D J Dix

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi Inhibition of hsp70-1 and hsp70-3 expression disrupts preimplantation embryogenesis and heightens embryo sensitivity to arsenic
    D J Dix
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Mol Reprod Dev 51:373-80. 1998
  2. ncbi Hsp70 expression and function during gametogenesis
    D J Dix
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Cell Stress Chaperones 2:73-7. 1997
  3. ncbi Development of a 950-gene DNA array for examining gene expression patterns in mouse testis
    J C Rockett
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Genome Biol 2:RESEARCH0014. 2001
  4. ncbi Application of DNA arrays to toxicology
    J C Rockett
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 107:681-5. 1999
  5. ncbi Developmentally regulated expression of Hsp70-2 and a Hsp70-2/lacZ transgene during spermatogenesis
    D J Dix
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Dev Biol 174:310-21. 1996
  6. ncbi DNA arrays: technology, options and toxicological applications
    J C Rockett
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, NC 27711, USA
    Xenobiotica 30:155-77. 2000
  7. ncbi Heat shock proteins Hsp70-1 and Hsp70-3 Are necessary and sufficient to prevent arsenite-induced dysmorphology in mouse embryos
    E S Hunter
    Reproductive Toxicology Division, National Health and Environmental Effects Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Mol Reprod Dev 59:285-93. 2001
  8. ncbi Effects of hyperthermia on spermatogenesis, apoptosis, gene expression, and fertility in adult male mice
    J C Rockett
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Biol Reprod 65:229-39. 2001
  9. ncbi HSP70-2 is part of the synaptonemal complex in mouse and hamster spermatocytes
    J W Allen
    National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Chromosoma 104:414-21. 1996
  10. ncbi Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility
    D J Dix
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Proc Natl Acad Sci U S A 93:3264-8. 1996

Collaborators

Detail Information

Publications14

  1. ncbi Inhibition of hsp70-1 and hsp70-3 expression disrupts preimplantation embryogenesis and heightens embryo sensitivity to arsenic
    D J Dix
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Mol Reprod Dev 51:373-80. 1998
    ..However, these results clearly indicate that some minimal amount of Hsp70-1 and/or Hsp70-3 is required for preimplantation embryogenesis, and that increasing the demand for Hsp70s by arsenic exposure heightens this requirement...
  2. ncbi Hsp70 expression and function during gametogenesis
    D J Dix
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Cell Stress Chaperones 2:73-7. 1997
    ..Examining the expression and function of Hsp70s in germ cells has provided significant insights into mechanisms of hsp70 gene regulation and Hsp70 protein function, as well as the developmental processes of gametogenesis...
  3. ncbi Development of a 950-gene DNA array for examining gene expression patterns in mouse testis
    J C Rockett
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Genome Biol 2:RESEARCH0014. 2001
    ..We found that suppliers did not provide an array to suit our particular interest in testicular toxicology, and therefore elected to design and produce our own...
  4. ncbi Application of DNA arrays to toxicology
    J C Rockett
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 107:681-5. 1999
    ..Arrays may also prove useful for monitoring genetic variability and its relationship to toxicant susceptibility in human populations...
  5. ncbi Developmentally regulated expression of Hsp70-2 and a Hsp70-2/lacZ transgene during spermatogenesis
    D J Dix
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Dev Biol 174:310-21. 1996
    ....
  6. ncbi DNA arrays: technology, options and toxicological applications
    J C Rockett
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, NC 27711, USA
    Xenobiotica 30:155-77. 2000
    ..This review discusses the technology behind the production of DNA arrays, the options available to those interested in applying them to their own research, and the possible toxicological applications of this exciting new technology...
  7. ncbi Heat shock proteins Hsp70-1 and Hsp70-3 Are necessary and sufficient to prevent arsenite-induced dysmorphology in mouse embryos
    E S Hunter
    Reproductive Toxicology Division, National Health and Environmental Effects Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Mol Reprod Dev 59:285-93. 2001
    ..These results indicate that Hsp70-1 and Hsp70-3 are both necessary and sufficient for preventing arsenite-induced dysmorphology in early-somite staged mouse embryos. Mol. Reprod. Dev. 59:285-293, 2001...
  8. ncbi Effects of hyperthermia on spermatogenesis, apoptosis, gene expression, and fertility in adult male mice
    J C Rockett
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Biol Reprod 65:229-39. 2001
    ..Thus, the array data identify numerous candidate genes for further analysis in the heat-shocked testis model, and suggest multiple possible mechanisms for heat shock-induced infertility...
  9. ncbi HSP70-2 is part of the synaptonemal complex in mouse and hamster spermatocytes
    J W Allen
    National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Chromosoma 104:414-21. 1996
    ..These findings are suggestive of a previously unsuspected sexual dimorphism in structure and/or function of the synaptonemal complex...
  10. ncbi Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility
    D J Dix
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Proc Natl Acad Sci U S A 93:3264-8. 1996
    ..These results suggest that HSP70-2 participates in synaptonemal complex function during meiosis in male germ cells and is linked to mechanisms that inhibit apoptosis...
  11. ncbi HSP70-2 is required for desynapsis of synaptonemal complexes during meiotic prophase in juvenile and adult mouse spermatocytes
    D J Dix
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Development 124:4595-603. 1997
    ....
  12. ncbi HSP70-2 is required for CDC2 kinase activity in meiosis I of mouse spermatocytes
    D Zhu
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Development 124:3007-14. 1997
    ..These studies provide novel in vivo evidence for a link between an HSP70 molecular chaperone and CDC2 kinase activity essential for the meiotic cell cycle in spermatogenesis...
  13. ncbi Expression of inducible Hsp70 enhances the proliferation of MCF-7 breast cancer cells and protects against the cytotoxic effects of hyperthermia
    J A Barnes
    National Research Council, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Cell Stress Chaperones 6:316-25. 2001
    ..The results of this study support existing evidence linking Hsp70 expression with cell growth and cytoprotection in human cancer cells...
  14. ncbi Effects of heat shock protein 70 (Hsp70) on arsenite-induced genotoxicity
    J A Barnes
    National Research Council, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Mol Mutagen 40:236-42. 2002
    ..We conclude that the dose and duration of As exposure influence the type as well as amount of chromosomal alteration produced and that inducible Hsp70 protects against both the clastogenic and aneugenic effects of this chemical...