Keith A Houck

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi Understanding mechanisms of toxicity: insights from drug discovery research
    Keith A Houck
    National Center for Computational Toxicology, Office Research and Development, United Stated Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 227:163-78. 2008
  2. ncbi Profiling bioactivity of the ToxCast chemical library using BioMAP primary human cell systems
    Keith A Houck
    National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    J Biomol Screen 14:1054-66. 2009
  3. ncbi Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals
    Daniel M Rotroff
    US Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, North Carolina, USA
    J Toxicol Environ Health B Crit Rev 13:329-46. 2010
  4. ncbi In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 118:485-92. 2010
  5. ncbi Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Chem Res Toxicol 24:451-62. 2011
  6. ncbi Endocrine profiling and prioritization of environmental chemicals using ToxCast data
    David M Reif
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 118:1714-20. 2010
  7. ncbi Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets
    Thomas B Knudsen
    National Center for Computational Toxicology B205 01, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 282:1-15. 2011
  8. ncbi Informing selection of nanomaterial concentrations for ToxCast in vitro testing based on occupational exposure potential
    Sumit Gangwal
    National Center for Computational Toxicology, Offce of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 119:1539-46. 2011
  9. ncbi Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment
    Barbara A Wetmore
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 125:157-74. 2012
  10. ncbi Predictive model of rat reproductive toxicity from ToxCast high throughput screening
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Biol Reprod 85:327-39. 2011

Collaborators

Detail Information

Publications19

  1. ncbi Understanding mechanisms of toxicity: insights from drug discovery research
    Keith A Houck
    National Center for Computational Toxicology, Office Research and Development, United Stated Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 227:163-78. 2008
    ..Integration of successful approaches will contribute towards building a systems approach to toxicology that will provide mechanistic understanding of the effects of chemicals on biological systems and aid in rationale risk assessments...
  2. ncbi Profiling bioactivity of the ToxCast chemical library using BioMAP primary human cell systems
    Keith A Houck
    National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    J Biomol Screen 14:1054-66. 2009
    ..This data set is being combined with additional ToxCast data sets for development of predictive toxicity models at the EPA...
  3. ncbi Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals
    Daniel M Rotroff
    US Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, North Carolina, USA
    J Toxicol Environ Health B Crit Rev 13:329-46. 2010
    ..Significant relative risk associations with rodent in vivo chronic toxicity effects are reported for the five major receptor pathways. These gene expression data are being incorporated into the larger ToxCast predictive modeling effort...
  4. ncbi In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 118:485-92. 2010
    ..The U.S. Environmental Protection Agency's ToxCast program aims to address these concerns by screening and prioritizing chemicals for potential human toxicity using in vitro assays and in silico approaches...
  5. ncbi Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Chem Res Toxicol 24:451-62. 2011
    ....
  6. ncbi Endocrine profiling and prioritization of environmental chemicals using ToxCast data
    David M Reif
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 118:1714-20. 2010
    ..S. EPA's Endocrine Disruptor Screening Program (EDSP) has been charged with screening pesticide chemicals and environmental contaminants for their potential to affect the endocrine systems of humans and wildlife...
  7. ncbi Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets
    Thomas B Knudsen
    National Center for Computational Toxicology B205 01, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 282:1-15. 2011
    ..The primary dataset, summary data and details on quality control checks are available for download at http://www.epa.gov/ncct/toxcast/...
  8. ncbi Informing selection of nanomaterial concentrations for ToxCast in vitro testing based on occupational exposure potential
    Sumit Gangwal
    National Center for Computational Toxicology, Offce of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 119:1539-46. 2011
    ..Selection of concentration levels for hazard evaluation based on real-world exposure scenarios is desirable...
  9. ncbi Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment
    Barbara A Wetmore
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 125:157-74. 2012
    ..The incorporation of dosimetry and exposure provide necessary context for interpretation of in vitro toxicity screening data and are important considerations in determining chemical testing priorities...
  10. ncbi Predictive model of rat reproductive toxicity from ToxCast high throughput screening
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Biol Reprod 85:327-39. 2011
    ....
  11. ncbi Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Chem Res Toxicol 23:578-90. 2010
    ....
  12. ncbi Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Sci Technol 44:5979-85. 2010
    ..Two dispersants, JD 2000 and SAF-RON GOLD, were significantly less cytotoxic than the others with LC50 values approaching or exceeding 1000 ppm...
  13. ncbi Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening
    Daniel M Rotroff
    National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 117:348-58. 2010
    ..Importantly, these tools are necessary to move beyond hazard rankings to estimates of possible in vivo responses based on in vitro screens...
  14. ncbi The ToxCast program for prioritizing toxicity testing of environmental chemicals
    David J Dix
    National Center for Computational Toxicology D343 03, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 95:5-12. 2007
    ..The resulting multidimensional data set provides an informatics challenge requiring appropriate computational methods for integrating various chemical, biological, and toxicological data into profiles and models predicting toxicity...
  15. ncbi T0901317 is a dual LXR/FXR agonist
    Keith A Houck
    RTP Laboratories, Eli Lilly and Company, Research Triangle Park, NC 27709, USA
    Mol Genet Metab 83:184-7. 2004
    ..Thus, the FXR activity of T0901317 must be considered when utilizing this agonist as a pharmacological tool to investigate LXR function...
  16. ncbi Cyclic AMP-independent activation of CYP3A4 gene expression by forskolin
    Michele S Dowless
    Lilly Research Laboratories, Eli Lilly and Co, 20 T.W. Alexander Drive, P.O. Box 13951, Research Triangle Park, NC 27709-3951, USA
    Eur J Pharmacol 512:9-13. 2005
    ..This activity was explained showing forskolin directly activated the pregnane-X-receptor, a known regulator of CYP3A genes...
  17. ncbi High-content screening assay for activators of the Wnt/Fzd pathway in primary human cells
    Kristen M Borchert
    Lilly Research Laboratories, Eli Lilly and Co, Research Triangle Park, NC, USA
    Assay Drug Dev Technol 3:133-41. 2005
    ..By combining standard immunofluorescence technology with automated fluorescence microscopy, we demonstrate the capability of screening cell-signaling pathways in primary human cells...
  18. ncbi A 15-ketosterol is a liver X receptor ligand that suppresses sterol-responsive element binding protein-2 activity
    Robert J Schmidt
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    J Lipid Res 47:1037-44. 2006
    ..Our data thus provide a molecular basis for the hypocholesterolemic activity of the 15-ketosterol and further suggest its potential antiatherosclerotic benefit as an LXR agonist...
  19. ncbi The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines
    Chafiq Hamdouchi
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Mol Cancer Ther 3:1-9. 2004
    ....