Research Topics
| Sd HesterSummaryAffiliation: U.S. Environmental Protection Agency Country: USA Publications
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Detail Information
Publications
Normal gene expression in male F344 rat nasal transitional and respiratory epitheliumSusan D Hester
US EPA, Research Triangle Park, NC, USA
Gene 285:301-10. 2002..g. ion channels). Such baseline data will contribute to further understanding the normal physiology of these cells and facilitate the interpretation of responses by the nasal epithelial cells to xenobiotic treatment or disease...- Formaldehyde-induced gene expression in F344 rat nasal respiratory epitheliumSusan D Hester
US Environmental Protection Agency, Research Triangle Park, NC, USA
Toxicology 187:13-24. 2003..Differential gene expression profiles may provide clues that could be used to define mechanisms involved in FA-induced nasal cancer... - Transcriptomic analysis of F344 rat nasal epithelium suggests that the lack of carcinogenic response to glutaraldehyde is due to its greater toxicity compared to formaldehydeS D Hester
Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27709, USA
Toxicol Pathol 33:415-24. 2005..The gene expression patterns suggest that glutaraldehyde's lack of carcinogenicity may be due to its greater toxicity from lack of DNA-repair, greater mitochondrial damage, and increased apoptosis... - Transcriptional profiles in liver from rats treated with tumorigenic and non-tumorigenic triazole conazole fungicides: Propiconazole, triadimefon, and myclobutanilSusan D Hester
Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Pathol 34:879-94. 2006..Pathway level analysis of altered gene expression resulted in a more complete description of the associated toxicological effects that can distinguish triadimefon from propiconazole and myclobutanil... - Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratoriesMichael J Boedigheimer
CDER, US FDA, Silver Spring, MD 20993, USA
BMC Genomics 9:285. 2008.... - Transcriptional responses in thyroid tissues from rats treated with a tumorigenic and a non-tumorigenic triazole conazole fungicideSusan D Hester
Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Appl Pharmacol 227:357-69. 2008..It is postulated that triadimefon induces oxidative response genes and activates the nuclear receptor, Ppargamma, initiating transcription of gene products and signaling to a series of genes involved in cell proliferation... - Acute toluene exposure alters expression of genes in the central nervous system associated with synaptic structure and functionSusan D Hester
Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Neurotoxicol Teratol 33:521-9. 2011..This report provides the first global genomic evidence that CNS pathways affected by toluene are strongly associated with neurological processes participating in synaptic transmission and plasticity... - Expression of AS3MT alters transcriptional profiles in human urothelial cells exposed to arseniteSd Hester
Cancer Biology Branch, ECD, NHEERL, US EPA, RTP, North Carolina, USA
Hum Exp Toxicol 28:49-61. 2009..Further analysis of these responses will help to characterize the role of AS3MT-catalyzed methylation in modulation of iAs(III) toxicity... - Comparison of comparative genomic hybridization technologies across microarray platformsSusan D Hester
Cellular Toxicology Branch, National Health and Environmental Effects Laboratory, U S Environmental Protection Agency, 109 T W Alexander Drive, Research Triangle Park, NC 27711, USA
J Biomol Tech 20:135-51. 2009..3. In the HL-60 genome, at least two of the five platforms detected five novel losses and five novel gains. This report provides guidance in the selection of platforms based on this wide-ranging evaluation of available CGH platforms... - Discrimination of tumorigenic triazole conazoles from phenobarbital by transcriptional analyses of mouse liver gene expressionStephen Nesnow
Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 110:68-83. 2009.... - Identification of interspecies concordance of mechanisms of arsenic-induced bladder cancerBanalata Sen
Environmental Carcinogenesis Division, US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
Toxicol In Vitro 21:1513-29. 2007.... - Toxicity profiles in rats treated with tumorigenic and nontumorigenic triazole conazole fungicides: Propiconazole, triadimefon, and myclobutanilDouglas C Wolf
Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, ORD, USEPA, Research Triangle Park, North Carolina 27711, USA
Toxicol Pathol 34:895-902. 2006..A unique pattern of toxic responses was not identified for each conazole and the hypothesized mode of action for triadimefon-induced thyroid gland tumors was not supported by the data... - Transcriptional profiles in liver from mice treated with hepatotumorigenic and nonhepatotumorigenic triazole conazole fungicides: Propiconazole, triadimefon, and myclobutanilWilliam O Ward
Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Pathol 34:863-78. 2006.... - Gene expression profiling of responses to dimethylarsinic acid in female F344 rat urotheliumBanalata Sen
US Environmental Protection Agency, National Health and Environmental Effects Laboratory, MD B143 06, 109 TW Alexander Drive, Research Triangle Park, NC 27711, USA
Toxicology 215:214-26. 2005..These data illustrate the utility of transcriptional profiling and its potential in predicting key mechanistic pathways involved in toxicity and as a time efficient tool to inform the mode of action analysis in risk assessment... - Toxicity profiles in mice treated with hepatotumorigenic and non-hepatotumorigenic triazole conazole fungicides: Propiconazole, triadimefon, and myclobutanilJames W Allen
Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Pathol 34:853-62. 2006..These findings serve to anchor other transcriptional profiling studies aimed at probing differences in key events and modes of action for tumorigenic and nontumorigenic conazoles... - Single or group housing altered hormonal physiology and affected pituitary and interstitial cell kineticsAbraham Nyska
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
J Toxicol Sci 27:449-57. 2002..This study indicates that the number of animals in a cage is associated with hormonal and cellular kinetic changes in the pituitary and testes, which could influence the incidence of tumors in these organs... - A mixture of ammonium perchlorate and sodium chlorate enhances alterations of the pituitary-thyroid axis caused by the individual chemicals in adult male F344 ratsMoazzam A Khan
National Research Council, Environmental Carcinogenesis Divisions, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Toxicol Pathol 33:776-83. 2005..1 + SC 1000, and AP 10 + SC 1000 mg/L). These data suggest that short-term exposure to the mixture of AP and SC enhances the effect of either chemical alone on the pituitary-thyroid axis in rats... - The transcriptional profile of the kidney in Tsc2 heterozygous mutant Long Evans (Eker) rats compared to wild-typeBanalata Sen
Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environment Protection Agency, Research Triangle Park, NC 27711, USA
Mutat Res 549:213-24. 2004.... - The carcinogenic response of Tsc2 mutant Long-Evans (Eker) rats to a mixture of drinking water disinfection by-products was less than additiveMichelle J Hooth
Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Sci 69:322-31. 2002..This study suggests that the default assumption of additivity may overestimate the carcinogenic effect of chemical mixtures in drinking water... - Induction of abasic sites by the drinking-water mutagen MX in Salmonella TA100Leon C King
Environmental Carcinogenesis Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Chem Biol Interact 180:340-3. 2009..001). These results provide some evidence for the ability of MX to induce abasic sites in cellular DNA. However, the lack of a dose response makes it unclear whether this DNA damage underlies the mutagenic activity of MX... - Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real timeJun Nakamura
Department of Environmental Sciences and Engineering, Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC 27599, USA
Nucleic Acids Res 31:e104. 2003..These results indicate that the analysis of intracellular NAD(P)H level using water-soluble tetrazolium salt can assess an imbalance of SSB repair in living cells in real time...