research Triangle Park, NC 27711, USA
Toxicol Appl Pharmacol 233:7-13. 2008..At the EPA National Center for Computational Toxicology, ACToR helps manage large data sets being used in a high-throughput environmental chemical screening and prioritization program called ToxCast... - A comparison of machine learning algorithms for chemical toxicity classification using a simulated multi-scale data modelRichard Judson
National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
BMC Bioinformatics 9:241. 2008..We present a novel model to simulate complex chemical-toxicology data sets and use this model to evaluate the relative performance of different machine learning (ML) methods... - Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessmentRichard S Judson
National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
Chem Res Toxicol 24:451-62. 2011.... - Using pathway modules as targets for assay development in xenobiotic screeningRichard S Judson
National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Mol Biosyst 8:531-42. 2012..These selected genes could then form the basis for a battery to test for pathway-chemical interactions under many biological contexts using throughput expression-based assays... - Environmental impact on vascular development predicted by high-throughput screeningNicole C Kleinstreuer
National Center for Computational Toxiciology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Environ Health Perspect 119:1596-603. 2011.... - Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening dataNisha S Sipes
National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 124:109-27. 2011..This work indicates the utility of HTS assays for developing pathway-level models predictive of developmental toxicity... - Endocrine profiling and prioritization of environmental chemicals using ToxCast dataDavid M Reif
National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Environ Health Perspect 118:1714-20. 2010..S. EPA's Endocrine Disruptor Screening Program (EDSP) has been charged with screening pesticide chemicals and environmental contaminants for their potential to affect the endocrine systems of humans and wildlife... - Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDBThomas B Knudsen
National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
Reprod Toxicol 28:209-19. 2009..This novel data model provides an important public resource for cross-scale modeling and predictive understanding of developmental processes and toxicities... - Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targetsThomas B Knudsen
National Center for Computational Toxicology B205 01, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicology 282:1-15. 2011..The primary dataset, summary data and details on quality control checks are available for download at http://www.epa.gov/ncct/toxcast/... - Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicalsDaniel M Rotroff
US Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, North Carolina, USA
J Toxicol Environ Health B Crit Rev 13:329-46. 2010..Significant relative risk associations with rodent in vivo chronic toxicity effects are reported for the five major receptor pathways. These gene expression data are being incorporated into the larger ToxCast predictive modeling effort... - Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast programMatthew T Martin
National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Chem Res Toxicol 23:578-90. 2010.... - Profiling chemicals based on chronic toxicity results from the U.S. EPA ToxRef DatabaseMatthew T Martin
National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Environ Health Perspect 117:392-9. 2009..These data are now accessible and mineable within ToxRefDB and are serving as a primary source of validation for U.S. EPA's ToxCast research program in predictive toxicology... - Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assayKelly J Chandler
National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
PLoS ONE 6:e18540. 2011..Taken together, these results provide an initial characterization of metabolic and regulatory pathways by which some environmental chemicals may act to disrupt ES cell growth and differentiation... - Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessmentBarbara A Wetmore
The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
Toxicol Sci 125:157-74. 2012..The incorporation of dosimetry and exposure provide necessary context for interpretation of in vitro toxicity screening data and are important considerations in determining chemical testing priorities... - Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screeningDaniel M Rotroff
National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 117:348-58. 2010..Importantly, these tools are necessary to move beyond hazard rankings to estimates of possible in vivo responses based on in vitro screens... - Using nuclear receptor activity to stratify hepatocarcinogensImran Shah
National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
PLoS ONE 6:e14584. 2011..Here we report on a systematic analysis of new in vitro human NR activity data on 309 environmental chemicals in relationship to their liver cancer-related chronic outcomes in rodents... - Predictive model of rat reproductive toxicity from ToxCast high throughput screeningMatthew T Martin
National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Biol Reprod 85:327-39. 2011.... - Profiling bioactivity of the ToxCast chemical library using BioMAP primary human cell systemsKeith A Houck
National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA
J Biomol Screen 14:1054-66. 2009..This data set is being combined with additional ToxCast data sets for development of predictive toxicity models at the EPA... - Aggregating Data for Computational Toxicology Applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) SystemRichard S Judson
U S EPA, National Center for Computational Toxicology, Research Triangle Park, NC 27709, USA E Mails M T M S G D M R P K D S J V A F S M E A C H A M R
Int J Mol Sci 13:1805-31. 2012..The entire system is built using open source tools and is freely available to download. This review describes the organization of the data repository and provides selected examples of use cases... - Profiling the reproductive toxicity of chemicals from multigeneration studies in the toxicity reference databaseMatthew T Martin
National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 110:181-90. 2009..Capturing this reproductive toxicity data in ToxRefDB supports ongoing retrospective analyses, test guideline revisions, and computational toxicology research... - Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing programMatthew T Martin
National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Syst Biol Reprod Med 58:3-9. 2012.... - Computational toxicology--a state of the science mini reviewRobert J Kavlock
National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Sci 103:14-27. 2008..The next few years should witness the early fruits of these efforts, but as the National Research Council indicates, the paradigm shift will take a long term investment and commitment to reach full potential... - Toxicity data informatics: supporting a new paradigm for toxicity predictionAnn M Richard
National Center for Computational Toxicology, U S Environmental Protection Agency, Research Triangle Park, NC, 27711
Toxicol Mech Methods 18:103-18. 2008.... - Restoring value to stalled Phase II compounds: the case for developing a novel compound for depression using pharmacogeneticsCarol Reed
Pharmacogenomics 6:95-100. 2005 - How many SNPs does a genome-wide haplotype map require?Richard Judson
Genaissance Pharmaceuticals, 5 Science Park, New Haven, CT 06511, USA
Pharmacogenomics 3:379-91. 2002..Finally, we estimate the experimental effort and cost required to complete a genome-wide haplotype survey...